UniProtKB - P41135 (ID1_RAT)
DNA-binding protein inhibitor ID-1
Id1
Functioni
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
- proteasome binding Source: RGD
- protein C-terminus binding Source: RGD
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: RGD
- protein self-association Source: RGD
- transcription regulator inhibitor activity Source: RGD
GO - Biological processi
- BMP signaling pathway Source: RGD
- brain development Source: RGD
- cell-abiotic substrate adhesion Source: RGD
- cell differentiation Source: GO_Central
- cellular response to dopamine Source: RGD
- cellular response to epidermal growth factor stimulus Source: RGD
- cellular response to nerve growth factor stimulus Source: RGD
- cellular response to peptide Source: RGD
- cellular response to transforming growth factor beta stimulus Source: RGD
- circadian regulation of gene expression Source: GO_Central
- circadian rhythm Source: RGD
- collagen metabolic process Source: RGD
- endothelial cell morphogenesis Source: RGD
- heart development Source: RGD
- lung morphogenesis Source: RGD
- lung vasculature development Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of dendrite morphogenesis Source: RGD
- negative regulation of DNA binding Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of endothelial cell differentiation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of osteoblast differentiation Source: RGD
- negative regulation of protein binding Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron differentiation Source: RGD
- positive regulation of actin filament bundle assembly Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of gene expression Source: RGD
- protein destabilization Source: RGD
- regulation of angiogenesis Source: RGD
- regulation of MAPK cascade Source: RGD
- regulation of vasculature development Source: RGD
- response to antibiotic Source: RGD
- response to organic cyclic compound Source: RGD
Keywordsi
Molecular function | Developmental protein, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-RNO-2559585, Oncogene Induced Senescence |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein inhibitor ID-1Alternative name(s): Inhibitor of DNA binding 1 Inhibitor of differentiation 1 |
Gene namesi | Name:Id1 Synonyms:Id-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2858, Id1 |
Subcellular locationi
Cytoskeleton
- centrosome Source: RGD
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127238 | 1 – 164 | DNA-binding protein inhibitor ID-1Add BLAST | 164 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P41135 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000021750, Expressed in stomach and 21 other tissues |
ExpressionAtlasi | P41135, baseline and differential |
Genevisiblei | P41135, RN |
Interactioni
Subunit structurei
Heterodimer with other HLH proteins.
Interacts with COPS5, IFI204, GATA4, NKX2-5, CLOCK and ARNTL/BMAL1 (By similarity). Isoform Short can form homodimers.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
- protein C-terminus binding Source: RGD
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: RGD
- protein self-association Source: RGD
Protein-protein interaction databases
BioGRIDi | 247301, 2 interactors |
IntActi | P41135, 2 interactors |
STRINGi | 10116.ENSRNOP00000052261 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 98 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 91 – 104 | Nuclear export signalBy similarityAdd BLAST | 14 |
Phylogenomic databases
eggNOGi | ENOG502RZP5, Eukaryota |
GeneTreei | ENSGT00940000161109 |
HOGENOMi | CLU_116790_0_0_1 |
InParanoidi | P41135 |
OMAi | QMNVFLQ |
OrthoDBi | 1624054at2759 |
PhylomeDBi | P41135 |
TreeFami | TF326217 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL
60 70 80 90 100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL
110 120 130 140 150
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILLWET
160
KATGGGCPPY FSGA
The sequence of this isoform differs from the canonical sequence as follows:
136-164: VRSESEYYIILLWETKATGGGCPPYFSGA → AACVPADDRILCR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 113 | G → A in BAA01633 (PubMed:7908517).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002110 | 136 – 164 | VRSES…YFSGA → AACVPADDRILCR in isoform Short. CuratedAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23148 mRNA Translation: AAA20403.1 D10862 mRNA Translation: BAA01633.1 M86708 mRNA Translation: AAA41090.1 |
PIRi | A53334 JC2111 |
RefSeqi | NP_036929.2, NM_012797.2 [P41135-2] |
Genome annotation databases
GeneIDi | 25261 |
KEGGi | rno:25261 |
UCSCi | RGD:2858, rat [P41135-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23148 mRNA Translation: AAA20403.1 D10862 mRNA Translation: BAA01633.1 M86708 mRNA Translation: AAA41090.1 |
PIRi | A53334 JC2111 |
RefSeqi | NP_036929.2, NM_012797.2 [P41135-2] |
3D structure databases
AlphaFoldDBi | P41135 |
SMRi | P41135 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247301, 2 interactors |
IntActi | P41135, 2 interactors |
STRINGi | 10116.ENSRNOP00000052261 |
Proteomic databases
PaxDbi | P41135 |
Genome annotation databases
GeneIDi | 25261 |
KEGGi | rno:25261 |
UCSCi | RGD:2858, rat [P41135-1] |
Organism-specific databases
CTDi | 3397 |
RGDi | 2858, Id1 |
Phylogenomic databases
eggNOGi | ENOG502RZP5, Eukaryota |
GeneTreei | ENSGT00940000161109 |
HOGENOMi | CLU_116790_0_0_1 |
InParanoidi | P41135 |
OMAi | QMNVFLQ |
OrthoDBi | 1624054at2759 |
PhylomeDBi | P41135 |
TreeFami | TF326217 |
Enzyme and pathway databases
Reactomei | R-RNO-2559585, Oncogene Induced Senescence |
Miscellaneous databases
PROi | PR:P41135 |
Gene expression databases
Bgeei | ENSRNOG00000021750, Expressed in stomach and 21 other tissues |
ExpressionAtlasi | P41135, baseline and differential |
Genevisiblei | P41135, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ID1_RAT | |
Accessioni | P41135Primary (citable) accession number: P41135 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |