UniProtKB - P41221 (WNT5A_HUMAN)
Protein Wnt-5a
WNT5A
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity).
Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754).
Mediates motility of melanoma cells (PubMed:17426020).
Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- chemoattractant activity involved in axon guidance Source: Ensembl
- cytokine activity Source: GO_Central
- frizzled binding Source: UniProtKB
- phospholipid binding Source: ARUK-UCL
- protein domain specific binding Source: Ensembl
- receptor ligand activity Source: BHF-UCL
- receptor tyrosine kinase-like orphan receptor binding Source: UniProtKB
GO - Biological processi
- activation of GTPase activity Source: Ensembl
- activation of protein kinase B activity Source: BHF-UCL
- anterior/posterior axis specification, embryo Source: Ensembl
- atrial septum development Source: Ensembl
- axon guidance Source: UniProtKB
- canonical Wnt signaling pathway Source: GO_Central
- cartilage development Source: UniProtKB-KW
- cell fate commitment Source: GO_Central
- cellular protein localization Source: UniProtKB
- cellular response to calcium ion Source: UniProtKB
- cellular response to interferon-gamma Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to retinoic acid Source: UniProtKB
- cellular response to transforming growth factor beta stimulus Source: UniProtKB
- cervix development Source: Ensembl
- chemoattraction of serotonergic neuron axon Source: Ensembl
- chemorepulsion of dopaminergic neuron axon Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- convergent extension involved in axis elongation Source: Ensembl
- convergent extension involved in organogenesis Source: Ensembl
- embryonic digit morphogenesis Source: Ensembl
- embryonic skeletal system development Source: BHF-UCL
- epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
- epithelial to mesenchymal transition Source: UniProtKB
- establishment of epithelial cell apical/basal polarity Source: Ensembl
- establishment of planar polarity Source: Ensembl
- excitatory synapse assembly Source: ParkinsonsUK-UCL
- face development Source: BHF-UCL
- genitalia development Source: BHF-UCL
- heart looping Source: Ensembl
- hematopoietic stem cell proliferation Source: BHF-UCL
- hindgut morphogenesis Source: Ensembl
- hypophysis morphogenesis Source: Ensembl
- inhibitory synapse assembly Source: ParkinsonsUK-UCL
- JNK cascade Source: Ensembl
- keratinocyte differentiation Source: BHF-UCL
- kidney development Source: Ensembl
- lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
- lens development in camera-type eye Source: BHF-UCL
- lung development Source: Ensembl
- male gonad development Source: UniProtKB
- mammary gland branching involved in thelarche Source: Ensembl
- melanocyte proliferation Source: Ensembl
- mesenchymal-epithelial cell signaling Source: Ensembl
- mesodermal to mesenchymal transition involved in gastrulation Source: Ensembl
- midgut development Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of axon extension involved in axon guidance Source: Ensembl
- negative regulation of BMP signaling pathway Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: MGI
- negative regulation of cell proliferation in midbrain Source: ParkinsonsUK-UCL
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of fat cell differentiation Source: BHF-UCL
- negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
- negative regulation of melanin biosynthetic process Source: Ensembl
- negative regulation of mesenchymal cell proliferation Source: UniProtKB
- negative regulation of prostatic bud formation Source: Ensembl
- negative regulation of synapse assembly Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- neuron differentiation Source: UniProtKB
- non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
- notochord morphogenesis Source: Ensembl
- olfactory bulb interneuron development Source: UniProtKB
- optic cup formation involved in camera-type eye development Source: BHF-UCL
- paraxial mesoderm formation Source: Ensembl
- planar cell polarity pathway involved in axis elongation Source: Ensembl
- planar cell polarity pathway involved in axon guidance Source: Ensembl
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
- planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
- planar cell polarity pathway involved in gastrula mediolateral intercalation Source: Ensembl
- planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- planar cell polarity pathway involved in neural tube closure Source: Ensembl
- planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
- planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
- planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cartilage development Source: Ensembl
- positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
- positive regulation of chemokine production Source: UniProtKB
- positive regulation of cytokine production involved in immune response Source: UniProtKB
- positive regulation of endocytosis Source: Ensembl
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of interleukin-8 production Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of macrophage activation Source: BHF-UCL
- positive regulation of macrophage cytokine production Source: UniProtKB
- positive regulation of meiotic nuclear division Source: Ensembl
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of neuron death Source: ARUK-UCL
- positive regulation of neuron projection arborization Source: ARUK-UCL
