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Protein

DNA-binding protein inhibitor ID-1

Gene

Id1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

GO - Molecular functioni

  • DNA binding transcription factor activity Source: Ensembl
  • proteasome binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein homodimerization activity Source: RGD
  • protein N-terminus binding Source: RGD
  • protein self-association Source: Ensembl
  • transcription factor binding Source: RGD

GO - Biological processi

  • BMP signaling pathway Source: Ensembl
  • brain development Source: RGD
  • cell-abiotic substrate adhesion Source: RGD
  • cellular response to dopamine Source: RGD
  • cellular response to epidermal growth factor stimulus Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to peptide Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • circadian rhythm Source: Ensembl
  • collagen metabolic process Source: Ensembl
  • endothelial cell morphogenesis Source: Ensembl
  • heart development Source: Ensembl
  • lung morphogenesis Source: Ensembl
  • lung vasculature development Source: Ensembl
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of dendrite morphogenesis Source: RGD
  • negative regulation of DNA binding transcription factor activity Source: Ensembl
  • negative regulation of endothelial cell differentiation Source: RGD
  • negative regulation of osteoblast differentiation Source: Ensembl
  • negative regulation of protein binding Source: RGD
  • negative regulation of protein homodimerization activity Source: Ensembl
  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: RGD
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of actin filament bundle assembly Source: RGD
  • positive regulation of epithelial cell proliferation Source: RGD
  • positive regulation of gene expression Source: RGD
  • protein destabilization Source: Ensembl
  • regulation of angiogenesis Source: Ensembl
  • regulation of MAPK cascade Source: Ensembl
  • regulation of vasculature development Source: RGD
  • response to antibiotic Source: Ensembl
  • response to organic cyclic compound Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-2559585 Oncogene Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-1
Alternative name(s):
Inhibitor of DNA binding 1
Inhibitor of differentiation 1
Gene namesi
Name:Id1
Synonyms:Id-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2858 Id1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272381 – 164DNA-binding protein inhibitor ID-1Add BLAST164

Post-translational modificationi

Phosphorylated in vitro by PKA and PKC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41135
PRIDEiP41135

Expressioni

Gene expression databases

BgeeiENSRNOG00000021750
ExpressionAtlasiP41135 baseline and differential
GenevisibleiP41135 RN

Interactioni

Subunit structurei

Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4, NKX2-5, CLOCK and ARNTL/BMAL1 (By similarity). Isoform Short can form homodimers.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • protein homodimerization activity Source: RGD
  • protein N-terminus binding Source: RGD
  • protein self-association Source: Ensembl
  • transcription factor binding Source: RGD

Protein-protein interaction databases

BioGridi247301, 2 interactors
IntActiP41135, 2 interactors
STRINGi10116.ENSRNOP00000052261

Structurei

3D structure databases

ProteinModelPortaliP41135
SMRiP41135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 98bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 104Nuclear export signalBy similarityAdd BLAST14

Phylogenomic databases

eggNOGiENOG410IWDR Eukaryota
ENOG4111VAY LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP41135
KOiK04680
OMAiYIWDLEL
OrthoDBiEOG091G0VHR
PhylomeDBiP41135
TreeFamiTF326217

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P41135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL
60 70 80 90 100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL
110 120 130 140 150
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILLWET
160
KATGGGCPPY FSGA
Length:164
Mass (Da):17,397
Last modified:February 1, 1995 - v1
Checksum:iC782DDF4C4892D6D
GO
Isoform Short (identifier: P41135-2) [UniParc]FASTAAdd to basket
Also known as: ID1.25

The sequence of this isoform differs from the canonical sequence as follows:
     136-164: VRSESEYYIILLWETKATGGGCPPYFSGA → AACVPADDRILCR

Show »
Length:148
Mass (Da):15,604
Checksum:i98D2128DB8A69EE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113G → A in BAA01633 (PubMed:7908517).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002110136 – 164VRSES…YFSGA → AACVPADDRILCR in isoform Short. CuratedAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23148 mRNA Translation: AAA20403.1
D10862 mRNA Translation: BAA01633.1
M86708 mRNA Translation: AAA41090.1
PIRiA53334
JC2111
RefSeqiNP_036929.2, NM_012797.2 [P41135-2]
UniGeneiRn.2113

Genome annotation databases

EnsembliENSRNOT00000029660; ENSRNOP00000052261; ENSRNOG00000021750 [P41135-2]
GeneIDi25261
KEGGirno:25261
UCSCiRGD:2858 rat [P41135-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiID1_RAT
AccessioniPrimary (citable) accession number: P41135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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