CSK

Functionⁱ

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.2 Publications

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.3 Publications

Cofactorⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	222	ATPPROSITE-ProRule annotation		1
Active siteⁱ	314	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	201 – 209	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19888460
kinase activity Source: Reactome
metal ion binding Source: UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity Source: GO_Central
proline-rich region binding Source: Ensembl
protein C-terminus binding
Source: ProtInc
Traceable author statementⁱ
- 8890164
protein kinase A catalytic subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17911601
protein phosphatase binding Source: Ensembl
protein tyrosine kinase activity Source: Reactome
signaling receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
adherens junction organization Source: GO_Central
brain development Source: Ensembl
cell differentiation Source: GO_Central
cellular response to peptide hormone stimulus Source: Ensembl
central nervous system development Source: GO_Central
innate immune response Source: GO_Central
negative regulation of bone resorption Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of ERK1 and ERK2 cascade Source: Ensembl
negative regulation of Golgi to plasma membrane protein transport
Source: UniProtKB
Inferred from direct assayⁱ
- 20605918
negative regulation of interleukin-6 production Source: Ensembl
negative regulation of kinase activity Source: Ensembl
negative regulation of low-density lipoprotein particle clearance Source: Ensembl
negative regulation of phagocytosis Source: Ensembl
oligodendrocyte differentiation Source: Ensembl
peptidyl-tyrosine autophosphorylation Source: GO_Central
positive regulation of MAP kinase activity Source: Ensembl
protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 1945408
regulation of cell proliferation Source: GO_Central
regulation of cytokine production Source: GO_Central
regulation of Fc receptor mediated stimulatory signaling pathway Source: GO_Central
T cell costimulation Source: Reactome
T cell receptor signaling pathway Source: Reactome
transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinase
Biological process	Adaptive immunity, Immunity
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-180292 GAB1 signalosome R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-389948 PD-1 signaling R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	P41240
SIGNORⁱ	P41240

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase CSK (EC:2.7.10.23 Publications) Alternative name(s): C-Src kinase Protein-tyrosine kinase CYL
Gene namesⁱ	Name:CSK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103653.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2444 CSK
MIMⁱ	124095 gene
neXtProtⁱ	NX_P41240

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	184	Y → F: Abolishes phosphorylation. 1 Publication	1
Mutagenesisⁱ	304	Y → F: Decreases activity by two-thirds and alters conformation. 1 Publication	1
Mutagenesisⁱ	364	S → A: Strong decrease of phosphorylation by PRKACA (catalytic subunit of PKA). 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1445
Open Targets More...OpenTargetsⁱ	ENSG00000103653
PharmGKBⁱ	PA26946

Chemistry databases

ChEMBLⁱ	CHEMBL2634
Drug and drug target database More...DrugBankⁱ	DB02010 Staurosporine DB05075 TG100801
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1994

Polymorphism and mutation databases

BioMutaⁱ	CSK
DMDMⁱ	729887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000088070	2 – 450	Tyrosine-protein kinase CSKAdd BLAST		449

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	184	Phosphotyrosine1 Publication	1
Modified residueⁱ	304	Phosphotyrosine1 Publication	1
Modified residueⁱ	364	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	416	Phosphotyrosine; by autocatalysis1 Publication	1

Post-translational modificationⁱ

Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P41240
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P41240
PaxDbⁱ	P41240
PeptideAtlas More...PeptideAtlasⁱ	P41240
PRIDEⁱ	P41240
ProteomicsDBⁱ	55450

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P41240

OGPⁱ

P41240

PTM databases

iPTMnetⁱ	P41240
PhosphoSitePlusⁱ	P41240

Expressionⁱ

Tissue specificityⁱ

Expressed in lung and macrophages.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000103653 Expressed in 220 organ(s), highest expression level in vagina
CleanExⁱ	HS_CSK
ExpressionAtlasⁱ	P41240 baseline and differential
Genevisibleⁱ	P41240 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011203 HPA026488 HPA028425