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
- positive regulation of ossification Source: BHF-UCL
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein catabolic process Source: MGI
- positive regulation of protein kinase C activity Source: CACAO
- positive regulation of protein kinase C signaling Source: UniProtKB
- positive regulation of protein localization to synapse Source: ParkinsonsUK-UCL
- positive regulation of response to cytokine stimulus Source: UniProtKB
- positive regulation of T cell chemotaxis Source: UniProtKB
- positive regulation of thymocyte apoptotic process Source: Ensembl
- positive regulation of timing of anagen Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCL
- post-anal tail morphogenesis Source: Ensembl
- postsynapse assembly Source: ParkinsonsUK-UCL
- presynapse assembly Source: ParkinsonsUK-UCL
- primary heart field specification Source: Ensembl
- primitive streak formation Source: Ensembl
- protein phosphorylation Source: Ensembl
- regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
- regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
- regulation of inflammatory response Source: ARUK-UCL
- regulation of postsynapse organization Source: SynGO
- regulation of postsynaptic cytosolic calcium ion concentration Source: SynGO
- regulation of synapse organization Source: SynGO
- response to organic substance Source: UniProtKB
- secondary heart field specification Source: Ensembl
- secondary palate development Source: BHF-UCL
- somitogenesis Source: Ensembl
- type B pancreatic cell development Source: Ensembl
- urinary bladder development Source: Ensembl
- uterus development Source: Ensembl
- vagina development Source: Ensembl
- Wnt signaling pathway Source: BHF-UCL
- Wnt signaling pathway, calcium modulating pathway Source: UniProtKB
- Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
- Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Chondrogenesis, Differentiation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | P41221 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-3772470, Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-4086398, Ca2+ pathway R-HSA-4086400, PCP/CE pathway R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | P41221 |
SIGNORi | P41221 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-5a |
Gene namesi | Name:WNT5A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12784, WNT5A |
MIMi | 164975, gene |
neXtProti | NX_P41221 |
VEuPathDBi | HostDB:ENSG00000114251 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: Reactome
- extracellular region Source: ARUK-UCL
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: Ensembl
- clathrin-coated endocytic vesicle membrane Source: Reactome
- endocytic vesicle membrane Source: Reactome
- extracellular matrix Source: Ensembl
- glutamatergic synapse Source: SynGO
- postsynapse Source: GOC
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Robinow syndrome, autosomal dominant 1 (DRS1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066623 | 83 | C → S in DRS1; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs786200925EnsemblClinVar. | 1 | |
Natural variantiVAR_083248 | 160 | S → C in DRS1; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083249 | 164 | C → CGC in DRS1. 1 Publication | 1 | |
Natural variantiVAR_066629 | 182 | C → R in DRS1; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387906663EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 7474 |
GeneReviewsi | WNT5A |
MalaCardsi | WNT5A |
MIMi | 180700, phenotype |
OpenTargetsi | ENSG00000114251 |
Orphaneti | 3107, Autosomal dominant Robinow syndrome |
PharmGKBi | PA37385 |
Miscellaneous databases
Pharosi | P41221, Tbio |
Genetic variation databases
BioMutai | WNT5A |
DMDMi | 212276478 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
PropeptideiPRO_0000352796 | 36 – 61 | By similarityAdd BLAST | 26 | |
ChainiPRO_0000041427 | 62 – 380 | Protein Wnt-5aAdd BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 104 ↔ 115 | By similarity | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 154 ↔ 162 | By similarity | ||
Disulfide bondi | 164 ↔ 182 | By similarity | ||
Disulfide bondi | 238 ↔ 252 | By similarity | ||
Disulfide bondi | 240 ↔ 247 | By similarity | ||
Lipidationi | 244 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 309 ↔ 340 | By similarity | ||
Glycosylationi | 312 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 325 ↔ 335 | By similarity | ||
Glycosylationi | 326 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 339 ↔ 379 | By similarity | ||
Disulfide bondi | 355 ↔ 370 | By similarity | ||
Disulfide bondi | 357 ↔ 367 | By similarity | ||
Disulfide bondi | 362 ↔ 363 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
EPDi | P41221 |
jPOSTi | P41221 |
MassIVEi | P41221 |
MaxQBi | P41221 |
PaxDbi | P41221 |
PeptideAtlasi | P41221 |
PRIDEi | P41221 |
ProteomicsDBi | 55429 [P41221-1] 55430 [P41221-2] |
PTM databases
GlyConnecti | 1672, 2 N-Linked glycans (1 site) |
GlyGeni | P41221, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P41221 |
PhosphoSitePlusi | P41221 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114251, Expressed in stromal cell of endometrium and 210 other tissues |
ExpressionAtlasi | P41221, baseline and differential |
Genevisiblei | P41221, HS |
Organism-specific databases
HPAi | ENSG00000114251, Tissue enhanced (endometrium, salivary gland) |
Interactioni
Subunit structurei
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (in vitro).
