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Protein

Kappa-type opioid receptor

Gene

OPRK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

GO - Molecular functioni

  • dynorphin receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: GO_Central
  • neuropeptide binding Source: GO_Central
  • opioid receptor activity Source: UniProtKB
  • receptor serine/threonine kinase binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP41145
SIGNORiP41145

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
Gene namesi
Name:OPRK1
Synonyms:OPRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000082556.10
HGNCiHGNC:8154 OPRK1
MIMi165196 gene
neXtProtiNX_P41145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularAdd BLAST57
Transmembranei58 – 85Helical; Name=1Add BLAST28
Topological domaini86 – 95Cytoplasmic10
Transmembranei96 – 119Helical; Name=2Add BLAST24
Topological domaini120 – 132ExtracellularAdd BLAST13
Transmembranei133 – 154Helical; Name=3Add BLAST22
Topological domaini155 – 173CytoplasmicAdd BLAST19
Transmembranei174 – 196Helical; Name=4Add BLAST23
Topological domaini197 – 222ExtracellularAdd BLAST26
Transmembranei223 – 247Helical; Name=5Add BLAST25
Topological domaini248 – 274CytoplasmicAdd BLAST27
Transmembranei275 – 296Helical; Name=6Add BLAST22
Topological domaini297 – 311ExtracellularAdd BLAST15
Transmembranei312 – 333Helical; Name=7Add BLAST22
Topological domaini334 – 380CytoplasmicAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4986
OpenTargetsiENSG00000082556
PharmGKBiPA31943

Chemistry databases

ChEMBLiCHEMBL237
DrugBankiDB01571 3-Methylfentanyl
DB01439 3-Methylthiofentanyl
DB05443 ADL 10-0101
DB06274 Alvimopan
DB00321 Amitriptyline
DB05104 Asimadoline
DB00921 Buprenorphine
DB00611 Butorphanol
DB01535 Carfentanil
DB00318 Codeine
DB05155 CR665
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01209 Dezocine
DB01565 Dihydromorphine
DB01548 Diprenorphine
DB09272 Eluxadoline
DB01497 Etorphine
DB00813 Fentanyl
DB01452 Heroin
DB00327 Hydromorphone
DB01221 Ketamine
DB06738 Ketobemidone
DB00854 Levorphanol
DB00836 Loperamide
DB00825 Menthol
DB06800 Methylnaltrexone
DB06148 Mianserin
DB00370 Mirtazapine
DB00295 Morphine
DB00844 Nalbuphine
DB01183 Naloxone
DB00704 Naltrexone
DB00497 Oxycodone
DB00652 Pentazocine
DB00454 Pethidine
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00899 Remifentanil
DB00708 Sufentanil
DB06204 Tapentadol
DB00193 Tramadol
DB05046 V1003
GuidetoPHARMACOLOGYi318

Polymorphism and mutation databases

BioMutaiOPRK1
DMDMi116242691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699671 – 380Kappa-type opioid receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi131 ↔ 210PROSITE-ProRule annotation1 Publication
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41145
PeptideAtlasiP41145
PRIDEiP41145
ProteomicsDBi55403

PTM databases

iPTMnetiP41145
PhosphoSitePlusiP41145

Expressioni

Tissue specificityi

Detected in brain and placenta.2 Publications

Gene expression databases

BgeeiENSG00000082556 Expressed in 76 organ(s), highest expression level in chorionic villus
CleanExiHS_OPRK1
ExpressionAtlasiP41145 baseline and differential
GenevisibleiP41145 HS

Organism-specific databases

HPAiCAB022595
HPA067549

Interactioni

Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPL1Q9H0R85EBI-925028,EBI-746969

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111031, 10 interactors
IntActiP41145, 10 interactors
MINTiP41145
STRINGi9606.ENSP00000265572

Chemistry databases

BindingDBiP41145

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP41145
SMRiP41145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP41145
KOiK04214
OMAiPFQSTEY
OrthoDBiEOG091G0HEN
PhylomeDBiP41145
TreeFamiTF315737

Family and domain databases

CDDicd15091 7tmA_Kappa_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000452 Kappa_opi_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00532 KAPPAOPIOIDR
PR00384 OPIOIDR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE
60 70 80 90 100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK
210 220 230 240 250
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG
310 320 330 340 350
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM
360 370 380
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV
Length:380
Mass (Da):42,645
Last modified:October 17, 2006 - v2
Checksum:i3DA6E9F90FB48825
GO
Isoform 2 (identifier: P41145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):33,319
Checksum:i86448C346FF7E35A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU84A0A087WU84_HUMAN
Kappa-type opioid receptor
OPRK1
366Annotation score:
E5RJI5E5RJI5_HUMAN
Kappa-type opioid receptor
OPRK1
116Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2D → E in AAA20985 (PubMed:8060324).Curated1
Sequence conflicti2D → E in AAM21070 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028067374D → N. Corresponds to variant dbSNP:rs9282808Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553131 – 89Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11053 mRNA Translation: AAA20985.1
U17298 mRNA Translation: AAC50158.1
L37362 mRNA Translation: AAA63906.1
AF498922 mRNA Translation: AAM21070.1
AK310233 mRNA No translation available.
AC009646 Genomic DNA No translation available.
BC099912 mRNA Translation: AAH99912.1
L36130 mRNA Translation: AAA63646.1
U16860 Genomic DNA Translation: AAA56758.1
CCDSiCCDS6152.1 [P41145-1]
CCDS64895.1 [P41145-2]
PIRiJC2338
RefSeqiNP_000903.2, NM_000912.4 [P41145-1]
NP_001269833.1, NM_001282904.1 [P41145-2]
NP_001305426.1, NM_001318497.1
UniGeneiHs.106795

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]
GeneIDi4986
KEGGihsa:4986
UCSCiuc003xrh.2 human [P41145-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Kappa opioid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11053 mRNA Translation: AAA20985.1
U17298 mRNA Translation: AAC50158.1
L37362 mRNA Translation: AAA63906.1
AF498922 mRNA Translation: AAM21070.1
AK310233 mRNA No translation available.
AC009646 Genomic DNA No translation available.
BC099912 mRNA Translation: AAH99912.1
L36130 mRNA Translation: AAA63646.1
U16860 Genomic DNA Translation: AAA56758.1
CCDSiCCDS6152.1 [P41145-1]
CCDS64895.1 [P41145-2]
PIRiJC2338
RefSeqiNP_000903.2, NM_000912.4 [P41145-1]
NP_001269833.1, NM_001282904.1 [P41145-2]
NP_001305426.1, NM_001318497.1
UniGeneiHs.106795

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
6B73X-ray3.10A/B54-358[»]
ProteinModelPortaliP41145
SMRiP41145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111031, 10 interactors
IntActiP41145, 10 interactors
MINTiP41145
STRINGi9606.ENSP00000265572

Chemistry databases

BindingDBiP41145
ChEMBLiCHEMBL237
DrugBankiDB01571 3-Methylfentanyl
DB01439 3-Methylthiofentanyl
DB05443 ADL 10-0101
DB06274 Alvimopan
DB00321 Amitriptyline
DB05104 Asimadoline
DB00921 Buprenorphine
DB00611 Butorphanol
DB01535 Carfentanil
DB00318 Codeine
DB05155 CR665
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01209 Dezocine
DB01565 Dihydromorphine
DB01548 Diprenorphine
DB09272 Eluxadoline
DB01497 Etorphine
DB00813 Fentanyl
DB01452 Heroin
DB00327 Hydromorphone
DB01221 Ketamine
DB06738 Ketobemidone
DB00854 Levorphanol
DB00836 Loperamide
DB00825 Menthol
DB06800 Methylnaltrexone
DB06148 Mianserin
DB00370 Mirtazapine
DB00295 Morphine
DB00844 Nalbuphine
DB01183 Naloxone
DB00704 Naltrexone
DB00497 Oxycodone
DB00652 Pentazocine
DB00454 Pethidine
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00899 Remifentanil
DB00708 Sufentanil
DB06204 Tapentadol
DB00193 Tramadol
DB05046 V1003
GuidetoPHARMACOLOGYi318

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41145
PhosphoSitePlusiP41145

Polymorphism and mutation databases

BioMutaiOPRK1
DMDMi116242691

Proteomic databases

PaxDbiP41145
PeptideAtlasiP41145
PRIDEiP41145
ProteomicsDBi55403

Protocols and materials databases

DNASUi4986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]
GeneIDi4986
KEGGihsa:4986
UCSCiuc003xrh.2 human [P41145-1]

Organism-specific databases

CTDi4986
DisGeNETi4986
EuPathDBiHostDB:ENSG00000082556.10
GeneCardsiOPRK1
HGNCiHGNC:8154 OPRK1
HPAiCAB022595
HPA067549
MIMi165196 gene
neXtProtiNX_P41145
OpenTargetsiENSG00000082556
PharmGKBiPA31943
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP41145
KOiK04214
OMAiPFQSTEY
OrthoDBiEOG091G0HEN
PhylomeDBiP41145
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP41145
SIGNORiP41145

Miscellaneous databases

GeneWikii%CE%9A-opioid_receptor
GenomeRNAii4986
PROiPR:P41145
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082556 Expressed in 76 organ(s), highest expression level in chorionic villus
CleanExiHS_OPRK1
ExpressionAtlasiP41145 baseline and differential
GenevisibleiP41145 HS

Family and domain databases

CDDicd15091 7tmA_Kappa_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000452 Kappa_opi_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00532 KAPPAOPIOIDR
PR00384 OPIOIDR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPRK_HUMAN
AccessioniPrimary (citable) accession number: P41145
Secondary accession number(s): E5RHC9, Q499G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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