UniProtKB - P41240 (CSK_HUMAN)
Tyrosine-protein kinase CSK
CSK
Functioni
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
2 PublicationsCatalytic activityi
- EC:2.7.10.23 Publications
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 222 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 314 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 201 – 209 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: ProtInc
- protein kinase A catalytic subunit binding Source: UniProtKB
- protein phosphatase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- adherens junction organization Source: GO_Central
- brain development Source: Ensembl
- cellular response to peptide hormone stimulus Source: Ensembl
- negative regulation of bone resorption Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- negative regulation of Golgi to plasma membrane protein transport Source: UniProtKB
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of kinase activity Source: Ensembl
- negative regulation of low-density lipoprotein particle clearance Source: Ensembl
- negative regulation of phagocytosis Source: Ensembl
- oligodendrocyte differentiation Source: Ensembl
- positive regulation of MAP kinase activity Source: Ensembl
- protein autophosphorylation Source: Ensembl
- protein phosphorylation Source: ProtInc
- regulation of Fc receptor mediated stimulatory signaling pathway Source: GO_Central
- T cell costimulation Source: Reactome
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P41240 |
Reactomei | R-HSA-180292, GAB1 signalosome R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-354192, Integrin signaling R-HSA-389948, PD-1 signaling R-HSA-5674135, MAP2K and MAPK activation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9013407, RHOH GTPase cycle R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9706369, Negative regulation of FLT3 |
SignaLinki | P41240 |
SIGNORi | P41240 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase CSK (EC:2.7.10.23 Publications)Alternative name(s): C-Src kinase Protein-tyrosine kinase CYL |
Gene namesi | Name:CSK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2444, CSK |
MIMi | 124095, gene |
neXtProti | NX_P41240 |
VEuPathDBi | HostDB:ENSG00000103653 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity
Note: Mainly cytoplasmic, also present in lipid rafts.By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell-cell junction Source: Ensembl
- cytoplasm Source: UniProtKB
- membrane raft Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 184 | Y → F: Abolishes phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 304 | Y → F: Decreases activity by two-thirds and alters conformation. 1 Publication | 1 | |
Mutagenesisi | 364 | S → A: Strong decrease of phosphorylation by PRKACA (catalytic subunit of PKA). 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1445 |
OpenTargetsi | ENSG00000103653 |
PharmGKBi | PA26946 |
Miscellaneous databases
Pharosi | P41240, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2634 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib DB02010, Staurosporine DB05075, TG-100801 |
DrugCentrali | P41240 |
GuidetoPHARMACOLOGYi | 1994 |
Genetic variation databases
BioMutai | CSK |
DMDMi | 729887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000088070 | 2 – 450 | Tyrosine-protein kinase CSKAdd BLAST | 449 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 184 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 304 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 364 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 416 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P41240 |
jPOSTi | P41240 |
MassIVEi | P41240 |
MaxQBi | P41240 |
PaxDbi | P41240 |
PeptideAtlasi | P41240 |
PRIDEi | P41240 |
ProteomicsDBi | 55450 |
2D gel databases
OGPi | P41240 |
PTM databases
GlyGeni | P41240, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P41240 |
MetOSitei | P41240 |
PhosphoSitePlusi | P41240 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000103653, Expressed in granulocyte and 233 other tissues |
ExpressionAtlasi | P41240, baseline and differential |
Genevisiblei | P41240, HS |
Organism-specific databases
HPAi | ENSG00000103653, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Homodimer (via SH3-domain) (PubMed:19888460).
Interacts with PTPN22 (PubMed:15208781).
Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081).
Interacts with SRCIN1 (PubMed:17525734).
Interacts with RHOH (PubMed:20851766).
Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-107' (PubMed:21930792).
Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity).
By similarity8 PublicationsBinary interactionsi
P41240
GO - Molecular functioni
- identical protein binding Source: IntAct
- proline-rich region binding Source: Ensembl
- protein C-terminus binding Source: ProtInc
- protein kinase A catalytic subunit binding Source: UniProtKB
- protein phosphatase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107832, 810 interactors |
ELMi | P41240 |
IntActi | P41240, 83 interactors |
MINTi | P41240 |
STRINGi | 9606.ENSP00000220003 |
Chemistry databases
BindingDBi | P41240 |
Miscellaneous databases
RNActi | P41240, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P41240 |
SMRi | P41240 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P41240 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 70 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 82 – 171 | SH2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 195 – 449 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 255 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 9 – 70 | Interaction with PTPN22By similarityAdd BLAST | 62 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157431 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P41240 |
OMAi | IVYEVMK |
PhylomeDBi | P41240 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd09937, SH2_csk_like, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035027, Csk-like_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA
60 70 80 90 100
KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE
110 120 130 140 150
TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM
160 170 180 190 200
QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT
210 220 230 240 250
IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ
260 270 280 290 300
LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE
310 320 330 340 350
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV
360 370 380 390 400
KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE
410 420 430 440 450
KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BU69 | H3BU69_HUMAN | Tyrosine-protein kinase CSK | CSK | 68 | Annotation score: | ||
H3BUM9 | H3BUM9_HUMAN | Tyrosine-protein kinase CSK | CSK | 110 | Annotation score: | ||
H3BN15 | H3BN15_HUMAN | Tyrosine-protein kinase CSK | CSK | 64 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041678 | 45 | P → L1 Publication | 1 | |
Natural variantiVAR_025203 | 287 | G → D1 PublicationCorresponds to variant dbSNP:rs34866753EnsemblClinVar. | 1 | |
Natural variantiVAR_025204 | 398 | R → Q1 PublicationCorresponds to variant dbSNP:rs34616395Ensembl. | 1 | |
Natural variantiVAR_025205 | 442 | H → R1 PublicationCorresponds to variant dbSNP:rs35556162Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60114 mRNA Translation: CAA42713.1 X59932 mRNA Translation: CAA42556.1 X74765 Genomic DNA Translation: CAB58562.1 CR541960 mRNA Translation: CAG46758.1 DQ075211 Genomic DNA Translation: AAY57329.1 BC104847 mRNA Translation: AAI04848.1 BC104875 mRNA Translation: AAI04876.1 BC106073 mRNA Translation: AAI06074.1 |
CCDSi | CCDS10269.1 |
PIRi | JH0559 |
RefSeqi | NP_001120662.1, NM_001127190.1 NP_004374.1, NM_004383.2 XP_005254222.1, XM_005254165.4 XP_016877414.1, XM_017021925.1 |
Genome annotation databases
Ensembli | ENST00000220003; ENSP00000220003; ENSG00000103653 ENST00000439220; ENSP00000414764; ENSG00000103653 ENST00000567571; ENSP00000454906; ENSG00000103653 |
GeneIDi | 1445 |
KEGGi | hsa:1445 |
MANE-Selecti | ENST00000220003.14; ENSP00000220003.9; NM_004383.3; NP_004374.1 |
UCSCi | uc002ays.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60114 mRNA Translation: CAA42713.1 X59932 mRNA Translation: CAA42556.1 X74765 Genomic DNA Translation: CAB58562.1 CR541960 mRNA Translation: CAG46758.1 DQ075211 Genomic DNA Translation: AAY57329.1 BC104847 mRNA Translation: AAI04848.1 BC104875 mRNA Translation: AAI04876.1 BC106073 mRNA Translation: AAI06074.1 |
CCDSi | CCDS10269.1 |
PIRi | JH0559 |
RefSeqi | NP_001120662.1, NM_001127190.1 NP_004374.1, NM_004383.2 XP_005254222.1, XM_005254165.4 XP_016877414.1, XM_017021925.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BYG | X-ray | 2.40 | A | 173-450 | [»] | |
1CSK | X-ray | 2.50 | A/B/C/D | 1-71 | [»] | |
3D7T | X-ray | 2.90 | A | 188-450 | [»] | |
3D7U | X-ray | 4.11 | A/C | 188-450 | [»] | |
3EAC | X-ray | 1.37 | A | 73-178 | [»] | |
3EAZ | X-ray | 1.31 | A | 73-178 | [»] | |
BMRBi | P41240 | |||||
SMRi | P41240 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107832, 810 interactors |
ELMi | P41240 |
IntActi | P41240, 83 interactors |
MINTi | P41240 |
STRINGi | 9606.ENSP00000220003 |
Chemistry databases
BindingDBi | P41240 |
ChEMBLi | CHEMBL2634 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib DB02010, Staurosporine DB05075, TG-100801 |
DrugCentrali | P41240 |
GuidetoPHARMACOLOGYi | 1994 |
PTM databases
GlyGeni | P41240, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P41240 |
MetOSitei | P41240 |
PhosphoSitePlusi | P41240 |
Genetic variation databases
BioMutai | CSK |
DMDMi | 729887 |
2D gel databases
OGPi | P41240 |
Proteomic databases
EPDi | P41240 |
jPOSTi | P41240 |
MassIVEi | P41240 |
MaxQBi | P41240 |
PaxDbi | P41240 |
PeptideAtlasi | P41240 |
PRIDEi | P41240 |
ProteomicsDBi | 55450 |
Protocols and materials databases
Antibodypediai | 4405, 784 antibodies from 42 providers |
DNASUi | 1445 |
Genome annotation databases
Ensembli | ENST00000220003; ENSP00000220003; ENSG00000103653 ENST00000439220; ENSP00000414764; ENSG00000103653 ENST00000567571; ENSP00000454906; ENSG00000103653 |
GeneIDi | 1445 |
KEGGi | hsa:1445 |
MANE-Selecti | ENST00000220003.14; ENSP00000220003.9; NM_004383.3; NP_004374.1 |
UCSCi | uc002ays.3, human |
Organism-specific databases
CTDi | 1445 |
DisGeNETi | 1445 |
GeneCardsi | CSK |
HGNCi | HGNC:2444, CSK |
HPAi | ENSG00000103653, Tissue enhanced (lymphoid) |
MIMi | 124095, gene |
neXtProti | NX_P41240 |
OpenTargetsi | ENSG00000103653 |
PharmGKBi | PA26946 |
VEuPathDBi | HostDB:ENSG00000103653 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157431 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P41240 |
OMAi | IVYEVMK |
PhylomeDBi | P41240 |
TreeFami | TF351634 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P41240 |
Reactomei | R-HSA-180292, GAB1 signalosome R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-354192, Integrin signaling R-HSA-389948, PD-1 signaling R-HSA-5674135, MAP2K and MAPK activation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9013407, RHOH GTPase cycle R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9706369, Negative regulation of FLT3 |
SignaLinki | P41240 |
SIGNORi | P41240 |
Miscellaneous databases
BioGRID-ORCSi | 1445, 72 hits in 1082 CRISPR screens |
ChiTaRSi | CSK, human |
EvolutionaryTracei | P41240 |
GeneWikii | C-src_tyrosine_kinase |
GenomeRNAii | 1445 |
Pharosi | P41240, Tchem |
PROi | PR:P41240 |
RNActi | P41240, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103653, Expressed in granulocyte and 233 other tissues |
ExpressionAtlasi | P41240, baseline and differential |
Genevisiblei | P41240, HS |
Family and domain databases
CDDi | cd09937, SH2_csk_like, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035027, Csk-like_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK_HUMAN | |
Accessioni | P41240Primary (citable) accession number: P41240 Secondary accession number(s): Q2M3N2, Q6FGZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 230 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families