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Protein

DNA-binding protein inhibitor ID-2

Gene

Id2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).By similarity

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription factor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-2
Alternative name(s):
Inhibitor of DNA binding 2
Inhibitor of differentiation 2
Gene namesi
Name:Id2
Synonyms:Id-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi2859 Id2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272441 – 134DNA-binding protein inhibitor ID-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated in vitro by CDK1, PKA and PKC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41137
PRIDEiP41137

PTM databases

iPTMnetiP41137
PhosphoSitePlusiP41137

Expressioni

Gene expression databases

BgeeiENSRNOG00000007237 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP41137 baseline and differential
GenevisibleiP41137 RN

Interactioni

Subunit structurei

Interacts with GATA4, IFI204, NR0B2 and NKX2-5. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Heterodimer with other HLH proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009491

Structurei

3D structure databases

ProteinModelPortaliP41137
SMRiP41137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 75bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 115Nuclear export signalBy similarity10

Domaini

The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.By similarity

Phylogenomic databases

eggNOGiENOG410IVXR Eukaryota
ENOG4111PGK LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP41137
KOiK17693
OMAiFPSEFMS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P41137-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV
60 70 80 90 100
PSIPQNKKVT KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQTSR
110 120 130
TPLTTLNTDI SILSLQASEF PSELMSNDSK VLCG
Length:134
Mass (Da):14,989
Last modified:February 1, 1995 - v1
Checksum:iA0D98D54EFDEB7B5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TPI4Q7TPI4_RAT
Ac2-300
Id2
376Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10863 mRNA Translation: BAA01634.1
BC086391 mRNA Translation: AAH86391.1
PIRiJC2112
RefSeqiNP_037192.1, NM_013060.3
UniGeneiRn.3272

Genome annotation databases

EnsembliENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237
GeneIDi25587
KEGGirno:25587

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10863 mRNA Translation: BAA01634.1
BC086391 mRNA Translation: AAH86391.1
PIRiJC2112
RefSeqiNP_037192.1, NM_013060.3
UniGeneiRn.3272

3D structure databases

ProteinModelPortaliP41137
SMRiP41137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009491

PTM databases

iPTMnetiP41137
PhosphoSitePlusiP41137

Proteomic databases

PaxDbiP41137
PRIDEiP41137

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237
GeneIDi25587
KEGGirno:25587

Organism-specific databases

CTDi3398
RGDi2859 Id2

Phylogenomic databases

eggNOGiENOG410IVXR Eukaryota
ENOG4111PGK LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP41137
KOiK17693
OMAiFPSEFMS

Miscellaneous databases

PROiPR:P41137

Gene expression databases

BgeeiENSRNOG00000007237 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP41137 baseline and differential
GenevisibleiP41137 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiID2_RAT
AccessioniPrimary (citable) accession number: P41137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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