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Protein

Protein BUD31 homolog

Gene

BUD31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the pre-mRNA splicing process (PubMed:28502770, PubMed:28076346). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737).1 Publication2 Publications

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: ProtInc
  • nuclear hormone receptor binding Source: UniProtKB
  • nuclear receptor transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BUD31 homolog1 Publication
Alternative name(s):
Protein EDG-21 Publication
Protein G10 homolog1 Publication
Gene namesi
Name:BUD31
Synonyms:EDG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106245.9
HGNCiHGNC:29629 BUD31
MIMi603477 gene
neXtProtiNX_P41223

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8896
OpenTargetsiENSG00000106245
PharmGKBiPA144596513

Polymorphism and mutation databases

BioMutaiBUD31

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938971 – 144Protein BUD31 homologAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP41223
MaxQBiP41223
PaxDbiP41223
PeptideAtlasiP41223
PRIDEiP41223
ProteomicsDBi55432

PTM databases

iPTMnetiP41223
PhosphoSitePlusiP41223

Expressioni

Tissue specificityi

Detected in epithelial and stromal cells in benign prostate hyperplasia tissue (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000106245 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_BUD31
ExpressionAtlasiP41223 baseline and differential
GenevisibleiP41223 HS

Organism-specific databases

HPAiHPA028943

Interactioni

Subunit structurei

Identified in the spliceosome C complex (PubMed:28502770, PubMed:28076346). May interact with AR (PubMed:25091737).1 Publication2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114413, 47 interactors
CORUMiP41223
IntActiP41223, 13 interactors
MINTiP41223
STRINGi9606.ENSP00000222969

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41223
SMRiP41223
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 67Interaction with AR1 Publication9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 10Nuclear localization signalSequence analysis9

Domaini

Contains a short sequence motif (Phe-Xaa-Xaa-Phe-Tyr) that can bind to AR and may modulate AR activity.1 Publication

Sequence similaritiesi

Belongs to the BUD31 (G10) family.Curated

Phylogenomic databases

eggNOGiKOG3404 Eukaryota
COG5132 LUCA
GeneTreeiENSGT00390000014300
HOGENOMiHOG000235066
HOVERGENiHBG080938
InParanoidiP41223
KOiK12873
OMAiCRGCSSD
OrthoDBiEOG091G0PEI
PhylomeDBiP41223
TreeFamiTF105609

Family and domain databases

InterProiView protein in InterPro
IPR018230 BUD31/G10-rel_CS
IPR001748 G10
PANTHERiPTHR19411 PTHR19411, 1 hit
PfamiView protein in Pfam
PF01125 G10, 1 hit
PRINTSiPR00322 G10
PROSITEiView protein in PROSITE
PS00997 G10_1, 1 hit
PS00998 G10_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF
60 70 80 90 100
RIHHQKTRYI FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL
110 120 130 140
CCLRCIQTRD TNFGTNCICR VPKSKLEVGR IIECTHCGCR GCSG
Length:144
Mass (Da):17,000
Last modified:October 10, 2002 - v2
Checksum:i520B8E74C97D0926
GO
Isoform 2 (identifier: P41223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-144: GRIIECTHCGCRGCSG → VMSDTQAWCCFQLKILP

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):17,331
Checksum:i00598D743480CF95
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCD9C9JCD9_HUMAN
Protein BUD31 homolog
BUD31
103Annotation score:
F8WCN7F8WCN7_HUMAN
Protein BUD31 homolog
BUD31
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → Q in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti12P → Q in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti24E → Q in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti24E → Q in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti70I → Y in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti70I → Y in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti75 – 79YEYCI → LDICY in AAA20008 (PubMed:7841202).Curated5
Sequence conflicti83Y → L in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti83Y → L in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti89I → L in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti89I → L in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti97 – 98YE → IG in AAA20008 (PubMed:7841202).Curated2
Sequence conflicti97 – 98YE → IG in AAB33291 (PubMed:7841202).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055558129 – 144GRIIE…RGCSG → VMSDTQAWCCFQLKILP in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11861 mRNA Translation: AAA20008.1
S77329 mRNA Translation: AAB33291.1
AK297784 mRNA Translation: BAH12665.1
AK316477 mRNA Translation: BAH14848.1
CR456951 mRNA Translation: CAG33232.1
AC004922 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23881.1
CH471091 Genomic DNA Translation: EAW76670.1
CH471091 Genomic DNA Translation: EAW76671.1
CH471091 Genomic DNA Translation: EAW76672.1
CH471091 Genomic DNA Translation: EAW76673.1
BC022821 mRNA Translation: AAH22821.1
BC104670 mRNA Translation: AAI04671.1
CCDSiCCDS5663.1 [P41223-1]
PIRiS52131
RefSeqiNP_003901.2, NM_003910.3 [P41223-1]
XP_005250727.1, XM_005250670.4 [P41223-2]
XP_005250728.1, XM_005250671.4 [P41223-2]
XP_005250731.1, XM_005250674.3 [P41223-1]
XP_016868249.1, XM_017012760.1 [P41223-2]
XP_016868250.1, XM_017012761.1 [P41223-2]
XP_016868251.1, XM_017012762.1 [P41223-1]
UniGeneiHs.380233

