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Entry version 217 (29 Sep 2021)
Sequence version 3 (30 Nov 2010)
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Protein

Glycine--tRNA ligase

Gene

GARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252).

Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017).

4 Publications

Miscellaneous

Human GlyRS uses direct ATP condensation to synthesize Ap4A, a unique amino acid-independent mechanism, in contrast to the classical amino acid-dependent mechanism for synthesis of Ap4A by a tRNA synthetase, that involves the generation of an enzyme-bound aminoacyl-AMP which is then attacked by ATP to form Ap4A.1 Publication

Caution

According to a report, variant Leu-635 induces reduced activity (PubMed:17544401). According to another report, it does not affect function (PubMed:25168514).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Ap4A synthesis is inhibited by tRNA, via the disruption of the second ATP-binding site by direct blocking and/or by tRNA-induced conformational change.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.049 sec(-1) for aminoacylation of tRNA(Gly).1 Publication
  1. KM=1.3 µM for tRNA(Gly(GCC))1 Publication
  2. KM=15 µM for glycine1 Publication
  3. KM=0.74 µM for tRNA(Gly)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei299GlycineCombined sources1 Publication2 Publications1
Binding sitei350GlycineCombined sources1 Publication2 Publications1
Binding sitei583ATPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi331 – 333ATPCombined sources2 Publications1 Publication3
Nucleotide bindingi342 – 343ATPCombined sources1 Publication2
Nucleotide bindingi457 – 458ATPCombined sources2 Publications1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Hydrolase, Ligase, Transferase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.14, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P41250

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-379716, Cytosolic tRNA aminoacylation
R-HSA-379726, Mitochondrial tRNA aminoacylation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P41250

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
P41250

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycine--tRNA ligase (EC:6.1.1.143 Publications)
Alternative name(s):
Diadenosine tetraphosphate synthetase1 Publication (EC:2.7.7.-1 Publication)
Short name:
Ap4A synthetase1 Publication
Glycyl-tRNA synthetase1 Publication
Short name:
GlyRS1 Publication
Glycyl-tRNA synthetase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GARS1Imported
Synonyms:GARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4162, GARS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600287, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41250

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000106105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Mitochondrion, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease 2D (CMT2D)10 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073187111A → V in CMT2D; shows a reduction in aminoacylation activity. 2 PublicationsCorresponds to variant dbSNP:rs370531212EnsemblClinVar.1
Natural variantiVAR_018718125E → G in CMT2D; phenotype overlapping with HMN5A; complements the defect of the wild-type gene in yeast; contrary to the wild-type protein, strongly binds to NRP1 and competes with VEGFA for NRP1-binding; displays slightly elevated aminoacylation activity over wild-type. 5 PublicationsCorresponds to variant dbSNP:rs137852645EnsemblClinVar.1
Natural variantiVAR_073188200D → N in CMT2D and HMN5A; shows a large reduction in aminoacylation activity. 2 PublicationsCorresponds to variant dbSNP:rs1554337369EnsemblClinVar.1
Natural variantiVAR_074016200D → Y in CMT2D. 1 Publication1
Natural variantiVAR_073189265S → F in CMT2D and HMN5A; shows a large reduction in aminoacylation activity; demonstrates a change in the subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs1554337974EnsemblClinVar.1
Natural variantiVAR_085141265S → Y in CMT2D; unknown pathological significance. 1 Publication1
Natural variantiVAR_074017292M → R in CMT2D. 1 PublicationCorresponds to variant dbSNP:rs1064795123EnsemblClinVar.1
Natural variantiVAR_018720294G → R in CMT2D; shows a large reduction in aminoacylation activity; does not impair transcription or translation or protein stability; contrary to the wild-type protein, strongly interacts with NRP1. 4 PublicationsCorresponds to variant dbSNP:rs137852643EnsemblClinVar.1
Natural variantiVAR_073190298P → L in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs137852648EnsemblClinVar.1
Natural variantiVAR_073191334I → F in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs1554338260EnsemblClinVar.1
Natural variantiVAR_073193554D → N in CMT2D; demonstrates no change in subcellular location pattern. 1 PublicationCorresponds to variant dbSNP:rs137852647EnsemblClinVar.1
Natural variantiVAR_073195652G → A in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs747080824EnsemblClinVar.1
Neuronopathy, distal hereditary motor, 5A (HMN5A)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018719183L → P in HMN5A; does not complement the defect of the wild-type gene in yeast; contrary to the wild-type protein, strongly interacts with NRP1. 4 PublicationsCorresponds to variant dbSNP:rs137852644EnsemblClinVar.1
Natural variantiVAR_073188200D → N in CMT2D and HMN5A; shows a large reduction in aminoacylation activity. 2 PublicationsCorresponds to variant dbSNP:rs1554337369EnsemblClinVar.1
Natural variantiVAR_073189265S → F in CMT2D and HMN5A; shows a large reduction in aminoacylation activity; demonstrates a change in the subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs1554337974EnsemblClinVar.1
Natural variantiVAR_073192472H → R in HMN5A; shows a large reduction in aminoacylation activity; does not complement the defect of the wild-type gene in yeast. 3 PublicationsCorresponds to variant dbSNP:rs1060502838EnsemblClinVar.1
Natural variantiVAR_018721580G → R in HMN5A; higher dimerization stability; loss of activity; shows a large reduction in aminoacylation activity. 4 PublicationsCorresponds to variant dbSNP:rs137852646EnsemblClinVar.1
Natural variantiVAR_079829598G → A in HMN5A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766280100Ensembl.1
Spinal muscular atrophy, infantile, James type (SMAJI)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of spinal muscular atrophy, a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAJI is a severe disease characterized by hypotonia manifesting in the first weeks or months of life, delayed motor development, motor regression, and muscle weakness and atrophy primarily affecting distal muscles. Additional variable features include feeding difficulties, poor overall growth, foot deformities, kyphosis, hyperlordosis, scoliosis, vocal cord dysfunction, and respiratory insufficiency.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_085142334I → N in SMAJI; loss of function; based on yeast complementation assay. 1 Publication1
Natural variantiVAR_085143652G → R in SMAJI. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi121R → A: Decrease in catalytic activity by about 10-fold. 1 Publication1
Mutagenesisi211C → R: Displays 62% of wild-type catalytic activity. Displays 20% of wild-type catalytic activity; when associated with G-125. 1 Publication1
Mutagenesisi337R → A: Decrease in catalytic activity by more than 10-fold. 1 Publication1
Mutagenesisi486 – 490Missing : Loss of catalytic activity. 1 Publication5
Mutagenesisi602R → A: Decrease in catalytic activity by more than 10-fold. 1 Publication1
Mutagenesisi658Y → F: Decrease in catalytic activity by more than 10-fold. 1 Publication1
Mutagenesisi729Q → A or N: Decrease in catalytic activity by about 10-fold. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
2617

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
GARS1

MalaCards human disease database

More...
MalaCardsi
GARS1
MIMi600794, phenotype
601472, phenotype
619042, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106105

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99938, Autosomal dominant Charcot-Marie-Tooth disease type 2D
139536, Distal hereditary motor neuropathy type 5

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28575

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P41250, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105815

Drug and drug target database

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DrugBanki
DB00145, Glycine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GARS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 36MitochondrionSequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007299837 – 739Glycine--tRNA ligaseSequence analysisAdd BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35PhosphoserineCombined sources1
Modified residuei204N6-acetyllysineCombined sources1
Modified residuei453PhosphotyrosineBy similarity1
Modified residuei501N6-acetyllysineCombined sources1
Modified residuei700PhosphoserineBy similarity1
Modified residuei736PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P41250

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P41250

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P41250

MaxQB - The MaxQuant DataBase

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MaxQBi
P41250

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P41250

PeptideAtlas

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PeptideAtlasi
P41250

PRoteomics IDEntifications database

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PRIDEi
P41250

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55453

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P41250, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P41250

MetOSite database of methionine sulfoxide sites

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MetOSitei
P41250

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P41250

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P41250

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in brain and spinal cord.1 Publication
Expressed in brain, spinal cord, muscle, heart and spleen.1 Publication
Expressed in brain, spinal cord, muscle, heart, spleen and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000106105, Expressed in secondary oocyte and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P41250, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41250, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000106105, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108887, 150 interactors

Database of interacting proteins

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DIPi
DIP-50471N

Protein interaction database and analysis system

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IntActi
P41250, 37 interactors

Molecular INTeraction database

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MINTi
P41250

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373918

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P41250, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41250

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P41250

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 119WHEP-TRSPROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni576 – 578Glycine bindingCombined sources2 Publications3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2298, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_015515_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41250

Identification of Orthologs from Complete Genome Data

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OMAi
EPSYGID

Database of Orthologous Groups

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OrthoDBi
1183820at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P41250

TreeFam database of animal gene trees

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TreeFami
TF343504

Family and domain databases

Conserved Domains Database

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CDDi
cd00774, GlyRS-like_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.800, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR027031, Gly-tRNA_synthase/POLG2
IPR033731, GlyRS-like_core
IPR009068, S15_NS1_RNA-bd
IPR002315, tRNA-synt_gly
IPR000738, WHEP-TRS_dom

