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UniProtKB - P41222 (PTGDS_HUMAN)

Entry version 205 (10 Feb 2021)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

Prostaglandin-H2 D-isomerase

Gene

PTGDS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).By similarity2 Publications

Miscellaneous

It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei65Nucleophile1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Mast cell degranulation, Prostaglandin biosynthesis, Prostaglandin metabolism, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS02989-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.3.99.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P41222

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P41222

SIGNOR Signaling Network Open Resource

More...SIGNORi		P41222

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000141

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin-H2 D-isomerase (EC:5.3.99.21 Publication)
Alternative name(s):
Beta-trace protein
Cerebrin-28
Glutathione-independent PGD synthase
Lipocalin-type prostaglandin-D synthase
Short name:
L-PGDS1 Publication
Prostaglandin-D2 synthase
Short name:
PGD2 synthase
Short name:
PGDS
Short name:
PGDS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGDS
Synonyms:PDS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9592, PTGDS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176803, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P41222

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000107317.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59K → A: Increases enzyme activity about two-fold. 1 Publication1
Mutagenesisi64M → A: Reduces enzyme activity almost ten-fold. 1 Publication1
Mutagenesisi65C → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi79L → A: Reduces enzyme activity over ten-fold. 1 Publication1
Mutagenesisi83F → A: Reduces enzyme activity about five-fold. 1 Publication1
Mutagenesisi131L → A: Reduces enzyme activity almost ten-fold. 1 Publication1
Mutagenesisi149Y → A: Increases enzyme activity about two-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5730

Open Targets

More...OpenTargetsi		ENSG00000107317

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P41222, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3430865

Drug and drug target database

More...DrugBanki		DB00162, Vitamin A

DrugCentral

More...DrugCentrali		P41222

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1380

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTGDS

Domain mapping of disease mutations (DMDM)

More...DMDMi		730305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 227 PublicationsAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001794523 – 190Prostaglandin-H2 D-isomeraseAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29O-linked (GalNAc...) serine1 Publication1
Glycosylationi51N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi78N-linked (GlcNAc...) (complex) asparagine5 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi89 ↔ 186By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-686

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P41222

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P41222

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41222

PeptideAtlas

More...PeptideAtlasi		P41222

PRoteomics IDEntifications database

More...PRIDEi		P41222

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55431

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P41222

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		685, 149 N-Linked glycans (3 sites), 19 O-Linked glycans (5 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P41222, 8 sites, 15 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41222

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P41222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.9 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy. Levels decrease slowly after 25 weeks.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107317, Expressed in trigeminal ganglion and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P41222, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P41222, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107317, Tissue enhanced (heart muscle, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111702, 24 interactors

Protein interaction database and analysis system

More...IntActi		P41222, 23 interactors

Molecular INTeraction database

More...MINTi		P41222

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360687

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P41222

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P41222, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P41222

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P41222

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6GK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00960000186615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_094061_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41222

Identification of Orthologs from Complete Genome Data

More...OMAi		KGPGQDF

Database of Orthologous Groups

More...OrthoDBi		1341030at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P41222

TreeFam database of animal gene trees

More...TreeFami		TF336103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012674, Calycin
IPR002345, Lipocalin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom
IPR002972, PstgldnD_synth

The PANTHER Classification System

More...PANTHERi		PTHR11430, PTHR11430, 1 hit
PTHR11430:SF86, PTHR11430:SF86, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00061, Lipocalin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50814, SSF50814, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00213, LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P41222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATHHTLWMG LALLGVLGDL QAAPEAQVSV QPNFQQDKFL GRWFSAGLAS 
        60         70         80         90        100
NSSWLREKKA ALSMCKSVVA PATDGGLNLT STFLRKNQCE TRTMLLQPAG 
       110        120        130        140        150
SLGSYSYRSP HWGSTYSVSV VETDYDQYAL LYSQGSKGPG EDFRMATLYS 
       160        170        180        190
RTQTPRAELK EKFTAFCKAQ GFTEDTIVFL PQTDKCMTEQ
Length:190
Mass (Da):21,029
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF35FE48AD0D5EF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQ11Q5SQ11_HUMAN
Glutathione-independent PGD synthas...
PTGDS
195Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5A1H0Y5A1_HUMAN
Glutathione-independent PGD synthas...
PTGDS
124Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPU3A0A1W2PPU3_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4L4H0Y4L4_HUMAN
Prostaglandin-H2 D-isomerase
PTGDS
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25E → P AA sequence (PubMed:8336140).Curated1
Sequence conflicti33N → L AA sequence (PubMed:9844724).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00427356R → Q. Corresponds to variant dbSNP:rs11552179Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M61900 mRNA Translation: AAA36494.2
M98538, M98537 Genomic DNA Translation: AAB51074.1
AY026356 mRNA Translation: AAK07679.1
DQ297141 Genomic DNA Translation: ABB84464.1
AK312817 mRNA Translation: BAG35674.1
AK075333 mRNA Translation: BAG52113.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88321.1
BC005939 mRNA Translation: AAH05939.1
BT019921 mRNA Translation: AAV38724.1
BT019922 mRNA Translation: AAV38725.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7019.1

