Protein Wnt-5a

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chemoattractant activity involved in axon guidance Source: Ensembl
• cytokine activity Source: Ensembl
• DNA-binding transcription factor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19847889
• frizzled binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18174455
• phospholipid binding Source: ARUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 25424568
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 18174455
• receptor tyrosine kinase-like orphan receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 18287027
• transcription regulatory region DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19847889

GO - Biological processⁱ

• activation of GTPase activity Source: Ensembl
• activation of JUN kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • 20034610
• activation of MAPK activity Source: BHF-UCLInferred from direct assayⁱ
  • 20034610
• activation of protein kinase B activity Source: BHF-UCLInferred from direct assayⁱ
  • 20034610
• anterior/posterior axis specification, embryo Source: Ensembl
• axon guidance Source: UniProtKB
• canonical Wnt signaling pathway Source: Ensembl
• cartilage development Source: UniProtKB-KW
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• cellular protein localization Source: UniProtKBInferred from direct assayⁱ
  • 19177143
• cellular response to calcium ion Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 18703641
• cellular response to interferon-gamma Source: UniProtKBInferred from expression patternⁱ
  • 18174455
• cellular response to lipopolysaccharide Source: UniProtKBInferred from expression patternⁱ
  • 18174455
• cellular response to retinoic acid Source: UniProtKB
• cellular response to transforming growth factor beta stimulus Source: UniProtKBInferred from expression patternⁱ
  • 15040835
• cervix development Source: Ensembl
• chemoattraction of serotonergic neuron axon Source: Ensembl
• chemorepulsion of dopaminergic neuron axon Source: Ensembl
• cochlea morphogenesis Source: Ensembl
• convergent extension involved in axis elongation Source: Ensembl
• convergent extension involved in organogenesis Source: Ensembl
• embryonic digit morphogenesis Source: Ensembl
• embryonic skeletal system development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 19918918
• epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
• epithelial to mesenchymal transition Source: UniProtKBInferred from expression patternⁱ
  • 12841867
• establishment of epithelial cell apical/basal polarity Source: Ensembl
• establishment of planar polarity Source: Ensembl
• excitatory synapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• face development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 19918918
• genitalia development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 19918918
• heart looping Source: Ensembl
• hematopoietic stem cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • 9787155
• hindgut morphogenesis Source: Ensembl
• hypophysis morphogenesis Source: Ensembl
• inhibitory synapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• keratinocyte differentiation Source: BHF-UCLInferred from expression patternⁱ
  • 19399181
• lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
• lens development in camera-type eye Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 16258938
• lung development Source: Ensembl
• male gonad development Source: UniProtKBInferred from expression patternⁱ
  • 17848411
• mammary gland branching involved in thelarche Source: Ensembl
• melanocyte proliferation Source: Ensembl
• membrane organization Source: Reactome
• mesenchymal-epithelial cell signaling Source: Ensembl
• mesodermal to mesenchymal transition involved in gastrulation Source: Ensembl
• midgut development Source: Ensembl
• negative regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • 19251946
• negative regulation of axon extension involved in axon guidance Source: Ensembl
• negative regulation of BMP signaling pathway Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 12952940
• negative regulation of cell proliferation in midbrain Source: ParkinsonsUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 24431302
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of fat cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20032469
• negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
• negative regulation of melanin biosynthetic process Source: Ensembl
• negative regulation of mesenchymal cell proliferation Source: UniProtKBInferred from direct assayⁱ
  • 19878652
• negative regulation of prostatic bud formation Source: Ensembl
• negative regulation of synapse assembly Source: Ensembl
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 19277043
• neuron differentiation Source: UniProtKB
• non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
• notochord morphogenesis Source: Ensembl
• olfactory bulb interneuron development Source: UniProtKB
• optic cup formation involved in camera-type eye development Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16258938
• paraxial mesoderm formation Source: Ensembl
• planar cell polarity pathway involved in axis elongation Source: Ensembl
• planar cell polarity pathway involved in axon guidance Source: Ensembl
• planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
• planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
• planar cell polarity pathway involved in gastrula mediolateral intercalation Source: Ensembl
• planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 22988876
• planar cell polarity pathway involved in neural tube closure Source: Ensembl
• planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
• planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
• planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
• positive regulation of angiogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17035633
• positive regulation of cartilage development Source: Ensembl
• positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
• positive regulation of chemokine biosynthetic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19520808
• positive regulation of cytokine secretion involved in immune response Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of endocytosis Source: Ensembl
• positive regulation of endothelial cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17035633
  • 17986384
• positive regulation of endothelial cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17986384
• positive regulation of fibroblast proliferation Source: UniProtKBInferred from direct assayⁱ
  • 19251946
• positive regulation of gene expression Source: ARUK-UCL
• positive regulation of G protein-coupled receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 19946729
• positive regulation of inflammatory response Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of interferon-gamma production Source: Ensembl
• positive regulation of interleukin-1 beta secretion Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of interleukin-6 production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of interleukin-8 secretion Source: Ensembl
• positive regulation of macrophage activation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of macrophage cytokine production Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of meiotic nuclear division Source: Ensembl
• positive regulation of mesenchymal cell proliferation Source: Ensembl
• positive regulation of neuron death Source: ARUK-UCL
• positive regulation of neuron projection arborization Source: ARUK-UCL
• positive regulation of neuron projection development Source: UniProtKB
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • 18287027
• positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
• positive regulation of ossification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20032469
• positive regulation of peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein catabolic process Source: MGIInferred from genetic interactionⁱ
  • 12952940
• positive regulation of protein kinase C activity Source: CACAOInferred from mutant phenotypeⁱ
  • 12086864
• positive regulation of protein kinase C signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19099253
• positive regulation of protein localization to synapse Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• positive regulation of response to cytokine stimulus Source: UniProtKBInferred from direct assayⁱ
  • 19399181
• positive regulation of T cell chemotaxis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19520808
• positive regulation of thymocyte apoptotic process Source: Ensembl
• positive regulation of timing of anagen Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19847889
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18174455
• positive regulation of tumor necrosis factor secretion Source: ARUK-UCL
• positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 19399181
• post-anal tail morphogenesis Source: Ensembl
• postsynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• presynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24449494
• primitive streak formation Source: Ensembl
• regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
• regulation of cellular protein localization Source: Ensembl
• regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
• regulation of inflammatory response Source: ARUK-UCLNon-traceable author statementⁱ
  • 21857966
• regulation of postsynapse organization Source: SynGOInferred from direct assayⁱ
  • 27402827
• regulation of postsynaptic cytosolic calcium ion concentration Source: SynGOInferred from direct assayⁱ
  • 27402827
• regulation of synapse organization Source: SynGOInferred from direct assayⁱ
  • 18986540
• response to organic substance Source: UniProtKBInferred from expression patternⁱ
  • 17486081
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 18413325
• somitogenesis Source: Ensembl
• type B pancreatic cell development Source: Ensembl
• urinary bladder development Source: Ensembl
• uterus development Source: Ensembl
• vagina development Source: Ensembl
• Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 20034610
• Wnt signaling pathway, calcium modulating pathway Source: BHF-UCLInferred from direct assayⁱ
  • 19946729
• Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • 24431302
• Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLNon-traceable author statementⁱ
  • 24431302
• wound healing Source: UniProtKBInferred from direct assayⁱ
  • 19878652

