OPRK1

Functionⁱ

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

GO - Molecular functionⁱ

dynorphin receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8755601
neuropeptide binding Source: GO_Central
opioid receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22437504
receptor serine/threonine kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7624359
adenylate cyclase-inhibiting opioid receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 22437504
behavioral response to cocaine Source: Ensembl
cellular response to glucose stimulus Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 7624359
conditioned place preference Source: Ensembl
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 8755601
eating behavior Source: Ensembl
estrous cycle Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
immune response
Source: UniProtKB
Inferred from direct assayⁱ
- 8755601
locomotory behavior Source: UniProtKB
maternal behavior Source: Ensembl
negative regulation of luteinizing hormone secretion Source: Ensembl
neuropeptide signaling pathway Source: GO_Central
opioid receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 8755601
phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
positive regulation of dopamine secretion Source: Ensembl
positive regulation of eating behavior Source: Ensembl
positive regulation of locomotion Source: Ensembl
positive regulation of p38MAPK cascade Source: Ensembl
positive regulation of potassium ion transmembrane transport Source: Ensembl
regulation of saliva secretion Source: UniProtKB
regulation of sensory perception of pain Source: Ensembl
response to acrylamide Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to insulin Source: Ensembl
response to morphine Source: Ensembl
response to radiation Source: Ensembl
sensory perception
Source: ProtInc
Traceable author statementⁱ
- 7624359
sensory perception of pain Source: UniProtKB
sensory perception of temperature stimulus Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Behavior

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P41145
SIGNORⁱ	P41145

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kappa-type opioid receptor Short name: K-OR-1 Short name: KOR-1
Gene namesⁱ	Name:OPRK1 Synonyms:OPRK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000082556.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8154 OPRK1
MIMⁱ	165196 gene
neXtProtⁱ	NX_P41145

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 57	ExtracellularAdd BLAST	57
Transmembraneⁱ	58 – 85	Helical; Name=1Add BLAST	28
Topological domainⁱ	86 – 95	Cytoplasmic	10
Transmembraneⁱ	96 – 119	Helical; Name=2Add BLAST	24
Topological domainⁱ	120 – 132	ExtracellularAdd BLAST	13
Transmembraneⁱ	133 – 154	Helical; Name=3Add BLAST	22
Topological domainⁱ	155 – 173	CytoplasmicAdd BLAST	19
Transmembraneⁱ	174 – 196	Helical; Name=4Add BLAST	23
Topological domainⁱ	197 – 222	ExtracellularAdd BLAST	26
Transmembraneⁱ	223 – 247	Helical; Name=5Add BLAST	25
Topological domainⁱ	248 – 274	CytoplasmicAdd BLAST	27
Transmembraneⁱ	275 – 296	Helical; Name=6Add BLAST	22
Topological domainⁱ	297 – 311	ExtracellularAdd BLAST	15
Transmembraneⁱ	312 – 333	Helical; Name=7Add BLAST	22
Topological domainⁱ	334 – 380	CytoplasmicAdd BLAST	47

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4986
Open Targets More...OpenTargetsⁱ	ENSG00000082556
PharmGKBⁱ	PA31943

Chemistry databases

ChEMBLⁱ	CHEMBL237
Drug and drug target database More...DrugBankⁱ	DB01571 3-Methylfentanyl DB01439 3-Methylthiofentanyl DB05443 ADL 10-0101 DB06274 Alvimopan DB00321 Amitriptyline DB05104 Asimadoline DB00921 Buprenorphine DB00611 Butorphanol DB01535 Carfentanil DB00318 Codeine DB05155 CR665 DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB01209 Dezocine DB01565 Dihydromorphine DB01548 Diprenorphine DB09272 Eluxadoline DB01497 Etorphine DB00813 Fentanyl DB01452 Heroin DB00327 Hydromorphone DB01221 Ketamine DB06738 Ketobemidone DB00854 Levorphanol DB00836 Loperamide DB00825 Menthol DB06800 Methylnaltrexone DB06148 Mianserin DB00370 Mirtazapine DB00295 Morphine DB00844 Nalbuphine DB01183 Naloxone DB00704 Naltrexone DB00497 Oxycodone DB00652 Pentazocine DB00454 Pethidine DB00396 Progesterone DB09396 Propoxyphene napsylate DB00899 Remifentanil DB00708 Sufentanil DB06204 Tapentadol DB00193 Tramadol DB05046 V1003
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	318

Polymorphism and mutation databases

BioMutaⁱ	OPRK1
DMDMⁱ	116242691

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069967	1 – 380	Kappa-type opioid receptorAdd BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	25	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	131 ↔ 210	PROSITE-ProRule annotation1 Publication
Lipidationⁱ	345	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P41145
PeptideAtlas More...PeptideAtlasⁱ	P41145
PRIDEⁱ	P41145
ProteomicsDBⁱ	55403

PTM databases

iPTMnetⁱ	P41145
PhosphoSitePlusⁱ	P41145

Expressionⁱ

Tissue specificityⁱ

Detected in brain and placenta.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000082556
CleanExⁱ	HS_OPRK1
ExpressionAtlasⁱ	P41145 baseline and differential
Genevisibleⁱ	P41145 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022595 HPA067549

HPAⁱ

CAB022595
HPA067549

Interactionⁱ

Subunit structureⁱ

Interacts with SLC9A3R1. Interacts with GABARAPL1.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GABARAPL1	Q9H0R8	5	EBI-925028,EBI-746969

With

Entry

#Exp.

IntAct

Notes

GABARAPL1

Q9H0R8

5

EBI-925028,EBI-746969

GO - Molecular functionⁱ

receptor serine/threonine kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111031, 10 interactors
IntActⁱ	P41145, 11 interactors
Molecular INTeraction database More...MINTⁱ	P41145
STRINGⁱ	9606.ENSP00000265572

Chemistry databases

BindingDBⁱ

P41145

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	57 – 86	Combined sources	30
Helixⁱ	88 – 90	Combined sources	3
Helixⁱ	93 – 109	Combined sources	17
Helixⁱ	112 – 121	Combined sources	10
Helixⁱ	127 – 159	Combined sources	33
Turnⁱ	163 – 166	Combined sources	4
Beta strandⁱ	167 – 169	Combined sources	3
Helixⁱ	170 – 196	Combined sources	27
Beta strandⁱ	197 – 201	Combined sources	5
Beta strandⁱ	203 – 206	Combined sources	4
Beta strandⁱ	208 – 212	Combined sources	5
Beta strandⁱ	215 – 217	Combined sources	3
Helixⁱ	219 – 233	Combined sources	15
Helixⁱ	236 – 259	Combined sources	24
Helixⁱ	267 – 299	Combined sources	33
Helixⁱ	309 – 333	Combined sources	25
Helixⁱ	335 – 345	Combined sources	11

3D structure databases

ProteinModelPortalⁱ	P41145
SMRⁱ	P41145
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118797
HOGENOMⁱ	HOG000230486
HOVERGENⁱ	HBG106919
InParanoidⁱ	P41145
KEGG Orthology (KO) More...KOⁱ	K04214
OMAⁱ	VRNTVQD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HEN
PhylomeDBⁱ	P41145
TreeFamⁱ	TF315737

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15091 7tmA_Kappa_opioid_R, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000452 Kappa_opi_rcpt IPR001418 Opioid_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00532 KAPPAOPIOIDR PR00384 OPIOIDR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P41145-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE 
        60         70         80         90        100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN 
       110        120        130        140        150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT 
       160        170        180        190        200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK 
       210        220        230        240        250
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI 
       260        270        280        290        300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG 
       310        320        330        340        350
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM 
       360        370        380
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV

Length:380

Mass (Da):42,645

Last modified:October 17, 2006 - v2

Checksum:ⁱ3DA6E9F90FB48825

GO

Isoform 2 (identifier: P41145-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-89: Missing.

