UniProtKB - P41145 (OPRK_HUMAN)
Kappa-type opioid receptor
OPRK1
Functioni
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
4 PublicationsGO - Molecular functioni
- dynorphin receptor activity Source: UniProtKB
- G protein-coupled opioid receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- receptor serine/threonine kinase binding Source: Ensembl
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtInc
- adenylate cyclase-inhibiting opioid receptor signaling pathway Source: UniProtKB
- behavioral response to cocaine Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- chemical synaptic transmission Source: ProtInc
- conditioned place preference Source: Ensembl
- defense response to virus Source: UniProtKB
- eating behavior Source: Ensembl
- estrous cycle Source: Ensembl
- G protein-coupled opioid receptor signaling pathway Source: UniProtKB
- immune response Source: UniProtKB
- locomotory behavior Source: UniProtKB
- maternal behavior Source: Ensembl
- negative regulation of luteinizing hormone secretion Source: Ensembl
- neuropeptide signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of dopamine secretion Source: Ensembl
- positive regulation of eating behavior Source: Ensembl
- positive regulation of locomotion Source: Ensembl
- positive regulation of p38MAPK cascade Source: Ensembl
- positive regulation of potassium ion transmembrane transport Source: Ensembl
- regulation of saliva secretion Source: UniProtKB
- regulation of sensory perception of pain Source: Ensembl
- response to acrylamide Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to insulin Source: Ensembl
- response to morphine Source: Ensembl
- response to radiation Source: Ensembl
- sensory perception Source: ProtInc
- sensory perception of pain Source: UniProtKB
- sensory perception of temperature stimulus Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Behavior |
Enzyme and pathway databases
PathwayCommonsi | P41145 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events R-HSA-9022699, MECP2 regulates neuronal receptors and channels |
SignaLinki | P41145 |
SIGNORi | P41145 |
Protein family/group databases
TCDBi | 9.A.14.13.32, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Kappa-type opioid receptorShort name: K-OR-1 Short name: KOR-1 |
Gene namesi | Name:OPRK1 Synonyms:OPRK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8154, OPRK1 |
MIMi | 165196, gene |
neXtProti | NX_P41145 |
VEuPathDBi | HostDB:ENSG00000082556 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- axon terminus Source: Ensembl
- dendrite Source: Ensembl
- integral component of membrane Source: UniProtKB
- integral component of synaptic vesicle membrane Source: Ensembl
- neuron projection Source: GO_Central
- perikaryon Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | ExtracellularAdd BLAST | 57 | |
Transmembranei | 58 – 85 | Helical; Name=1Add BLAST | 28 | |
Topological domaini | 86 – 95 | Cytoplasmic | 10 | |
Transmembranei | 96 – 119 | Helical; Name=2Add BLAST | 24 | |
Topological domaini | 120 – 132 | ExtracellularAdd BLAST | 13 | |
Transmembranei | 133 – 154 | Helical; Name=3Add BLAST | 22 | |
Topological domaini | 155 – 173 | CytoplasmicAdd BLAST | 19 | |
Transmembranei | 174 – 196 | Helical; Name=4Add BLAST | 23 | |
Topological domaini | 197 – 222 | ExtracellularAdd BLAST | 26 | |
Transmembranei | 223 – 247 | Helical; Name=5Add BLAST | 25 | |
Topological domaini | 248 – 274 | CytoplasmicAdd BLAST | 27 | |
Transmembranei | 275 – 296 | Helical; Name=6Add BLAST | 22 | |
Topological domaini | 297 – 311 | ExtracellularAdd BLAST | 15 | |
Transmembranei | 312 – 333 | Helical; Name=7Add BLAST | 22 | |
Topological domaini | 334 – 380 | CytoplasmicAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4986 |
OpenTargetsi | ENSG00000082556 |
PharmGKBi | PA31943 |
Miscellaneous databases
Pharosi | P41145, Tclin |
Chemistry databases
ChEMBLi | CHEMBL237 |
DrugBanki | DB01571, 3-Methylfentanyl DB01439, 3-Methylthiofentanyl DB05443, ADL 10-0101 DB06274, Alvimopan DB00321, Amitriptyline DB01238, Aripiprazole DB05104, Asimadoline DB00289, Atomoxetine DB00921, Buprenorphine DB00611, Butorphanol DB09173, Butyrfentanyl DB01535, Carfentanil DB00318, Codeine DB05155, CR665 DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB01209, Dezocine DB01452, Diamorphine DB01565, Dihydromorphine DB01548, Diprenorphine DB09272, Eluxadoline DB01497, Etorphine DB00813, Fentanyl DB00327, Hydromorphone DB01221, Ketamine DB06738, Ketobemidone DB00555, Lamotrigine DB00825, Levomenthol DB00854, Levorphanol DB00836, Loperamide DB14146, Loxicodegol DB00454, Meperidine DB06800, Methylnaltrexone DB06148, Mianserin DB00370, Mirtazapine DB00295, Morphine DB06409, Morphine glucuronide DB00844, Nalbuphine DB11691, Naldemedine DB06230, Nalmefene DB01183, Naloxone DB00704, Naltrexone DB11130, Opium DB00497, Oxycodone DB00652, Pentazocine DB11186, Pentoxyverine DB09209, Pholcodine DB00396, Progesterone DB00899, Remifentanil DB00708, Sufentanil DB06204, Tapentadol DB00193, Tramadol DB05046, V1003 |
