DNA-binding protein inhibitor ID-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2."
    Li X., Luo Y., Starremans P.G., McNamara C.A., Pei Y., Zhou J.
    Nat. Cell Biol. 7:1202-1212(2005) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro

GO - Biological processⁱ

• adipose tissue development Source: RGDInferred from sequence orthologyⁱ
  • "Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation."
    Park K.W., Waki H., Villanueva C.J., Monticelli L.A., Hong C., Kang S., MacDougald O.A., Goldrath A.W., Tontonoz P.
    Mol. Endocrinol. 22:2038-2048(2008) [PubMed] [Europe PMC] [Abstract]
• adult locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice."
    Havrda M.C., Paolella B.R., Ward N.M., Holroyd K.B.
    Dis Model Mech 6:819-827(2013) [PubMed] [Europe PMC] [Abstract]
• bundle of His development Source: RGDInferred from sequence orthologyⁱ
  • "A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development."
    Moskowitz I.P., Kim J.B., Moore M.L., Wolf C.M., Peterson M.A., Shendure J., Nobrega M.A., Yokota Y., Berul C., Izumo S., Seidman J.G., Seidman C.E.
    Cell 129:1365-1376(2007) [PubMed] [Europe PMC] [Abstract]
• cell development Source: RGDInferred from sequence orthologyⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J. Exp. Med. 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell maturation Source: RGDInferred from sequence orthologyⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J. Exp. Med. 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis involved in neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice."
    Havrda M.C., Paolella B.R., Ward N.M., Holroyd K.B.
    Dis Model Mech 6:819-827(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to follicle-stimulating hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP."
    Scobey M.J., Fix C.A., Walker W.H.
    J. Biol. Chem. 279:16064-16070(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to lithium ion Source: RGDInferred from sequence orthologyⁱ
  • "Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme."
    Rajagopal J., Carroll T.J., Guseh J.S., Bores S.A., Blank L.J., Anderson W.J., Yu J., Zhou Q., McMahon A.P., Melton D.A.
    Development 135:1625-1634(2008) [PubMed] [Europe PMC] [Abstract]
• cellular senescence Source: UniProtKB
• circadian regulation of gene expression Source: UniProtKB
• circadian rhythm Source: RGDInferred from sequence orthologyⁱ
  • "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]
  • "ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver."
    Hou T.Y., Ward S.M., Murad J.M., Watson N.P., Israel M.A., Duffield G.E.
    J. Biol. Chem. 284:31735-31745(2009) [PubMed] [Europe PMC] [Abstract]
• embryonic digestive tract morphogenesis Source: UniProtKB
• endodermal digestive tract morphogenesis Source: UniProtKB
• entrainment of circadian clock Source: RGDInferred from sequence orthologyⁱ
  • "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]
• entrainment of circadian clock by photoperiod Source: UniProtKB
• enucleate erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages."
    Iavarone A., King E.R., Dai X.M., Leone G., Stanley E.R., Lasorella A.
    Nature 432:1040-1045(2004) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
• heart development Source: RGDInferred from sequence orthologyⁱ
  • "Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells."
    Fraidenraich D., Stillwell E., Romero E., Wilkes D., Manova K., Basson C.T., Benezra R.
    Science 306:247-252(2004) [PubMed] [Europe PMC] [Abstract]
• leukocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice."
    Kusunoki T., Sugai M., Katakai T., Omatsu Y., Iyoda T., Inaba K., Nakahata T., Shimizu A., Yokota Y.
    J. Allergy Clin. Immunol. 111:136-142(2003) [PubMed] [Europe PMC] [Abstract]
• locomotor rhythm Source: UniProtKB
• mammary gland alveolus development Source: UniProtKB
• mammary gland epithelial cell proliferation Source: UniProtKB
• membranous septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development."
    Moskowitz I.P., Wang J., Peterson M.A., Pu W.T., Mackinnon A.C., Oxburgh L., Chu G.C., Sarkar M., Berul C., Smoot L., Robertson E.J., Schwartz R., Seidman J.G., Seidman C.E.
    Proc. Natl. Acad. Sci. U.S.A. 108:4006-4011(2011) [PubMed] [Europe PMC] [Abstract]
• metanephros development Source: RGDInferred from sequence orthologyⁱ
  • "Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans."
    Aoki Y., Mori S., Kitajima K., Yokoyama O., Kanamaru H., Okada K., Yokota Y.
    Genes Cells 9:1287-1296(2004) [PubMed] [Europe PMC] [Abstract]
• natural killer cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J. Exp. Med. 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of B cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins."
    Ji M., Li H., Suh H.C., Klarmann K.D., Yokota Y., Keller J.R.
    Blood 112:1068-1077(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins."
    Sun X.H., Copeland N.G., Jenkins N.A., Baltimore D.
    Mol. Cell. Biol. 11:5603-5611(1991) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1."
    Kim H.J., Kim J.Y., Park Y.Y., Choi H.S.
    Nucleic Acids Res. 31:6860-6872(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J. Biol. Chem. 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neural precursor cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev. Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev. Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
  • "Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis."
    Havrda M.C., Harris B.T., Mantani A., Ward N.M., Paolella B.R., Cuzon V.C., Yeh H.H., Israel M.A.
    J. Neurosci. 28:14074-14086(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of oligodendrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development."
    Wang S., Sdrulla A., Johnson J.E., Yokota Y., Barres B.A.
    Neuron 29:603-614(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice."
    Wu E.X., Tang H., Asai T., Yan S.D.
    Neurosci. Lett. 365:223-227(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1."
    Kim H.J., Kim J.Y., Park Y.Y., Choi H.S.
    Nucleic Acids Res. 31:6860-6872(2003) [PubMed] [Europe PMC] [Abstract]
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev. Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
  • "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]
  • "The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis."
    Espira L., Lamoureux L., Jones S.C., Gerard R.D., Dixon I.M., Czubryt M.P.
    J. Mol. Cell. Cardiol. 47:188-195(2009) [PubMed] [Europe PMC] [Abstract]
  • "The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."
    Ward S.M., Fernando S.J., Hou T.Y., Duffield G.E.
    J. Biol. Chem. 285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J. Biol. Chem. 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
  • "The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP."
    Scobey M.J., Fix C.A., Walker W.H.
    J. Biol. Chem. 279:16064-16070(2004) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDInferred from expression patternⁱ
  • Ref.1