HPAⁱ

CAB011203
HPA026488
HPA028425

Interactionⁱ

Subunit structureⁱ

Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP (PubMed:21930792).Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity).By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		7	EBI-1380630,EBI-1380630
IGF1R	P08069	5	EBI-1380630,EBI-475981
PAG1	Q9NWQ8	3	EBI-1380630,EBI-2828115
PTPRC	P08575	3	EBI-1380630,EBI-1341
PXN	P49023	2	EBI-1380630,EBI-702209
SRC	P00523	6	EBI-1380630,EBI-848039	From Gallus gallus.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19888460
proline-rich region binding Source: Ensembl
protein C-terminus binding
Source: ProtInc
Traceable author statementⁱ
- 8890164
protein kinase A catalytic subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17911601
protein phosphatase binding Source: Ensembl
signaling receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107832, 58 interactors
ELMⁱ	P41240
IntActⁱ	P41240, 40 interactors
Molecular INTeraction database More...MINTⁱ	P41240
STRINGⁱ	9606.ENSP00000220003

Chemistry databases

BindingDBⁱ

P41240

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	12 – 18	Combined sources	7
Beta strandⁱ	35 – 41	Combined sources	7
Beta strandⁱ	47 – 51	Combined sources	5
Beta strandⁱ	57 – 61	Combined sources	5
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	77 – 79	Combined sources	3
Beta strandⁱ	83 – 86	Combined sources	4
Helixⁱ	89 – 95	Combined sources	7
Beta strandⁱ	103 – 108	Combined sources	6
Beta strandⁱ	116 – 122	Combined sources	7
Beta strandⁱ	125 – 130	Combined sources	6
Beta strandⁱ	132 – 134	Combined sources	3
Beta strandⁱ	137 – 144	Combined sources	8
Beta strandⁱ	146 – 148	Combined sources	3
Helixⁱ	149 – 158	Combined sources	10
Beta strandⁱ	163 – 165	Combined sources	3
Helixⁱ	192 – 194	Combined sources	3
Beta strandⁱ	195 – 203	Combined sources	9
Beta strandⁱ	208 – 214	Combined sources	7
Beta strandⁱ	217 – 223	Combined sources	7
Helixⁱ	231 – 235	Combined sources	5
Helixⁱ	237 – 240	Combined sources	4
Beta strandⁱ	251 – 255	Combined sources	5
Beta strandⁱ	263 – 266	Combined sources	4
Helixⁱ	274 – 285	Combined sources	12
Helixⁱ	288 – 307	Combined sources	20
Helixⁱ	317 – 319	Combined sources	3
Beta strandⁱ	320 – 322	Combined sources	3
Beta strandⁱ	328 – 330	Combined sources	3
Turnⁱ	350 – 352	Combined sources	3
Helixⁱ	355 – 360	Combined sources	6
Helixⁱ	365 – 380	Combined sources	16
Helixⁱ	392 – 394	Combined sources	3
Helixⁱ	395 – 399	Combined sources	5
Turnⁱ	400 – 402	Combined sources	3
Helixⁱ	413 – 422	Combined sources	10
Helixⁱ	427 – 429	Combined sources	3
Helixⁱ	433 – 446	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P41240
SMRⁱ	P41240
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P41240

EvolutionaryTraceⁱ

P41240

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 70	SH3PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	82 – 171	SH2PROSITE-ProRule annotationAdd BLAST	90
Domainⁱ	195 – 449	Protein kinasePROSITE-ProRule annotationAdd BLAST	255

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	9 – 70	Interaction with PTPN22By similarityAdd BLAST		62

Domainⁱ

The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119011
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	P41240
KEGG Orthology (KO) More...KOⁱ	K05728
OMAⁱ	WALNMKD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PB
PhylomeDBⁱ	P41240
TreeFamⁱ	TF351634

