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Protein

B-cell lymphoma 6 protein

Gene

BCL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.14 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processImmunity, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
SIGNORiP41182

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma 6 protein
Short name:
BCL-6
Alternative name(s):
B-cell lymphoma 5 protein
Short name:
BCL-5
Protein LAZ-3
Zinc finger and BTB domain-containing protein 27
Zinc finger protein 51
Gene namesi
Name:BCL6
Synonyms:BCL5, LAZ3, ZBTB27, ZNF51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000113916.17
HGNCiHGNC:1001 BCL6
MIMi109565 gene
neXtProtiNX_P41182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain (PubMed:10469447, PubMed:10753856, PubMed:12414651, PubMed:11821949). Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions (PubMed:11821949). Translocation t(3;7)(q27;p12) with IKZF1 gene 5'non-coding region (PubMed:10753856). Translocation t(3;6)(q27;p21) with Histone H4 (PubMed:12414651). Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1 (PubMed:10469447).4 Publications
A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21N → K: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with A-116 and 376-Q--Q-379. 1 Publication1
Mutagenesisi59S → A: Abolished ubiquitination by the SCF(FBXL17) complex. 1 Publication1
Mutagenesisi116H → A: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and 376-Q--Q-379. 1 Publication1
Mutagenesisi190T → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi250S → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi260S → A: Strongly reduces interaction with PIN1. 1 Publication1
Mutagenesisi333S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi343S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi376 – 379KKYK → QQYQ: Abolishes interaction with HDAC2 and MTA3 as well as transcriptional repressor and transforming activities. Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and A-116. 2 Publications4
Mutagenesisi376K → R: No effect on acetylation. 1 Publication1
Mutagenesisi377K → R: No effect on acetylation. 1 Publication1
Mutagenesisi379K → R: Abolishes acetylation. No effect on interaction with MTA3, NCOR1 and NCOR2. 2 Publications1
Mutagenesisi520 – 523CNEC → GNEG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi548 – 551CDRC → GDRG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi576 – 579CNIC → GNIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi604 – 607CETC → GETG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4
Mutagenesisi632 – 635CEIC → GEIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi660 – 663CEKC → GEKG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi604
MalaCardsiBCL6
OpenTargetsiENSG00000113916
Orphaneti545 Follicular lymphoma
480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
98839 Intravascular large B-cell lymphoma
98838 Primary mediastinal large B-cell lymphoma
PharmGKBiPA25312

Chemistry databases

GuidetoPHARMACOLOGYi2957

Polymorphism and mutation databases

BioMutaiBCL6
DMDMi728952

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470981 – 706B-cell lymphoma 6 proteinAdd BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333Phosphoserine; by MAPK1Combined sources1 Publication1
Modified residuei343Phosphoserine; by MAPK11 Publication1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379N6-acetyllysine1 Publication1
Modified residuei404PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.3 Publications
Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).3 Publications
Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP41182
MaxQBiP41182
PaxDbiP41182
PeptideAtlasiP41182
PRIDEiP41182
ProteomicsDBi55413
55414 [P41182-2]
TopDownProteomicsiP41182-2 [P41182-2]

PTM databases

iPTMnetiP41182
PhosphoSitePlusiP41182

Expressioni

Tissue specificityi

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.8 Publications

Inductioni

Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.2 Publications

Gene expression databases

BgeeiENSG00000113916 Expressed in 230 organ(s), highest expression level in urinary bladder
CleanExiHS_BCL6
ExpressionAtlasiP41182 baseline and differential
GenevisibleiP41182 HS

Organism-specific databases

HPAiCAB000307
HPA004899
HPA050645

Interactioni

Subunit structurei

Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.12 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107076, 118 interactors
CORUMiP41182
DIPiDIP-2651N
IntActiP41182, 124 interactors
MINTiP41182
STRINGi9606.ENSP00000232014

Structurei

Secondary structure

1706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41182
SMRiP41182
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41182

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni376 – 379Required for interaction with NuRD complex and for transcriptional repressor activity4

Domaini

The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).By similarity1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150977
HOGENOMiHOG000001556
HOVERGENiHBG004831
InParanoidiP41182
KOiK15618
OMAiTEMCLHT
OrthoDBiEOG091G025U
PhylomeDBiP41182
TreeFamiTF330912

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL
60 70 80 90 100
MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG
110 120 130 140 150
NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM
160 170 180 190 200
PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH
210 220 230 240 250
LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS
260 270 280 290 300
PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS
310 320 330 340 350
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS
360 370 380 390 400
KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL
410 420 430 440 450
GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV
460 470 480 490 500
NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE
510 520 530 540 550
MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR
560 570 580 590 600
CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK
610 620 630 640 650
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR
660 670 680 690 700
IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP

ELPKAC
Length:706
Mass (Da):78,846
Last modified:February 1, 1995 - v1
Checksum:iE38D83C213DAE2D0
GO
Isoform 2 (identifier: P41182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-569: Missing.

