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UniProtKB - P41208 (CETN2_HUMAN)

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Protein

Centrin-2

Gene

CETN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).1 Publication

Miscellaneous

Binds two moles of calcium per mole of protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi114 – 1251Add BLAST12
Calcium bindingi150 – 1612Add BLAST12

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centriole replication Source: UniProtKB
  • ciliary basal body-plasma membrane docking Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • global genome nucleotide-excision repair Source: Reactome
  • mitotic cell cycle Source: UniProtKB
  • nucleotide-excision repair Source: UniProtKB
  • nucleotide-excision repair, DNA damage recognition Source: Reactome
  • nucleotide-excision repair, preincision complex assembly Source: Reactome
  • regulation of cytokinesis Source: UniProtKB
  • regulation of G2/M transition of mitotic cell cycle Source: Reactome
  • spermatogenesis Source: Ensembl
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, Mitosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiP41208

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-2
Alternative name(s):
Caltractin isoform 1
Gene namesi
Name:CETN2
Synonyms:CALT, CEN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147400.8
HGNCiHGNC:1867 CETN2
MIMi300006 gene
neXtProtiNX_P41208

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1069
OpenTargetsiENSG00000147400
PharmGKBiPA26420

Polymorphism and mutation databases

BioMutaiCETN2
DMDMi729052

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000735612 – 172Centrin-2Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei26PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP41208
MaxQBiP41208
PaxDbiP41208
PeptideAtlasiP41208
PRIDEiP41208
ProteomicsDBi55415
TopDownProteomicsiP41208

PTM databases

iPTMnetiP41208
PhosphoSitePlusiP41208

Expressioni

Gene expression databases

BgeeiENSG00000147400
CleanExiHS_CETN2
GenevisibleiP41208 HS

Organism-specific databases

HPAiHPA028956

Interactioni

Subunit structurei

Monomer. Homooligomer. Interacts with CCP110, SFI1. Component of the XPC complex composed of XPC, RAD23B and CETN2. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388).8 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi107496, 66 interactors
IntActiP41208, 41 interactors
STRINGi9606.ENSP00000359300

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Helixi27 – 38Combined sources12
Beta strandi46 – 49Combined sources4
Helixi50 – 52Combined sources3
Helixi53 – 59Combined sources7
Helixi66 – 76Combined sources11
Turni77 – 79Combined sources3
Beta strandi82 – 85Combined sources4
Helixi86 – 113Combined sources28
Beta strandi115 – 117Combined sources3
Beta strandi118 – 121Combined sources4
Helixi123 – 132Combined sources10
Helixi139 – 149Combined sources11
Beta strandi150 – 152Combined sources3
Beta strandi153 – 157Combined sources5
Helixi159 – 166Combined sources8

3D structure databases

ProteinModelPortaliP41208
SMRiP41208
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41208

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 25Required for self-assemblyAdd BLAST24

Sequence similaritiesi

Belongs to the centrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP41208
KOiK10840
OMAiEFFAIMT
OrthoDBiEOG091G0RLZ
PhylomeDBiP41208
TreeFamiTF101141

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000629 RNA-helicase_DEAD-box_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV 
        60         70         80         90        100
KELKVAMRAL GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK 
       110        120        130        140        150
DTKEEILKAF KLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD 
       160        170 
RDGDGEVSEQ EFLRIMKKTS LY
Length:172
Mass (Da):19,738
Last modified:February 1, 1995 - v1
Checksum:i59CFD706AD7011B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72964 mRNA Translation: CAA51467.1
U82671 Genomic DNA No translation available.
AK311940 mRNA Translation: BAG34881.1
BT007256 mRNA Translation: AAP35920.1
AY919675 Genomic DNA Translation: AAW82436.1
CH471172 Genomic DNA Translation: EAW72900.1
BC005334 mRNA Translation: AAH05334.1
BC013873 mRNA Translation: AAH13873.1
CCDSiCCDS14716.1
PIRiA49652
RefSeqiNP_004335.1, NM_004344.1
UniGeneiHs.82794

Genome annotation databases

EnsembliENST00000370277; ENSP00000359300; ENSG00000147400
GeneIDi1069
KEGGihsa:1069
UCSCiuc004fgq.4 human

Similar proteinsi

Entry informationi

Entry nameiCETN2_HUMAN
AccessioniPrimary (citable) accession number: P41208
Secondary accession number(s): B2R4T4, Q53XW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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