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UniProtKB - P41236 (IPP2_HUMAN)
Protein
Protein phosphatase inhibitor 2
Gene
PPP1R2
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of protein-phosphatase 1.
GO - Molecular functioni
- protein phosphatase inhibitor activity Source: GO_Central
- protein serine/threonine phosphatase inhibitor activity Source: ProtInc
GO - Biological processi
- generation of precursor metabolites and energy Source: ProtInc
- glycogen metabolic process Source: UniProtKB-KW
- regulation of phosphoprotein phosphatase activity Source: GO_Central
- regulation of signal transduction Source: InterPro
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Biological process | Carbohydrate metabolism, Glycogen metabolism |
Enzyme and pathway databases
PathwayCommonsi | P41236 |
SignaLinki | P41236 |
SIGNORi | P41236 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase inhibitor 2Short name: IPP-2 |
Gene namesi | Name:PPP1R2 Synonyms:IPP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9288, PPP1R2 |
MIMi | 601792, gene |
neXtProti | NX_P41236 |
VEuPathDBi | HostDB:ENSG00000184203 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5504 |
OpenTargetsi | ENSG00000184203 |
PharmGKBi | PA33641 |
Miscellaneous databases
Pharosi | P41236, Tbio |
Genetic variation databases
BioMutai | PPP1R2 |
DMDMi | 729856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000071481 | 2 – 205 | Protein phosphatase inhibitor 2Add BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 44 | Phosphoserine; by ATM1 Publication | 1 | |
Modified residuei | 73 | Phosphothreonine; by GSK3By similarity | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 92 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 121 | Phosphoserine1 Publication | 1 | |
Modified residuei | 122 | Phosphoserine1 Publication | 1 | |
Modified residuei | 127 | Phosphoserine1 Publication | 1 | |
Modified residuei | 130 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity2 Publications
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P41236 |
jPOSTi | P41236 |
MassIVEi | P41236 |
MaxQBi | P41236 |
PaxDbi | P41236 |
PeptideAtlasi | P41236 |
PRIDEi | P41236 |
ProteomicsDBi | 55448 |
TopDownProteomicsi | P41236 |
PTM databases
GlyGeni | P41236, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P41236 |
MetOSitei | P41236 |
PhosphoSitePlusi | P41236 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184203, Expressed in testis and 241 other tissues |
ExpressionAtlasi | P41236, baseline and differential |
Genevisiblei | P41236, HS |
Organism-specific databases
HPAi | ENSG00000184203, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with PP1.
1 PublicationBinary interactionsi
P41236
Protein-protein interaction databases
BioGRIDi | 111497, 55 interactors |
DIPi | DIP-781N |
ELMi | P41236 |
IntActi | P41236, 18 interactors |
MINTi | P41236 |
STRINGi | 9606.ENSP00000484580 |
Miscellaneous databases
RNActi | P41236, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 44 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 12 – 17 | Required for binding PPP1CCBy similarity | 6 | |
Regioni | 43 – 55 | Required for binding PPP1CCBy similarityAdd BLAST | 13 | |
Regioni | 111 – 142 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 147 – 150 | Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity | 4 | |
Regioni | 163 – 205 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 30 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 166 – 180 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 181 – 205 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the protein phosphatase inhibitor 2 family.Curated
Phylogenomic databases
eggNOGi | KOG4041, Eukaryota |
GeneTreei | ENSGT00390000004757 |
InParanoidi | P41236 |
OMAi | YRVHEQA |
OrthoDBi | 1321970at2759 |
PhylomeDBi | P41236 |
TreeFami | TF105536 |
Family and domain databases
DisProti | DP00816 |
InterProi | View protein in InterPro IPR007062, PPI-2 |
PANTHERi | PTHR12398, PTHR12398, 1 hit |
Pfami | View protein in Pfam PF04979, IPP-2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P41236-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL
110 120 130 140 150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN
KLRSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EMN6 | E7EMN6_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 170 | Annotation score: | ||
E7EUI7 | E7EUI7_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 80 | Annotation score: | ||
H7C416 | H7C416_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 54 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78873 mRNA Translation: CAA55475.1 Z29646 mRNA Translation: CAA82754.1 U68111 , U68106, U68107, U68108, U68109, U68110 Genomic DNA Translation: AAC51206.1 AJ133812 mRNA Translation: CAB41680.1 AY063767 mRNA Translation: AAL48322.1 BC007655 mRNA Translation: AAH07655.1 |
CCDSi | CCDS3309.1 |
PIRi | S42406 |
RefSeqi | NP_001303254.1, NM_001316325.1 NP_006232.1, NM_006241.7 |
Genome annotation databases
Ensembli | ENST00000618156; ENSP00000484580; ENSG00000184203 |
GeneIDi | 5504 |
KEGGi | hsa:5504 |
MANE-Selecti | ENST00000618156.5; ENSP00000484580.1; NM_006241.8; NP_006232.1 |
UCSCi | uc032sob.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78873 mRNA Translation: CAA55475.1 Z29646 mRNA Translation: CAA82754.1 U68111 , U68106, U68107, U68108, U68109, U68110 Genomic DNA Translation: AAC51206.1 AJ133812 mRNA Translation: CAB41680.1 AY063767 mRNA Translation: AAL48322.1 BC007655 mRNA Translation: AAH07655.1 |
CCDSi | CCDS3309.1 |
PIRi | S42406 |
RefSeqi | NP_001303254.1, NM_001316325.1 NP_006232.1, NM_006241.7 |
3D structure databases
BMRBi | P41236 |
SMRi | P41236 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111497, 55 interactors |
DIPi | DIP-781N |
ELMi | P41236 |
IntActi | P41236, 18 interactors |
MINTi | P41236 |
STRINGi | 9606.ENSP00000484580 |
PTM databases
GlyGeni | P41236, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P41236 |
MetOSitei | P41236 |
PhosphoSitePlusi | P41236 |
Genetic variation databases
BioMutai | PPP1R2 |
DMDMi | 729856 |
Proteomic databases
EPDi | P41236 |
jPOSTi | P41236 |
MassIVEi | P41236 |
MaxQBi | P41236 |
PaxDbi | P41236 |
PeptideAtlasi | P41236 |
PRIDEi | P41236 |
ProteomicsDBi | 55448 |
TopDownProteomicsi | P41236 |
Protocols and materials databases
Antibodypediai | 33909, 331 antibodies from 28 providers |
DNASUi | 5504 |
Genome annotation databases
Ensembli | ENST00000618156; ENSP00000484580; ENSG00000184203 |
GeneIDi | 5504 |
KEGGi | hsa:5504 |
MANE-Selecti | ENST00000618156.5; ENSP00000484580.1; NM_006241.8; NP_006232.1 |
UCSCi | uc032sob.2, human |
Organism-specific databases
CTDi | 5504 |
DisGeNETi | 5504 |
GeneCardsi | PPP1R2 |
HGNCi | HGNC:9288, PPP1R2 |
HPAi | ENSG00000184203, Low tissue specificity |
MIMi | 601792, gene |
neXtProti | NX_P41236 |
OpenTargetsi | ENSG00000184203 |
PharmGKBi | PA33641 |
VEuPathDBi | HostDB:ENSG00000184203 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4041, Eukaryota |
GeneTreei | ENSGT00390000004757 |
InParanoidi | P41236 |
OMAi | YRVHEQA |
OrthoDBi | 1321970at2759 |
PhylomeDBi | P41236 |
TreeFami | TF105536 |
Enzyme and pathway databases
PathwayCommonsi | P41236 |
SignaLinki | P41236 |
SIGNORi | P41236 |
Miscellaneous databases
BioGRID-ORCSi | 5504, 604 hits in 1021 CRISPR screens |
ChiTaRSi | PPP1R2, human |
GeneWikii | PPP1R2 |
GenomeRNAii | 5504 |
Pharosi | P41236, Tbio |
PROi | PR:P41236 |
RNActi | P41236, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184203, Expressed in testis and 241 other tissues |
ExpressionAtlasi | P41236, baseline and differential |
Genevisiblei | P41236, HS |
Family and domain databases
DisProti | DP00816 |
InterProi | View protein in InterPro IPR007062, PPI-2 |
PANTHERi | PTHR12398, PTHR12398, 1 hit |
Pfami | View protein in Pfam PF04979, IPP-2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IPP2_HUMAN | |
Accessioni | P41236Primary (citable) accession number: P41236 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families