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09937 SH2_csk_like, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035026 CSK IPR035027 Csk-like_SH2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF307 PTHR24418:SF307, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P41240-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA 
        60         70         80         90        100
KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE 
       110        120        130        140        150
TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM 
       160        170        180        190        200
QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT 
       210        220        230        240        250
IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ 
       260        270        280        290        300
LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
       310        320        330        340        350
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV 
       360        370        380        390        400
KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE 
       410        420        430        440        450
KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Length:450

Mass (Da):50,704

Last modified:February 1, 1995 - v1

Checksum:ⁱ431023A88C54E00C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BU69	H3BU69_HUMAN	Tyrosine-protein kinase CSK Tyrosine-protein kinase CSK	CSK	68	Annotation score:
H3BUM9	H3BUM9_HUMAN	Tyrosine-protein kinase CSK Tyrosine-protein kinase CSK	CSK	110	Annotation score:
H3BN15	H3BN15_HUMAN	Tyrosine-protein kinase CSK Tyrosine-protein kinase CSK	CSK	64	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041678	45	P → L1 Publication	1
Natural variantⁱVAR_025203	287	G → D1 PublicationCorresponds to variant dbSNP:rs34866753Ensembl.	1
Natural variantⁱVAR_025204	398	R → Q1 PublicationCorresponds to variant dbSNP:rs34616395Ensembl.	1
Natural variantⁱVAR_025205	442	H → R1 PublicationCorresponds to variant dbSNP:rs35556162Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60114 mRNA Translation: CAA42713.1 X59932 mRNA Translation: CAA42556.1 X74765 Genomic DNA Translation: CAB58562.1 CR541960 mRNA Translation: CAG46758.1 DQ075211 Genomic DNA Translation: AAY57329.1 BC104847 mRNA Translation: AAI04848.1 BC104875 mRNA Translation: AAI04876.1 BC106073 mRNA Translation: AAI06074.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10269.1
PIRⁱ	JH0559
NCBI Reference Sequences More...RefSeqⁱ	NP_001120662.1, NM_001127190.1 NP_004374.1, NM_004383.2 XP_005254222.1, XM_005254165.4 XP_016877414.1, XM_017021925.1
UniGeneⁱ	Hs.77793

Genome annotation databases

Ensemblⁱ	ENST00000220003; ENSP00000220003; ENSG00000103653 ENST00000439220; ENSP00000414764; ENSG00000103653 ENST00000567571; ENSP00000454906; ENSG00000103653
GeneIDⁱ	1445
KEGGⁱ	hsa:1445
UCSC genome browser More...UCSCⁱ	uc002ays.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P41240	Tyrosine-protein kinase		HUMAN		450	UniRef100_P41240
Tyrosine-protein kinase		PANTR		450
Tyrosine-protein kinase		PONAB		450
Tyrosine-protein kinase		CERAT		450
Tyrosine-protein kinase		RHIRO		450
+8

Protein	Similar proteins		Species	Score	Length	Source
P41240	Tyrosine-protein kinase CSK	)	RAT		450	UniRef90_P41240
Tyrosine-protein kinase CSK	)	MOUSE		450
Tyrosine-protein kinase CSK		CHICK		450
Tyrosine-protein kinase		HUMAN		450
Tyrosine-protein kinase		PANTR		450
+128

Protein	Similar proteins		Species	Score	Length	Source
P41240	Tyrosine-protein kinase CSK	)	MOUSE		450	UniRef50_P41240
Tyrosine-protein kinase CSK	)	RAT		450
Tyrosine-protein kinase CSK		CHICK		450
Tyrosine-protein kinase CSK		BOVIN		450
Tyrosine-protein kinase		HUMAN		450
+366

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60114 mRNA Translation: CAA42713.1 X59932 mRNA Translation: CAA42556.1 X74765 Genomic DNA Translation: CAB58562.1 CR541960 mRNA Translation: CAG46758.1 DQ075211 Genomic DNA Translation: AAY57329.1 BC104847 mRNA Translation: AAI04848.1 BC104875 mRNA Translation: AAI04876.1 BC106073 mRNA Translation: AAI06074.1
CCDSⁱ	CCDS10269.1
PIRⁱ	JH0559
RefSeqⁱ	NP_001120662.1, NM_001127190.1 NP_004374.1, NM_004383.2 XP_005254222.1, XM_005254165.4 XP_016877414.1, XM_017021925.1
UniGeneⁱ	Hs.77793

