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Entry version 142 (13 Feb 2019)
Sequence version 3 (17 Oct 2006)
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Protein

Patatin-like phospholipase domain-containing protein 4

Gene

PNPLA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid hydrolase.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43NucleophilePROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163560 Triglyceride catabolism

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000312

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Patatin-like phospholipase domain-containing protein 4 (EC:3.1.1.3)
Alternative name(s):
Protein GS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNPLA4
Synonyms:DXS1283E, GS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000006757.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24887 PNPLA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300102 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41247

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in PNPLA4 may play a role in mitochondrial disorders characterized by complex IV deficiency.1 Publication

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
8228

Open Targets

More...
OpenTargetsi
ENSG00000006757

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134910531

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNPLA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584601 – 253Patatin-like phospholipase domain-containing protein 4Add BLAST253

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41247

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P41247

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41247

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41247

PeptideAtlas

More...
PeptideAtlasi
P41247

PRoteomics IDEntifications database

More...
PRIDEi
P41247

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55451
55452 [P41247-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined, including heart, brain, placenta, lung, liver, muscle, kidney, pancreas and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000006757 Expressed in 212 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41247 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41247 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003656

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113861, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370430

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P41247

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 176PNPLAPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi41 – 45GXSXGPROSITE-ProRule annotation5
Motifi163 – 165DGA/GPROSITE-ProRule annotation3

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3773 Eukaryota
ENOG410XSQS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007467

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053620

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41247

KEGG Orthology (KO)

More...
KOi
K11157

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYKGQKW

Database of Orthologous Groups

More...
OrthoDBi
1204225at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41247

TreeFam database of animal gene trees

More...
TreeFami
TF314272

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07222 Pat_PNPLA4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR033562 PLPL
IPR033902 PNPLA4
IPR002641 PNPLA_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12406 PTHR12406, 1 hit
PTHR12406:SF39 PTHR12406:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01734 Patatin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52151 SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51635 PNPLA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P41247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKHINLSFAA CGFLGIYHLG AASALCRHGK KLVKDVKAFA GASAGSLVAS
60 70 80 90 100
VLLTAPEKIE ECNQFTYKFA EEIRRQSFGA VTPGYDFMAR LRSGMESILP
110 120 130 140 150
PSAHELAQNR LHVSITNAKT RENHLVSTFS SREDLIKVLL ASSFVPIYAG
160 170 180 190 200
LKLVEYKGQK WVDGGLTNAL PILPVGRTVT ISPFSGRLDI SPQDKGQLDL
210 220 230 240 250
YVNIAKQDIM LSLANLVRLN QALFPPSKRK MESLYQCGFD DTVKFLLKEN

WFE
Length:253
Mass (Da):27,980
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FFA94F460BA03AC
GO
Isoform 2 (identifier: P41247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: No experimental confirmation available.
Show »
Length:166
Mass (Da):18,629
Checksum:i10EC3F315041F786
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZF6C9IZF6_HUMAN
Patatin-like phospholipase domain-c...
PNPLA4
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02806848V → G1 PublicationCorresponds to variant dbSNP:rs17856615Ensembl.1
Natural variantiVAR_053816113V → I. Corresponds to variant dbSNP:rs2231791Ensembl.1
Natural variantiVAR_028069134D → G1 PublicationCorresponds to variant dbSNP:rs17851825Ensembl.1
Natural variantiVAR_028070187R → Q. Corresponds to variant dbSNP:rs2231793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430891 – 87Missing in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03886 mRNA Translation: AAA16491.1
U08893
, U08888, U08889, U08890, U08891, U08892 Genomic DNA Translation: AAA17838.1
AK289888 mRNA Translation: BAF82577.1
AK304586 mRNA Translation: BAG65374.1
AC005296 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98752.1
BC020746 mRNA Translation: AAH20746.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14129.1 [P41247-1]
CCDS55368.1 [P41247-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A55183

NCBI Reference Sequences

More...
RefSeqi
NP_001135861.1, NM_001142389.1 [P41247-1]
NP_001166143.1, NM_001172672.1 [P41247-2]
NP_004641.1, NM_004650.2 [P41247-1]
XP_011543890.1, XM_011545588.1 [P41247-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.264

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381042; ENSP00000370430; ENSG00000006757 [P41247-1]
ENST00000444736; ENSP00000415245; ENSG00000006757 [P41247-1]
ENST00000537427; ENSP00000443157; ENSG00000006757 [P41247-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8228

UCSC genome browser

More...
UCSCi
uc011mhq.2 human [P41247-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03886 mRNA Translation: AAA16491.1
U08893
, U08888, U08889, U08890, U08891, U08892 Genomic DNA Translation: AAA17838.1
AK289888 mRNA Translation: BAF82577.1
AK304586 mRNA Translation: BAG65374.1
AC005296 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98752.1
BC020746 mRNA Translation: AAH20746.1
CCDSiCCDS14129.1 [P41247-1]
CCDS55368.1 [P41247-2]
PIRiA55183
RefSeqiNP_001135861.1, NM_001142389.1 [P41247-1]
NP_001166143.1, NM_001172672.1 [P41247-2]
NP_004641.1, NM_004650.2 [P41247-1]
XP_011543890.1, XM_011545588.1 [P41247-1]
UniGeneiHs.264

3D structure databases

ProteinModelPortaliP41247
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113861, 5 interactors
STRINGi9606.ENSP00000370430

Chemistry databases

SwissLipidsiSLP:000000312

PTM databases

iPTMnetiP41247
PhosphoSitePlusiP41247

Polymorphism and mutation databases

BioMutaiPNPLA4
DMDMi116242718

Proteomic databases

EPDiP41247
jPOSTiP41247
MaxQBiP41247
PaxDbiP41247
PeptideAtlasiP41247
PRIDEiP41247
ProteomicsDBi55451
55452 [P41247-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381042; ENSP00000370430; ENSG00000006757 [P41247-1]
ENST00000444736; ENSP00000415245; ENSG00000006757 [P41247-1]
ENST00000537427; ENSP00000443157; ENSG00000006757 [P41247-2]
GeneIDi8228
KEGGihsa:8228
UCSCiuc011mhq.2 human [P41247-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8228
DisGeNETi8228
EuPathDBiHostDB:ENSG00000006757.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PNPLA4
HGNCiHGNC:24887 PNPLA4
HPAiHPA003656
MIMi300102 gene
neXtProtiNX_P41247
OpenTargetsiENSG00000006757
PharmGKBiPA134910531

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3773 Eukaryota
ENOG410XSQS LUCA
GeneTreeiENSGT00940000162022
HOGENOMiHOG000007467
HOVERGENiHBG053620
InParanoidiP41247
KOiK11157
OMAiEYKGQKW
OrthoDBi1204225at2759
PhylomeDBiP41247
TreeFamiTF314272

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8228

Protein Ontology

More...
PROi
PR:P41247

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000006757 Expressed in 212 organ(s), highest expression level in oocyte
ExpressionAtlasiP41247 baseline and differential
GenevisibleiP41247 HS

Family and domain databases

CDDicd07222 Pat_PNPLA4, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR033562 PLPL
IPR033902 PNPLA4
IPR002641 PNPLA_dom
PANTHERiPTHR12406 PTHR12406, 1 hit
PTHR12406:SF39 PTHR12406:SF39, 1 hit
PfamiView protein in Pfam
PF01734 Patatin, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51635 PNPLA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41247
Secondary accession number(s): A8K1H3, B4E362, Q8WW83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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