Interacts with PORCN.
Interacts with WLS (By similarity).
Interacts with glypican GCP3 (PubMed:14610063).
Interacts with PKD1 (via extracellular domain) (PubMed:27214281).
By similarity3 PublicationsBinary interactionsi
P41221
With | #Exp. | IntAct |
---|---|---|
WIF1 [Q9Y5W5] | 2 | EBI-6594545,EBI-3922719 |
GO - Molecular functioni
- chemoattractant activity involved in axon guidance Source: Ensembl
- cytokine activity Source: GO_Central
- frizzled binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- receptor ligand activity Source: BHF-UCL
- receptor tyrosine kinase-like orphan receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113311, 67 interactors |
DIPi | DIP-29735N |
IntActi | P41221, 24 interactors |
MINTi | P41221 |
STRINGi | 9606.ENSP00000264634 |
Miscellaneous databases
RNActi | P41221, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158894 |
HOGENOMi | CLU_033039_0_1_1 |
InParanoidi | P41221 |
OMAi | EGELNSC |
OrthoDBi | 695671at2759 |
PhylomeDBi | P41221 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR026538, Wnt5a IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF33, PTHR12027:SF33, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG
60 70 80 90 100
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG
110 120 130 140 150
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM
160 170 180 190 200
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR
210 220 230 240 250
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK
260 270 280 290 300
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV
310 320 330 340 350
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV
360 370 380
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J8I8 | C9J8I8_HUMAN | Protein Wnt | WNT5A | 214 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066623 | 83 | C → S in DRS1; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs786200925EnsemblClinVar. | 1 | |
Natural variantiVAR_083248 | 160 | S → C in DRS1; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083249 | 164 | C → CGC in DRS1. 1 Publication | 1 | |
Natural variantiVAR_066629 | 182 | C → R in DRS1; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387906663EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035594 | 1 – 15 | Missing in isoform 2. 2 PublicationsAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20861 mRNA Translation: AAA16842.1 AK290375 mRNA Translation: BAF83064.1 AK290869 mRNA Translation: BAF83558.1 CH471055 Genomic DNA Translation: EAW65310.1 BC064694 mRNA Translation: AAH64694.1 |
CCDSi | CCDS46850.1 [P41221-1] CCDS58835.1 [P41221-2] |
PIRi | A48914 |
RefSeqi | NP_001243034.1, NM_001256105.1 [P41221-2] NP_003383.2, NM_003392.4 [P41221-1] XP_006713387.1, XM_006713324.1 XP_011532387.1, XM_011534085.2 [P41221-2] XP_011532388.1, XM_011534086.2 [P41221-2] XP_011532389.1, XM_011534087.2 XP_011532390.1, XM_011534088.2 [P41221-2] XP_011532391.1, XM_011534089.1 [P41221-2] XP_016862617.1, XM_017007128.1 [P41221-2] |
Genome annotation databases
Ensembli | ENST00000264634.9; ENSP00000264634.4; ENSG00000114251.15 ENST00000474267.5; ENSP00000417310.1; ENSG00000114251.15 ENST00000497027.5; ENSP00000420104.1; ENSG00000114251.15 [P41221-2] |
GeneIDi | 7474 |
KEGGi | hsa:7474 |
MANE-Selecti | ENST00000264634.9; ENSP00000264634.4; NM_003392.7; NP_003383.4 |
UCSCi | uc003dhn.5, human [P41221-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20861 mRNA Translation: AAA16842.1 AK290375 mRNA Translation: BAF83064.1 AK290869 mRNA Translation: BAF83558.1 CH471055 Genomic DNA Translation: EAW65310.1 BC064694 mRNA Translation: AAH64694.1 |
