Elk4

Functionⁱ

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	5 – 85	ETSPROSITE-ProRule annotationAdd BLAST		81

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: GO_Central
histone H3 deacetylation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription by RNA polymerase II Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ETS domain-containing protein Elk-4 Alternative name(s): Serum response factor accessory protein 1 Short name: SAP-1 Short name: SRF accessory protein 1
Gene namesⁱ	Name:Elk4 Synonyms:Sap1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:102853 Elk4

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204100	1 – 430	ETS domain-containing protein Elk-4Add BLAST		430

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	166	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P41158
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P41158
PaxDbⁱ	P41158
PRIDEⁱ	P41158

PTM databases

iPTMnetⁱ	P41158
PhosphoSitePlusⁱ	P41158

Expressionⁱ

Tissue specificityⁱ

Lung and liver.

Gene expression databases

Bgeeⁱ	ENSMUSG00000026436
CleanExⁱ	MM_ELK4
ExpressionAtlasⁱ	P41158 baseline and differential
Genevisibleⁱ	P41158 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SIRT7.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027696

STRINGⁱ

10090.ENSMUSP00000027696

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P41158
SMRⁱ	P41158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000237332
HOVERGENⁱ	HBG004344
InParanoidⁱ	P41158
KEGG Orthology (KO) More...KOⁱ	K04376
OMAⁱ	ICWTSNN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0COO
TreeFamⁱ	TF317732

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P41158-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN 
        60         70         80         90        100
KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR 
       110        120        130        140        150
IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT 
       160        170        180        190        200
LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE 
       210        220        230        240        250
PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT 
       260        270        280        290        300
PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK 
       310        320        330        340        350
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA 
       360        370        380        390        400
SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP 
       410        420        430
SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT

Length:430

Mass (Da):46,826

Last modified:July 27, 2011 - v2

Checksum:ⁱ76CF28AB7627AB5F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	99	G → A in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	206	F → C in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	228	S → F in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	307	P → A in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	340	L → S in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	395	T → M in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	409	F → L in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	415	D → E in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	419	T → L in CAA85358 (PubMed:7958835).Curated	1
Sequence conflictⁱ	426	D → R in CAA85358 (PubMed:7958835).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z36885 mRNA Translation: CAA85358.1 CH466520 Genomic DNA Translation: EDL39692.1 BC144844 mRNA Translation: AAI44845.1 BC145795 mRNA Translation: AAI45796.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35704.1
PIRⁱ	I48755
NCBI Reference Sequences More...RefSeqⁱ	NP_031949.2, NM_007923.2 XP_006529189.1, XM_006529126.3 XP_006529190.1, XM_006529127.3 XP_006529191.1, XM_006529128.3 XP_006529192.1, XM_006529129.3 XP_006529193.1, XM_006529130.3
UniGeneⁱ	Mm.254233 Mm.482266

Genome annotation databases

Ensemblⁱ	ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436 ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436
GeneIDⁱ	13714
KEGGⁱ	mmu:13714
UCSC genome browser More...UCSCⁱ	uc007cob.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P41158	Uncharacterized protein (Fragment)		MOUSE		307
ETS domain-containing protein Elk-4 (Fragment)		MOUSE		306

Protein	Similar proteins		Species	Score	Length
P41158	Uncharacterized protein (Fragment)		MOUSE		307
UPI00077DD8D1		PERMB		437
Uncharacterized protein		NEOLE		433
UPI0004ED5D9E		NANGA		432
ELK4, ETS transcription factor		RAT		430
+9

Protein	Similar proteins		Species	Score	Length
P41158	Uncharacterized protein (Fragment)		MOUSE		307
UPI00077DD8D1		PERMB		437
Uncharacterized protein		NEOLE		433
UPI0004ED5D9E		NANGA		432
UPI000A3293BD		MESAU		430
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z36885 mRNA Translation: CAA85358.1 CH466520 Genomic DNA Translation: EDL39692.1 BC144844 mRNA Translation: AAI44845.1 BC145795 mRNA Translation: AAI45796.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35704.1
PIRⁱ	I48755
NCBI Reference Sequences More...RefSeqⁱ	NP_031949.2, NM_007923.2 XP_006529189.1, XM_006529126.3 XP_006529190.1, XM_006529127.3 XP_006529191.1, XM_006529128.3 XP_006529192.1, XM_006529129.3 XP_006529193.1, XM_006529130.3
UniGeneⁱ	Mm.254233 Mm.482266

3D structure databases

ProteinModelPortalⁱ	P41158
SMRⁱ	P41158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027696

STRINGⁱ

10090.ENSMUSP00000027696

PTM databases

iPTMnetⁱ	P41158
PhosphoSitePlusⁱ	P41158

Proteomic databases

EPDⁱ	P41158
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P41158
PaxDbⁱ	P41158
PRIDEⁱ	P41158

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436 ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436
GeneIDⁱ	13714
KEGGⁱ	mmu:13714
UCSC genome browser More...UCSCⁱ	uc007cob.1 mouse

Organism-specific databases

CTDⁱ	2005
MGIⁱ	MGI:102853 Elk4

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000237332
HOVERGENⁱ	HBG004344
InParanoidⁱ	P41158
KEGG Orthology (KO) More...KOⁱ	K04376
OMAⁱ	ICWTSNN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0COO
TreeFamⁱ	TF317732

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P41158
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026436
CleanExⁱ	MM_ELK4
ExpressionAtlasⁱ	P41158 baseline and differential
Genevisibleⁱ	P41158 MM

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELK4_MOUSE
Accessionⁱ	P41158Primary (citable) accession number: P41158 Secondary accession number(s): A6H693
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	July 27, 2011
	Last modified:	March 28, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P41158 (ELK4_MOUSE)

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ETS domain-containing protein Elk-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