Protein Wnt-5a

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chemoattractant activity involved in axon guidance Source: Ensembl
• cytokine activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• phospholipid binding Source: ARUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4."
    Bian W.J., Miao W.Y., He S.J., Wan Z.F., Luo Z.G., Yu X.
    Dev Neurobiol 75:805-822(2015) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• receptor tyrosine kinase-like orphan receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a."
    Fukuda T., Chen L., Endo T., Tang L., Lu D., Castro J.E., Widhopf G.F., Rassenti L.Z., Cantwell M.J., Prussak C.E., Carson D.A., Kipps T.J.
    Proc Natl Acad Sci U S A 105:3047-3052(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of GTPase activity Source: Ensembl
• activation of JUN kinase activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Expression of Wnt5a in tooth germs and the related signal transduction analysis."
    Peng L., Dong G., Xu P., Ren L.B., Wang C.L., Aragon M., Zhou X.D., Ye L.
    Arch Oral Biol 55:108-114(2010) [PubMed] [Europe PMC] [Abstract]
• activation of MAPK activity Source: BHF-UCLInferred from direct assayⁱ
  • "Expression of Wnt5a in tooth germs and the related signal transduction analysis."
    Peng L., Dong G., Xu P., Ren L.B., Wang C.L., Aragon M., Zhou X.D., Ye L.
    Arch Oral Biol 55:108-114(2010) [PubMed] [Europe PMC] [Abstract]
• activation of protein kinase B activity Source: BHF-UCLInferred from direct assayⁱ
  • "Expression of Wnt5a in tooth germs and the related signal transduction analysis."
    Peng L., Dong G., Xu P., Ren L.B., Wang C.L., Aragon M., Zhou X.D., Ye L.
    Arch Oral Biol 55:108-114(2010) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior axis specification, embryo Source: Ensembl
• atrial septum development Source: Ensembl
• axon guidance Source: UniProtKB
• canonical Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: UniProtKB-KW
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular protein localization Source: UniProtKBInferred from direct assayⁱ
  • "Wnt5A activates the calpain-mediated cleavage of filamin A."
    O'Connell M.P., Fiori J.L., Baugher K.M., Indig F.E., French A.D., Camilli T.C., Frank B.P., Earley R., Hoek K.S., Hasskamp J.H., Elias E.G., Taub D.D., Bernier M., Weeraratna A.T.
    J Invest Dermatol 129:1782-1789(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to calcium ion Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia."
    Pacheco I.I., Macleod R.J.
    Am J Physiol Gastrointest Liver Physiol 295:G748-59(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to interferon-gamma Source: UniProtKBInferred from expression patternⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: UniProtKBInferred from expression patternⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to retinoic acid Source: UniProtKB
• cellular response to transforming growth factor beta stimulus Source: UniProtKBInferred from expression patternⁱ
  • "Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells."
    Zhou S., Eid K., Glowacki J.
    J Bone Miner Res 19:463-470(2004) [PubMed] [Europe PMC] [Abstract]
• cervix development Source: Ensembl
• chemoattraction of serotonergic neuron axon Source: Ensembl
• chemorepulsion of dopaminergic neuron axon Source: Ensembl
• cochlea morphogenesis Source: Ensembl
• convergent extension involved in axis elongation Source: Ensembl
• convergent extension involved in organogenesis Source: Ensembl
• embryonic digit morphogenesis Source: Ensembl
• embryonic skeletal system development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.10

    "WNT5A mutations in patients with autosomal dominant Robinow syndrome."
    Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., Schleiffarth J.R., Billington C.J. Jr., van Bokhoven H., Hoogeboom J.M., Mazzeu J.F., Petryk A., Schimmenti L.A., Brunner H.G., Ekker S.C., Lohr J.L.
    Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANTS DRS1 SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS1 SER-83 AND ARG-182.
• epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
• epithelial to mesenchymal transition Source: UniProtKBInferred from expression patternⁱ
  • "Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells."
    Taki M., Kamata N., Yokoyama K., Fujimoto R., Tsutsumi S., Nagayama M.
    Cancer Sci 94:593-597(2003) [PubMed] [Europe PMC] [Abstract]
• establishment of epithelial cell apical/basal polarity Source: Ensembl
• establishment of planar polarity Source: Ensembl
• excitatory synapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• face development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.10

    "WNT5A mutations in patients with autosomal dominant Robinow syndrome."
    Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., Schleiffarth J.R., Billington C.J. Jr., van Bokhoven H., Hoogeboom J.M., Mazzeu J.F., Petryk A., Schimmenti L.A., Brunner H.G., Ekker S.C., Lohr J.L.
    Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANTS DRS1 SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS1 SER-83 AND ARG-182.
• genitalia development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.10

    "WNT5A mutations in patients with autosomal dominant Robinow syndrome."
    Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., Schleiffarth J.R., Billington C.J. Jr., van Bokhoven H., Hoogeboom J.M., Mazzeu J.F., Petryk A., Schimmenti L.A., Brunner H.G., Ekker S.C., Lohr J.L.
    Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANTS DRS1 SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS1 SER-83 AND ARG-182.
• heart looping Source: Ensembl
• hematopoietic stem cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "Role of members of the Wnt gene family in human hematopoiesis."
    Van Den Berg D.J., Sharma A.K., Bruno E., Hoffman R.
    Blood 92:3189-3202(1998) [PubMed] [Europe PMC] [Abstract]
• hindgut morphogenesis Source: Ensembl
• hypophysis morphogenesis Source: Ensembl
• inhibitory synapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• keratinocyte differentiation Source: BHF-UCLInferred from expression patternⁱ
  • "Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon."
    Romanowska M., Evans A., Kellock D., Bray S.E., McLean K., Donandt S., Foerster J.
    PLoS One 4:e5354-e5354(2009) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: Ensembl
• lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
• lens development in camera-type eye Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
    Fokina V.M., Frolova E.I.
    Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
• lung development Source: Ensembl
• male gonad development Source: UniProtKBInferred from expression patternⁱ
  • "Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester."
    O'Shaughnessy P.J., Baker P.J., Monteiro A., Cassie S., Bhattacharya S., Fowler P.A.
    J Clin Endocrinol Metab 92:4792-4801(2007) [PubMed] [Europe PMC] [Abstract]
• mammary gland branching involved in thelarche Source: Ensembl
• melanocyte proliferation Source: Ensembl
• membrane organization Source: Reactome
• mesenchymal-epithelial cell signaling Source: Ensembl
• mesodermal to mesenchymal transition involved in gastrulation Source: Ensembl
• midgut development Source: Ensembl
• negative regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis."
    Vuga L.J., Ben-Yehudah A., Kovkarova-Naumovski E., Oriss T., Gibson K.F., Feghali-Bostwick C., Kaminski N.
    Am J Respir Cell Mol Biol 41:583-589(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of axon extension involved in axon guidance Source: Ensembl
• negative regulation of BMP signaling pathway Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."
    Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J., Yang Y.
    J. Cell Biol. 162:899-908(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell proliferation in midbrain Source: ParkinsonsUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of fat cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes."
    Bilkovski R., Schulte D.M., Oberhauser F., Gomolka M., Udelhoven M., Hettich M.M., Roth B., Heidenreich A., Gutschow C., Krone W., Laudes M.
    J Biol Chem 285:6170-6178(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
• negative regulation of melanin biosynthetic process Source: Ensembl
• negative regulation of mesenchymal cell proliferation Source: UniProtKBInferred from direct assayⁱ
  • "WNT5A inhibits human dental papilla cell proliferation and migration."
    Peng L., Ye L., Dong G., Ren L.B., Wang C.L., Xu P., Zhou X.D.
    Biochem Biophys Res Commun 390:1072-1078(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of prostatic bud formation Source: Ensembl
• negative regulation of synapse assembly Source: Ensembl
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer."
    Kawano Y., Diez S., Uysal-Onganer P., Darrington R.S., Waxman J., Kypta R.M.
    Br J Cancer 100:1165-1174(2009) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: UniProtKB
• non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
• notochord morphogenesis Source: Ensembl
• olfactory bulb interneuron development Source: UniProtKB
• optic cup formation involved in camera-type eye development Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
    Fokina V.M., Frolova E.I.
    Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
• paraxial mesoderm formation Source: Ensembl
• planar cell polarity pathway involved in axis elongation Source: Ensembl
• planar cell polarity pathway involved in axon guidance Source: Ensembl
• planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
• planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
• planar cell polarity pathway involved in gastrula mediolateral intercalation Source: Ensembl
• planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
• planar cell polarity pathway involved in neural tube closure Source: Ensembl
• planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
• planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
• planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
• positive regulation of angiogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2."
    Masckauchan T.N., Agalliu D., Vorontchikhina M., Ahn A., Parmalee N.L., Li C.M., Khoo A., Tycko B., Brown A.M., Kitajewski J.
    Mol Biol Cell 17:5163-5172(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cartilage development Source: Ensembl
• positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
• positive regulation of cell killing Source: Reactome
• positive regulation of chemokine production Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration."
    Ghosh M.C., Collins G.D., Vandanmagsar B., Patel K., Brill M., Carter A., Lustig A., Becker K.G., Wood W.W., Emeche C.D., French A.D., O'Connell M.P., Xu M., Weeraratna A.T., Taub D.D.
