Tef

Functionⁱ

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.

GO - Molecular functionⁱ

protein heterodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 1916262
protein homodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 1916262
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1916262
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 1916262
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1916262

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: GO_Central
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 1916262
rhythmic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thyrotroph embryonic factor
Gene namesⁱ	Name:Tef
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	3841 Tef

RGDⁱ

3841 Tef

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	218	K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication	1
Mutagenesisⁱ	219	K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication	1
Mutagenesisⁱ	221	K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication	1
Mutagenesisⁱ	222	K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication	1
Mutagenesisⁱ	266	L → V: Diminishes DNA-binding. 1 Publication	1
Mutagenesisⁱ	273	L → V: Diminishes DNA-binding. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076515	1 – 301	Thyrotroph embryonic factorAdd BLAST		301

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	30	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P41224
PRIDEⁱ	P41224

Expressionⁱ

Tissue specificityⁱ

Expressed exclusively in the rostral portion of the anterior pituitary during embryogenesis. Found in several tissues in juvenile and adult rats.

Developmental stageⁱ

Expressed up to embryonic day 14 and specifically in the anterior pituitary during embryogenesis.

Inductionⁱ

Accumulates according to a robust circadian rhythm.By similarity

Gene expression databases

Bgeeⁱ	ENSRNOG00000019383
ExpressionAtlasⁱ	P41224 baseline and differential
Genevisibleⁱ	P41224 RN

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000026258

STRINGⁱ

10116.ENSRNOP00000026258

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P41224
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	231 – 294	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	233 – 253	Basic motifPROSITE-ProRule annotationAdd BLAST		21
Regionⁱ	254 – 261	Leucine-zipperPROSITE-ProRule annotation		8

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	164 – 215	Pro-rich (proline/acidic region (PAR))Add BLAST		52

Sequence similaritiesⁱ

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3119 Eukaryota ENOG410YJ8G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039070
HOGENOMⁱ	HOG000234383
HOVERGENⁱ	HBG004983
InParanoidⁱ	P41224
KEGG Orthology (KO) More...KOⁱ	K09058
PhylomeDBⁱ	P41224
TreeFamⁱ	TF315869

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR029832 TEF/VBP
PANTHERⁱ	PTHR11988:SF24 PTHR11988:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P41224-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEAGGGKKP PVEPQAGPGP GRAAGERGLS GSFPLVLKKL MENPPRETRL 
        60         70         80         90        100
DKEKGKEKLE EDESAAASTM AVSASLMPPI WDKTIPYDGE SFHLEYMDLD 
       110        120        130        140        150
EFLLENGIPA SPTHLAQNLL LPVAELEGKE SASSSTASPP SSSTAIFQPS 
       160        170        180        190        200
ETVSSTESSL EKERETPSPI DPNCVEVDVN FNPDPADLVL SSVPGGELFN 
       210        220        230        240        250
PRKHKFAEED LKPQPMIKKA KKVFVPDEQK DEKYWTRRKK NNVAAKRSRD 
       260        270        280        290        300
ARRLKENQIT IRAAFLEKEN TALRTEVAEL RKEVGKCKTI VSKYETKYGP 

L

Length:301

Mass (Da):33,159

Last modified:December 6, 2005 - v3

Checksum:ⁱ2EDFB924F6D2D5F3

GO

Sequence cautionⁱ

The sequence AAB20032 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC101895 mRNA Translation: AAI01896.1 S58745 mRNA Translation: AAB20032.1 Different initiation.
PIRⁱ	A40579
NCBI Reference Sequences More...RefSeqⁱ	NP_062067.2, NM_019194.2
UniGeneⁱ	Rn.59871

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026258; ENSRNOP00000026258; ENSRNOG00000019383
GeneIDⁱ	29362
KEGGⁱ	rno:29362
UCSC genome browser More...UCSCⁱ	RGD:3841 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P41224	TEF, PAR bZIP transcription factor		CANLF		311
UPI0001C6148D		RABIT		310
TEF, PAR bZIP transcription factor		BOVIN		310
UPI000576103E		Bison bison bison		231
Thyrotroph embryonic factor isoform 1 (Fragment)		SHEEP		52
+106

Protein	Similar proteins		Species	Score	Length
P41224	TEF, PAR bZIP transcription factor		CANLF		311
TEF, PAR bZIP transcription factor		BOVIN		310
UPI000576103E		Bison bison bison		231
Thyrotroph embryonic factor isoform 1 (Fragment)		SHEEP		52
UPI0001C6148D		RABIT		310
+332

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC101895 mRNA Translation: AAI01896.1 S58745 mRNA Translation: AAB20032.1 Different initiation.
PIRⁱ	A40579
NCBI Reference Sequences More...RefSeqⁱ	NP_062067.2, NM_019194.2
UniGeneⁱ	Rn.59871

3D structure databases

ProteinModelPortalⁱ	P41224
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000026258

STRINGⁱ

10116.ENSRNOP00000026258

Proteomic databases

PaxDbⁱ	P41224
PRIDEⁱ	P41224

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026258; ENSRNOP00000026258; ENSRNOG00000019383
GeneIDⁱ	29362
KEGGⁱ	rno:29362
UCSC genome browser More...UCSCⁱ	RGD:3841 rat

Organism-specific databases

CTDⁱ	7008
Rat genome database More...RGDⁱ	3841 Tef

Phylogenomic databases

eggNOGⁱ	KOG3119 Eukaryota ENOG410YJ8G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039070
HOGENOMⁱ	HOG000234383
HOVERGENⁱ	HBG004983
InParanoidⁱ	P41224
KEGG Orthology (KO) More...KOⁱ	K09058
PhylomeDBⁱ	P41224
TreeFamⁱ	TF315869

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P41224

PROⁱ

PR:P41224

Gene expression databases

Bgeeⁱ	ENSRNOG00000019383
ExpressionAtlasⁱ	P41224 baseline and differential
Genevisibleⁱ	P41224 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR029832 TEF/VBP
PANTHERⁱ	PTHR11988:SF24 PTHR11988:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TEF_RAT
Accessionⁱ	P41224Primary (citable) accession number: P41224 Secondary accession number(s): Q3T1I8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	December 6, 2005
	Last modified:	May 23, 2018
	This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - P41224 (TEF_RAT)

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Thyrotroph embryonic factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