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Protein

OX-2 membrane glycoprotein

Gene

CD200

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
CD_antigen: CD200
Gene namesi
Name:CD200
Synonyms:MOX1, MOX2
ORF Names:My033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000091972.18
HGNCiHGNC:7203 CD200
MIMi155970 gene
neXtProtiNX_P41217

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 232ExtracellularSequence analysisAdd BLAST202
Transmembranei233 – 259HelicalSequence analysisAdd BLAST27
Topological domaini260 – 278CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4345
OpenTargetsiENSG00000091972
PharmGKBiPA30911

Chemistry databases

ChEMBLiCHEMBL3712870

Polymorphism and mutation databases

BioMutaiCD200
DMDMi311033489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001512431 – 278OX-2 membrane glycoproteinAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP41217
MaxQBiP41217
PaxDbiP41217
PeptideAtlasiP41217
PRIDEiP41217
ProteomicsDBi55419
55420 [P41217-2]
55421 [P41217-3]
TopDownProteomicsiP41217-3 [P41217-3]

PTM databases

iPTMnetiP41217
PhosphoSitePlusiP41217

Expressioni

Gene expression databases

BgeeiENSG00000091972 Expressed in 212 organ(s), highest expression level in chorionic villus
CleanExiHS_CD200
ExpressionAtlasiP41217 baseline and differential
GenevisibleiP41217 HS

Organism-specific databases

HPAiHPA031149

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200R1Q8TD462EBI-3910563,EBI-4314412

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110486, 2 interactors
IntActiP41217, 2 interactors
STRINGi9606.ENSP00000420298

Structurei

3D structure databases

ProteinModelPortaliP41217
SMRiP41217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 141Ig-like V-typeAdd BLAST111
Domaini142 – 232Ig-like C2-typeAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWZ9 Eukaryota
ENOG410YRD3 LUCA
GeneTreeiENSGT00530000063970
HOVERGENiHBG031790
InParanoidiP41217
KOiK06556
OMAiNKGFWFS
OrthoDBiEOG091G0FSB
PhylomeDBiP41217
TreeFamiTF334493

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR033321 CD200
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PANTHERiPTHR23277:SF72 PTHR23277:SF72, 1 hit
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK
60 70 80 90 100
CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG
110 120 130 140 150
LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK
160 170 180 190 200
FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH
210 220 230 240 250
IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVILL
260 270
VLISILLYWK RHRNQDRGEL SQGVQKMT
Length:278
Mass (Da):31,264
Last modified:November 2, 2010 - v4
Checksum:i38DF327B382CC970
GO
Isoform 2 (identifier: P41217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-278: GELSQGVQKMT → EP

Show »
Length:269
Mass (Da):30,331
Checksum:i7EE08BD6760BACEC
GO
Isoform 3 (identifier: P41217-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
     268-278: GELSQGVQKMT → EP

Show »
Length:294
Mass (Da):32,975
Checksum:iD40A34379E9D7A3B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7G1F8W7G1_HUMAN
OX-2 membrane glycoprotein
CD200
195Annotation score:
F8WC99F8WC99_HUMAN
OX-2 membrane glycoprotein
CD200
150Annotation score:
U3KQG5U3KQG5_HUMAN
OX-2 membrane glycoprotein
CD200
202Annotation score:
F8WEX3F8WEX3_HUMAN
OX-2 membrane glycoprotein
CD200
76Annotation score:
U3KQQ2U3KQQ2_HUMAN
OX-2 membrane glycoprotein
CD200
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181N → D in AAT37533 (Ref. 1) Curated1
Sequence conflicti225F → S in AAT37533 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02760511S → C4 PublicationsCorresponds to variant dbSNP:rs1131199Ensembl.1
Natural variantiVAR_02760646P → T1 PublicationCorresponds to variant dbSNP:rs2272022Ensembl.1
Natural variantiVAR_05611076V → G. Corresponds to variant dbSNP:rs35465733Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0400274L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_002613268 – 278GELSQGVQKMT → EP in isoform 2 and isoform 3. 5 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603771 mRNA Translation: AAT37533.1
AF063591 mRNA Translation: AAG43150.1
AK297194 mRNA Translation: BAG59681.1
AK074972 mRNA Translation: BAG52043.1
AC112487 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79672.1
CH471052 Genomic DNA Translation: EAW79676.1
BC022522 mRNA Translation: AAH22522.1
BC031103 mRNA Translation: AAH31103.1
X05323
, X05324, X05325, X05326 Genomic DNA Translation: CAA28943.1
CCDSiCCDS2965.1 [P41217-2]
CCDS33818.1 [P41217-3]
PIRiA47639
RefSeqiNP_001004196.2, NM_001004196.3 [P41217-3]
NP_001305757.1, NM_001318828.1
NP_005935.4, NM_005944.6 [P41217-2]
XP_005247539.1, XM_005247482.2 [P41217-1]
UniGeneiHs.79015

