UniProtKB - P41236 (IPP2_HUMAN)
Protein
Protein phosphatase inhibitor 2
Gene
PPP1R2
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of protein-phosphatase 1.
GO - Molecular functioni
- protein phosphatase inhibitor activity Source: GO_Central
- protein serine/threonine phosphatase inhibitor activity Source: ProtInc
GO - Biological processi
- generation of precursor metabolites and energy Source: ProtInc
- glycogen metabolic process Source: UniProtKB-KW
- regulation of phosphoprotein phosphatase activity Source: GO_Central
- regulation of signal transduction Source: InterPro
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Biological process | Carbohydrate metabolism, Glycogen metabolism |
Enzyme and pathway databases
SignaLinki | P41236 |
SIGNORi | P41236 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase inhibitor 2Short name: IPP-2 |
Gene namesi | Name:PPP1R2 Synonyms:IPP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184203.7 |
HGNCi | HGNC:9288 PPP1R2 |
MIMi | 601792 gene |
neXtProti | NX_P41236 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5504 |
OpenTargetsi | ENSG00000184203 |
PharmGKBi | PA33641 |
Polymorphism and mutation databases
BioMutai | PPP1R2 |
DMDMi | 729856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000071481 | 2 – 205 | Protein phosphatase inhibitor 2Add BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 44 | Phosphoserine; by ATM1 Publication | 1 | |
Modified residuei | 73 | Phosphothreonine; by GSK3By similarity | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 92 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 121 | Phosphoserine1 Publication | 1 | |
Modified residuei | 122 | Phosphoserine1 Publication | 1 | |
Modified residuei | 127 | Phosphoserine1 Publication | 1 | |
Modified residuei | 130 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity2 Publications
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P41236 |
jPOSTi | P41236 |
MaxQBi | P41236 |
PaxDbi | P41236 |
PeptideAtlasi | P41236 |
PRIDEi | P41236 |
ProteomicsDBi | 55448 |
TopDownProteomicsi | P41236 |
PTM databases
iPTMneti | P41236 |
PhosphoSitePlusi | P41236 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184203 Expressed in 230 organ(s), highest expression level in testis |
ExpressionAtlasi | P41236 baseline and differential |
Genevisiblei | P41236 HS |
Organism-specific databases
HPAi | HPA043729 HPA059420 |
Interactioni
Subunit structurei
Heterodimer with PP1.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 111497, 51 interactors |
DIPi | DIP-781N |
ELMi | P41236 |
IntActi | P41236, 16 interactors |
MINTi | P41236 |
STRINGi | 9606.ENSP00000328178 |
Structurei
3D structure databases
DisProti | DP00816 |
ProteinModelPortali | P41236 |
SMRi | P41236 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 17 | Required for binding PPP1CCBy similarity | 6 | |
Regioni | 43 – 55 | Required for binding PPP1CCBy similarityAdd BLAST | 13 | |
Regioni | 147 – 150 | Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity | 4 |
Sequence similaritiesi
Belongs to the protein phosphatase inhibitor 2 family.Curated
Phylogenomic databases
eggNOGi | KOG4041 Eukaryota ENOG4111SYV LUCA |
GeneTreei | ENSGT00390000004757 |
HOVERGENi | HBG006170 |
InParanoidi | P41236 |
KOi | K16833 |
OMAi | MHYNEGR |
OrthoDBi | 1321970at2759 |
PhylomeDBi | P41236 |
TreeFami | TF105536 |
Family and domain databases
InterProi | View protein in InterPro IPR007062 PPI-2 |
PANTHERi | PTHR12398 PTHR12398, 1 hit |
Pfami | View protein in Pfam PF04979 IPP-2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P41236-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL
