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Protein

Leptin

Gene

LEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4+CD25- T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).By similarity2 Publications9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hormone activity Source: GO_Central
  • peptide hormone receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2586552 Signaling by Leptin
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P41159

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P41159

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LeptinImported
Alternative name(s):
Obese protein
Obesity factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LEPImported
Synonyms:OBImported, OBSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000174697.4

Human Gene Nomenclature Database

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HGNCi
HGNC:6553 LEP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164160 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41159

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leptin deficiency (LEPD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.
See also OMIM:614962
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075144100D → Y in LEPD; no effect on secretion; does not bind or activate LEPR. 1 PublicationCorresponds to variant dbSNP:rs724159998EnsemblClinVar.1
Natural variantiVAR_008094105R → W in LEPD. 1 PublicationCorresponds to variant dbSNP:rs104894023EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
3952

MalaCards human disease database

More...
MalaCardsi
LEP
MIMi614962 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000174697

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
66628 Obesity due to congenital leptin deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA228

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LEP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001768522 – 167LeptinAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 167

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41159

PeptideAtlas

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PeptideAtlasi
P41159

PRoteomics IDEntifications database

More...
PRIDEi
P41159

ProteomicsDB human proteome resource

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ProteomicsDBi
12681
55406

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P41159

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41159

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by secretin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174697 Expressed in 104 organ(s), highest expression level in adipose tissue of abdominal region

CleanEx database of gene expression profiles

More...
CleanExi
HS_LEP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P41159 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41159 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB010490
HPA030721

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIGLEC6.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110143, 5 interactors

Database of interacting proteins

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DIPi
DIP-6116N

Protein interaction database and analysis system

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IntActi
P41159, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312652

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P41159

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41159

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P41159

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the leptin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVT0 Eukaryota
ENOG410Y7NT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000252923

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007860

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41159

KEGG Orthology (KO)

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KOi
K05424

Identification of Orthologs from Complete Genome Data

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OMAi
QISNDLE

Database of Orthologous Groups

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OrthoDBi
EOG091G0Y82

Database for complete collections of gene phylogenies

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PhylomeDBi
P41159

TreeFam database of animal gene trees

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TreeFami
TF105086

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000065 Leptin

The PANTHER Classification System

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PANTHERi
PTHR11724 PTHR11724, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02024 Leptin, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001837 Leptin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00495 LEPTIN

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD005698 Leptin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47266 SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P41159-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS
60 70 80 90 100
VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND
110 120 130 140 150
LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL
160
QGSLQDMLWQ LDLSPGC
Length:167
Mass (Da):18,641
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC91A121E92D37B69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96Q → R in AAB63507 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00419649Missing . 1
Natural variantiVAR_00419794V → M2 PublicationsCorresponds to variant dbSNP:rs17151919EnsemblClinVar.1
Natural variantiVAR_075144100D → Y in LEPD; no effect on secretion; does not bind or activate LEPR. 1 PublicationCorresponds to variant dbSNP:rs724159998EnsemblClinVar.1
Natural variantiVAR_008094105R → W in LEPD. 1 PublicationCorresponds to variant dbSNP:rs104894023EnsemblClinVar.1
Natural variantiVAR_011955110V → M. Corresponds to variant dbSNP:rs1800564Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U18915 mRNA Translation: AAA60470.1
D49487 mRNA Translation: BAA08448.1
U43653 mRNA Translation: AAC50400.1
U43415 Genomic DNA Translation: AAC31660.1
D63710 Genomic DNA Translation: BAA09839.1
D63519 Genomic DNA Translation: BAA09787.1
AF008123 mRNA Translation: AAB63507.1
AY996373 Genomic DNA Translation: AAX81413.1
BC060830 mRNA Translation: AAH60830.1
BC069452 mRNA Translation: AAH69452.1
BC069527 mRNA Translation: AAH69527.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5800.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38952 LTHU
I53166

NCBI Reference Sequences

More...
RefSeqi
NP_000221.1, NM_000230.2
XP_005250397.1, XM_005250340.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.194236

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308868; ENSP00000312652; ENSG00000174697

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3952

UCSC genome browser

More...
UCSCi
uc003vml.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Leptin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18915 mRNA Translation: AAA60470.1
D49487 mRNA Translation: BAA08448.1
U43653 mRNA Translation: AAC50400.1
U43415 Genomic DNA Translation: AAC31660.1
D63710 Genomic DNA Translation: BAA09839.1
D63519 Genomic DNA Translation: BAA09787.1
AF008123 mRNA Translation: AAB63507.1
AY996373 Genomic DNA Translation: AAX81413.1
BC060830 mRNA Translation: AAH60830.1
BC069452 mRNA Translation: AAH69452.1
BC069527 mRNA Translation: AAH69527.1
CCDSiCCDS5800.1
PIRiA38952 LTHU
I53166
RefSeqiNP_000221.1, NM_000230.2
XP_005250397.1, XM_005250340.4
UniGeneiHs.194236

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AX8X-ray2.40A22-167[»]
ProteinModelPortaliP41159
SMRiP41159
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110143, 5 interactors
DIPiDIP-6116N
IntActiP41159, 4 interactors
STRINGi9606.ENSP00000312652

PTM databases

iPTMnetiP41159
PhosphoSitePlusiP41159

Polymorphism and mutation databases

BioMutaiLEP

Proteomic databases

PaxDbiP41159
PeptideAtlasiP41159
PRIDEiP41159
ProteomicsDBi12681
55406

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3952
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308868; ENSP00000312652; ENSG00000174697
GeneIDi3952
KEGGihsa:3952
UCSCiuc003vml.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3952
DisGeNETi3952
EuPathDBiHostDB:ENSG00000174697.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LEP
HGNCiHGNC:6553 LEP
HPAiCAB010490
HPA030721
MalaCardsiLEP
MIMi164160 gene
614962 phenotype
neXtProtiNX_P41159
OpenTargetsiENSG00000174697
Orphaneti66628 Obesity due to congenital leptin deficiency
PharmGKBiPA228

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IVT0 Eukaryota
ENOG410Y7NT LUCA
GeneTreeiENSGT00390000011772
HOGENOMiHOG000252923
HOVERGENiHBG007860
InParanoidiP41159
KOiK05424
OMAiQISNDLE
OrthoDBiEOG091G0Y82
PhylomeDBiP41159
TreeFamiTF105086

Enzyme and pathway databases

ReactomeiR-HSA-2586552 Signaling by Leptin
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SignaLinkiP41159
SIGNORiP41159

Miscellaneous databases

EvolutionaryTraceiP41159

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Leptin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3952

Protein Ontology

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PROi
PR:P41159

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000174697 Expressed in 104 organ(s), highest expression level in adipose tissue of abdominal region
CleanExiHS_LEP
ExpressionAtlasiP41159 baseline and differential
GenevisibleiP41159 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000065 Leptin
PANTHERiPTHR11724 PTHR11724, 1 hit
PfamiView protein in Pfam
PF02024 Leptin, 1 hit
PIRSFiPIRSF001837 Leptin, 1 hit
PRINTSiPR00495 LEPTIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005698 Leptin, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41159
Secondary accession number(s): O15158, Q56A88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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