The PANTHER Classification System

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PANTHERi
PTHR10745, PTHR10745, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF00458, WHEP-TRS, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01043, TRNASYNTHGLY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00991, WHEP-TRS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47060, SSF47060, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00389, glyS_dimeric, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit
PS00762, WHEP_TRS_1, 1 hit
PS51185, WHEP_TRS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: P41250-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSPRPVLLR GARAALLLLL PPRLLARPSL LLRRSLSAAS CPPISLPAAA
60 70 80 90 100
SRSSMDGAGA EEVLAPLRLA VRQQGDLVRK LKEDKAPQVD VDKAVAELKA
110 120 130 140 150
RKRVLEAKEL ALQPKDDIVD RAKMEDTLKR RFFYDQAFAI YGGVSGLYDF
160 170 180 190 200
GPVGCALKNN IIQTWRQHFI QEEQILEIDC TMLTPEPVLK TSGHVDKFAD
210 220 230 240 250
FMVKDVKNGE CFRADHLLKA HLQKLMSDKK CSVEKKSEME SVLAQLDNYG
260 270 280 290 300
QQELADLFVN YNVKSPITGN DLSPPVSFNL MFKTFIGPGG NMPGYLRPET
310 320 330 340 350
AQGIFLNFKR LLEFNQGKLP FAAAQIGNSF RNEISPRSGL IRVREFTMAE
360 370 380 390 400
IEHFVDPSEK DHPKFQNVAD LHLYLYSAKA QVSGQSARKM RLGDAVEQGV
410 420 430 440 450
INNTVLGYFI GRIYLYLTKV GISPDKLRFR QHMENEMAHY ACDCWDAESK
460 470 480 490 500
TSYGWIEIVG CADRSCYDLS CHARATKVPL VAEKPLKEPK TVNVVQFEPS
510 520 530 540 550
KGAIGKAYKK DAKLVMEYLA ICDECYITEM EMLLNEKGEF TIETEGKTFQ
560 570 580 590 600
LTKDMINVKR FQKTLYVEEV VPNVIEPSFG LGRIMYTVFE HTFHVREGDE
610 620 630 640 650
QRTFFSFPAV VAPFKCSVLP LSQNQEFMPF VKELSEALTR HGVSHKVDDS
660 670 680 690 700
SGSIGRRYAR TDEIGVAFGV TIDFDTVNKT PHTATLRDRD SMRQIRAEIS
710 720 730
ELPSIVQDLA NGNITWADVE ARYPLFEGQE TGKKETIEE
Length:739
Mass (Da):83,166
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4C001CEBF985C59
GO
Isoform 2Curated (identifier: P41250-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: The isoform 2 translation is regulated by an Internal Ribosome Entry Site (IRES) and an upstream Open Reading Frame. Both are important in hindering the synthesis of the mitochondrial GARS and target the translation of the cytosolic enzyme to ER-bound ribosomes.1 Publication
Show »
Length:685
Mass (Da):77,531
Checksum:iD63AF159912F0750
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C443H7C443_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
570Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGZ8A0A6Q8PGZ8_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
745Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFZ6A0A6Q8PFZ6_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
546Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHI7A0A6Q8PHI7_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
606Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGA8A0A6Q8PGA8_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
683Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGI6A0A6Q8PGI6_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF45A0A6Q8PF45_HUMAN
Glycine--tRNA ligase
GARS1
350Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PH49A0A6Q8PH49_HUMAN
Glycine--tRNA ligase
GARS1
350Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHH9A0A6Q8PHH9_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
705Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGW4A0A6Q8PGW4_HUMAN
Diadenosine tetraphosphate syntheta...
GARS1
616Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA57001 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA86443 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 18Missing in BAG58412 (PubMed:14702039).Curated10
Sequence conflicti205D → G in BAG51964 (PubMed:14702039).Curated1
Sequence conflicti530M → I in AAA86443 (PubMed:7753621).Curated1
Sequence conflicti634L → S in BAG51964 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05486542P → ACombined sources5 PublicationsCorresponds to variant dbSNP:rs1049402EnsemblClinVar.1
Natural variantiVAR_073187111A → V in CMT2D; shows a reduction in aminoacylation activity. 2 PublicationsCorresponds to variant dbSNP:rs370531212EnsemblClinVar.1
Natural variantiVAR_018718125E → G in CMT2D; phenotype overlapping with HMN5A; complements the defect of the wild-type gene in yeast; contrary to the wild-type protein, strongly binds to NRP1 and competes with VEGFA for NRP1-binding; displays slightly elevated aminoacylation activity over wild-type. 5 PublicationsCorresponds to variant dbSNP:rs137852645EnsemblClinVar.1
Natural variantiVAR_018719183L → P in HMN5A; does not complement the defect of the wild-type gene in yeast; contrary to the wild-type protein, strongly interacts with NRP1. 4 PublicationsCorresponds to variant dbSNP:rs137852644EnsemblClinVar.1
Natural variantiVAR_073188200D → N in CMT2D and HMN5A; shows a large reduction in aminoacylation activity. 2 PublicationsCorresponds to variant dbSNP:rs1554337369EnsemblClinVar.1
Natural variantiVAR_074016200D → Y in CMT2D. 1 Publication1
Natural variantiVAR_073189265S → F in CMT2D and HMN5A; shows a large reduction in aminoacylation activity; demonstrates a change in the subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs1554337974EnsemblClinVar.1
Natural variantiVAR_085141265S → Y in CMT2D; unknown pathological significance. 1 Publication1
Natural variantiVAR_054866268T → I Found in a patient with mild left ventricular posterior wall hypertrophy, exercise intolerance and lactic acidosis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs2230310EnsemblClinVar.1
Natural variantiVAR_074017292M → R in CMT2D. 1 PublicationCorresponds to variant dbSNP:rs1064795123EnsemblClinVar.1
Natural variantiVAR_018720294G → R in CMT2D; shows a large reduction in aminoacylation activity; does not impair transcription or translation or protein stability; contrary to the wild-type protein, strongly interacts with NRP1. 4 PublicationsCorresponds to variant dbSNP:rs137852643EnsemblClinVar.1
Natural variantiVAR_073190298P → L in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs137852648EnsemblClinVar.1
Natural variantiVAR_079827310R → Q Probable disease-associated variant found in a patient with growth retardation, microcephaly, thinning of the corpus callosum, decreased white matter and brain stem involvement, as well as large calvaria, cerebellar vermis atrophy, dysmorphic features, prominent epicanthal folds, hypotelorism, high-arched palate, delayed motor milestones, apnea and sparse thin scalp hair; reduces to less than 1% aminoacylation activity. 1 PublicationCorresponds to variant dbSNP:rs1135401748EnsemblClinVar.1
Natural variantiVAR_073191334I → F in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs1554338260EnsemblClinVar.1
Natural variantiVAR_085142334I → N in SMAJI; loss of function; based on yeast complementation assay. 1 Publication1
Natural variantiVAR_054867388R → Q. Corresponds to variant dbSNP:rs17159287EnsemblClinVar.1
Natural variantiVAR_079828412R → C Found in a patient with mild left ventricular posterior wall hypertrophy, exercise intolerance and lactic acidosis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770924455EnsemblClinVar.1
Natural variantiVAR_073192472H → R in HMN5A; shows a large reduction in aminoacylation activity; does not complement the defect of the wild-type gene in yeast. 3 PublicationsCorresponds to variant dbSNP:rs1060502838EnsemblClinVar.1
Natural variantiVAR_073193554D → N in CMT2D; demonstrates no change in subcellular location pattern. 1 PublicationCorresponds to variant dbSNP:rs137852647EnsemblClinVar.1
Natural variantiVAR_018721580G → R in HMN5A; higher dimerization stability; loss of activity; shows a large reduction in aminoacylation activity. 4 PublicationsCorresponds to variant dbSNP:rs137852646EnsemblClinVar.1
Natural variantiVAR_079829598G → A in HMN5A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766280100Ensembl.1
Natural variantiVAR_073194635S → L Has no effect on subcellular localization; results in reduced activity. 3 PublicationsCorresponds to variant dbSNP:rs201358272EnsemblClinVar.1
Natural variantiVAR_073195652G → A in CMT2D; shows a large reduction in aminoacylation activity; demonstrates a change in subcellular location pattern; does not associate with granules. 2 PublicationsCorresponds to variant dbSNP:rs747080824EnsemblClinVar.1
Natural variantiVAR_085143652G → R in SMAJI. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0609701 – 54Missing in isoform 2. ImportedAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D30658 mRNA Translation: BAA06338.1
U09510 mRNA Translation: AAA86443.1 Different initiation.
AK074524 mRNA Translation: BAG51964.1
AK295490 mRNA Translation: BAG58412.1
AC005154 Genomic DNA No translation available.
AC006969 Genomic DNA No translation available.
AC004976 Genomic DNA Translation: AAC71652.1
AACC02000087 Genomic DNA Translation: EAL24449.1
BC007722 mRNA Translation: AAH07722.1
BC007755 mRNA Translation: AAH07755.1
U09587 mRNA Translation: AAA57001.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43564.1 [P41250-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A55314

NCBI Reference Sequences

More...
RefSeqi
NP_001303701.1, NM_001316772.1 [P41250-2]
NP_002038.2, NM_002047.3 [P41250-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389266; ENSP00000373918; ENSG00000106105 [P41250-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2617

UCSC genome browser

More...
UCSCi
uc003tbm.4, human [P41250-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30658 mRNA Translation: BAA06338.1
U09510 mRNA Translation: AAA86443.1 Different initiation.
AK074524 mRNA Translation: BAG51964.1
AK295490 mRNA Translation: BAG58412.1
AC005154 Genomic DNA No translation available.
AC006969 Genomic DNA No translation available.
AC004976 Genomic DNA Translation: AAC71652.1
AACC02000087 Genomic DNA Translation: EAL24449.1
BC007722 mRNA Translation: AAH07722.1
BC007755 mRNA Translation: AAH07755.1
U09587 mRNA Translation: AAA57001.1 Different initiation.
CCDSiCCDS43564.1 [P41250-1]
PIRiA55314
RefSeqiNP_001303701.1, NM_001316772.1 [P41250-2]
NP_002038.2, NM_002047.3 [P41250-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PMEX-ray2.90A55-739[»]
2PMFX-ray2.85A55-739[»]
2Q5HX-ray3.00A55-739[»]
2Q5IX-ray2.80A55-739[»]
2ZT5X-ray2.50A55-739[»]
2ZT6X-ray3.08A55-739[»]
2ZT7X-ray2.70A55-739[»]
2ZT8X-ray3.35A55-739[»]
2ZXFX-ray3.40A55-739[»]
4KQEX-ray2.74A55-739[»]
4KR2X-ray3.29A114-739[»]
4KR3X-ray3.24A114-739[»]
4QEIX-ray2.88A118-739[»]
5E6MX-ray2.93A/B55-739[»]
SMRiP41250
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108887, 150 interactors
DIPiDIP-50471N
IntActiP41250, 37 interactors
MINTiP41250
STRINGi9606.ENSP00000373918

