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Protein

Lymphotoxin-beta

Gene

Ltb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

GO - Molecular functioni

GO - Biological processi

  • gene expression Source: MGI
  • immune response Source: InterPro
  • lymph node development Source: MGI
  • positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
  • skin development Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-beta
Short name:
LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name:
TNF-C
Tumor necrosis factor ligand superfamily member 3
Gene namesi
Name:Ltb
Synonyms:Tnfc, Tnfsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104796 Ltb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 306ExtracellularSequence analysisAdd BLAST258

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854901 – 306Lymphotoxin-betaAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP41155
PaxDbiP41155
PRIDEiP41155

PTM databases

iPTMnetiP41155
PhosphoSitePlusiP41155

Expressioni

Gene expression databases

BgeeiENSMUSG00000024399
CleanExiMM_LTB
ExpressionAtlasiP41155 baseline and differential
GenevisibleiP41155 MM

Interactioni

Subunit structurei

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201218, 2 interactors
IntActiP41155, 1 interactor
STRINGi10090.ENSMUSP00000025262

Structurei

3D structure databases

ProteinModelPortaliP41155
SMRiP41155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJP9 Eukaryota
ENOG410ZHBF LUCA
GeneTreeiENSGT00390000007066
HOGENOMiHOG000273916
HOVERGENiHBG000209
InParanoidiP41155
KOiK03157
OMAiYCHVGYR
OrthoDBiEOG091G0J9M
PhylomeDBiP41155
TreeFamiTF337780

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002961 TNF_C
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF29 PTHR11471:SF29, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01237 TNFC
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD
60 70 80 90 100
QGRRVEKIIG SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS
110 120 130 140 150
RNLASTSQGP VAQSSREASA WMTILSPAAD STPDPGVQQL PKGEPETDLN
160 170 180 190 200
PELPAAHLIG AWMSGQGLSW EASQEEAFLR SGAQFSPTHG LALPQDGVYY
210 220 230 240 250
LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP ELLLEGAETV
260 270 280 290 300
TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF

GAVMVG
Length:306
Mass (Da):32,329
Last modified:February 1, 1995 - v1
Checksum:iB7D276AB84A22549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12029 Genomic DNA Translation: AAA67716.1
U16984 Genomic DNA Translation: AAB60493.1
U16985 mRNA Translation: AAA70089.1
U06950 Unassigned DNA Translation: AAA18592.1
AF109719 Genomic DNA Translation: AAC82483.1
CCDSiCCDS28690.1
PIRiI49139
RefSeqiNP_032544.1, NM_008518.2
UniGeneiMm.1715

Genome annotation databases

EnsembliENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399
GeneIDi16994
KEGGimmu:16994
UCSCiuc008cgp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTNFC_MOUSE
AccessioniPrimary (citable) accession number: P41155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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