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Entry version 171 (08 May 2019)
Sequence version 3 (21 Aug 2007)
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Protein

Eukaryotic translation initiation factor 2D

Gene

EIF2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.2 Publications

Caution

Was previously erroneously called ligatin, a trafficking receptor for phosphoglycoproteins, while ligatin is actually a distinct 10 kDa filamentous membrane protein encoded by a still unidentified gene.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2D
Short name:
eIF2d
Alternative name(s):
Hepatocellular carcinoma-associated antigen 56
Ligatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF2D
Synonyms:HCA56, LGTN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6583 EIF2D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613709 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41214

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000143486

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30355

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF2D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158957575

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001306111 – 584Eukaryotic translation initiation factor 2DAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei254PhosphoserineBy similarity1
Modified residuei361PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41214

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P41214

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41214

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41214

PeptideAtlas

More...
PeptideAtlasi
P41214

PRoteomics IDEntifications database

More...
PRIDEi
P41214

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55417
55418 [P41214-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41214

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41214

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Found during embryonic development and in early differentiated states.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143486 Expressed in 219 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P41214 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41214 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028220

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108259, 26 interactors

Protein interaction database and analysis system

More...
IntActi
P41214, 3 interactors

Molecular INTeraction database

More...
MINTi
P41214

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271764

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P41214

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 173PUAPROSITE-ProRule annotationAdd BLAST81
Domaini491 – 564SUI1PROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF2D family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2522 Eukaryota
ENOG410XSAV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074865

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41214

KEGG Orthology (KO)

More...
KOi
K15027

Identification of Orthologs from Complete Genome Data

More...
OMAi
MFLKPYR

Database of Orthologous Groups

More...
OrthoDBi
401807at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41214

TreeFam database of animal gene trees

More...
TreeFami
TF105830

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11608 eIF2D_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039757 EIF2D
IPR039759 eIF2D_SUI1
IPR041366 Pre-PUA
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR036885 SWIB_MDM2_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12217 PTHR12217, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17832 Pre-PUA, 1 hit
PF01253 SUI1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00359 PUA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47592 SSF47592, 1 hit
SSF55159 SSF55159, 1 hit
SSF88697 SSF88697, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50890 PUA, 1 hit
PS50296 SUI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI
60 70 80 90 100
VKLYAHKGDA VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP
110 120 130 140 150
LVLEKLVGGA DLMLPGLVMP PAGLPQVQKG DLCAISLVGN RAPVAIGVAA
160 170 180 190 200
MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG NKSSPPSIAP LALDSADLSE
210 220 230 240 250
EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE APEDTSTRGL
260 270 280 290 300
NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC
310 320 330 340 350
CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP
360 370 380 390 400
RITSFVIPEP SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH
410 420 430 440 450
KKGSFLEGSE VRTIVINYAK KNDLVDADNK NLVRLDPILC DCILEKNEQH
460 470 480 490 500
TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE PIVKKGRICP IDITLAQRAS
510 520 530 540 550
NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA KDSLQVQIQG
560 570 580
NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK
Length:584
Mass (Da):64,706
Last modified:August 21, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC302B63268231154
GO
Isoform 2 (identifier: P41214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-300: Missing.

Show »
Length:460
Mass (Da):51,013
Checksum:i6ED8D2011C9ECB29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SY38Q5SY38_HUMAN
Eukaryotic translation initiation f...
EIF2D
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVB6A0A087WVB6_HUMAN
Eukaryotic translation initiation f...
EIF2D
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1L6A0A087X1L6_HUMAN
Eukaryotic translation initiation f...
EIF2D
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X202A0A087X202_HUMAN
Eukaryotic translation initiation f...
EIF2D
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11N → D in BAA91942 (PubMed:14702039).Curated1
Sequence conflicti66S → N in AAF34185 (PubMed:12097419).Curated1
Sequence conflicti66S → N in AAF74205 (PubMed:12097419).Curated1
Sequence conflicti210T → N in AAF34185 (PubMed:12097419).Curated1
Sequence conflicti304 – 308GRQLD → DDNWT in AAD41909 (PubMed:2482295).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052507210T → I. Corresponds to variant dbSNP:rs35252702Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006300177 – 300Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF220417 mRNA Translation: AAF34185.2
AF262403 mRNA Translation: AAF74205.1
AK001852 mRNA Translation: BAA91942.1
AL591846 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93536.1
CH471100 Genomic DNA Translation: EAW93540.1
BC001585 mRNA Translation: AAH01585.1
BC039134 mRNA Translation: AAH39134.2
BC058905 mRNA Translation: AAH58905.1
AL162001 mRNA Translation: CAB82330.1
AF159586 mRNA Translation: AAD41909.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1465.1 [P41214-1]
CCDS55680.1 [P41214-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A60697
T47178

NCBI Reference Sequences

More...
RefSeqi
NP_001188407.1, NM_001201478.1 [P41214-2]
NP_008824.2, NM_006893.2 [P41214-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271764; ENSP00000271764; ENSG00000143486 [P41214-1]
ENST00000367114; ENSP00000356081; ENSG00000143486 [P41214-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1939

UCSC genome browser

More...
UCSCi
uc001heh.4 human [P41214-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220417 mRNA Translation: AAF34185.2
AF262403 mRNA Translation: AAF74205.1
AK001852 mRNA Translation: BAA91942.1
AL591846 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93536.1
CH471100 Genomic DNA Translation: EAW93540.1
BC001585 mRNA Translation: AAH01585.1
BC039134 mRNA Translation: AAH39134.2
BC058905 mRNA Translation: AAH58905.1
AL162001 mRNA Translation: CAB82330.1
AF159586 mRNA Translation: AAD41909.1
CCDSiCCDS1465.1 [P41214-1]
CCDS55680.1 [P41214-2]
PIRiA60697
T47178
RefSeqiNP_001188407.1, NM_001201478.1 [P41214-2]
NP_008824.2, NM_006893.2 [P41214-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OA3electron microscopy4.3001-584[»]
5OA9X-ray1.80A380-584[»]
5W2FX-ray1.40A380-584[»]
SMRiP41214
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108259, 26 interactors
IntActiP41214, 3 interactors
MINTiP41214
STRINGi9606.ENSP00000271764

PTM databases

iPTMnetiP41214
PhosphoSitePlusiP41214

Polymorphism and mutation databases

BioMutaiEIF2D
DMDMi158957575

Proteomic databases

EPDiP41214
jPOSTiP41214
MaxQBiP41214
PaxDbiP41214
PeptideAtlasiP41214
PRIDEiP41214
ProteomicsDBi55417
55418 [P41214-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1939
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271764; ENSP00000271764; ENSG00000143486 [P41214-1]
ENST00000367114; ENSP00000356081; ENSG00000143486 [P41214-2]
GeneIDi1939
KEGGihsa:1939
UCSCiuc001heh.4 human [P41214-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1939

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF2D
HGNCiHGNC:6583 EIF2D
HPAiHPA028220
MIMi613709 gene
neXtProtiNX_P41214
OpenTargetsiENSG00000143486
PharmGKBiPA30355

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG2522 Eukaryota
ENOG410XSAV LUCA
GeneTreeiENSGT00550000074865
InParanoidiP41214
KOiK15027
OMAiMFLKPYR
OrthoDBi401807at2759
PhylomeDBiP41214
TreeFamiTF105830

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF2D human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LGTN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1939

Protein Ontology

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PROi
PR:P41214

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000143486 Expressed in 219 organ(s), highest expression level in ectocervix
ExpressionAtlasiP41214 baseline and differential
GenevisibleiP41214 HS

Family and domain databases

CDDicd11608 eIF2D_C, 1 hit
Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR039757 EIF2D
IPR039759 eIF2D_SUI1
IPR041366 Pre-PUA
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR036885 SWIB_MDM2_dom_sf
PANTHERiPTHR12217 PTHR12217, 1 hit
PfamiView protein in Pfam
PF17832 Pre-PUA, 1 hit
PF01253 SUI1, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF55159 SSF55159, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
PS50296 SUI1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIF2D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41214
Secondary accession number(s): Q5SY40
, Q8IXV3, Q96DG3, Q96TG7, Q9NR27, Q9NSN0, Q9NV18, Q9NZ21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 21, 2007
Last modified: May 8, 2019
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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