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UniProtKB - P41145 (OPRK_HUMAN)

Entry version 180 (13 Feb 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Kappa-type opioid receptor

Gene

OPRK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-9022699 MECP2 regulates neuronal receptors and channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P41145

SIGNOR Signaling Network Open Resource

More...SIGNORi		P41145

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OPRK1
Synonyms:OPRK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000082556.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:8154 OPRK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		165196 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P41145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57ExtracellularAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 85Helical; Name=1Add BLAST28
Topological domaini86 – 95Cytoplasmic10
Transmembranei96 – 119Helical; Name=2Add BLAST24
Topological domaini120 – 132ExtracellularAdd BLAST13
Transmembranei133 – 154Helical; Name=3Add BLAST22
Topological domaini155 – 173CytoplasmicAdd BLAST19
Transmembranei174 – 196Helical; Name=4Add BLAST23
Topological domaini197 – 222ExtracellularAdd BLAST26
Transmembranei223 – 247Helical; Name=5Add BLAST25
Topological domaini248 – 274CytoplasmicAdd BLAST27
Transmembranei275 – 296Helical; Name=6Add BLAST22
Topological domaini297 – 311ExtracellularAdd BLAST15
Transmembranei312 – 333Helical; Name=7Add BLAST22
Topological domaini334 – 380CytoplasmicAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4986

Open Targets

More...OpenTargetsi		ENSG00000082556

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31943

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL237

Drug and drug target database

More...DrugBanki		DB01571 3-Methylfentanyl
DB01439 3-Methylthiofentanyl
DB05443 ADL 10-0101
DB06274 Alvimopan
DB00321 Amitriptyline
DB05104 Asimadoline
DB00921 Buprenorphine
DB00611 Butorphanol
DB01535 Carfentanil
DB00318 Codeine
DB05155 CR665
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01209 Dezocine
DB01565 Dihydromorphine
DB01548 Diprenorphine
DB09272 Eluxadoline
DB01497 Etorphine
DB00813 Fentanyl
DB01452 Heroin
DB00327 Hydromorphone
DB01221 Ketamine
DB06738 Ketobemidone
DB00854 Levorphanol
DB00836 Loperamide
DB00825 Menthol
DB06800 Methylnaltrexone
DB06148 Mianserin
DB00370 Mirtazapine
DB00295 Morphine
DB00844 Nalbuphine
DB01183 Naloxone
DB00704 Naltrexone
DB00497 Oxycodone
DB00652 Pentazocine
DB00454 Pethidine
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00899 Remifentanil
DB00708 Sufentanil
DB06204 Tapentadol
DB00193 Tramadol
DB05046 V1003

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		318

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OPRK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242691

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000699671 – 380Kappa-type opioid receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131 ↔ 210PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P41145

PeptideAtlas

More...PeptideAtlasi		P41145

PRoteomics IDEntifications database

More...PRIDEi		P41145

ProteomicsDB human proteome resource

More...ProteomicsDBi		55403

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P41145

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P41145

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000082556 Expressed in 76 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P41145 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P41145 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB022595
HPA067549

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPL1Q9H0R85EBI-925028,EBI-746969

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111031, 10 interactors

Protein interaction database and analysis system

More...IntActi		P41145, 10 interactors

Molecular INTeraction database

More...MINTi		P41145

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265572

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P41145

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
6B73X-ray3.10A/B54-358[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P41145

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P41145

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000230486

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG106919

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P41145

KEGG Orthology (KO)

More...KOi		K04214

Identification of Orthologs from Complete Genome Data

More...OMAi		PFQSTEY

Database of Orthologous Groups

More...OrthoDBi		1107148at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P41145

TreeFam database of animal gene trees

More...TreeFami		TF315737

Family and domain databases

Conserved Domains Database

More...CDDi		cd15091 7tmA_Kappa_opioid_R, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000452 Kappa_opi_rcpt
IPR001418 Opioid_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237 GPCRRHODOPSN
PR00532 KAPPAOPIOIDR
PR00384 OPIOIDR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P41145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE 
        60         70         80         90        100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN 
       110        120        130        140        150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT 
       160        170        180        190        200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK 
       210        220        230        240        250
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI 
       260        270        280        290        300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG 
       310        320        330        340        350
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM 
       360        370        380
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV
Length:380
Mass (Da):42,645
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DA6E9F90FB48825
GO
Isoform 2 (identifier: P41145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):33,319
Checksum:i86448C346FF7E35A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU84A0A087WU84_HUMAN
Kappa-type opioid receptor
OPRK1
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJI5E5RJI5_HUMAN
Kappa-type opioid receptor
OPRK1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2D → E in AAA20985 (PubMed:8060324).Curated1
Sequence conflicti2D → E in AAM21070 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028067374D → N. Corresponds to variant dbSNP:rs9282808Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553131 – 89Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U11053 mRNA Translation: AAA20985.1
U17298 mRNA Translation: AAC50158.1
L37362 mRNA Translation: AAA63906.1
AF498922 mRNA Translation: AAM21070.1
AK310233 mRNA No translation available.
AC009646 Genomic DNA No translation available.
BC099912 mRNA Translation: AAH99912.1
L36130 mRNA Translation: AAA63646.1
U16860 Genomic DNA Translation: AAA56758.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6152.1 [P41145-1]
CCDS64895.1 [P41145-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC2338

