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Entry version 205 (08 May 2019)
Sequence version 1 (01 Feb 1995)
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Protein

B-cell lymphoma 6 protein

Gene

BCL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.14 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processImmunity, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-9614657 FOXO-mediated transcription of cell death genes

SIGNOR Signaling Network Open Resource

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SIGNORi
P41182

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell lymphoma 6 protein
Short name:
BCL-6
Alternative name(s):
B-cell lymphoma 5 protein
Short name:
BCL-5
Protein LAZ-3
Zinc finger and BTB domain-containing protein 27
Zinc finger protein 51
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL6
Synonyms:BCL5, LAZ3, ZBTB27, ZNF51
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1001 BCL6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
109565 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41182

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain (PubMed:10469447, PubMed:10753856, PubMed:12414651, PubMed:11821949). Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions (PubMed:11821949). Translocation t(3;7)(q27;p12) with IKZF1 gene 5'non-coding region (PubMed:10753856). Translocation t(3;6)(q27;p21) with Histone H4 (PubMed:12414651). Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1 (PubMed:10469447).4 Publications
A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21N → K: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with A-116 and 376-Q--Q-379. 1 Publication1
Mutagenesisi59S → A: Abolished ubiquitination by the SCF(FBXL17) complex. 1 Publication1
Mutagenesisi116H → A: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and 376-Q--Q-379. 1 Publication1
Mutagenesisi190T → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi250S → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi260S → A: Strongly reduces interaction with PIN1. 1 Publication1
Mutagenesisi333S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi343S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi376 – 379KKYK → QQYQ: Abolishes interaction with HDAC2 and MTA3 as well as transcriptional repressor and transforming activities. Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and A-116. 2 Publications4
Mutagenesisi376K → R: No effect on acetylation. 1 Publication1
Mutagenesisi377K → R: No effect on acetylation. 1 Publication1
Mutagenesisi379K → R: Abolishes acetylation. No effect on interaction with MTA3, NCOR1 and NCOR2. 2 Publications1
Mutagenesisi520 – 523CNEC → GNEG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi548 – 551CDRC → GDRG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi576 – 579CNIC → GNIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi604 – 607CETC → GETG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4
Mutagenesisi632 – 635CEIC → GEIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi660 – 663CEKC → GEKG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
604

MalaCards human disease database

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MalaCardsi
BCL6

Open Targets

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OpenTargetsi
ENSG00000113916

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
545 Follicular lymphoma
480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
98839 Intravascular large B-cell lymphoma
98838 Primary mediastinal large B-cell lymphoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25312

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2957

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
BCL6

Domain mapping of disease mutations (DMDM)

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DMDMi
728952

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470981 – 706B-cell lymphoma 6 proteinAdd BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333Phosphoserine; by MAPK1Combined sources1 Publication1
Modified residuei343Phosphoserine; by MAPK11 Publication1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379N6-acetyllysine1 Publication1
Modified residuei404PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.3 Publications
Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).3 Publications
Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P41182

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P41182

MaxQB - The MaxQuant DataBase

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MaxQBi
P41182

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P41182

PeptideAtlas

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PeptideAtlasi
P41182

PRoteomics IDEntifications database

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PRIDEi
P41182

ProteomicsDB human proteome resource

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ProteomicsDBi
55413
55414 [P41182-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P41182-2 [P41182-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P41182

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P41182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.8 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113916 Expressed in 230 organ(s), highest expression level in urinary bladder

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P41182 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41182 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB000307
HPA004899
HPA050645

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107076, 132 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P41182

Database of interacting proteins

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DIPi
DIP-2651N

Protein interaction database and analysis system

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IntActi
P41182, 124 interactors