« Hide

        10         20         30         40         50
MKTATNIYIF NLALADALVT TTMPFQSTVY LMNSWPFGDV LCKIVISIDY 
        60         70         80         90        100
YNMFTSIFTL TMMSVDRYIA VCHPVKALDF RTPLKAKIIN ICIWLLSSSV 
       110        120        130        140        150
GISAIVLGGT KVREDVDVIE CSLQFPDDDY SWWDLFMKIC VFIFAFVIPV 
       160        170        180        190        200
LIIIVCYTLM ILRLKSVRLL SGSREKDRNL RRITRLVLVV VAVFVVCWTP 
       210        220        230        240        250
IHIFILVEAL GSTSHSTAAL SSYYFCIALG YTNSSLNPIL YAFLDENFKR 
       260        270        280        290 
CFRDFCFPLK MRMERQSTSR VRNTVQDPAY LRDIDGMNKP V

Note: No experimental confirmation available.

Show »

Length:291

Mass (Da):33,319

Checksum:ⁱ86448C346FF7E35A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2	D → E in AAA20985 (PubMed:8060324).Curated		1
Sequence conflictⁱ	2	D → E in AAM21070 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_028067	374	D → N. Corresponds to variant dbSNP:rs9282808Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055313	1 – 89	Missing in isoform 2. 1 PublicationAdd BLAST		89

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U11053 mRNA Translation: AAA20985.1 U17298 mRNA Translation: AAC50158.1 L37362 mRNA Translation: AAA63906.1 AF498922 mRNA Translation: AAM21070.1 AK310233 mRNA No translation available. AC009646 Genomic DNA No translation available. BC099912 mRNA Translation: AAH99912.1 L36130 mRNA Translation: AAA63646.1 U16860 Genomic DNA Translation: AAA56758.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6152.1 [P41145-1] CCDS64895.1 [P41145-2]
PIRⁱ	JC2338
NCBI Reference Sequences More...RefSeqⁱ	NP_000903.2, NM_000912.4 [P41145-1] NP_001269833.1, NM_001282904.1 [P41145-2] NP_001305426.1, NM_001318497.1
UniGeneⁱ	Hs.106795

Genome annotation databases

Ensemblⁱ	ENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1] ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1] ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2] ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]
GeneIDⁱ	4986
KEGGⁱ	hsa:4986
UCSC genome browser More...UCSCⁱ	uc003xrh.2 human [P41145-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P41145	UPI00073FAEA1		HUMAN		409
P41145-2				291

Protein	Similar proteins		Species	Score	Length
P41145	UPI00073FAEA1		HUMAN		409
Uncharacterized protein		MACMU		381
Uncharacterized protein		MACFA		381
Kappa-type opioid receptor		MOUSE		380
Kappa-type opioid receptor		RAT		380
+16

Protein	Similar proteins		Species	Score	Length
P41145	UPI0004BD788C		EQUPR		453
UPI000B4FEA55		NEOSC		419
UPI0005BE8900		PTEVA		415
UPI0007868521		ROUAE		415
UPI0004ED3F53		NANGA		407
+547

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Kappa opioid receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U11053 mRNA Translation: AAA20985.1 U17298 mRNA Translation: AAC50158.1 L37362 mRNA Translation: AAA63906.1 AF498922 mRNA Translation: AAM21070.1 AK310233 mRNA No translation available. AC009646 Genomic DNA No translation available. BC099912 mRNA Translation: AAH99912.1 L36130 mRNA Translation: AAA63646.1 U16860 Genomic DNA Translation: AAA56758.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6152.1 [P41145-1] CCDS64895.1 [P41145-2]
PIRⁱ	JC2338
NCBI Reference Sequences More...RefSeqⁱ	NP_000903.2, NM_000912.4 [P41145-1] NP_001269833.1, NM_001282904.1 [P41145-2] NP_001305426.1, NM_001318497.1
UniGeneⁱ	Hs.106795

