UniProtKB - P41243 (MATK_RAT)
Protein
Megakaryocyte-associated tyrosine-protein kinase
Gene
Matk
Organism
Rattus norvegicus (Rat)
Status
Functioni
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 221 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 311 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 200 – 208 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 |
Reactomei | R-RNO-8863795, Downregulation of ERBB2 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Megakaryocyte-associated tyrosine-protein kinase (EC:2.7.10.2)Alternative name(s): Protein kinase BATK Tyrosine-protein kinase CTK |
Gene namesi | Name:Matk Synonyms:Batk, Ctk |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69058, Matk |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088075 | 1 – 467 | Megakaryocyte-associated tyrosine-protein kinaseAdd BLAST | 467 |
Proteomic databases
PaxDbi | P41243 |
PRIDEi | P41243 |
PTM databases
iPTMneti | P41243 |
PhosphoSitePlusi | P41243 |
Expressioni
Tissue specificityi
Enriched in lymphoid tissues.
Gene expression databases
Bgeei | ENSRNOG00000020431, Expressed in frontal cortex and 21 other tissues |
Genevisiblei | P41243, RN |
Interactioni
Subunit structurei
Interacts with KIT.
By similarityProtein-protein interaction databases
BioGRIDi | 248843, 1 interactor |
IntActi | P41243, 1 interactor |
STRINGi | 10116.ENSRNOP00000027730 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 69 | SH3PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 81 – 170 | SH2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 194 – 443 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 250 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.PROSITE-ProRule annotation
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000160775 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P41243 |
OMAi | WHPSPIS |
OrthoDBi | 491765at2759 |
PhylomeDBi | P41243 |
Family and domain databases
CDDi | cd09937, SH2_csk_like, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035027, Csk-like_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
P41243-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH
60 70 80 90 100
HSSGQEGLLA AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED
110 120 130 140 150
GLFLVRESAR HPGDYVLCVS FGRDVIHYRV LHRDGHLTID EAVCFCNLMD
160 170 180 190 200
MVEHYTRDKG AICTKLVKPK RKQGAKSAEE ELAKAGWLLD LQHLTLGAQI
210 220 230 240 250
GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT KLQHRNLVRL
260 270 280 290 300
LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME
310 320 330 340 350
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW
360 370 380 390 400
TAPEALKNGR FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG
410 420 430 440 450
YRMEPPDSCP GPVHTLMGSC WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP
460
AGGQEAEGSA PTRSQDP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L34542 Genomic DNA Translation: AAA64524.1 BC087726 mRNA Translation: AAH87726.1 |
PIRi | I56579 |
RefSeqi | NP_068631.1, NM_021859.2 XP_006241051.1, XM_006240989.3 XP_006241052.1, XM_006240990.3 XP_008763350.1, XM_008765128.2 |
Genome annotation databases
Ensembli | ENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431 |
GeneIDi | 60450 |
KEGGi | rno:60450 |
UCSCi | RGD:69058, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L34542 Genomic DNA Translation: AAA64524.1 BC087726 mRNA Translation: AAH87726.1 |
PIRi | I56579 |
RefSeqi | NP_068631.1, NM_021859.2 XP_006241051.1, XM_006240989.3 XP_006241052.1, XM_006240990.3 XP_008763350.1, XM_008765128.2 |
3D structure databases
BMRBi | P41243 |
SMRi | P41243 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248843, 1 interactor |
IntActi | P41243, 1 interactor |
STRINGi | 10116.ENSRNOP00000027730 |
PTM databases
iPTMneti | P41243 |
PhosphoSitePlusi | P41243 |
Proteomic databases
PaxDbi | P41243 |
PRIDEi | P41243 |
Genome annotation databases
Ensembli | ENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431 |
GeneIDi | 60450 |
KEGGi | rno:60450 |
UCSCi | RGD:69058, rat |
Organism-specific databases
CTDi | 4145 |
RGDi | 69058, Matk |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000160775 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P41243 |
OMAi | WHPSPIS |
OrthoDBi | 491765at2759 |
PhylomeDBi | P41243 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 |
Reactomei | R-RNO-8863795, Downregulation of ERBB2 signaling |
Miscellaneous databases
PROi | PR:P41243 |
Gene expression databases
Bgeei | ENSRNOG00000020431, Expressed in frontal cortex and 21 other tissues |
Genevisiblei | P41243, RN |
Family and domain databases
CDDi | cd09937, SH2_csk_like, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035027, Csk-like_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MATK_RAT | |
Accessioni | P41243Primary (citable) accession number: P41243 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families