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Protein

Prostaglandin-H2 D-isomerase

Gene

PTGDS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.2 Publications

Miscellaneous

It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei65Nucleophile1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fatty acid binding Source: UniProtKB
  • prostaglandin-D synthase activity Source: UniProtKB
  • retinoid binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS02989-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
5.3.99.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

SIGNOR Signaling Network Open Resource

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SIGNORi
P41222

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000141

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin-H2 D-isomerase (EC:5.3.99.2)
Alternative name(s):
Beta-trace protein
Cerebrin-28
Glutathione-independent PGD synthase
Lipocalin-type prostaglandin-D synthase
Prostaglandin-D2 synthase
Short name:
PGD2 synthase
Short name:
PGDS
Short name:
PGDS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGDS
Synonyms:PDS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000107317.11

Human Gene Nomenclature Database

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HGNCi
HGNC:9592 PTGDS

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176803 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41222

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59K → A: Increases enzyme activity about two-fold. 1 Publication1
Mutagenesisi64M → A: Reduces enzyme activity almost ten-fold. 1 Publication1
Mutagenesisi65C → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi79L → A: Reduces enzyme activity over ten-fold. 1 Publication1
Mutagenesisi83F → A: Reduces enzyme activity about five-fold. 1 Publication1
Mutagenesisi131L → A: Reduces enzyme activity almost ten-fold. 1 Publication1
Mutagenesisi149Y → A: Increases enzyme activity about two-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5730

Open Targets

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OpenTargetsi
ENSG00000107317

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33945

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430865

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTGDS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
730305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 227 PublicationsAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001794523 – 190Prostaglandin-H2 D-isomeraseAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29O-linked (GalNAc...) serine1 Publication1
Glycosylationi51N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi78N-linked (GlcNAc...) (complex) asparagine5 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi89 ↔ 186By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P41222

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P41222

PeptideAtlas

More...
PeptideAtlasi
P41222

PRoteomics IDEntifications database

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PRIDEi
P41222

ProteomicsDB human proteome resource

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ProteomicsDBi
55431

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P41222

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
685

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41222

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P41222

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P41222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.9 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy. Levels decrease slowly after 25 weeks.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107317 Expressed in 220 organ(s), highest expression level in trigeminal ganglion

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTGDS

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41222 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41222 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009916
HPA004938

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111702, 20 interactors

Protein interaction database and analysis system

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IntActi
P41222, 16 interactors

Molecular INTeraction database

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MINTi
P41222

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360687

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P41222

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWPX-ray2.00A/B23-190[»]
3O19X-ray1.66A29-190[»]
3O22X-ray1.40A29-190[»]
3O2YX-ray1.70A/B29-190[»]
4IMNX-ray2.09A23-190[»]
4IMOX-ray1.88A23-190[»]
4ORRX-ray1.40A1-190[»]
4ORSX-ray1.40A/B1-190[»]
4ORUX-ray1.55A/B1-190[»]
4ORWX-ray1.66A/B1-190[»]
4ORXX-ray1.60A/B1-190[»]
4ORYX-ray1.80A/B/C/D/E/F/G/H1-190[»]
4OS0X-ray1.75A/B1-190[»]
4OS3X-ray1.40A/B1-190[»]
4OS8X-ray1.69A/B1-190[»]
5WY9X-ray1.45A23-190[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P41222

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41222

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P41222

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II11 Eukaryota
ENOG4111YRI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00920000149140

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106490

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41222

KEGG Orthology (KO)

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KOi
K01830

Identification of Orthologs from Complete Genome Data

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OMAi
HMATLYS

Database of Orthologous Groups

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OrthoDBi
1401257at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P41222

TreeFam database of animal gene trees

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TreeFami
TF336103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002972 PstgldnD_synth

The PANTHER Classification System

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PANTHERi
PTHR11430 PTHR11430, 1 hit
PTHR11430:SF86 PTHR11430:SF86, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50814 SSF50814, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00213 LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P41222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATHHTLWMG LALLGVLGDL QAAPEAQVSV QPNFQQDKFL GRWFSAGLAS
60 70 80 90 100
NSSWLREKKA ALSMCKSVVA PATDGGLNLT STFLRKNQCE TRTMLLQPAG
110 120 130 140 150
SLGSYSYRSP HWGSTYSVSV VETDYDQYAL LYSQGSKGPG EDFRMATLYS
160 170 180 190
RTQTPRAELK EKFTAFCKAQ GFTEDTIVFL PQTDKCMTEQ
Length:190
Mass (Da):21,029
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF35FE48AD0D5EF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQ11Q5SQ11_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPU3A0A1W2PPU3_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5A1H0Y5A1_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4L4H0Y4L4_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25E → P AA sequence (PubMed:8336140).Curated1
Sequence conflicti33N → L AA sequence (PubMed:9844724).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00427356R → Q. Corresponds to variant dbSNP:rs11552179Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M61900 mRNA Translation: AAA36494.2
M98538, M98537 Genomic DNA Translation: AAB51074.1
AY026356 mRNA Translation: AAK07679.1
DQ297141 Genomic DNA Translation: ABB84464.1
AK312817 mRNA Translation: BAG35674.1
AK075333 mRNA Translation: BAG52113.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88321.1
BC005939 mRNA Translation: AAH05939.1
BT019921 mRNA Translation: AAV38724.1
BT019922 mRNA Translation: AAV38725.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7019.1