Genome annotation databases

EnsembliENST00000222969; ENSP00000222969; ENSG00000106245 [P41223-1]
ENST00000403633; ENSP00000386023; ENSG00000106245 [P41223-1]
GeneIDi8896
KEGGihsa:8896
UCSCiuc003uqf.4 human [P41223-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11861 mRNA Translation: AAA20008.1
S77329 mRNA Translation: AAB33291.1
AK297784 mRNA Translation: BAH12665.1
AK316477 mRNA Translation: BAH14848.1
CR456951 mRNA Translation: CAG33232.1
AC004922 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23881.1
CH471091 Genomic DNA Translation: EAW76670.1
CH471091 Genomic DNA Translation: EAW76671.1
CH471091 Genomic DNA Translation: EAW76672.1
CH471091 Genomic DNA Translation: EAW76673.1
BC022821 mRNA Translation: AAH22821.1
BC104670 mRNA Translation: AAI04671.1
CCDSiCCDS5663.1 [P41223-1]
PIRiS52131
RefSeqiNP_003901.2, NM_003910.3 [P41223-1]
XP_005250727.1, XM_005250670.4 [P41223-2]
XP_005250728.1, XM_005250671.4 [P41223-2]
XP_005250731.1, XM_005250674.3 [P41223-1]
XP_016868249.1, XM_017012760.1 [P41223-2]
XP_016868250.1, XM_017012761.1 [P41223-2]
XP_016868251.1, XM_017012762.1 [P41223-1]
UniGeneiHs.380233

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OEDX-ray2.79B56-70[»]
4OH6X-ray3.56B56-70[»]
4OKBX-ray2.95B56-70[»]
5MQFelectron microscopy5.90Q1-144[»]
5XJCelectron microscopy3.60N1-144[»]
5YZGelectron microscopy4.10N1-144[»]
5Z56electron microscopy5.10N1-144[»]
5Z57electron microscopy6.50N1-144[»]
6FF4electron microscopy16.00Q1-144[»]
ProteinModelPortaliP41223
SMRiP41223
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114413, 47 interactors
CORUMiP41223
IntActiP41223, 13 interactors
MINTiP41223
STRINGi9606.ENSP00000222969

PTM databases

iPTMnetiP41223
PhosphoSitePlusiP41223

Polymorphism and mutation databases

BioMutaiBUD31

Proteomic databases

EPDiP41223
MaxQBiP41223
PaxDbiP41223
PeptideAtlasiP41223
PRIDEiP41223
ProteomicsDBi55432

Protocols and materials databases

DNASUi8896
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222969; ENSP00000222969; ENSG00000106245 [P41223-1]
ENST00000403633; ENSP00000386023; ENSG00000106245 [P41223-1]
GeneIDi8896
KEGGihsa:8896
UCSCiuc003uqf.4 human [P41223-1]

Organism-specific databases

CTDi8896
DisGeNETi8896
EuPathDBiHostDB:ENSG00000106245.9
GeneCardsiBUD31
HGNCiHGNC:29629 BUD31
HPAiHPA028943
MIMi603477 gene
neXtProtiNX_P41223
OpenTargetsiENSG00000106245
PharmGKBiPA144596513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3404 Eukaryota
COG5132 LUCA
GeneTreeiENSGT00390000014300
HOGENOMiHOG000235066
HOVERGENiHBG080938
InParanoidiP41223
KOiK12873
OMAiCRGCSSD
OrthoDBiEOG091G0PEI
PhylomeDBiP41223
TreeFamiTF105609

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiBUD31 human
GenomeRNAii8896
PROiPR:P41223
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106245 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_BUD31
ExpressionAtlasiP41223 baseline and differential
GenevisibleiP41223 HS

Family and domain databases

InterProiView protein in InterPro
IPR018230 BUD31/G10-rel_CS
IPR001748 G10
PANTHERiPTHR19411 PTHR19411, 1 hit
PfamiView protein in Pfam
PF01125 G10, 1 hit
PRINTSiPR00322 G10
PROSITEiView protein in PROSITE
PS00997 G10_1, 1 hit
PS00998 G10_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBUD31_HUMAN
AccessioniPrimary (citable) accession number: P41223
Secondary accession number(s): A4D274
, B7Z4S9, D6W5S6, Q6IB53, Q9UDV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 10, 2002
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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