DNA-binding protein inhibitor ID-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• transcription regulator inhibitor activity Source: RGD
• transmembrane transporter binding Source: RGD

GO - Biological processⁱ

• adipose tissue development Source: RGD
• adult locomotory behavior Source: RGD
• bundle of His development Source: RGD
• cell development Source: RGD
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell maturation Source: RGD
• cell morphogenesis involved in neuron differentiation Source: RGD
• cellular response to follicle-stimulating hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP."
    Scobey M.J., Fix C.A., Walker W.H.
    J Biol Chem 279:16064-16070(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to lithium ion Source: RGD
• cellular senescence Source: UniProtKB
• circadian regulation of gene expression Source: UniProtKB
• circadian rhythm Source: RGD
• embryonic digestive tract morphogenesis Source: UniProtKB
• endodermal digestive tract morphogenesis Source: UniProtKB
• entrainment of circadian clock Source: RGD
• entrainment of circadian clock by photoperiod Source: UniProtKB
• enucleate erythrocyte differentiation Source: RGD
• epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
• heart development Source: RGD
• leukocyte differentiation Source: RGD
• locomotor rhythm Source: UniProtKB
• mammary gland alveolus development Source: UniProtKB
• mammary gland epithelial cell proliferation Source: UniProtKB
• membranous septum morphogenesis Source: RGD
• metanephros development Source: RGD
• natural killer cell differentiation Source: RGD
• negative regulation of B cell differentiation Source: RGD
• negative regulation of core promoter binding Source: RGD
• negative regulation of DNA binding Source: RGD
• negative regulation of DNA-binding transcription factor activity Source: RGD
• negative regulation of gene expression Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J Biol Chem 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of muscle cell differentiation Source: RGD
• negative regulation of neuron differentiation Source: RGD
• negative regulation of oligodendrocyte differentiation Source: RGD
• negative regulation of osteoblast differentiation Source: RGD
• negative regulation of transcription, DNA-templated Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J Biol Chem 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
  • "The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP."
    Scobey M.J., Fix C.A., Walker W.H.
    J Biol Chem 279:16064-16070(2004) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDInferred from expression patternⁱ
  • Ref.1

    "Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation."
    Nagata Y., Todokoro K.
    Biochem. Biophys. Res. Commun. 199:1355-1362(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• neuron fate commitment Source: UniProtKB
• olfactory bulb development Source: RGD
• oligodendrocyte development Source: RGD
• Peyer's patch development Source: RGD
• positive regulation of astrocyte differentiation Source: RGD
• positive regulation of blood pressure Source: UniProtKB
• positive regulation of cell cycle Source: RGDInferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J Biol Chem 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J Biol Chem 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGD
• positive regulation of fat cell differentiation Source: RGD
• positive regulation of gene expression Source: UniProtKB
• positive regulation of macrophage differentiation Source: RGD
• positive regulation of smooth muscle cell proliferation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: UniProtKB
• regulation of circadian rhythm Source: UniProtKB
• regulation of G1/S transition of mitotic cell cycle Source: RGD
• regulation of gene expression Source: UniProtKB
• regulation of lipid metabolic process Source: UniProtKB
• regulation of neural precursor cell proliferation Source: UniProtKB
• regulation of neuron differentiation Source: UniProtKB
• thigmotaxis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• transmembrane transporter binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV 
        60         70         80         90        100
PSIPQNKKVT KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQTSR 
       110        120        130 
TPLTTLNTDI SILSLQASEF PSELMSNDSK VLCG                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