Note: No experimental confirmation available.
Show »
Length:650
Mass (Da):72,367
Checksum:iADDA180461FAFCE4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCS5C9JCS5_HUMAN
B-cell lymphoma 6 protein
BCL6
121Annotation score:
C9JL16C9JL16_HUMAN
B-cell lymphoma 6 protein
BCL6
104Annotation score:
A0A0C4DH53A0A0C4DH53_HUMAN
B-cell lymphoma 6 protein
BCL6
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347S → A in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti393E → G in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti498P → A in AAC50054 (PubMed:8235596).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052709252N → S. Corresponds to variant dbSNP:rs34463990Ensembl.1
Natural variantiVAR_019970493A → T. Corresponds to variant dbSNP:rs2229362EnsemblClinVar.1
Natural variantiVAR_014825676H → Y. Corresponds to variant dbSNP:rs1056936Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042709514 – 569Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21943 mRNA Translation: CAA79937.1
U00115 mRNA Translation: AAC50054.1
S67779 mRNA No translation available.
EU139066 mRNA Translation: ABX45135.1
AC072022 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78140.1
CH471052 Genomic DNA Translation: EAW78141.1
BC150184 mRNA Translation: AAI50185.1
CCDSiCCDS3289.1 [P41182-1]
CCDS46975.1 [P41182-2]
PIRiA48752
I52586
RefSeqiNP_001124317.1, NM_001130845.1 [P41182-1]
NP_001128210.1, NM_001134738.1 [P41182-2]
NP_001697.2, NM_001706.4 [P41182-1]
XP_005247751.1, XM_005247694.3 [P41182-1]
XP_011511364.1, XM_011513062.2 [P41182-2]
UniGeneiHs.478588

Genome annotation databases

EnsembliENST00000232014; ENSP00000232014; ENSG00000113916 [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916 [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916 [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916 [P41182-2]
GeneIDi604
KEGGihsa:604
UCSCiuc003frp.4 human [P41182-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21943 mRNA Translation: CAA79937.1
U00115 mRNA Translation: AAC50054.1
S67779 mRNA No translation available.
EU139066 mRNA Translation: ABX45135.1
AC072022 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78140.1
CH471052 Genomic DNA Translation: EAW78141.1
BC150184 mRNA Translation: AAI50185.1
CCDSiCCDS3289.1 [P41182-1]
CCDS46975.1 [P41182-2]
PIRiA48752
I52586
RefSeqiNP_001124317.1, NM_001130845.1 [P41182-1]
NP_001128210.1, NM_001134738.1 [P41182-2]
NP_001697.2, NM_001706.4 [P41182-1]
XP_005247751.1, XM_005247694.3 [P41182-1]
XP_011511364.1, XM_011513062.2 [P41182-2]
UniGeneiHs.478588

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2LCENMR-A540-602[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
3LBZX-ray2.30A/B5-129[»]
4CP3X-ray2.30A/B9-128[»]
4U2MX-ray2.23A/B/C/D5-129[»]
5H7GX-ray1.85A/B5-129[»]
5H7HX-ray1.95A5-129[»]
5MW2X-ray2.35A5-129[»]
5MW6X-ray1.65A/B5-129[»]
5MWDX-ray1.85A5-129[»]
5N1XX-ray1.72A9-128[»]
B/C7-127[»]
D9-125[»]
5N1ZX-ray1.81A6-128[»]
5N20X-ray1.38A6-128[»]
5N21X-ray1.58A/B7-128[»]
5X4MX-ray1.65A5-129[»]
5X4NX-ray1.94A5-129[»]
5X4OX-ray2.05A5-129[»]
5X4PX-ray2.06A5-129[»]
5X4QX-ray2.00A5-129[»]
5X9OX-ray1.58A5-129[»]
5X9PX-ray1.86A5-129[»]
ProteinModelPortaliP41182
SMRiP41182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107076, 118 interactors
CORUMiP41182
DIPiDIP-2651N
IntActiP41182, 124 interactors
MINTiP41182
STRINGi9606.ENSP00000232014

Chemistry databases

GuidetoPHARMACOLOGYi2957

PTM databases

iPTMnetiP41182
PhosphoSitePlusiP41182

Polymorphism and mutation databases

BioMutaiBCL6
DMDMi728952

Proteomic databases

EPDiP41182
MaxQBiP41182
PaxDbiP41182
PeptideAtlasiP41182
PRIDEiP41182
ProteomicsDBi55413
55414 [P41182-2]
TopDownProteomicsiP41182-2 [P41182-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232014; ENSP00000232014; ENSG00000113916 [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916 [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916 [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916 [P41182-2]
GeneIDi604
KEGGihsa:604
UCSCiuc003frp.4 human [P41182-1]

Organism-specific databases

CTDi604
DisGeNETi604
EuPathDBiHostDB:ENSG00000113916.17
GeneCardsiBCL6
HGNCiHGNC:1001 BCL6
HPAiCAB000307
HPA004899
HPA050645
MalaCardsiBCL6
MIMi109565 gene
neXtProtiNX_P41182
OpenTargetsiENSG00000113916
Orphaneti545 Follicular lymphoma
480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
98839 Intravascular large B-cell lymphoma
98838 Primary mediastinal large B-cell lymphoma
PharmGKBiPA25312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150977
HOGENOMiHOG000001556
HOVERGENiHBG004831
InParanoidiP41182
KOiK15618
OMAiTEMCLHT
OrthoDBiEOG091G025U
PhylomeDBiP41182
TreeFamiTF330912

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
SIGNORiP41182

Miscellaneous databases

ChiTaRSiBCL6 human
EvolutionaryTraceiP41182
GeneWikiiBCL6
GenomeRNAii604
PROiPR:P41182
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113916 Expressed in 230 organ(s), highest expression level in urinary bladder
CleanExiHS_BCL6
ExpressionAtlasiP41182 baseline and differential
GenevisibleiP41182 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBCL6_HUMAN
AccessioniPrimary (citable) accession number: P41182
Secondary accession number(s): A7E241, B8PSA7, D3DNV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 200 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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