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Entry version 176 (13 Feb 2019)
Sequence version 4 (02 Nov 2010)
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Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled purinergic nucleotide receptor activity Source: InterPro
  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-5683826 Surfactant metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P41231

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.16 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
P2U receptor 1
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RY2
Synonyms:P2RU1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175591.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8541 P2RY2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600041 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41231

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 70CytoplasmicSequence analysisAdd BLAST11
Transmembranei71 – 93Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 152CytoplasmicSequence analysisAdd BLAST23
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 220Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 269Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini270 – 287ExtracellularSequence analysisAdd BLAST18
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 377CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5029

Open Targets

More...
OpenTargetsi
ENSG00000175591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32870

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4398

Drug and drug target database

More...
DrugBanki
DB04983 Denufosol
DB05390 INS 316
DB04786 Suramin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
324

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P2RY2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700131 – 377P2Y purinoceptor 2Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41231

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P41231

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41231

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41231

PeptideAtlas

More...
PeptideAtlasi
P41231

PRoteomics IDEntifications database

More...
PRIDEi
P41231

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55440

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41231

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41231

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Spleen, testis, kidney, liver, lung, heart and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175591 Expressed in 123 organ(s), highest expression level in gastrocnemius

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41231 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022642

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111068, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P41231

Protein interaction database and analysis system

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IntActi
P41231, 1 interactor

Molecular INTeraction database

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MINTi
P41231

STRING: functional protein association networks

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STRINGi
9606.ENSP00000310305

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P41231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P41231

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIAQ Eukaryota
ENOG410XQNZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231307

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101120

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41231

KEGG Orthology (KO)

More...
KOi
K04269

Identification of Orthologs from Complete Genome Data

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OMAi
DELGYKC

Database of Orthologous Groups

More...
OrthoDBi
1077455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41231

TreeFam database of animal gene trees

More...
TreeFami
TF350009

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15373 7tmA_P2Y2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000356 P2Y2_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24231:SF17 PTHR24231:SF17, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00594 P2Y2PRNOCPTR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL
60 70 80 90 100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP
110 120 130 140 150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA
160 170 180 190 200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS
210 220 230 240 250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV
260 270 280 290 300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
310 320 330 340 350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE
360 370
DVLGSSEDSR RTESTPAGSE NTKDIRL
Length:377
Mass (Da):42,273
Last modified:November 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF71DAF4A8DCB4062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350E → G in AAC04923 (PubMed:8159738).Curated1
Sequence conflicti359S → F in AAC04923 (PubMed:8159738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05487046P → L5 PublicationsCorresponds to variant dbSNP:rs2511241Ensembl.1
Natural variantiVAR_054871312R → S1 PublicationCorresponds to variant dbSNP:rs3741156Ensembl.1
Natural variantiVAR_054872334R → C2 PublicationsCorresponds to variant dbSNP:rs1626154Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07225 mRNA Translation: AAC04923.1
AY136753 mRNA Translation: AAN01279.1
AK313942 mRNA Translation: BAG36660.1
AP002761 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74882.1
BC012104 mRNA Translation: AAH12104.1
BC028135 mRNA Translation: AAH28135.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8219.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A54946

NCBI Reference Sequences

More...
RefSeqi
NP_002555.3, NM_002564.3
NP_788085.2, NM_176071.2
NP_788086.2, NM_176072.2
XP_005274076.1, XM_005274019.4
XP_005274077.1, XM_005274020.4
XP_005274078.1, XM_005274021.4
XP_011543376.1, XM_011545074.2
XP_016873328.1, XM_017017839.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.339
Hs.572077

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311131; ENSP00000310305; ENSG00000175591
ENST00000393596; ENSP00000377221; ENSG00000175591
ENST00000393597; ENSP00000377222; ENSG00000175591

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5029

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5029

UCSC genome browser

More...
UCSCi
uc001otj.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA Translation: AAC04923.1
AY136753 mRNA Translation: AAN01279.1
AK313942 mRNA Translation: BAG36660.1
AP002761 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74882.1
BC012104 mRNA Translation: AAH12104.1
BC028135 mRNA Translation: AAH28135.1
CCDSiCCDS8219.1
PIRiA54946
RefSeqiNP_002555.3, NM_002564.3
NP_788085.2, NM_176071.2
NP_788086.2, NM_176072.2
XP_005274076.1, XM_005274019.4
XP_005274077.1, XM_005274020.4
XP_005274078.1, XM_005274021.4
XP_011543376.1, XM_011545074.2
XP_016873328.1, XM_017017839.1
UniGeneiHs.339
Hs.572077

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111068, 3 interactors
CORUMiP41231
IntActiP41231, 1 interactor
MINTiP41231
STRINGi9606.ENSP00000310305

Chemistry databases

BindingDBiP41231
ChEMBLiCHEMBL4398
DrugBankiDB04983 Denufosol
DB05390 INS 316
DB04786 Suramin
GuidetoPHARMACOLOGYi324

Protein family/group databases

TCDBi9.A.14.13.16 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP41231
PhosphoSitePlusiP41231

Polymorphism and mutation databases

BioMutaiP2RY2
DMDMi311033490

Proteomic databases

EPDiP41231
jPOSTiP41231
MaxQBiP41231
PaxDbiP41231
PeptideAtlasiP41231
PRIDEiP41231
ProteomicsDBi55440

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5029
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591
ENST00000393596; ENSP00000377221; ENSG00000175591
ENST00000393597; ENSP00000377222; ENSG00000175591
GeneIDi5029
KEGGihsa:5029
UCSCiuc001otj.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5029
DisGeNETi5029
EuPathDBiHostDB:ENSG00000175591.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
P2RY2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009916
HGNCiHGNC:8541 P2RY2
HPAiCAB022642
MIMi600041 gene
neXtProtiNX_P41231
OpenTargetsiENSG00000175591
PharmGKBiPA32870

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIAQ Eukaryota
ENOG410XQNZ LUCA
GeneTreeiENSGT00940000153332
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiP41231
KOiK04269
OMAiDELGYKC
OrthoDBi1077455at2759
PhylomeDBiP41231
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-5683826 Surfactant metabolism
SignaLinkiP41231

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
P2RY2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5029

Protein Ontology

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PROi
PR:P41231

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000175591 Expressed in 123 organ(s), highest expression level in gastrocnemius
GenevisibleiP41231 HS

Family and domain databases

CDDicd15373 7tmA_P2Y2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000356 P2Y2_rcpt
PANTHERiPTHR24231:SF17 PTHR24231:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00594 P2Y2PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RY2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: February 13, 2019
This is version 176 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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