DrugCentrali | P41145 |
GuidetoPHARMACOLOGYi | 318 |
Genetic variation databases
BioMutai | OPRK1 |
DMDMi | 116242691 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069967 | 1 – 380 | Kappa-type opioid receptorAdd BLAST | 380 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 39 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 131 ↔ 210 | PROSITE-ProRule annotation1 Publication | ||
Lipidationi | 345 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P41145 |
PeptideAtlasi | P41145 |
PRIDEi | P41145 |
ProteomicsDBi | 15940 55403 [P41145-1] |
PTM databases
GlyGeni | P41145, 2 sites |
iPTMneti | P41145 |
PhosphoSitePlusi | P41145 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000082556, Expressed in chorionic villus and 87 other tissues |
ExpressionAtlasi | P41145, baseline and differential |
Genevisiblei | P41145, HS |
Organism-specific databases
HPAi | ENSG00000082556, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with SLC9A3R1.
Interacts with GABARAPL1.
3 PublicationsBinary interactionsi
P41145
With | #Exp. | IntAct |
---|---|---|
APLNR [P35414] | 3 | EBI-925028,EBI-2875891 |
GABARAPL1 [Q9H0R8] | 5 | EBI-925028,EBI-746969 |
NKG7 [Q16617] | 3 | EBI-925028,EBI-3919611 |
GO - Molecular functioni
- receptor serine/threonine kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111031, 11 interactors |
IntActi | P41145, 11 interactors |
MINTi | P41145 |
STRINGi | 9606.ENSP00000265572 |
Chemistry databases
BindingDBi | P41145 |
Miscellaneous databases
RNActi | P41145, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P41145 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000157341 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P41145 |
OMAi | FPFKMRM |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P41145 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000452, Kappa_opi_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00532, KAPPAOPIOIDR PR00384, OPIOIDR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE
60 70 80 90 100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK
210 220 230 240 250
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG
310 320 330 340 350
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM
360 370 380
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZI09 | A0A5F9ZI09_HUMAN | Kappa-type opioid receptor | OPRK1 | 409 | Annotation score: | ||
E5RJI5 | E5RJI5_HUMAN | Kappa-type opioid receptor | OPRK1 | 116 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | D → E in AAA20985 (PubMed:8060324).Curated | 1 | |
Sequence conflicti | 2 | D → E in AAM21070 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028067 | 374 | D → N. Corresponds to variant dbSNP:rs9282808EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055313 | 1 – 89 | Missing in isoform 2. 1 PublicationAdd BLAST | 89 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11053 mRNA Translation: AAA20985.1 U17298 mRNA Translation: AAC50158.1 L37362 mRNA Translation: AAA63906.1 AF498922 mRNA Translation: AAM21070.1 AK310233 mRNA No translation available. AC009646 Genomic DNA No translation available. BC099912 mRNA Translation: AAH99912.1 L36130 mRNA Translation: AAA63646.1 U16860 Genomic DNA Translation: AAA56758.1 |
CCDSi | CCDS6152.1 [P41145-1] CCDS64895.1 [P41145-2] |
PIRi | JC2338 |
RefSeqi | NP_000903.2, NM_000912.4 [P41145-1] NP_001269833.1, NM_001282904.1 [P41145-2] NP_001305426.1, NM_001318497.1 |
Genome annotation databases
Ensembli | ENST00000265572; ENSP00000265572; ENSG00000082556 ENST00000520287; ENSP00000429706; ENSG00000082556 ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2] |
GeneIDi | 4986 |
KEGGi | hsa:4986 |
MANE-Selecti | ENST00000265572.8; ENSP00000265572.3; NM_000912.5; NP_000903.2 |
