UniProtKB - P41137 (ID2_RAT)
DNA-binding protein inhibitor ID-2
Id2
Functioni
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- transcription regulator inhibitor activity Source: RGD
- transmembrane transporter binding Source: RGD
GO - Biological processi
- adipose tissue development Source: RGD
- adult locomotory behavior Source: RGD
- bundle of His development Source: RGD
- cell development Source: RGD
- cell differentiation Source: GO_Central
- cell maturation Source: RGD
- cell morphogenesis involved in neuron differentiation Source: RGD
- cellular response to follicle-stimulating hormone stimulus Source: RGD
- cellular response to lithium ion Source: RGD
- cellular senescence Source: UniProtKB
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: RGD
- embryonic digestive tract morphogenesis Source: UniProtKB
- endodermal digestive tract morphogenesis Source: UniProtKB
- entrainment of circadian clock Source: RGD
- entrainment of circadian clock by photoperiod Source: UniProtKB
- enucleate erythrocyte differentiation Source: RGD
- epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
- heart development Source: RGD
- leukocyte differentiation Source: RGD
- locomotor rhythm Source: UniProtKB
- mammary gland alveolus development Source: UniProtKB
- mammary gland epithelial cell proliferation Source: UniProtKB
- membranous septum morphogenesis Source: RGD
- metanephros development Source: RGD
- natural killer cell differentiation Source: RGD
- negative regulation of B cell differentiation Source: RGD
- negative regulation of core promoter binding Source: RGD
- negative regulation of DNA binding Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of muscle cell differentiation Source: RGD
- negative regulation of neuron differentiation Source: RGD
- negative regulation of oligodendrocyte differentiation Source: RGD
- negative regulation of osteoblast differentiation Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron differentiation Source: RGD
- neuron fate commitment Source: UniProtKB
- olfactory bulb development Source: RGD
- oligodendrocyte development Source: RGD
- Peyer's patch development Source: RGD
- positive regulation of astrocyte differentiation Source: RGD
- positive regulation of blood pressure Source: UniProtKB
- positive regulation of cell cycle Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of erythrocyte differentiation Source: RGD
- positive regulation of fat cell differentiation Source: RGD
- positive regulation of gene expression Source: UniProtKB
- positive regulation of macrophage differentiation Source: RGD
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of G1/S transition of mitotic cell cycle Source: RGD
- regulation of gene expression Source: UniProtKB
- regulation of lipid metabolic process Source: UniProtKB
- regulation of neural precursor cell proliferation Source: UniProtKB
- regulation of neuron differentiation Source: UniProtKB
- thigmotaxis Source: RGD
Keywordsi
Molecular function | Developmental protein, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein inhibitor ID-2Alternative name(s): Inhibitor of DNA binding 2 Inhibitor of differentiation 2 |
Gene namesi | Name:Id2 Synonyms:Id-2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2859, Id2 |
Subcellular locationi
Cytosol
- cytosol Source: RGD
Nucleus
- nucleus Source: MGI
Other locations
- chromatin Source: RGD
- cytoplasm Source: MGI
- euchromatin Source: RGD
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127244 | 1 – 134 | DNA-binding protein inhibitor ID-2Add BLAST | 134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P41137 |
PTM databases
iPTMneti | P41137 |
PhosphoSitePlusi | P41137 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000007237, Expressed in female gonad and 20 other tissues |
ExpressionAtlasi | P41137, baseline and differential |
Genevisiblei | P41137, RN |
Interactioni
Subunit structurei
Interacts with GATA4, IFI204, NR0B2 and NKX2-5.
Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Heterodimer with other HLH proteins.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- transmembrane transporter binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009491 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 75 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 106 – 115 | Nuclear export signalBy similarity | 10 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502RZP5, Eukaryota |
GeneTreei | ENSGT00940000156464 |
HOGENOMi | CLU_116790_2_1_1 |
InParanoidi | P41137 |
OMAi | SFRKNGA |
OrthoDBi | 1624054at2759 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV
60 70 80 90 100
PSIPQNKKVT KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQTSR
110 120 130
TPLTTLNTDI SILSLQASEF PSELMSNDSK VLCG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7TPI4 | Q7TPI4_RAT | Ac2-300 | Id2 | 376 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10863 mRNA Translation: BAA01634.1 BC086391 mRNA Translation: AAH86391.1 |
PIRi | JC2112 |
RefSeqi | NP_037192.1, NM_013060.3 |
Genome annotation databases
Ensembli | ENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237 |
GeneIDi | 25587 |
KEGGi | rno:25587 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10863 mRNA Translation: BAA01634.1 BC086391 mRNA Translation: AAH86391.1 |
PIRi | JC2112 |
RefSeqi | NP_037192.1, NM_013060.3 |
3D structure databases
AlphaFoldDBi | P41137 |
SMRi | P41137 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009491 |
PTM databases
iPTMneti | P41137 |
PhosphoSitePlusi | P41137 |
Proteomic databases
PaxDbi | P41137 |
Genome annotation databases
Ensembli | ENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237 |
GeneIDi | 25587 |
KEGGi | rno:25587 |
Organism-specific databases
CTDi | 3398 |
RGDi | 2859, Id2 |
Phylogenomic databases
eggNOGi | ENOG502RZP5, Eukaryota |
GeneTreei | ENSGT00940000156464 |
HOGENOMi | CLU_116790_2_1_1 |
InParanoidi | P41137 |
OMAi | SFRKNGA |
OrthoDBi | 1624054at2759 |
Miscellaneous databases
PROi | PR:P41137 |
Gene expression databases
Bgeei | ENSRNOG00000007237, Expressed in female gonad and 20 other tissues |
ExpressionAtlasi | P41137, baseline and differential |
Genevisiblei | P41137, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ID2_RAT | |
Accessioni | P41137Primary (citable) accession number: P41137 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |