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Entry version 190 (22 Apr 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Regulator of G-protein signaling 2

Gene

RGS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).By similarity1 Publication5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor
Biological processCell cycle, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P41220

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Short name:
RGS2
Alternative name(s):
Cell growth-inhibiting gene 31 protein
G0/G1 switch regulatory protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS2
Synonyms:G0S8
ORF Names:GIG31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9998 RGS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600861 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41220

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1M → L: Loss of isoform 1 expression. 1 Publication1
Mutagenesisi5M → L: Loss of isoform 2 expression. 1 Publication1
Mutagenesisi16M → L: Loss of isoform 3 expression. 1 Publication1
Mutagenesisi33M → L: Loss of isoform 4 expression. 1 Publication1
Mutagenesisi37L → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi38L → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi41W → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi45L → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi48F → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi49L → D: Impairs association with plasma membrane. 1 Publication1
Mutagenesisi79L → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with E-86; L-87; S-90; K-102; F-105; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi86E → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; L-87; S-90; K-102; F-105; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi87L → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; S-90; K-102; F-105; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi90S → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; K-102; F-105; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi102K → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; S-90; F-105; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi105F → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; S-90; K-102; I-110; E-111 and L-114. 1 Publication1
Mutagenesisi106C → S: Changes specificity and confers GNAI1 binding; when associated with D-184. Strongly increases affinity for GNAI1 and GNAI3; when associated with D-184 and K-191. 2 Publications1
Mutagenesisi110I → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; S-90; K-102; F-105; E-111 and L-114. 1 Publication1
Mutagenesisi111E → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; S-90; K-102; F-105; I-110 and L-114. 1 Publication1
Mutagenesisi114L → A: Near loss of EIF2B5 binding and inhibition of in vitro translation; when associated with L-79; E-86; L-87; S-90; K-102; F-105; I-110 and E-111. 1 Publication1
Mutagenesisi149N → A: Decreases GTPase accelerating function but has no effect on translation inhibitory activity, suggesting that its role in translation is independent of its effects on G proteins. 1 Publication1
Mutagenesisi184N → D: Changes specificity and confers GNAI1 binding; when associated with D-184. Strongly increases affinity for GNAI1 and GNAI3; when associated with S-106 and K-191. 2 Publications1
Mutagenesisi191E → K: Strongly increases affinity for GNAI1 and GNAI3; when associated with S-106 and D-184. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5997

Open Targets

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OpenTargetsi
ENSG00000116741

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34372

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P41220 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RGS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
729545

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041781 – 211Regulator of G-protein signaling 2Add BLAST211

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P41220

MaxQB - The MaxQuant DataBase

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MaxQBi
P41220

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P41220

PeptideAtlas

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PeptideAtlasi
P41220

PRoteomics IDEntifications database

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PRIDEi
P41220

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55425 [P41220-1]
55426 [P41220-2]
55427 [P41220-3]
55428 [P41220-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41220

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P41220

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P41220

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000116741 Expressed in secondary oocyte and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P41220 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41220 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000116741 Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAQ (PubMed:18434541, PubMed:19478087, PubMed:28784619). Does not interact with GNAI1 and GNAI3 (PubMed:18434541, PubMed:19478087).

Interacts with EIF2B5 (PubMed:19736320).

Interacts with PRKG1 (isoform alpha) (PubMed:14608379).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111929, 70 interactors

Database of interacting proteins

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DIPi
DIP-44289N

Protein interaction database and analysis system

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IntActi
P41220, 61 interactors

Molecular INTeraction database

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MINTi
P41220

STRING: functional protein association networks

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STRINGi
9606.ENSP00000235382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P41220 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41220

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P41220

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 199RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 66Necessary for membrane association1 PublicationAdd BLAST35
Regioni79 – 116Necessary to inhibit protein synthesis1 PublicationAdd BLAST38

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157937

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_059863_3_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41220

KEGG Orthology (KO)

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KOi
K18154

Identification of Orthologs from Complete Genome Data

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OMAi
HDCGPMD

Database for complete collections of gene phylogenies

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PhylomeDBi
P41220

TreeFam database of animal gene trees

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TreeFami
TF315837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.196.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016137 RGS
IPR034947 RGS2
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3

The PANTHER Classification System

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PANTHERi
PTHR10845:SF43 PTHR10845:SF43, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48097 SSF48097, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: P41220-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Length:211
Mass (Da):24,382
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFFE4AE47EF9AD8F
GO
Isoform 2 (identifier: P41220-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Show »
Length:207
Mass (Da):23,964
Checksum:iE5DCCB2F18E09F51
GO
Isoform 3 (identifier: P41220-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Note: Lacks type V adenylyl cyclase (AC) inhibitory function.Curated
Show »
Length:196
Mass (Da):22,666
Checksum:i2F5BF7609CD4172A
GO
Isoform 4 (identifier: P41220-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: Lacks type V adenylyl cyclase (AC) inhibitory function.Curated
Show »
Length:179
Mass (Da):20,780
Checksum:i6CF0306689DC7A54
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0792382Q → L Rare polymorphism; decreased down-regulation of angiotensin-activated signaling pathway; decreased RGS2 protein abundance. 3 PublicationsCorresponds to variant dbSNP:rs141030117Ensembl.1
Natural variantiVAR_0792392Q → R Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 3 PublicationsCorresponds to variant dbSNP:rs141030117Ensembl.1
Natural variantiVAR_0792403S → G Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs145125159Ensembl.1
Natural variantiVAR_0792414A → V Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs142499684Ensembl.1
Natural variantiVAR_0792425M → V Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 3 PublicationsCorresponds to variant dbSNP:rs193051407Ensembl.1
Natural variantiVAR_07924318K → N Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs74466425Ensembl.1
Natural variantiVAR_07924423G → D Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs148489044EnsemblClinVar.1
Natural variantiVAR_07924540D → Y Rare polymorphism; decreased down-regulation of angiotensin-activated signaling pathway; reduced localization at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs201233692Ensembl.1
Natural variantiVAR_07924644R → H Rare polymorphism; decreased down-regulation of angiotensin-activated signaling pathway; reduced localization at the cell membrane. 3 PublicationsCorresponds to variant dbSNP:rs200339834Ensembl.1
Natural variantiVAR_07924750Q → K Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs80221024Ensembl.1
Natural variantiVAR_07924855P → L Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs140811638Ensembl.1
Natural variantiVAR_07924978Q → H Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 Publications1
Natural variantiVAR_07925099A → G Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs139237239Ensembl.1
Natural variantiVAR_079251110I → V Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs146862218Ensembl.1
Natural variantiVAR_079252188R → H Rare polymorphism; decreased down-regulation of angiotensin-activated signaling pathway; reduced interaction with GNAQ. 2 PublicationsCorresponds to variant dbSNP:rs369752935Ensembl.1
Natural variantiVAR_079253196Q → R Rare polymorphism; no effect on down-regulation of angiotensin-activated signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs112707798Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0412981 – 32Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0412971 – 15Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0412961 – 4Missing in isoform 2. 1 Publication4

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L13391 Genomic DNA Translation: AAA20680.1
L13463 mRNA Translation: AAC37587.1
AF493926 mRNA Translation: AAM12640.1
AY971351 mRNA Translation: AAY40361.1
AK313668 mRNA Translation: BAG36420.1
BT007065 mRNA Translation: AAP35728.1
CR457410 mRNA Translation: CAG33691.1
AL035407 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91231.1
BC007049 mRNA Translation: AAH07049.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1377.1 [P41220-1]

Protein sequence database of the Protein Information Resource

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PIRi
I53020

NCBI Reference Sequences

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RefSeqi
NP_002914.1, NM_002923.3 [P41220-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000235382; ENSP00000235382; ENSG00000116741 [P41220-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5997

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5997

UCSC genome browser

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UCSCi
uc001gsl.4 human [P41220-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13391 Genomic DNA Translation: AAA20680.1
L13463 mRNA Translation: AAC37587.1
AF493926 mRNA Translation: AAM12640.1
AY971351 mRNA Translation: AAY40361.1
AK313668 mRNA Translation: BAG36420.1
BT007065 mRNA Translation: AAP35728.1
CR457410 mRNA Translation: CAG33691.1
AL035407 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91231.1
BC007049 mRNA Translation: AAH07049.1
CCDSiCCDS1377.1 [P41220-1]
PIRiI53020
RefSeqiNP_002914.1, NM_002923.3 [P41220-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AF0X-ray2.30A71-203[»]
2V4ZX-ray2.80B71-209[»]
4EKCX-ray7.40B/D72-203[»]
4EKDX-ray2.71B72-203[»]
SMRiP41220
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111929, 70 interactors
DIPiDIP-44289N
IntActiP41220, 61 interactors
MINTiP41220
STRINGi9606.ENSP00000235382

PTM databases

iPTMnetiP41220
PhosphoSitePlusiP41220
SwissPalmiP41220

Polymorphism and mutation databases

BioMutaiRGS2
DMDMi729545

Proteomic databases

MassIVEiP41220
MaxQBiP41220
PaxDbiP41220
PeptideAtlasiP41220
PRIDEiP41220
ProteomicsDBi55425 [P41220-1]
55426 [P41220-2]
55427 [P41220-3]
55428 [P41220-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34461 273 antibodies

The DNASU plasmid repository

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DNASUi
5997

Genome annotation databases

EnsembliENST00000235382; ENSP00000235382; ENSG00000116741 [P41220-1]
GeneIDi5997
KEGGihsa:5997
UCSCiuc001gsl.4 human [P41220-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5997
DisGeNETi5997

GeneCards: human genes, protein and diseases

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GeneCardsi
RGS2
HGNCiHGNC:9998 RGS2
HPAiENSG00000116741 Tissue enhanced (blood)
MIMi600861 gene
neXtProtiNX_P41220
OpenTargetsiENSG00000116741
PharmGKBiPA34372

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000157937
HOGENOMiCLU_059863_3_2_1
InParanoidiP41220
KOiK18154
OMAiHDCGPMD
PhylomeDBiP41220
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
SIGNORiP41220

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RGS2 human
EvolutionaryTraceiP41220

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RGS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5997
PharosiP41220 Tbio

Protein Ontology

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PROi
PR:P41220
RNActiP41220 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000116741 Expressed in secondary oocyte and 235 other tissues
ExpressionAtlasiP41220 baseline and differential
GenevisibleiP41220 HS

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034947 RGS2
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF43 PTHR10845:SF43, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41220
Secondary accession number(s): Q6I9U5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 22, 2020
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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