Protein sequence database of the Protein Information Resource

More...PIRi		A44455
PH1567

NCBI Reference Sequences

More...RefSeqi		NP_000945.3, NM_000954.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371625; ENSP00000360687; ENSG00000107317

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5730

UCSC genome browser

More...UCSCi		uc004cke.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61900 mRNA Translation: AAA36494.2
M98538, M98537 Genomic DNA Translation: AAB51074.1
AY026356 mRNA Translation: AAK07679.1
DQ297141 Genomic DNA Translation: ABB84464.1
AK312817 mRNA Translation: BAG35674.1
AK075333 mRNA Translation: BAG52113.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88321.1
BC005939 mRNA Translation: AAH05939.1
BT019921 mRNA Translation: AAV38724.1
BT019922 mRNA Translation: AAV38725.1
CCDSiCCDS7019.1
PIRiA44455
PH1567
RefSeqiNP_000945.3, NM_000954.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWPX-ray2.00A/B23-190[»]
3O19X-ray1.66A29-190[»]
3O22X-ray1.40A29-190[»]
3O2YX-ray1.70A/B29-190[»]
4IMNX-ray2.09A23-190[»]
4IMOX-ray1.88A23-190[»]
4ORRX-ray1.40A1-190[»]
4ORSX-ray1.40A/B1-190[»]
4ORUX-ray1.55A/B1-190[»]
4ORWX-ray1.66A/B1-190[»]
4ORXX-ray1.60A/B1-190[»]
4ORYX-ray1.80A/B/C/D/E/F/G/H1-190[»]
4OS0X-ray1.75A/B1-190[»]
4OS3X-ray1.40A/B1-190[»]
4OS8X-ray1.69A/B1-190[»]
5WY9X-ray1.45A23-190[»]
SMRiP41222
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111702, 24 interactors
IntActiP41222, 23 interactors
MINTiP41222
STRINGi9606.ENSP00000360687

Chemistry databases

BindingDBiP41222
ChEMBLiCHEMBL3430865
DrugBankiDB00162, Vitamin A
DrugCentraliP41222
GuidetoPHARMACOLOGYi1380
SwissLipidsiSLP:000000141

PTM databases

GlyConnecti685, 149 N-Linked glycans (3 sites), 19 O-Linked glycans (5 sites)
GlyGeniP41222, 8 sites, 15 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
iPTMnetiP41222
PhosphoSitePlusiP41222

Genetic variation databases

BioMutaiPTGDS
DMDMi730305

2D gel databases

UCD-2DPAGEiP41222

Proteomic databases

CPTACiCPTAC-686
jPOSTiP41222
MassIVEiP41222
PaxDbiP41222
PeptideAtlasiP41222
PRIDEiP41222
ProteomicsDBi55431

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P41222, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1507, 351 antibodies

The DNASU plasmid repository

More...DNASUi		5730

Genome annotation databases

EnsembliENST00000371625; ENSP00000360687; ENSG00000107317
GeneIDi5730
KEGGihsa:5730
UCSCiuc004cke.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5730
DisGeNETi5730

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTGDS
HGNCiHGNC:9592, PTGDS
HPAiENSG00000107317, Tissue enhanced (heart muscle, retina)
MIMi176803, gene
neXtProtiNX_P41222
OpenTargetsiENSG00000107317
PharmGKBiPA33945
VEuPathDBiHostDB:ENSG00000107317.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S6GK, Eukaryota
GeneTreeiENSGT00960000186615
HOGENOMiCLU_094061_1_1_1
InParanoidiP41222
OMAiKGPGQDF
OrthoDBi1341030at2759
PhylomeDBiP41222
TreeFamiTF336103

Enzyme and pathway databases

BioCyciMetaCyc:HS02989-MONOMER
BRENDAi5.3.99.2, 2681
PathwayCommonsiP41222
ReactomeiR-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiP41222
SIGNORiP41222

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5730, 0 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTGDS, human
EvolutionaryTraceiP41222

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Prostaglandin_D2_synthase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5730
PharosiP41222, Tbio

Protein Ontology

More...PROi		PR:P41222
RNActiP41222, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107317, Expressed in trigeminal ganglion and 234 other tissues
ExpressionAtlasiP41222, baseline and differential
GenevisibleiP41222, HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674, Calycin
IPR002345, Lipocalin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom
IPR002972, PstgldnD_synth
PANTHERiPTHR11430, PTHR11430, 1 hit
PTHR11430:SF86, PTHR11430:SF86, 1 hit
PfamiView protein in Pfam
PF00061, Lipocalin, 1 hit
SUPFAMiSSF50814, SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213, LIPOCALIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGDS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41222
Secondary accession number(s): B2R727
, Q5SQ10, Q7M4P3, Q9UC22, Q9UCC9, Q9UCD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 10, 2021
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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