NCBI Reference Sequences

More...RefSeqi		NP_000903.2, NM_000912.4 [P41145-1]
NP_001269833.1, NM_001282904.1 [P41145-2]
NP_001305426.1, NM_001318497.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.106795

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4986

UCSC genome browser

More...UCSCi		uc003xrh.2 human [P41145-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Kappa opioid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11053 mRNA Translation: AAA20985.1
U17298 mRNA Translation: AAC50158.1
L37362 mRNA Translation: AAA63906.1
AF498922 mRNA Translation: AAM21070.1
AK310233 mRNA No translation available.
AC009646 Genomic DNA No translation available.
BC099912 mRNA Translation: AAH99912.1
L36130 mRNA Translation: AAA63646.1
U16860 Genomic DNA Translation: AAA56758.1
CCDSiCCDS6152.1 [P41145-1]
CCDS64895.1 [P41145-2]
PIRiJC2338
RefSeqiNP_000903.2, NM_000912.4 [P41145-1]
NP_001269833.1, NM_001282904.1 [P41145-2]
NP_001305426.1, NM_001318497.1
UniGeneiHs.106795

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
6B73X-ray3.10A/B54-358[»]
ProteinModelPortaliP41145
SMRiP41145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111031, 10 interactors
IntActiP41145, 10 interactors
MINTiP41145
STRINGi9606.ENSP00000265572

Chemistry databases

BindingDBiP41145
ChEMBLiCHEMBL237
DrugBankiDB01571 3-Methylfentanyl
DB01439 3-Methylthiofentanyl
DB05443 ADL 10-0101
DB06274 Alvimopan
DB00321 Amitriptyline
DB05104 Asimadoline
DB00921 Buprenorphine
DB00611 Butorphanol
DB01535 Carfentanil
DB00318 Codeine
DB05155 CR665
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01209 Dezocine
DB01565 Dihydromorphine
DB01548 Diprenorphine
DB09272 Eluxadoline
DB01497 Etorphine
DB00813 Fentanyl
DB01452 Heroin
DB00327 Hydromorphone
DB01221 Ketamine
DB06738 Ketobemidone
DB00854 Levorphanol
DB00836 Loperamide
DB00825 Menthol
DB06800 Methylnaltrexone
DB06148 Mianserin
DB00370 Mirtazapine
DB00295 Morphine
DB00844 Nalbuphine
DB01183 Naloxone
DB00704 Naltrexone
DB00497 Oxycodone
DB00652 Pentazocine
DB00454 Pethidine
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00899 Remifentanil
DB00708 Sufentanil
DB06204 Tapentadol
DB00193 Tramadol
DB05046 V1003
GuidetoPHARMACOLOGYi318

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP41145
PhosphoSitePlusiP41145

Polymorphism and mutation databases

BioMutaiOPRK1
DMDMi116242691

Proteomic databases

PaxDbiP41145
PeptideAtlasiP41145
PRIDEiP41145
ProteomicsDBi55403

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556 [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556 [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556 [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556 [P41145-2]
GeneIDi4986
KEGGihsa:4986
UCSCiuc003xrh.2 human [P41145-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4986
DisGeNETi4986
EuPathDBiHostDB:ENSG00000082556.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		OPRK1
HGNCiHGNC:8154 OPRK1
HPAiCAB022595
HPA067549
MIMi165196 gene
neXtProtiNX_P41145
OpenTargetsiENSG00000082556
PharmGKBiPA31943

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000157341
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP41145
KOiK04214
OMAiPFQSTEY
OrthoDBi1107148at2759
PhylomeDBiP41145
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-9022699 MECP2 regulates neuronal receptors and channels
SignaLinkiP41145
SIGNORiP41145

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		%CE%9A-opioid_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4986

Protein Ontology

More...PROi		PR:P41145

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000082556 Expressed in 76 organ(s), highest expression level in chorionic villus
ExpressionAtlasiP41145 baseline and differential
GenevisibleiP41145 HS

Family and domain databases

CDDicd15091 7tmA_Kappa_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000452 Kappa_opi_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00532 KAPPAOPIOIDR
PR00384 OPIOIDR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPRK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41145
Secondary accession number(s): E5RHC9, Q499G4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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