Protein sequence database of the Protein Information Resource

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PIRi
A44455
PH1567

NCBI Reference Sequences

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RefSeqi
NP_000945.3, NM_000954.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.446429

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371625; ENSP00000360687; ENSG00000107317

Database of genes from NCBI RefSeq genomes

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GeneIDi
5730

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5730

UCSC genome browser

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UCSCi
uc004cke.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61900 mRNA Translation: AAA36494.2
M98538, M98537 Genomic DNA Translation: AAB51074.1
AY026356 mRNA Translation: AAK07679.1
DQ297141 Genomic DNA Translation: ABB84464.1
AK312817 mRNA Translation: BAG35674.1
AK075333 mRNA Translation: BAG52113.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88321.1
BC005939 mRNA Translation: AAH05939.1
BT019921 mRNA Translation: AAV38724.1
BT019922 mRNA Translation: AAV38725.1
CCDSiCCDS7019.1
PIRiA44455
PH1567
RefSeqiNP_000945.3, NM_000954.5
UniGeneiHs.446429

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWPX-ray2.00A/B23-190[»]
3O19X-ray1.66A29-190[»]
3O22X-ray1.40A29-190[»]
3O2YX-ray1.70A/B29-190[»]
4IMNX-ray2.09A23-190[»]
4IMOX-ray1.88A23-190[»]
4ORRX-ray1.40A1-190[»]
4ORSX-ray1.40A/B1-190[»]
4ORUX-ray1.55A/B1-190[»]
4ORWX-ray1.66A/B1-190[»]
4ORXX-ray1.60A/B1-190[»]
4ORYX-ray1.80A/B/C/D/E/F/G/H1-190[»]
4OS0X-ray1.75A/B1-190[»]
4OS3X-ray1.40A/B1-190[»]
4OS8X-ray1.69A/B1-190[»]
5WY9X-ray1.45A23-190[»]
ProteinModelPortaliP41222
SMRiP41222
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111702, 20 interactors
IntActiP41222, 16 interactors
MINTiP41222
STRINGi9606.ENSP00000360687

Chemistry databases

BindingDBiP41222
ChEMBLiCHEMBL3430865
SwissLipidsiSLP:000000141

PTM databases

GlyConnecti685
iPTMnetiP41222
PhosphoSitePlusiP41222
UniCarbKBiP41222

Polymorphism and mutation databases

BioMutaiPTGDS
DMDMi730305

2D gel databases

UCD-2DPAGEiP41222

Proteomic databases

jPOSTiP41222
PaxDbiP41222
PeptideAtlasiP41222
PRIDEiP41222
ProteomicsDBi55431

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5730
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371625; ENSP00000360687; ENSG00000107317
GeneIDi5730
KEGGihsa:5730
UCSCiuc004cke.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5730
DisGeNETi5730
EuPathDBiHostDB:ENSG00000107317.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PTGDS
HGNCiHGNC:9592 PTGDS
HPAiCAB009916
HPA004938
MIMi176803 gene
neXtProtiNX_P41222
OpenTargetsiENSG00000107317
PharmGKBiPA33945

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II11 Eukaryota
ENOG4111YRI LUCA
GeneTreeiENSGT00920000149140
HOVERGENiHBG106490
InParanoidiP41222
KOiK01830
OMAiHMATLYS
OrthoDBi1401257at2759
PhylomeDBiP41222
TreeFamiTF336103

Enzyme and pathway databases

BioCyciMetaCyc:HS02989-MONOMER
BRENDAi5.3.99.2 2681
ReactomeiR-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SIGNORiP41222

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTGDS human
EvolutionaryTraceiP41222

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Prostaglandin_D2_synthase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5730

Protein Ontology

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PROi
PR:P41222

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107317 Expressed in 220 organ(s), highest expression level in trigeminal ganglion
CleanExiHS_PTGDS
ExpressionAtlasiP41222 baseline and differential
GenevisibleiP41222 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002972 PstgldnD_synth
PANTHERiPTHR11430 PTHR11430, 1 hit
PTHR11430:SF86 PTHR11430:SF86, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGDS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41222
Secondary accession number(s): B2R727
, Q5SQ10, Q7M4P3, Q9UC22, Q9UCC9, Q9UCD9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 16, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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