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Protein

Delta-type opioid receptor

Gene

OPRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.3 Publications

GO - Molecular functioni

  • enkephalin receptor activity Source: UniProtKB
  • neuropeptide binding Source: GO_Central
  • opioid receptor activity Source: UniProtKB
  • receptor serine/threonine kinase binding Source: Ensembl

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • adult locomotory behavior Source: Ensembl
  • cellular response to growth factor stimulus Source: Ensembl
  • cellular response to hypoxia Source: ParkinsonsUK-UCL
  • cellular response to toxic substance Source: ParkinsonsUK-UCL
  • chemical synaptic transmission Source: GO_Central
  • cytokine-mediated signaling pathway Source: Reactome
  • eating behavior Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • immune response Source: ProtInc
  • negative regulation of gene expression Source: ParkinsonsUK-UCL
  • negative regulation of protein oligomerization Source: ParkinsonsUK-UCL
  • neuropeptide signaling pathway Source: GO_Central
  • opioid receptor signaling pathway Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of CREB transcription factor activity Source: ParkinsonsUK-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of calcium ion transport Source: Ensembl
  • regulation of mitochondrial membrane potential Source: ParkinsonsUK-UCL
  • regulation of sensory perception of pain Source: Ensembl
  • sensory perception of pain Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-6785807 Interleukin-4 and 13 signaling
SignaLinkiP41143
SIGNORiP41143

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-type opioid receptor
Short name:
D-OR-1
Short name:
DOR-1
Gene namesi
Name:OPRD1
Synonyms:OPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116329.10
HGNCiHGNC:8153 OPRD1
MIMi165195 gene
neXtProtiNX_P41143

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularBy similarityAdd BLAST47
Transmembranei48 – 75Helical; Name=1By similarityAdd BLAST28
Topological domaini76 – 85CytoplasmicBy similarity10
Transmembranei86 – 110Helical; Name=2By similarityAdd BLAST25
Topological domaini111 – 122ExtracellularBy similarityAdd BLAST12
Transmembranei123 – 144Helical; Name=3By similarityAdd BLAST22
Topological domaini145 – 163CytoplasmicBy similarityAdd BLAST19
Transmembranei164 – 186Helical; Name=4By similarityAdd BLAST23
Topological domaini187 – 206ExtracellularBy similarityAdd BLAST20
Transmembranei207 – 238Helical; Name=5By similarityAdd BLAST32
Topological domaini239 – 261CytoplasmicBy similarityAdd BLAST23
Transmembranei262 – 284Helical; Name=6By similarityAdd BLAST23
Topological domaini285 – 299ExtracellularBy similarityAdd BLAST15
Transmembranei300 – 321Helical; Name=7By similarityAdd BLAST22
Topological domaini322 – 372CytoplasmicBy similarityAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4985
OpenTargetsiENSG00000116329
PharmGKBiPA31942

Chemistry databases

ChEMBLiCHEMBL236
DrugBankiDB01571 3-Methylfentanyl
DB01439 3-Methylthiofentanyl
DB05050 ADL5859
DB06274 Alvimopan
DB00321 Amitriptyline
DB00921 Buprenorphine
DB00611 Butorphanol
DB01535 Carfentanil
DB00318 Codeine
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB01565 Dihydromorphine
DB01444 Dimethylthiambutene
DB01081 Diphenoxylate
DB01548 Diprenorphine
DB09272 Eluxadoline
DB01497 Etorphine
DB00813 Fentanyl
DB01452 Heroin
DB00956 Hydrocodone
DB00327 Hydromorphone
DB01221 Ketamine
DB06738 Ketobemidone
DB00854 Levorphanol
DB00836 Loperamide
DB00333 Methadone
DB00295 Morphine
DB00844 Nalbuphine
DB01183 Naloxone
DB00704 Naltrexone
DB00497 Oxycodone
DB01192 Oxymorphone
DB09396 Propoxyphene napsylate
DB00899 Remifentanil
DB00708 Sufentanil
DB06204 Tapentadol
DB00193 Tramadol
GuidetoPHARMACOLOGYi317

Polymorphism and mutation databases

BioMutaiOPRD1
DMDMi311033488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699621 – 372Delta-type opioid receptorAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi333S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PaxDbiP41143
PeptideAtlasiP41143
PRIDEiP41143
ProteomicsDBi55402

PTM databases

iPTMnetiP41143
PhosphoSitePlusiP41143

Expressioni

Tissue specificityi

Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.2 Publications

Gene expression databases

BgeeiENSG00000116329
CleanExiHS_OPRD1
ExpressionAtlasiP41143 baseline and differential
GenevisibleiP41143 HS

Organism-specific databases

HPAiHPA070831

Interactioni

Subunit structurei

May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111030, 17 interactors
ELMiP41143
IntActiP41143, 10 interactors
MINTiP41143
STRINGi9606.ENSP00000234961

Chemistry databases

BindingDBiP41143

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 76Combined sources37
Helixi78 – 80Combined sources3
Helixi83 – 100Combined sources18
Helixi102 – 111Combined sources10
Helixi118 – 151Combined sources34
Turni153 – 155Combined sources3
Helixi156 – 159Combined sources4
Helixi162 – 186Combined sources25
Beta strandi187 – 192Combined sources6
Beta strandi195 – 200Combined sources6
Beta strandi203 – 205Combined sources3
Helixi206 – 220Combined sources15
Helixi223 – 242Combined sources20
Beta strandi246 – 249Combined sources4
Helixi250 – 286Combined sources37
Helixi294 – 321Combined sources28
Helixi323 – 334Combined sources12

3D structure databases

ProteinModelPortaliP41143
SMRiP41143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP41143
KOiK04213
OMAiLCRAPCG
OrthoDBiEOG091G0HEN
PhylomeDBiP41143
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000321 Delta_opi_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00525 DELTAOPIOIDR
PR00237 GPCRRHODOPSN
PR00384 OPIOIDR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI
60 70 80 90 100
AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS
110 120 130 140 150
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV
160 170 180 190 200
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML
210 220 230 240 250
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK
260 270 280 290 300
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL
310 320 330 340 350
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE
360 370
ATARERVTAC TPSDGPGGGA AA
Length:372
Mass (Da):40,369
Last modified:November 2, 2010 - v4
Checksum:i9D483FC39BA2BAE4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208327C → F Improved maturation and increased expression at the cell surface. 4 PublicationsCorresponds to variant dbSNP:rs1042114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07882 mRNA Translation: AAA18789.2
U10504 mRNA Translation: AAA83426.1
EU883570 mRNA Translation: ACG60644.1
AL009181 Genomic DNA No translation available.
CCDSiCCDS329.1
PIRiI38532
RefSeqiNP_000902.3, NM_000911.3
UniGeneiHs.372

Genome annotation databases

EnsembliENST00000234961; ENSP00000234961; ENSG00000116329
GeneIDi4985
KEGGihsa:4985
UCSCiuc001brf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOPRD_HUMAN
AccessioniPrimary (citable) accession number: P41143
Secondary accession number(s): B5B0B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: July 18, 2018
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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