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UniProtKB - P41236 (IPP2_HUMAN)

Entry version 179 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of protein-phosphatase 1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P41236

SIGNOR Signaling Network Open Resource

More...SIGNORi		P41236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R2
Synonyms:IPP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9288 PPP1R2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601792 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P41236

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5504

Open Targets

More...OpenTargetsi		ENSG00000184203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33641

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P41236

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP1R2

Domain mapping of disease mutations (DMDM)

More...DMDMi		729856

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714812 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei44Phosphoserine; by ATM1 Publication1
Modified residuei73Phosphothreonine; by GSK3By similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphothreonineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P41236

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P41236

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P41236

MaxQB - The MaxQuant DataBase

More...MaxQBi		P41236

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41236

PeptideAtlas

More...PeptideAtlasi		P41236

PRoteomics IDEntifications database

More...PRIDEi		P41236

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55448

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P41236

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41236

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P41236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184203 Expressed in 230 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P41236 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P41236 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA043729
HPA059420

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with PP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111497, 51 interactors

Database of interacting proteins

More...DIPi		DIP-781N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P41236

Protein interaction database and analysis system

More...IntActi		P41236, 16 interactors

Molecular INTeraction database

More...MINTi		P41236

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000484580

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein phosphatase inhibitor 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4041 Eukaryota
ENOG4111SYV LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004757

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41236

KEGG Orthology (KO)

More...KOi		K16833

Identification of Orthologs from Complete Genome Data

More...OMAi		PKYRVHE

Database of Orthologous Groups

More...OrthoDBi		1321970at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P41236

TreeFam database of animal gene trees

More...TreeFami		TF105536

Family and domain databases

Database of protein disorder

More...DisProti		DP00816

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007062 PPI-2

The PANTHER Classification System

More...PANTHERi		PTHR12398 PTHR12398, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04979 IPP-2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P41236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM 
        60         70         80         90        100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL 
       110        120        130        140        150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE 
       160        170        180        190        200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN 

KLRSS
Length:205
Mass (Da):23,015
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFC005B07CD5ABFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMN6E7EMN6_HUMAN
Protein phosphatase inhibitor 2
PPP1R2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUI7E7EUI7_HUMAN
Protein phosphatase inhibitor 2
PPP1R2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C416H7C416_HUMAN
Protein phosphatase inhibitor 2
PPP1R2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X78873 mRNA Translation: CAA55475.1
Z29646 mRNA Translation: CAA82754.1
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA Translation: AAC51206.1
AJ133812 mRNA Translation: CAB41680.1
AY063767 mRNA Translation: AAL48322.1
BC007655 mRNA Translation: AAH07655.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3309.1

Protein sequence database of the Protein Information Resource

More...PIRi		S42406

NCBI Reference Sequences

More...RefSeqi		NP_001303254.1, NM_001316325.1
NP_006232.1, NM_006241.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000618156; ENSP00000484580; ENSG00000184203

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5504

UCSC genome browser

More...UCSCi		uc032sob.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78873 mRNA Translation: CAA55475.1
Z29646 mRNA Translation: CAA82754.1
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA Translation: AAC51206.1
AJ133812 mRNA Translation: CAB41680.1
AY063767 mRNA Translation: AAL48322.1
BC007655 mRNA Translation: AAH07655.1
CCDSiCCDS3309.1
PIRiS42406
RefSeqiNP_001303254.1, NM_001316325.1
NP_006232.1, NM_006241.7

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi111497, 51 interactors
DIPiDIP-781N
ELMiP41236
IntActiP41236, 16 interactors
MINTiP41236
STRINGi9606.ENSP00000484580

PTM databases

iPTMnetiP41236
PhosphoSitePlusiP41236

Polymorphism and mutation databases

BioMutaiPPP1R2
DMDMi729856

Proteomic databases

EPDiP41236
jPOSTiP41236
MassIVEiP41236
MaxQBiP41236
PaxDbiP41236
PeptideAtlasiP41236
PRIDEiP41236
ProteomicsDBi55448
TopDownProteomicsiP41236

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5504

Genome annotation databases

EnsembliENST00000618156; ENSP00000484580; ENSG00000184203
GeneIDi5504
KEGGihsa:5504
UCSCiuc032sob.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5504
DisGeNETi5504

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP1R2
HGNCiHGNC:9288 PPP1R2
HPAiHPA043729
HPA059420
MIMi601792 gene
neXtProtiNX_P41236
OpenTargetsiENSG00000184203
PharmGKBiPA33641

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4041 Eukaryota
ENOG4111SYV LUCA
GeneTreeiENSGT00390000004757
InParanoidiP41236
KOiK16833
OMAiPKYRVHE
OrthoDBi1321970at2759
PhylomeDBiP41236
TreeFamiTF105536

Enzyme and pathway databases

SignaLinkiP41236
SIGNORiP41236

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP1R2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP1R2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5504
PharosiP41236

Protein Ontology

More...PROi		PR:P41236

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184203 Expressed in 230 organ(s), highest expression level in testis
ExpressionAtlasiP41236 baseline and differential
GenevisibleiP41236 HS

Family and domain databases

DisProtiDP00816
InterProiView protein in InterPro
IPR007062 PPI-2
PANTHERiPTHR12398 PTHR12398, 1 hit
PfamiView protein in Pfam
PF04979 IPP-2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41236
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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