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2A0D	model	-	A	1-380	[»]
	2IQN	model	-	A	55-348	[»]
	4DJH	X-ray	2.90	A/B	43-358	[»]
	6B73	X-ray	3.10	A/B	54-358	[»]
ProteinModelPortalⁱ	P41145
SMRⁱ	P41145
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111031, 10 interactors
IntActⁱ	P41145, 11 interactors
Molecular INTeraction database More...MINTⁱ	P41145
STRINGⁱ	9606.ENSP00000265572

Chemistry databases

BindingDBⁱ	P41145
ChEMBLⁱ	CHEMBL237
Drug and drug target database More...DrugBankⁱ	DB01571 3-Methylfentanyl DB01439 3-Methylthiofentanyl DB05443 ADL 10-0101 DB06274 Alvimopan DB00321 Amitriptyline DB05104 Asimadoline DB00921 Buprenorphine DB00611 Butorphanol DB01535 Carfentanil DB00318 Codeine DB05155 CR665 DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB01209 Dezocine DB01565 Dihydromorphine DB01548 Diprenorphine DB09272 Eluxadoline DB01497 Etorphine DB00813 Fentanyl DB01452 Heroin DB00327 Hydromorphone DB01221 Ketamine DB06738 Ketobemidone DB00854 Levorphanol DB00836 Loperamide DB00825 Menthol DB06800 Methylnaltrexone DB06148 Mianserin DB00370 Mirtazapine DB00295 Morphine DB00844 Nalbuphine DB01183 Naloxone DB00704 Naltrexone DB00497 Oxycodone DB00652 Pentazocine DB00454 Pethidine DB00396 Progesterone DB09396 Propoxyphene napsylate DB00899 Remifentanil DB00708 Sufentanil DB06204 Tapentadol DB00193 Tramadol DB05046 V1003
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	318

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P41145
PhosphoSitePlusⁱ	P41145

Polymorphism and mutation databases

BioMutaⁱ	OPRK1
DMDMⁱ	116242691

Proteomic databases

PaxDbⁱ	P41145
PeptideAtlas More...PeptideAtlasⁱ	P41145
PRIDEⁱ	P41145
ProteomicsDBⁱ	55403

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4986
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1] ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1] ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2] ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]
GeneIDⁱ	4986
KEGGⁱ	hsa:4986
UCSC genome browser More...UCSCⁱ	uc003xrh.2 human [P41145-1]

Organism-specific databases

CTDⁱ	4986
DisGeNET More...DisGeNETⁱ	4986
EuPathDBⁱ	HostDB:ENSG00000082556.10
GeneCardsⁱ	OPRK1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8154 OPRK1
Human Protein Atlas More...HPAⁱ	CAB022595 HPA067549
MIMⁱ	165196 gene
neXtProtⁱ	NX_P41145
Open Targets More...OpenTargetsⁱ	ENSG00000082556
PharmGKBⁱ	PA31943
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118797
HOGENOMⁱ	HOG000230486
HOVERGENⁱ	HBG106919
InParanoidⁱ	P41145
KEGG Orthology (KO) More...KOⁱ	K04214
OMAⁱ	VRNTVQD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HEN
PhylomeDBⁱ	P41145
TreeFamⁱ	TF315737

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P41145
SIGNORⁱ	P41145

Miscellaneous databases

GeneWikiⁱ	%CE%9A-opioid_receptor
GenomeRNAiⁱ	4986
Protein Ontology More...PROⁱ	PR:P41145
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000082556
CleanExⁱ	HS_OPRK1
ExpressionAtlasⁱ	P41145 baseline and differential
Genevisibleⁱ	P41145 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15091 7tmA_Kappa_opioid_R, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000452 Kappa_opi_rcpt IPR001418 Opioid_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00532 KAPPAOPIOIDR PR00384 OPIOIDR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPRK_HUMAN
Accessionⁱ	P41145Primary (citable) accession number: P41145 Secondary accession number(s): E5RHC9, Q499G4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	October 17, 2006
	Last modified:	July 18, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P41145 (OPRK_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Kappa-type opioid receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