110 120 130 140 150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN
KLRSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EMN6 | E7EMN6_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 170 | Annotation score: | ||
H7C416 | H7C416_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 54 | Annotation score: | ||
E7EUI7 | E7EUI7_HUMAN | Protein phosphatase inhibitor 2 | PPP1R2 | 80 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78873 mRNA Translation: CAA55475.1 Z29646 mRNA Translation: CAA82754.1 U68111 U68110 Genomic DNA Translation: AAC51206.1 AJ133812 mRNA Translation: CAB41680.1 AY063767 mRNA Translation: AAL48322.1 BC007655 mRNA Translation: AAH07655.1 |
CCDSi | CCDS3309.1 |
PIRi | S42406 |
RefSeqi | NP_001303254.1, NM_001316325.1 NP_006232.1, NM_006241.7 |
UniGenei | Hs.535731 Hs.706920 |
Genome annotation databases
Ensembli | ENST00000618156; ENSP00000484580; ENSG00000184203 |
GeneIDi | 5504 |
KEGGi | hsa:5504 |
UCSCi | uc032sob.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78873 mRNA Translation: CAA55475.1 Z29646 mRNA Translation: CAA82754.1 U68111 U68110 Genomic DNA Translation: AAC51206.1 AJ133812 mRNA Translation: CAB41680.1 AY063767 mRNA Translation: AAL48322.1 BC007655 mRNA Translation: AAH07655.1 |
CCDSi | CCDS3309.1 |
PIRi | S42406 |
RefSeqi | NP_001303254.1, NM_001316325.1 NP_006232.1, NM_006241.7 |
UniGenei | Hs.535731 Hs.706920 |
3D structure databases
DisProti | DP00816 |
ProteinModelPortali | P41236 |
SMRi | P41236 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 111497, 51 interactors |
DIPi | DIP-781N |
ELMi | P41236 |
IntActi | P41236, 16 interactors |
MINTi | P41236 |
STRINGi | 9606.ENSP00000328178 |
PTM databases
iPTMneti | P41236 |
PhosphoSitePlusi | P41236 |
Polymorphism and mutation databases
BioMutai | PPP1R2 |
DMDMi | 729856 |
Proteomic databases
EPDi | P41236 |
jPOSTi | P41236 |
MaxQBi | P41236 |
PaxDbi | P41236 |
PeptideAtlasi | P41236 |
PRIDEi | P41236 |
ProteomicsDBi | 55448 |
TopDownProteomicsi | P41236 |
Protocols and materials databases
DNASUi | 5504 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000618156; ENSP00000484580; ENSG00000184203 |
GeneIDi | 5504 |
KEGGi | hsa:5504 |
UCSCi | uc032sob.2 human |
Organism-specific databases
CTDi | 5504 |
DisGeNETi | 5504 |
EuPathDBi | HostDB:ENSG00000184203.7 |
GeneCardsi | PPP1R2 |
H-InvDBi | HIX0032078 HIX0166147 HIX0166426 HIX0166678 HIX0167196 HIX0200910 |
HGNCi | HGNC:9288 PPP1R2 |
HPAi | HPA043729 HPA059420 |
MIMi | 601792 gene |
neXtProti | NX_P41236 |
OpenTargetsi | ENSG00000184203 |
PharmGKBi | PA33641 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4041 Eukaryota ENOG4111SYV LUCA |
GeneTreei | ENSGT00390000004757 |
HOVERGENi | HBG006170 |
InParanoidi | P41236 |
KOi | K16833 |
OMAi | MHYNEGR |
OrthoDBi | 1321970at2759 |
PhylomeDBi | P41236 |
TreeFami | TF105536 |
Enzyme and pathway databases
SignaLinki | P41236 |
SIGNORi | P41236 |
Miscellaneous databases
GeneWikii | PPP1R2 |
GenomeRNAii | 5504 |
PROi | PR:P41236 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184203 Expressed in 230 organ(s), highest expression level in testis |
ExpressionAtlasi | P41236 baseline and differential |
Genevisiblei | P41236 HS |
Family and domain databases
InterProi | View protein in InterPro IPR007062 PPI-2 |
PANTHERi | PTHR12398 PTHR12398, 1 hit |
Pfami | View protein in Pfam PF04979 IPP-2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | IPP2_HUMAN | |
Accessioni | P41236Primary (citable) accession number: P41236 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 13, 2019 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot