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Protein

Peripherin

Gene

PRPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III neuronal intermediate filament protein.

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin
Alternative name(s):
Neurofilament 4
Gene namesi
Name:PRPH
Synonyms:NEF4, PRPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135406.13
HGNCiHGNC:9461 PRPH
MIMi170710 gene
neXtProtiNX_P41219

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi5630
MalaCardsiPRPH
OpenTargetsiENSG00000135406
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33816

Polymorphism and mutation databases

BioMutaiPRPH
DMDMi118585871

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637791 – 470PeripherinAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Nitrated tyrosineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei379Nitrated tyrosineBy similarity1
Modified residuei470PhosphotyrosineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

EPDiP41219
MaxQBiP41219
PaxDbiP41219
PeptideAtlasiP41219
PRIDEiP41219
ProteomicsDBi55423
55424 [P41219-2]

PTM databases

iPTMnetiP41219
PhosphoSitePlusiP41219
SwissPalmiP41219

Expressioni

Gene expression databases

BgeeiENSG00000135406
CleanExiHS_PRPH
ExpressionAtlasiP41219 baseline and differential
GenevisibleiP41219 HS

Organism-specific databases

HPAiCAB002437
HPA039277
HPA063887

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111614, 24 interactors
IntActiP41219, 37 interactors
MINTiP41219
STRINGi9606.ENSP00000257860

Structurei

3D structure databases

ProteinModelPortaliP41219
SMRiP41219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 407IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 99HeadAdd BLAST99
Regioni100 – 132Coil 1AAdd BLAST33
Regioni133 – 143Linker 1Add BLAST11
Regioni144 – 239Coil 1BAdd BLAST96
Regioni240 – 262Linker 2Add BLAST23
Regioni263 – 405Coil 2Add BLAST143
Regioni406 – 470TailAdd BLAST65

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiP41219
KOiK07607
OMAiYDKVDFT
OrthoDBiEOG091G12MK
PhylomeDBiP41219
TreeFamiTF330122

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
IPR002957 Keratin_I
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHHPSGLRA GFSSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSAS
60 70 80 90 100
PSSSVRLGSF RSPRAGAGAL LRLPSERLDF SMAEALNQEF LATRSNEKQE
110 120 130 140 150
LQELNDRFAN FIEKVRFLEQ QNAALRGELS QARGQEPARA DQLCQQELRE
160 170 180 190 200
LRRELELLGR ERDRVQVERD GLAEDLAALK QRLEEETRKR EDAEHNLVLF
210 220 230 240 250
RKDVDDATLS RLELERKIES LMDEIEFLKK LHEEELRDLQ VSVESQQVQQ
260 270 280 290 300
VEVEATVKPE LTAALRDIRA QYESIAAKNL QEAEEWYKSK YADLSDAANR
310 320 330 340 350
NHEALRQAKQ EMNESRRQIQ SLTCEVDGLR GTNEALLRQL RELEEQFALE
360 370 380 390 400
AGGYQAGAAR LEEELRQLKE EMARHLREYQ ELLNVKMALD IEIATYRKLL
410 420 430 440 450
EGEESRISVP VHSFASLNIK TTVPEVEPPQ DSHSRKTVLI KTIETRNGEV
460 470
VTESQKEQRS ELDKSSAHSY
Length:470
Mass (Da):53,651
Last modified:October 31, 2006 - v2
Checksum:i4ABEAB96088719D6
GO
Isoform 2 (identifier: P41219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: E → EQ

Note: No experimental confirmation available. Gene prediction based on similarity to orthologs.
Show »
Length:471
Mass (Da):53,779
Checksum:i8138A4773E53D86A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68G → R in AAA60190 (PubMed:7806235).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021159449E → EQ in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14565 Genomic DNA Translation: AAA60190.1
AC125611 Genomic DNA No translation available.
BC032703 mRNA Translation: AAH32703.1
CCDSiCCDS8783.1 [P41219-1]
PIRiA55185
RefSeqiNP_006253.2, NM_006262.3 [P41219-1]
XP_005269082.1, XM_005269025.1 [P41219-2]
UniGeneiHs.37044

Genome annotation databases

EnsembliENST00000257860; ENSP00000257860; ENSG00000135406 [P41219-1]
GeneIDi5630
KEGGihsa:5630
UCSCiuc001rtu.4 human [P41219-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPERI_HUMAN
AccessioniPrimary (citable) accession number: P41219
Secondary accession number(s): Q8N577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 31, 2006
Last modified: July 18, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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