CCDSi | CCDS46850.1 [P41221-1] CCDS58835.1 [P41221-2] |
PIRi | A48914 |
RefSeqi | NP_001243034.1, NM_001256105.1 [P41221-2] NP_003383.2, NM_003392.4 [P41221-1] XP_006713387.1, XM_006713324.1 XP_011532387.1, XM_011534085.2 [P41221-2] XP_011532388.1, XM_011534086.2 [P41221-2] XP_011532389.1, XM_011534087.2 XP_011532390.1, XM_011534088.2 [P41221-2] XP_011532391.1, XM_011534089.1 [P41221-2] XP_016862617.1, XM_017007128.1 [P41221-2] |
3D structure databases
AlphaFoldDBi | P41221 |
SMRi | P41221 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113311, 67 interactors |
DIPi | DIP-29735N |
IntActi | P41221, 24 interactors |
MINTi | P41221 |
STRINGi | 9606.ENSP00000264634 |
PTM databases
GlyConnecti | 1672, 2 N-Linked glycans (1 site) |
GlyGeni | P41221, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P41221 |
PhosphoSitePlusi | P41221 |
Genetic variation databases
BioMutai | WNT5A |
DMDMi | 212276478 |
Proteomic databases
EPDi | P41221 |
jPOSTi | P41221 |
MassIVEi | P41221 |
MaxQBi | P41221 |
PaxDbi | P41221 |
PeptideAtlasi | P41221 |
PRIDEi | P41221 |
ProteomicsDBi | 55429 [P41221-1] 55430 [P41221-2] |
Protocols and materials databases
Antibodypediai | 31456, 593 antibodies from 39 providers |
DNASUi | 7474 |
Genome annotation databases
Ensembli | ENST00000264634.9; ENSP00000264634.4; ENSG00000114251.15 ENST00000474267.5; ENSP00000417310.1; ENSG00000114251.15 ENST00000497027.5; ENSP00000420104.1; ENSG00000114251.15 [P41221-2] |
GeneIDi | 7474 |
KEGGi | hsa:7474 |
MANE-Selecti | ENST00000264634.9; ENSP00000264634.4; NM_003392.7; NP_003383.4 |
UCSCi | uc003dhn.5, human [P41221-1] |
Organism-specific databases
CTDi | 7474 |
DisGeNETi | 7474 |
GeneCardsi | WNT5A |
GeneReviewsi | WNT5A |
HGNCi | HGNC:12784, WNT5A |
HPAi | ENSG00000114251, Tissue enhanced (endometrium, salivary gland) |
MalaCardsi | WNT5A |
MIMi | 164975, gene 180700, phenotype |
neXtProti | NX_P41221 |
OpenTargetsi | ENSG00000114251 |
Orphaneti | 3107, Autosomal dominant Robinow syndrome |
PharmGKBi | PA37385 |
VEuPathDBi | HostDB:ENSG00000114251 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158894 |
HOGENOMi | CLU_033039_0_1_1 |
InParanoidi | P41221 |
OMAi | EGELNSC |
OrthoDBi | 695671at2759 |
PhylomeDBi | P41221 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | P41221 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-3772470, Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-4086398, Ca2+ pathway R-HSA-4086400, PCP/CE pathway R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | P41221 |
SIGNORi | P41221 |
Miscellaneous databases
BioGRID-ORCSi | 7474, 6 hits in 1063 CRISPR screens |
ChiTaRSi | WNT5A, human |
GeneWikii | WNT5A |
GenomeRNAii | 7474 |
Pharosi | P41221, Tbio |
PROi | PR:P41221 |
RNActi | P41221, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114251, Expressed in stromal cell of endometrium and 210 other tissues |
ExpressionAtlasi | P41221, baseline and differential |
Genevisiblei | P41221, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR026538, Wnt5a IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF33, PTHR12027:SF33, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT5A_HUMAN | |
Accessioni | P41221Primary (citable) accession number: P41221 Secondary accession number(s): A8K4A4, Q6P278 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | November 4, 2008 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families