    "Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation."
    Nagata Y., Todokoro K.
    Biochem. Biophys. Res. Commun. 199:1355-1362(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• neuron fate commitment Source: UniProtKB
• olfactory bulb development Source: RGDInferred from sequence orthologyⁱ
  • "Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis."
    Havrda M.C., Harris B.T., Mantani A., Ward N.M., Paolella B.R., Cuzon V.C., Yeh H.H., Israel M.A.
    J. Neurosci. 28:14074-14086(2008) [PubMed] [Europe PMC] [Abstract]
• oligodendrocyte development Source: RGDInferred from sequence orthologyⁱ
  • "A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development."
    Wang S., Sdrulla A., Johnson J.E., Yokota Y., Barres B.A.
    Neuron 29:603-614(2001) [PubMed] [Europe PMC] [Abstract]
• Peyer's patch development Source: RGDInferred from sequence orthologyⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J. Exp. Med. 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of astrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis."
    Havrda M.C., Harris B.T., Mantani A., Ward N.M., Paolella B.R., Cuzon V.C., Yeh H.H., Israel M.A.
    J. Neurosci. 28:14074-14086(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood pressure Source: UniProtKB
• positive regulation of cell cycle Source: RGDInferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J. Biol. Chem. 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle arrest Source: UniProtKB
• positive regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation."
    Matsumura M.E., Lobe D.R., McNamara C.A.
    J. Biol. Chem. 277:7293-7297(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins."
    Ji M., Li H., Suh H.C., Klarmann K.D., Yokota Y., Keller J.R.
    Blood 112:1068-1077(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation."
    Park K.W., Waki H., Villanueva C.J., Monticelli L.A., Hong C., Kang S., MacDougald O.A., Goldrath A.W., Tontonoz P.
    Mol. Endocrinol. 22:2038-2048(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: UniProtKB
• positive regulation of macrophage differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages."
    Iavarone A., King E.R., Dai X.M., Leone G., Stanley E.R., Lasorella A.
    Nature 432:1040-1045(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smooth muscle cell proliferation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: UniProtKB
• regulation of circadian rhythm Source: UniProtKB
• regulation of G1/S transition of mitotic cell cycle Source: RGDInferred from sequence orthologyⁱ
  • "Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2."
    Li X., Luo Y., Starremans P.G., McNamara C.A., Pei Y., Zhou J.
    Nat. Cell Biol. 7:1202-1212(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: UniProtKB
• regulation of lipid metabolic process Source: UniProtKB
• regulation of neural precursor cell proliferation Source: UniProtKB
• regulation of neuron differentiation Source: UniProtKB
• thigmotaxis Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice."
    Havrda M.C., Paolella B.R., Ward N.M., Holroyd K.B.
    Dis Model Mech 6:819-827(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2."
    Li X., Luo Y., Starremans P.G., McNamara C.A., Pei Y., Zhou J.
    Nat. Cell Biol. 7:1202-1212(2005) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV 
        60         70         80         90        100
PSIPQNKKVT KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQTSR 
       110        120        130 
TPLTTLNTDI SILSLQASEF PSELMSNDSK VLCG                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