UCSCi | uc003xrh.2, human [P41145-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Kappa opioid receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11053 mRNA Translation: AAA20985.1 U17298 mRNA Translation: AAC50158.1 L37362 mRNA Translation: AAA63906.1 AF498922 mRNA Translation: AAM21070.1 AK310233 mRNA No translation available. AC009646 Genomic DNA No translation available. BC099912 mRNA Translation: AAH99912.1 L36130 mRNA Translation: AAA63646.1 U16860 Genomic DNA Translation: AAA56758.1 |
CCDSi | CCDS6152.1 [P41145-1] CCDS64895.1 [P41145-2] |
PIRi | JC2338 |
RefSeqi | NP_000903.2, NM_000912.4 [P41145-1] NP_001269833.1, NM_001282904.1 [P41145-2] NP_001305426.1, NM_001318497.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DJH | X-ray | 2.90 | A/B | 43-358 | [»] | |
6B73 | X-ray | 3.10 | A/B | 54-358 | [»] | |
6VI4 | X-ray | 3.30 | A/B | 54-358 | [»] | |
SMRi | P41145 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111031, 11 interactors |
IntActi | P41145, 11 interactors |
MINTi | P41145 |
STRINGi | 9606.ENSP00000265572 |
Chemistry databases
BindingDBi | P41145 |
ChEMBLi | CHEMBL237 |
DrugBanki | DB01571, 3-Methylfentanyl DB01439, 3-Methylthiofentanyl DB05443, ADL 10-0101 DB06274, Alvimopan DB00321, Amitriptyline DB01238, Aripiprazole DB05104, Asimadoline DB00289, Atomoxetine DB00921, Buprenorphine DB00611, Butorphanol DB09173, Butyrfentanyl DB01535, Carfentanil DB00318, Codeine DB05155, CR665 DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB01209, Dezocine DB01452, Diamorphine DB01565, Dihydromorphine DB01548, Diprenorphine DB09272, Eluxadoline DB01497, Etorphine DB00813, Fentanyl DB00327, Hydromorphone DB01221, Ketamine DB06738, Ketobemidone DB00555, Lamotrigine DB00825, Levomenthol DB00854, Levorphanol DB00836, Loperamide DB14146, Loxicodegol DB00454, Meperidine DB06800, Methylnaltrexone DB06148, Mianserin DB00370, Mirtazapine DB00295, Morphine DB06409, Morphine glucuronide DB00844, Nalbuphine DB11691, Naldemedine DB06230, Nalmefene DB01183, Naloxone DB00704, Naltrexone DB11130, Opium DB00497, Oxycodone DB00652, Pentazocine DB11186, Pentoxyverine DB09209, Pholcodine DB00396, Progesterone DB00899, Remifentanil DB00708, Sufentanil DB06204, Tapentadol DB00193, Tramadol DB05046, V1003 |
DrugCentrali | P41145 |
GuidetoPHARMACOLOGYi | 318 |
Protein family/group databases
TCDBi | 9.A.14.13.32, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P41145, 2 sites |
iPTMneti | P41145 |
PhosphoSitePlusi | P41145 |
Genetic variation databases
BioMutai | OPRK1 |
DMDMi | 116242691 |
Proteomic databases
PaxDbi | P41145 |
PeptideAtlasi | P41145 |
PRIDEi | P41145 |
ProteomicsDBi | 15940 55403 [P41145-1] |
Protocols and materials databases
ABCDi | P41145, 1 sequenced antibody |
Antibodypediai | 11640, 399 antibodies from 38 providers |
DNASUi | 4986 |
Genome annotation databases
Ensembli | ENST00000265572; ENSP00000265572; ENSG00000082556 ENST00000520287; ENSP00000429706; ENSG00000082556 ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2] |
GeneIDi | 4986 |
KEGGi | hsa:4986 |
MANE-Selecti | ENST00000265572.8; ENSP00000265572.3; NM_000912.5; NP_000903.2 |
UCSCi | uc003xrh.2, human [P41145-1] |
Organism-specific databases
CTDi | 4986 |
DisGeNETi | 4986 |
GeneCardsi | OPRK1 |
HGNCi | HGNC:8154, OPRK1 |
HPAi | ENSG00000082556, Tissue enriched (brain) |
MIMi | 165196, gene |
neXtProti | NX_P41145 |
OpenTargetsi | ENSG00000082556 |
PharmGKBi | PA31943 |
VEuPathDBi | HostDB:ENSG00000082556 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000157341 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P41145 |
OMAi | FPFKMRM |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P41145 |
TreeFami | TF315737 |
Enzyme and pathway databases
PathwayCommonsi | P41145 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events R-HSA-9022699, MECP2 regulates neuronal receptors and channels |
SignaLinki | P41145 |
SIGNORi | P41145 |
Miscellaneous databases
BioGRID-ORCSi | 4986, 5 hits in 1037 CRISPR screens |
GeneWikii | %CE%9A-opioid_receptor |
GenomeRNAii | 4986 |
Pharosi | P41145, Tclin |
PROi | PR:P41145 |
RNActi | P41145, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000082556, Expressed in chorionic villus and 87 other tissues |
ExpressionAtlasi | P41145, baseline and differential |
Genevisiblei | P41145, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000452, Kappa_opi_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00532, KAPPAOPIOIDR PR00384, OPIOIDR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OPRK_HUMAN | |
Accessioni | P41145Primary (citable) accession number: P41145 Secondary accession number(s): E5RHC9, Q499G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families