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BYG	X-ray	2.40	A	173-450	[»]
	1CSK	X-ray	2.50	A/B/C/D	1-71	[»]
	3D7T	X-ray	2.90	A	188-450	[»]
	3D7U	X-ray	4.11	A/C	188-450	[»]
	3EAC	X-ray	1.37	A	73-178	[»]
	3EAZ	X-ray	1.31	A	73-178	[»]
ProteinModelPortalⁱ	P41240
SMRⁱ	P41240
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107832, 58 interactors
ELMⁱ	P41240
IntActⁱ	P41240, 40 interactors
MINTⁱ	P41240
STRINGⁱ	9606.ENSP00000220003

Chemistry databases

BindingDBⁱ	P41240
ChEMBLⁱ	CHEMBL2634
DrugBankⁱ	DB02010 Staurosporine DB05075 TG100801
GuidetoPHARMACOLOGYⁱ	1994

PTM databases

iPTMnetⁱ	P41240
PhosphoSitePlusⁱ	P41240

Polymorphism and mutation databases

BioMutaⁱ	CSK
DMDMⁱ	729887

2D gel databases

OGPⁱ	P41240

OGPⁱ

P41240

Proteomic databases

EPDⁱ	P41240
MaxQBⁱ	P41240
PaxDbⁱ	P41240
PeptideAtlasⁱ	P41240
PRIDEⁱ	P41240
ProteomicsDBⁱ	55450

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1445
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000220003; ENSP00000220003; ENSG00000103653 ENST00000439220; ENSP00000414764; ENSG00000103653 ENST00000567571; ENSP00000454906; ENSG00000103653
GeneIDⁱ	1445
KEGGⁱ	hsa:1445
UCSCⁱ	uc002ays.3 human

Organism-specific databases

CTDⁱ	1445
DisGeNETⁱ	1445
EuPathDBⁱ	HostDB:ENSG00000103653.16
GeneCardsⁱ	CSK
HGNCⁱ	HGNC:2444 CSK
HPAⁱ	CAB011203 HPA026488 HPA028425
MIMⁱ	124095 gene
neXtProtⁱ	NX_P41240
OpenTargetsⁱ	ENSG00000103653
PharmGKBⁱ	PA26946
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000119011
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	P41240
KOⁱ	K05728
OMAⁱ	WALNMKD
OrthoDBⁱ	EOG091G05PB
PhylomeDBⁱ	P41240
TreeFamⁱ	TF351634

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-180292 GAB1 signalosome R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-389948 PD-1 signaling R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	P41240
SIGNORⁱ	P41240

Miscellaneous databases

ChiTaRSⁱ	CSK human
EvolutionaryTraceⁱ	P41240
GeneWikiⁱ	C-src_tyrosine_kinase
GenomeRNAiⁱ	1445
Protein Ontology More...PROⁱ	PR:P41240
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103653 Expressed in 220 organ(s), highest expression level in vagina
CleanExⁱ	HS_CSK
ExpressionAtlasⁱ	P41240 baseline and differential
Genevisibleⁱ	P41240 HS

Family and domain databases

CDDⁱ	cd09937 SH2_csk_like, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035026 CSK IPR035027 Csk-like_SH2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF307 PTHR24418:SF307, 1 hit
Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSK_HUMAN
Accessionⁱ	P41240Primary (citable) accession number: P41240 Secondary accession number(s): Q2M3N2, Q6FGZ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	September 12, 2018
	This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P41240 (CSK_HUMAN)

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Tyrosine-protein kinase CSK

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Keywords - Cellular componenti

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Keywords - PTMi

Proteomic databases

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GO - Molecular functioni

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Keywords - Coding sequence diversityi

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Sequence databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