    Blood 114:1366-1373(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytokine production involved in immune response Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endocytosis Source: Ensembl
• positive regulation of endothelial cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2."
    Masckauchan T.N., Agalliu D., Vorontchikhina M., Ahn A., Parmalee N.L., Li C.M., Khoo A., Tycko B., Brown A.M., Kitajewski J.
    Mol Biol Cell 17:5163-5172(2006) [PubMed] [Europe PMC] [Abstract]
  • "Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration."
    Cheng C.W., Yeh J.C., Fan T.P., Smith S.K., Charnock-Jones D.S.
    Biochem Biophys Res Commun 365:285-290(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration."
    Cheng C.W., Yeh J.C., Fan T.P., Smith S.K., Charnock-Jones D.S.
    Biochem Biophys Res Commun 365:285-290(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fibroblast proliferation Source: UniProtKBInferred from direct assayⁱ
  • "WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis."
    Vuga L.J., Ben-Yehudah A., Kovkarova-Naumovski E., Oriss T., Gibson K.F., Feghali-Bostwick C., Kaminski N.
    Am J Respir Cell Mol Biol 41:583-589(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: ARUK-UCL
• positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: Ensembl
• positive regulation of inflammatory response Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma production Source: Ensembl
• positive regulation of interleukin-1 beta production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-8 production Source: Ensembl
• positive regulation of JNK cascade Source: Ensembl
• positive regulation of macrophage activation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage cytokine production Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of meiotic nuclear division Source: Ensembl
• positive regulation of mesenchymal cell proliferation Source: Ensembl
• positive regulation of neuron death Source: ARUK-UCL
• positive regulation of neuron projection arborization Source: ARUK-UCL
• positive regulation of neuron projection development Source: UniProtKB
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a."
    Fukuda T., Chen L., Endo T., Tang L., Lu D., Castro J.E., Widhopf G.F., Rassenti L.Z., Cantwell M.J., Prussak C.E., Carson D.A., Kipps T.J.
    Proc Natl Acad Sci U S A 105:3047-3052(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
• positive regulation of ossification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes."
    Bilkovski R., Schulte D.M., Oberhauser F., Gomolka M., Udelhoven M., Hettich M.M., Roth B., Heidenreich A., Gutschow C., Krone W., Laudes M.
    J Biol Chem 285:6170-6178(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein catabolic process Source: MGIInferred from genetic interactionⁱ
  • "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."
    Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J., Yang Y.
    J. Cell Biol. 162:899-908(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein kinase C activity Source: CACAOInferred from mutant phenotypeⁱ
  • "Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma."
    Weeraratna A.T., Jiang Y., Hostetter G., Rosenblatt K., Duray P., Bittner M., Trent J.M.
    Cancer Cell 1:279-288(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein kinase C signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma."
    Dissanayake S.K., Weeraratna A.T.
    Methods Mol Biol 468:157-172(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to synapse Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of response to cytokine stimulus Source: UniProtKBInferred from direct assayⁱ
  • "Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon."
    Romanowska M., Evans A., Kellock D., Bray S.E., McLean K., Donandt S., Foerster J.
    PLoS One 4:e5354-e5354(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell chemotaxis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration."
    Ghosh M.C., Collins G.D., Vandanmagsar B., Patel K., Brill M., Carter A., Lustig A., Becker K.G., Wood W.W., Emeche C.D., French A.D., O'Connell M.P., Xu M., Weeraratna A.T., Taub D.D.
    Blood 114:1366-1373(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of thymocyte apoptotic process Source: Ensembl
• positive regulation of timing of anagen Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • "SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia."
    Pizzatti L., Binato R., Cofre J., Gomes B.E., Dobbin J., Haussmann M.E., D'Azambuja D., Bouzas L.F., Abdelhay E.
    Genes Chromosomes Cancer 49:107-118(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: ARUK-UCL
• positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon."
    Romanowska M., Evans A., Kellock D., Bray S.E., McLean K., Donandt S., Foerster J.
    PLoS One 4:e5354-e5354(2009) [PubMed] [Europe PMC] [Abstract]
• post-anal tail morphogenesis Source: Ensembl
• postsynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• presynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• primary heart field specification Source: Ensembl
• primitive streak formation Source: Ensembl
• protein phosphorylation Source: Ensembl
• regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
• regulation of cellular protein localization Source: Ensembl
• regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
• regulation of inflammatory response Source: ARUK-UCLNon-traceable author statementⁱ
  • "WNT5A signaling contributes to Abeta-induced neuroinflammation and neurotoxicity."