Chemistry databases

ChEMBLiCHEMBL4105815
DrugBankiDB00145, Glycine

Protein family/group databases

MoonProtiP41250

PTM databases

GlyGeniP41250, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP41250
MetOSiteiP41250
PhosphoSitePlusiP41250
SwissPalmiP41250

Genetic variation databases

BioMutaiGARS
DMDMi313104283

Proteomic databases

EPDiP41250
jPOSTiP41250
MassIVEiP41250
MaxQBiP41250
PaxDbiP41250
PeptideAtlasiP41250
PRIDEiP41250
ProteomicsDBi55453

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P41250, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6744, 363 antibodies

The DNASU plasmid repository

More...
DNASUi
2617

Genome annotation databases

EnsembliENST00000389266; ENSP00000373918; ENSG00000106105 [P41250-1]
GeneIDi2617
KEGGihsa:2617
UCSCiuc003tbm.4, human [P41250-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2617
DisGeNETi2617

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GARS1
GeneReviewsiGARS1
HGNCiHGNC:4162, GARS1
HPAiENSG00000106105, Low tissue specificity
MalaCardsiGARS1
MIMi600287, gene
600794, phenotype
601472, phenotype
619042, phenotype
neXtProtiNX_P41250
OpenTargetsiENSG00000106105
Orphaneti99938, Autosomal dominant Charcot-Marie-Tooth disease type 2D
139536, Distal hereditary motor neuropathy type 5
PharmGKBiPA28575
VEuPathDBiHostDB:ENSG00000106105

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2298, Eukaryota
GeneTreeiENSGT00940000153759
HOGENOMiCLU_015515_1_0_1
InParanoidiP41250
OMAiEPSYGID
OrthoDBi1183820at2759
PhylomeDBiP41250
TreeFamiTF343504

Enzyme and pathway databases

BRENDAi6.1.1.14, 2681
PathwayCommonsiP41250
ReactomeiR-HSA-379716, Cytosolic tRNA aminoacylation
R-HSA-379726, Mitochondrial tRNA aminoacylation
SABIO-RKiP41250

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2617, 774 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GARS, human
EvolutionaryTraceiP41250

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Glycine%E2%80%94tRNA_ligase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2617
PharosiP41250, Tbio

Protein Ontology

More...
PROi
PR:P41250
RNActiP41250, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106105, Expressed in secondary oocyte and 250 other tissues
ExpressionAtlasiP41250, baseline and differential
GenevisibleiP41250, HS

Family and domain databases

CDDicd00774, GlyRS-like_core, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR027031, Gly-tRNA_synthase/POLG2
IPR033731, GlyRS-like_core
IPR009068, S15_NS1_RNA-bd
IPR002315, tRNA-synt_gly
IPR000738, WHEP-TRS_dom
PANTHERiPTHR10745, PTHR10745, 1 hit
PfamiView protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF00458, WHEP-TRS, 1 hit
PRINTSiPR01043, TRNASYNTHGLY
SMARTiView protein in SMART
SM00991, WHEP-TRS, 1 hit
SUPFAMiSSF47060, SSF47060, 1 hit
TIGRFAMsiTIGR00389, glyS_dimeric, 1 hit
PROSITEiView protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit
PS00762, WHEP_TRS_1, 1 hit
PS51185, WHEP_TRS_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGARS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41250
Secondary accession number(s): A0A090N8G0
, B3KQA2, B4DIA0, Q969Y1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 30, 2010
Last modified: September 29, 2021
This is version 217 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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