DNA-binding protein inhibitor ID-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.1

    "Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization."
    Springhorn J.P., Singh K., Kelly R.A., Smith T.W.
    J. Biol. Chem. 269:5132-5136(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• proteasome binding Source: RGDInferred from physical interactionⁱ
  • "The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain."
    Puram S.V., Kim A.H., Park H.Y., Anckar J., Bonni A.
    Cell Rep 4:19-30(2013) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization."
    Springhorn J.P., Singh K., Kelly R.A., Smith T.W.
    J. Biol. Chem. 269:5132-5136(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: RGDInferred from physical interactionⁱ
  • "The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain."
    Puram S.V., Kim A.H., Park H.Y., Anckar J., Bonni A.
    Cell Rep 4:19-30(2013) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: RGD
• transcription regulator inhibitor activity Source: RGD

GO - Biological processⁱ

• BMP signaling pathway Source: RGD
• brain development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Id1, Id2, and Id3 gene expression in neural cells during development."
    Tzeng S.F., de Vellis J.
    Glia 24:372-381(1998) [PubMed] [Europe PMC] [Abstract]
• cell-abiotic substrate adhesion Source: RGDInferred from expression patternⁱ
  • "Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells."
    Vincent K.J., Jones E., Arthur M.J., Smart D.E., Trim J., Wright M.C., Mann D.A.
    Gut 49:713-719(2001) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to dopamine Source: RGDInferred from expression patternⁱ
  • "Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress."
    Konishi H., Ogawa T., Nakagomi S., Inoue K., Tohyama M., Kiyama H.
    Neuroscience 169:1527-1534(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to epidermal growth factor stimulus Source: RGDInferred from expression patternⁱ
  • "Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells."
    Einarson M.B., Chao M.V.
    Mol Cell Biol 15:4175-4183(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to nerve growth factor stimulus Source: RGDInferred from expression patternⁱ
  • "Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells."
    Einarson M.B., Chao M.V.
    Mol Cell Biol 15:4175-4183(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to peptide Source: RGDInferred from expression patternⁱ
  • "Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors."
    Persson A.I., Bull C., Eriksson P.S.
    Eur J Neurosci 23:2277-2288(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: RGDInferred from expression patternⁱ
  • "Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells."
    Wiercinska E., Wickert L., Denecke B., Said H.M., Hamzavi J., Gressner A.M., Thorikay M., ten Dijke P., Mertens P.R., Breitkopf K., Dooley S.
    Hepatology 43:1032-1041(2006) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• circadian rhythm Source: RGD
• collagen metabolic process Source: RGD
• endothelial cell morphogenesis Source: RGD
• heart development Source: RGD
• lung morphogenesis Source: RGD
• lung vasculature development Source: RGD
• negative regulation of apoptotic process Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "TGF-beta repression of Id2 induces apoptosis in gut epithelial cells."
    Cao Y., Liu X., Zhang W., Deng X., Zhang H., Liu Y., Chen L., Thompson E.A., Townsend C.M. Jr., Ko T.C.
    Oncogene 28:1089-1098(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning."
    Patil M., Sharma B.K., Elattar S., Chang J., Kapil S., Yuan J., Satyanarayana A.
    Diabetes 66:1611-1625(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of dendrite morphogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons."
    Kim A.H., Puram S.V., Bilimoria P.M., Ikeuchi Y., Keough S., Wong M., Rowitch D., Bonni A.
    Cell 136:322-336(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells."
    Einarson M.B., Chao M.V.
    Mol Cell Biol 15:4175-4183(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: RGD
• negative regulation of endothelial cell differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury."
    Yu Y., Gao Y., Qin J., Kuang C.Y., Song M.B., Yu S.Y., Cui B., Chen J.F., Huang L.
    Basic Res Cardiol 105:713-724(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGD
• negative regulation of osteoblast differentiation Source: RGD
• negative regulation of protein binding Source: RGDInferred from mutant phenotypeⁱ
  • "The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain."
    Puram S.V., Kim A.H., Park H.Y., Anckar J., Bonni A.
    Cell Rep 4:19-30(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain."
    Puram S.V., Kim A.H., Park H.Y., Anckar J., Bonni A.
    Cell Rep 4:19-30(2013) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDInferred from expression patternⁱ
  • Ref.3

    "Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation."
    Nagata Y., Todokoro K.
    Biochem. Biophys. Res. Commun. 199:1355-1362(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of actin filament bundle assembly Source: RGDInferred from mutant phenotypeⁱ
  • "Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells."
    Wiercinska E., Wickert L., Denecke B., Said H.M., Hamzavi J., Gressner A.M., Thorikay M., ten Dijke P., Mertens P.R., Breitkopf K., Dooley S.
    Hepatology 43:1032-1041(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells."
    Chen J., Sun W., Zheng Y., Xiong H., Cai Y.
    J Neurosci Res 91:515-526(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells."
    Chen J., Sun W., Zheng Y., Xiong H., Cai Y.
    J Neurosci Res 91:515-526(2013) [PubMed] [Europe PMC] [Abstract]
• protein destabilization Source: RGD
• regulation of angiogenesis Source: RGD
• regulation of MAPK cascade Source: RGD
• regulation of vasculature development Source: RGDInferred from mutant phenotypeⁱ
  • "Regeneration of three layers vascular wall by using BMP2-treated MSC involving HIF-1alpha and Id1 expressions through JAK/STAT pathways."
    Belmokhtar K., Bourguignon T., Worou M.E., Khamis G., Bonnet P., Domenech J., Eder V.
    Stem Cell Rev Rep 7:847-859(2011) [PubMed] [Europe PMC] [Abstract]
• response to antibiotic Source: RGD
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress."
    Konishi H., Ogawa T., Nakagomi S., Inoue K., Tohyama M., Kiyama H.
    Neuroscience 169:1527-1534(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGDInferred from physical interactionⁱ
  • Ref.1

    "Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization."
    Springhorn J.P., Singh K., Kelly R.A., Smith T.W.
    J. Biol. Chem. 269:5132-5136(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• protein C-terminus binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization."
    Springhorn J.P., Singh K., Kelly R.A., Smith T.W.
    J. Biol. Chem. 269:5132-5136(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: RGDInferred from physical interactionⁱ
  • "The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain."
    Puram S.V., Kim A.H., Park H.Y., Anckar J., Bonni A.
    Cell Rep 4:19-30(2013) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140        150
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILLWET 
       160 
KATGGGCPPY FSGA                                        

        10         20         30         40         50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140 
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEAACVP ADDRILCR   

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