    Li B., Zhong L., Yang X., Andersson T., Huang M., Tang S.J.
    PLoS One 6:e22920-e22920(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of postsynapse organization Source: SynGOInferred from direct assayⁱ
  • "Wnt-5a/Frizzled9 Receptor Signaling through the Galphao-Gbetagamma Complex Regulates Dendritic Spine Formation."
    Ramirez V.T., Ramos-Fernandez E., Henriquez J.P., Lorenzo A., Inestrosa N.C.
    J Biol Chem 291:19092-19107(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of postsynaptic cytosolic calcium ion concentration Source: SynGOInferred from direct assayⁱ
  • "Wnt-5a/Frizzled9 Receptor Signaling through the Galphao-Gbetagamma Complex Regulates Dendritic Spine Formation."
    Ramirez V.T., Ramos-Fernandez E., Henriquez J.P., Lorenzo A., Inestrosa N.C.
    J Biol Chem 291:19092-19107(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of synapse organization Source: SynGOInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: UniProtKBInferred from expression patternⁱ
  • "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer."
    Wang Q., Williamson M., Bott S., Brookman-Amissah N., Freeman A., Nariculam J., Hubank M.J., Ahmed A., Masters J.R.
    Oncogene 26:6560-6565(2007) [PubMed] [Europe PMC] [Abstract]
• secondary heart field specification Source: Ensembl
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate."
    Chiquet B.T., Blanton S.H., Burt A., Ma D., Stal S., Mulliken J.B., Hecht J.T.
    Hum Mol Genet 17:2212-2218(2008) [PubMed] [Europe PMC] [Abstract]
• somitogenesis Source: Ensembl
• type B pancreatic cell development Source: Ensembl
• urinary bladder development Source: Ensembl
• uterus development Source: Ensembl
• vagina development Source: Ensembl
• Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Expression of Wnt5a in tooth germs and the related signal transduction analysis."
    Peng L., Dong G., Xu P., Ren L.B., Wang C.L., Aragon M., Zhou X.D., Ye L.
    Arch Oral Biol 55:108-114(2010) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway, calcium modulating pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration."
    Cheng C.W., Yeh J.C., Fan T.P., Smith S.K., Charnock-Jones D.S.
    Biochem Biophys Res Commun 365:285-290(2008) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLNon-traceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: UniProtKBInferred from direct assayⁱ
  • "WNT5A inhibits human dental papilla cell proliferation and migration."
    Peng L., Ye L., Dong G., Ren L.B., Wang C.L., Xu P., Zhou X.D.
    Biochem Biophys Res Commun 390:1072-1078(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• chemoattractant activity involved in axon guidance Source: Ensembl
• cytokine activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: UniProtKBInferred from physical interactionⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCLInferred by curatorⁱ
  • "Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10."
    Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G.
    Arterioscler Thromb Vasc Biol 28:504-510(2008) [PubMed] [Europe PMC] [Abstract]
• receptor tyrosine kinase-like orphan receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a."
    Fukuda T., Chen L., Endo T., Tang L., Lu D., Castro J.E., Widhopf G.F., Rassenti L.Z., Cantwell M.J., Prussak C.E., Carson D.A., Kipps T.J.
    Proc Natl Acad Sci U S A 105:3047-3052(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG 
        60         70         80         90        100
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG 
       110        120        130        140        150
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM 
       160        170        180        190        200
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR 
       210        220        230        240        250
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK 
       260        270        280        290        300
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 
       310        320        330        340        350
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV 
       360        370        380
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK                       

        10         20         30         40         50
MAGSAMSSKF FLVALAIFFS FAQVVIEANS WWSLGMNNPV QMSEVYIIGA 
        60         70         80         90        100
QPLCSQLAGL SQGQKKLCHL YQDHMQYIGE GAKTGIKECQ YQFRHRRWNC 
       110        120        130        140        150
STVDNTSVFG RVMQIGSRET AFTYAVSAAG VVNAMSRACR EGELSTCGCS 
       160        170        180        190        200
RAARPKDLPR DWLWGGCGDN IDYGYRFAKE FVDARERERI HAKGSYESAR 
       210        220        230        240        250
ILMNLHNNEA GRRTVYNLAD VACKCHGVSG SCSLKTCWLQ LADFRKVGDA 
       260        270        280        290        300
LKEKYDSAAA MRLNSRGKLV QVNSRFNSPT TQDLVYIDPS PDYCVRNEST 
       310        320        330        340        350
GSLGTQGRLC NKTSEGMDGC ELMCCGRGYD QFKTVQTERC HCKFHWCCYV 
       360 
KCKKCTEIVD QFVCK                                       

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families