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• chemoattractant activity involved in axon guidance Source: Ensembl
• cytokine activity Source: Ensembl
• frizzled binding Source: UniProtKBInferred from physical interactionⁱ
  • 18174455
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCLInferred by curatorⁱ
  • 18174455
• receptor tyrosine kinase-like orphan receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 18287027

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG 
        60         70         80         90        100
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG 
       110        120        130        140        150
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM 
       160        170        180        190        200
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR 
       210        220        230        240        250
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK 
       260        270        280        290        300
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 
       310        320        330        340        350
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV 
       360        370        380
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK                       

        10         20         30         40         50
MAGSAMSSKF FLVALAIFFS FAQVVIEANS WWSLGMNNPV QMSEVYIIGA 
        60         70         80         90        100
QPLCSQLAGL SQGQKKLCHL YQDHMQYIGE GAKTGIKECQ YQFRHRRWNC 
       110        120        130        140        150
STVDNTSVFG RVMQIGSRET AFTYAVSAAG VVNAMSRACR EGELSTCGCS 
       160        170        180        190        200
RAARPKDLPR DWLWGGCGDN IDYGYRFAKE FVDARERERI HAKGSYESAR 
       210        220        230        240        250
ILMNLHNNEA GRRTVYNLAD VACKCHGVSG SCSLKTCWLQ LADFRKVGDA 
       260        270        280        290        300
LKEKYDSAAA MRLNSRGKLV QVNSRFNSPT TQDLVYIDPS PDYCVRNEST 
       310        320        330        340        350
GSLGTQGRLC NKTSEGMDGC ELMCCGRGYD QFKTVQTERC HCKFHWCCYV 
       360 
KCKKCTEIVD QFVCK                                       

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM