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Protein

Myeloid cell nuclear differentiation antigen

Gene

MNDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid cell nuclear differentiation antigen
Gene namesi
Name:MNDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163563.7
HGNCiHGNC:7183 MNDA
MIMi159553 gene
neXtProtiNX_P41218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4332
OpenTargetsiENSG00000163563
PharmGKBiPA30895

Polymorphism and mutation databases

BioMutaiMNDA
DMDMi730038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537241 – 407Myeloid cell nuclear differentiation antigenAdd BLAST407

Proteomic databases

EPDiP41218
PaxDbiP41218
PeptideAtlasiP41218
PRIDEiP41218
ProteomicsDBi55422

PTM databases

iPTMnetiP41218
PhosphoSitePlusiP41218

Expressioni

Tissue specificityi

Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.1 Publication

Inductioni

Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.1 Publication

Gene expression databases

BgeeiENSG00000163563 Expressed in 210 organ(s), highest expression level in bone marrow
CleanExiHS_MNDA
ExpressionAtlasiP41218 baseline and differential
GenevisibleiP41218 HS

Organism-specific databases

HPAiHPA034532
HPA073215

Interactioni

Subunit structurei

Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

Binary interactionsi

WithEntry#Exp.IntActNotes
NSD3Q9BZ952EBI-2829677,EBI-3390132

Protein-protein interaction databases

BioGridi110475, 7 interactors
IntActiP41218, 163 interactors
MINTiP41218
STRINGi9606.ENSP00000357123

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41218
SMRiP41218
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41218

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88PyrinPROSITE-ProRule annotationAdd BLAST88
Domaini196 – 394HIN-200PROSITE-ProRule annotationAdd BLAST199

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 137Nuclear localization signalSequence analysis7

Domaini

Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOGENOMiHOG000033871
HOVERGENiHBG006122
InParanoidiP41218
OMAiGKWHNIK
OrthoDBiEOG091G02W0
PhylomeDBiP41218
TreeFamiTF337385

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR004021 HIN200/IF120x
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P41218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD
60 70 80 90 100
LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP
110 120 130 140 150
VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK
160 170 180 190 200
VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV
210 220 230 240 250
DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK
260 270 280 290 300
VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII
310 320 330 340 350
EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV
360 370 380 390 400
VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK

EGPMNVN
Length:407
Mass (Da):45,836
Last modified:February 1, 1995 - v1
Checksum:iF4943C38033C5A83
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6P3H0Y6P3_HUMAN
Myeloid cell nuclear differentiatio...
MNDA
104Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034107156S → R. Corresponds to variant dbSNP:rs35417083Ensembl.1
Natural variantiVAR_012055286V → L. Corresponds to variant dbSNP:rs1056771Ensembl.1
Natural variantiVAR_020483357H → Y. Corresponds to variant dbSNP:rs2276403Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81750 mRNA Translation: AAA69696.1
BC032319 mRNA Translation: AAH32319.1
CCDSiCCDS1177.1
PIRiI55525
RefSeqiNP_002423.1, NM_002432.2
UniGeneiHs.153837

Genome annotation databases

EnsembliENST00000368141; ENSP00000357123; ENSG00000163563
GeneIDi4332
KEGGihsa:4332

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81750 mRNA Translation: AAA69696.1
BC032319 mRNA Translation: AAH32319.1
CCDSiCCDS1177.1
PIRiI55525
RefSeqiNP_002423.1, NM_002432.2
UniGeneiHs.153837

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBGNMR-A1-90[»]
5H7QX-ray1.45A4-98[»]
5WPZX-ray2.00A/B/C/D/E/F4-98[»]
ProteinModelPortaliP41218
SMRiP41218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110475, 7 interactors
IntActiP41218, 163 interactors
MINTiP41218
STRINGi9606.ENSP00000357123

PTM databases

iPTMnetiP41218
PhosphoSitePlusiP41218

Polymorphism and mutation databases

BioMutaiMNDA
DMDMi730038

Proteomic databases

EPDiP41218
PaxDbiP41218
PeptideAtlasiP41218
PRIDEiP41218
ProteomicsDBi55422

Protocols and materials databases

DNASUi4332
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368141; ENSP00000357123; ENSG00000163563
GeneIDi4332
KEGGihsa:4332

Organism-specific databases

CTDi4332
DisGeNETi4332
EuPathDBiHostDB:ENSG00000163563.7
GeneCardsiMNDA
HGNCiHGNC:7183 MNDA
HPAiHPA034532
HPA073215
MIMi159553 gene
neXtProtiNX_P41218
OpenTargetsiENSG00000163563
PharmGKBiPA30895
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOGENOMiHOG000033871
HOVERGENiHBG006122
InParanoidiP41218
OMAiGKWHNIK
OrthoDBiEOG091G02W0
PhylomeDBiP41218
TreeFamiTF337385

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiMNDA human
EvolutionaryTraceiP41218
GeneWikiiMNDA
GenomeRNAii4332
PROiPR:P41218
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163563 Expressed in 210 organ(s), highest expression level in bone marrow
CleanExiHS_MNDA
ExpressionAtlasiP41218 baseline and differential
GenevisibleiP41218 HS

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR004021 HIN200/IF120x
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNDA_HUMAN
AccessioniPrimary (citable) accession number: P41218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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