UniProtKB - P41158 (ELK4_MOUSE)
Protein
ETS domain-containing protein Elk-4
Gene
Elk4
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 5 – 85 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: GO_Central
- histone H3 deacetylation Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: ETS domain-containing protein Elk-4Alternative name(s): Serum response factor accessory protein 1 Short name: SAP-1 Short name: SRF accessory protein 1 |
Gene namesi | Name:Elk4 Synonyms:Sap1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102853, Elk4 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204100 | 1 – 430 | ETS domain-containing protein Elk-4Add BLAST | 430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P41158 |
MaxQBi | P41158 |
PaxDbi | P41158 |
PRIDEi | P41158 |
ProteomicsDBi | 275741 |
PTM databases
iPTMneti | P41158 |
PhosphoSitePlusi | P41158 |
Expressioni
Tissue specificityi
Lung and liver.
Gene expression databases
Bgeei | ENSMUSG00000026436, Expressed in saccule of membranous labyrinth and 307 other tissues |
Genevisiblei | P41158, MM |
Interactioni
Subunit structurei
Interacts with SIRT7.
By similarityProtein-protein interaction databases
BioGRIDi | 199431, 1 interactor |
STRINGi | 10090.ENSMUSP00000083743 |
Miscellaneous databases
RNActi | P41158, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158900 |
HOGENOMi | CLU_036905_1_0_1 |
InParanoidi | P41158 |
OMAi | SQSCAKS |
OrthoDBi | 981551at2759 |
TreeFami | TF317732 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P41158-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN
60 70 80 90 100
KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR
110 120 130 140 150
IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT
160 170 180 190 200
LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE
210 220 230 240 250
PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT
260 270 280 290 300
PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
310 320 330 340 350
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA
360 370 380 390 400
SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP
410 420 430
SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GXH8 | A0A1B0GXH8_MOUSE | ETS domain-containing protein Elk-4 | Elk4 | 306 | Annotation score: | ||
F6ZCI1 | F6ZCI1_MOUSE | ETS domain-containing protein Elk-4 | Elk4 | 290 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | G → A in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 206 | F → C in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 228 | S → F in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 307 | P → A in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 340 | L → S in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 395 | T → M in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 409 | F → L in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 415 | D → E in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 419 | T → L in CAA85358 (PubMed:7958835).Curated | 1 | |
Sequence conflicti | 426 | D → R in CAA85358 (PubMed:7958835).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36885 mRNA Translation: CAA85358.1 CH466520 Genomic DNA Translation: EDL39692.1 BC144844 mRNA Translation: AAI44845.1 BC145795 mRNA Translation: AAI45796.1 |
CCDSi | CCDS35704.1 |
PIRi | I48755 |
RefSeqi | NP_031949.2, NM_007923.2 XP_006529189.1, XM_006529126.3 XP_006529190.1, XM_006529127.3 XP_006529191.1, XM_006529128.3 XP_006529192.1, XM_006529129.3 XP_006529193.1, XM_006529130.3 |
Genome annotation databases
Ensembli | ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436 ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436 |
GeneIDi | 13714 |
KEGGi | mmu:13714 |
UCSCi | uc007cob.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36885 mRNA Translation: CAA85358.1 CH466520 Genomic DNA Translation: EDL39692.1 BC144844 mRNA Translation: AAI44845.1 BC145795 mRNA Translation: AAI45796.1 |
CCDSi | CCDS35704.1 |
PIRi | I48755 |
RefSeqi | NP_031949.2, NM_007923.2 XP_006529189.1, XM_006529126.3 XP_006529190.1, XM_006529127.3 XP_006529191.1, XM_006529128.3 XP_006529192.1, XM_006529129.3 XP_006529193.1, XM_006529130.3 |
3D structure databases
SMRi | P41158 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199431, 1 interactor |
STRINGi | 10090.ENSMUSP00000083743 |
PTM databases
iPTMneti | P41158 |
PhosphoSitePlusi | P41158 |
Proteomic databases
EPDi | P41158 |
MaxQBi | P41158 |
PaxDbi | P41158 |
PRIDEi | P41158 |
ProteomicsDBi | 275741 |
Protocols and materials databases
Antibodypediai | 20682, 139 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436 ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436 |
GeneIDi | 13714 |
KEGGi | mmu:13714 |
UCSCi | uc007cob.1, mouse |
Organism-specific databases
CTDi | 2005 |
MGIi | MGI:102853, Elk4 |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158900 |
HOGENOMi | CLU_036905_1_0_1 |
InParanoidi | P41158 |
OMAi | SQSCAKS |
OrthoDBi | 981551at2759 |
TreeFami | TF317732 |
Miscellaneous databases
BioGRID-ORCSi | 13714, 0 hits in 53 CRISPR screens |
ChiTaRSi | Elk4, mouse |
PROi | PR:P41158 |
RNActi | P41158, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026436, Expressed in saccule of membranous labyrinth and 307 other tissues |
Genevisiblei | P41158, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELK4_MOUSE | |
Accessioni | P41158Primary (citable) accession number: P41158 Secondary accession number(s): A6H693 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families