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UniProtKB - P41224 (TEF_RAT)
Protein
Thyrotroph embryonic factor
Gene
Tef
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- double-stranded DNA binding Source: RGD
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Thyrotroph embryonic factor |
Gene namesi | Name:Tef |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3841, Tef |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 218 | K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication | 1 | |
Mutagenesisi | 219 | K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication | 1 | |
Mutagenesisi | 221 | K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication | 1 | |
Mutagenesisi | 222 | K → A: 30-fold decrease in affinity for prolactin recognition element. 1 Publication | 1 | |
Mutagenesisi | 266 | L → V: Diminishes DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 273 | L → V: Diminishes DNA-binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076515 | 1 – 301 | Thyrotroph embryonic factorAdd BLAST | 301 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P41224 |
Expressioni
Tissue specificityi
Expressed exclusively in the rostral portion of the anterior pituitary during embryogenesis. Found in several tissues in juvenile and adult rats.
Developmental stagei
Expressed up to embryonic day 14 and specifically in the anterior pituitary during embryogenesis.
Inductioni
Accumulates according to a robust circadian rhythm.By similarity
Gene expression databases
Bgeei | ENSRNOG00000019383, Expressed in skeletal muscle tissue and 21 other tissues |
ExpressionAtlasi | P41224, baseline and differential |
Genevisiblei | P41224, RN |
Interactioni
Subunit structurei
Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026258 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 294 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 130 – 174 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 233 – 253 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 254 – 261 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 64 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 130 – 156 | Polar residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000156578 |
HOGENOMi | CLU_051922_2_0_1 |
InParanoidi | P41224 |
OrthoDBi | 1023460at2759 |
PhylomeDBi | P41224 |
TreeFami | TF315869 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR040223, PAR_bZIP IPR029832, TEF/VBP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF24, PTHR11988:SF24, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P41224-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEAGGGKKP PVEPQAGPGP GRAAGERGLS GSFPLVLKKL MENPPRETRL
60 70 80 90 100
DKEKGKEKLE EDESAAASTM AVSASLMPPI WDKTIPYDGE SFHLEYMDLD
110 120 130 140 150
EFLLENGIPA SPTHLAQNLL LPVAELEGKE SASSSTASPP SSSTAIFQPS
160 170 180 190 200
ETVSSTESSL EKERETPSPI DPNCVEVDVN FNPDPADLVL SSVPGGELFN
210 220 230 240 250
PRKHKFAEED LKPQPMIKKA KKVFVPDEQK DEKYWTRRKK NNVAAKRSRD
260 270 280 290 300
ARRLKENQIT IRAAFLEKEN TALRTEVAEL RKEVGKCKTI VSKYETKYGP
L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5ZT24 | A0A8I5ZT24_RAT | Thyrotroph embryonic factor | Tef | 285 | Annotation score: |
Sequence cautioni
The sequence AAB20032 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC101895 mRNA Translation: AAI01896.1 S58745 mRNA Translation: AAB20032.1 Different initiation. |
PIRi | A40579 |
RefSeqi | NP_062067.2, NM_019194.2 |
Genome annotation databases
Ensembli | ENSRNOT00000026258; ENSRNOP00000026258; ENSRNOG00000019383 |
GeneIDi | 29362 |
KEGGi | rno:29362 |
UCSCi | RGD:3841, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC101895 mRNA Translation: AAI01896.1 S58745 mRNA Translation: AAB20032.1 Different initiation. |
PIRi | A40579 |
RefSeqi | NP_062067.2, NM_019194.2 |
3D structure databases
AlphaFoldDBi | P41224 |
SMRi | P41224 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026258 |
Proteomic databases
PaxDbi | P41224 |
Genome annotation databases
Ensembli | ENSRNOT00000026258; ENSRNOP00000026258; ENSRNOG00000019383 |
GeneIDi | 29362 |
KEGGi | rno:29362 |
UCSCi | RGD:3841, rat |
Organism-specific databases
CTDi | 7008 |
RGDi | 3841, Tef |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000156578 |
HOGENOMi | CLU_051922_2_0_1 |
InParanoidi | P41224 |
OrthoDBi | 1023460at2759 |
PhylomeDBi | P41224 |
TreeFami | TF315869 |
Miscellaneous databases
PROi | PR:P41224 |
Gene expression databases
Bgeei | ENSRNOG00000019383, Expressed in skeletal muscle tissue and 21 other tissues |
ExpressionAtlasi | P41224, baseline and differential |
Genevisiblei | P41224, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR040223, PAR_bZIP IPR029832, TEF/VBP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF24, PTHR11988:SF24, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TEF_RAT | |
Accessioni | P41224Primary (citable) accession number: P41224 Secondary accession number(s): Q3T1I8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | December 6, 2005 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families