Molecular INTeraction database

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MINTi
P41182

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384371

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2LCENMR-A540-602[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
3LBZX-ray2.30A/B5-129[»]
4CP3X-ray2.30A/B9-128[»]
4U2MX-ray2.23A/B/C/D5-129[»]
5H7GX-ray1.85A/B5-129[»]
5H7HX-ray1.95A5-129[»]
5MW2X-ray2.35A5-129[»]
5MW6X-ray1.65A/B5-129[»]
5MWDX-ray1.85A5-129[»]
5N1XX-ray1.72A9-128[»]
B/C7-127[»]
D9-125[»]
5N1ZX-ray1.81A6-128[»]
5N20X-ray1.38A6-128[»]
5N21X-ray1.58A/B7-128[»]
5X4MX-ray1.65A5-129[»]
5X4NX-ray1.94A5-129[»]
5X4OX-ray2.05A5-129[»]
5X4PX-ray2.06A5-129[»]
5X4QX-ray2.00A5-129[»]
5X9OX-ray1.58A5-129[»]
5X9PX-ray1.86A5-129[»]
6C3LX-ray1.46A/B5-129[»]
6C3NX-ray2.53A/B1-129[»]
6EW6X-ray1.39A6-128[»]
6EW7X-ray1.60A/B7-128[»]
6EW8X-ray1.84A6-129[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41182

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P41182

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni376 – 379Required for interaction with NuRD complex and for transcriptional repressor activity4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).By similarity1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156311

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000001556

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41182

KEGG Orthology (KO)

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KOi
K15618

Identification of Orthologs from Complete Genome Data

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OMAi
YSRPAME

Database of Orthologous Groups

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OrthoDBi
1443035at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P41182

TreeFam database of animal gene trees

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TreeFami
TF330912

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL
60 70 80 90 100
MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG
110 120 130 140 150
NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM
160 170 180 190 200
PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH
210 220 230 240 250
LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS
260 270 280 290 300
PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS
310 320 330 340 350
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS
360 370 380 390 400
KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL
410 420 430 440 450
GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV
460 470 480 490 500
NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE
510 520 530 540 550
MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR
560 570 580 590 600
CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK
610 620 630 640 650
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR
660 670 680 690 700
IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP

ELPKAC
Length:706
Mass (Da):78,846
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE38D83C213DAE2D0
GO
Isoform 2 (identifier: P41182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-569: Missing.

Note: No experimental confirmation available.
Show »
Length:650
Mass (Da):72,367
Checksum:iADDA180461FAFCE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCS5C9JCS5_HUMAN
B-cell lymphoma 6 protein
BCL6
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JL16C9JL16_HUMAN
B-cell lymphoma 6 protein
BCL6
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH53A0A0C4DH53_HUMAN
B-cell lymphoma 6 protein
BCL6
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti347S → A in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti393E → G in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti498P → A in AAC50054 (PubMed:8235596).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052709252N → S. Corresponds to variant dbSNP:rs34463990Ensembl.1
Natural variantiVAR_019970493A → T. Corresponds to variant dbSNP:rs2229362EnsemblClinVar.1
Natural variantiVAR_014825676H → Y. Corresponds to variant dbSNP:rs1056936Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042709514 – 569Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z21943 mRNA Translation: CAA79937.1
U00115 mRNA Translation: AAC50054.1
S67779 mRNA No translation available.
EU139066 mRNA Translation: ABX45135.1
AC072022 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78140.1
CH471052 Genomic DNA Translation: EAW78141.1
BC150184 mRNA Translation: AAI50185.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3289.1 [P41182-1]
CCDS46975.1 [P41182-2]

Protein sequence database of the Protein Information Resource

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PIRi
A48752
I52586

NCBI Reference Sequences

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RefSeqi
NP_001124317.1, NM_001130845.1 [P41182-1]
NP_001128210.1, NM_001134738.1 [P41182-2]
NP_001697.2, NM_001706.4 [P41182-1]
XP_005247751.1, XM_005247694.3 [P41182-1]
XP_011511364.1, XM_011513062.2 [P41182-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000232014; ENSP00000232014; ENSG00000113916 [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916 [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916 [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916 [P41182-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
604

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:604

UCSC genome browser

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UCSCi
uc003frp.4 human [P41182-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21943 mRNA Translation: CAA79937.1
U00115 mRNA Translation: AAC50054.1
S67779 mRNA No translation available.
EU139066 mRNA Translation: ABX45135.1
AC072022 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78140.1
CH471052 Genomic DNA Translation: EAW78141.1
BC150184 mRNA Translation: AAI50185.1
CCDSiCCDS3289.1 [P41182-1]
CCDS46975.1 [P41182-2]
PIRiA48752
I52586
RefSeqiNP_001124317.1, NM_001130845.1 [P41182-1]
NP_001128210.1, NM_001134738.1 [P41182-2]
NP_001697.2, NM_001706.4 [P41182-1]
XP_005247751.1, XM_005247694.3 [P41182-1]
XP_011511364.1, XM_011513062.2 [P41182-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2LCENMR-A540-602[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
3LBZX-ray2.30A/B5-129[»]
4CP3X-ray2.30A/B9-128[»]
4U2MX-ray2.23A/B/C/D5-129[»]
5H7GX-ray1.85A/B5-129[»]
5H7HX-ray1.95A5-129[»]
5MW2X-ray2.35A5-129[»]
5MW6X-ray1.65A/B5-129[»]
5MWDX-ray1.85A5-129[»]
5N1XX-ray1.72A9-128[»]
B/C7-127[»]
D9-125[»]
5N1ZX-ray1.81A6-128[»]
5N20X-ray1.38A6-128[»]
5N21X-ray1.58A/B7-128[»]
5X4MX-ray1.65A5-129[»]
5X4NX-ray1.94A5-129[»]
5X4OX-ray2.05A5-129[»]
5X4PX-ray2.06A5-129[»]
5X4QX-ray2.00A5-129[»]
5X9OX-ray1.58A5-129[»]
5X9PX-ray1.86A5-129[»]
6C3LX-ray1.46A/B5-129[»]
6C3NX-ray2.53A/B1-129[»]
6EW6X-ray1.39A6-128[»]
6EW7X-ray1.60A/B7-128[»]
6EW8X-ray1.84A6-129[»]
SMRiP41182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107076, 132 interactors
CORUMiP41182
DIPiDIP-2651N
IntActiP41182, 124 interactors
MINTiP41182
STRINGi9606.ENSP00000384371

Chemistry databases

GuidetoPHARMACOLOGYi2957

PTM databases

iPTMnetiP41182
PhosphoSitePlusiP41182

Polymorphism and mutation databases

BioMutaiBCL6
DMDMi728952

Proteomic databases

EPDiP41182
jPOSTiP41182
MaxQBiP41182
PaxDbiP41182
PeptideAtlasiP41182
PRIDEiP41182
ProteomicsDBi55413
55414 [P41182-2]
TopDownProteomicsiP41182-2 [P41182-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232014; ENSP00000232014; ENSG00000113916 [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916 [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916 [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916 [P41182-2]
GeneIDi604
KEGGihsa:604
UCSCiuc003frp.4 human [P41182-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
604
DisGeNETi604

GeneCards: human genes, protein and diseases

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GeneCardsi
BCL6
HGNCiHGNC:1001 BCL6
HPAiCAB000307
HPA004899
HPA050645
MalaCardsiBCL6
MIMi109565 gene
neXtProtiNX_P41182
OpenTargetsiENSG00000113916
Orphaneti545 Follicular lymphoma
480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
98839 Intravascular large B-cell lymphoma
98838 Primary mediastinal large B-cell lymphoma
PharmGKBiPA25312

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156311
HOGENOMiHOG000001556
InParanoidiP41182
KOiK15618
OMAiYSRPAME
OrthoDBi1443035at2759
PhylomeDBiP41182
TreeFamiTF330912

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-9614657 FOXO-mediated transcription of cell death genes
SIGNORiP41182

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCL6 human
EvolutionaryTraceiP41182

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BCL6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
604

Protein Ontology

More...
PROi
PR:P41182

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113916 Expressed in 230 organ(s), highest expression level in urinary bladder
ExpressionAtlasiP41182 baseline and differential
GenevisibleiP41182 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41182
Secondary accession number(s): A7E241, B8PSA7, D3DNV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 8, 2019
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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