Genome annotation databases

EnsembliENST00000315711; ENSP00000312766; ENSG00000091972 [P41217-2]
ENST00000473539; ENSP00000420298; ENSG00000091972 [P41217-3]
GeneIDi4345
KEGGihsa:4345
UCSCiuc003dyw.4 human [P41217-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603771 mRNA Translation: AAT37533.1
AF063591 mRNA Translation: AAG43150.1
AK297194 mRNA Translation: BAG59681.1
AK074972 mRNA Translation: BAG52043.1
AC112487 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79672.1
CH471052 Genomic DNA Translation: EAW79676.1
BC022522 mRNA Translation: AAH22522.1
BC031103 mRNA Translation: AAH31103.1
X05323
, X05324, X05325, X05326 Genomic DNA Translation: CAA28943.1
CCDSiCCDS2965.1 [P41217-2]
CCDS33818.1 [P41217-3]
PIRiA47639
RefSeqiNP_001004196.2, NM_001004196.3 [P41217-3]
NP_001305757.1, NM_001318828.1
NP_005935.4, NM_005944.6 [P41217-2]
XP_005247539.1, XM_005247482.2 [P41217-1]
UniGeneiHs.79015

3D structure databases

ProteinModelPortaliP41217
SMRiP41217
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110486, 2 interactors
IntActiP41217, 2 interactors
STRINGi9606.ENSP00000420298

Chemistry databases

ChEMBLiCHEMBL3712870

PTM databases

iPTMnetiP41217
PhosphoSitePlusiP41217

Polymorphism and mutation databases

BioMutaiCD200
DMDMi311033489

Proteomic databases

EPDiP41217
MaxQBiP41217
PaxDbiP41217
PeptideAtlasiP41217
PRIDEiP41217
ProteomicsDBi55419
55420 [P41217-2]
55421 [P41217-3]
TopDownProteomicsiP41217-3 [P41217-3]

Protocols and materials databases

DNASUi4345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315711; ENSP00000312766; ENSG00000091972 [P41217-2]
ENST00000473539; ENSP00000420298; ENSG00000091972 [P41217-3]
GeneIDi4345
KEGGihsa:4345
UCSCiuc003dyw.4 human [P41217-1]

Organism-specific databases

CTDi4345
DisGeNETi4345
EuPathDBiHostDB:ENSG00000091972.18
GeneCardsiCD200
HGNCiHGNC:7203 CD200
HPAiHPA031149
MIMi155970 gene
neXtProtiNX_P41217
OpenTargetsiENSG00000091972
PharmGKBiPA30911
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZ9 Eukaryota
ENOG410YRD3 LUCA
GeneTreeiENSGT00530000063970
HOVERGENiHBG031790
InParanoidiP41217
KOiK06556
OMAiNKGFWFS
OrthoDBiEOG091G0FSB
PhylomeDBiP41217
TreeFamiTF334493

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiCD200 human
GeneWikiiCD200
GenomeRNAii4345
PROiPR:P41217
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091972 Expressed in 212 organ(s), highest expression level in chorionic villus
CleanExiHS_CD200
ExpressionAtlasiP41217 baseline and differential
GenevisibleiP41217 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR033321 CD200
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PANTHERiPTHR23277:SF72 PTHR23277:SF72, 1 hit
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOX2G_HUMAN
AccessioniPrimary (citable) accession number: P41217
Secondary accession number(s): B3KQI1
, B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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