Id1

Functionⁱ

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proteasome binding
Source: RGD
Inferred from physical interactionⁱ
- 23831032
protein C-terminus binding
Source: RGD
Inferred from direct assayⁱ
- 8106493
protein homodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 8106493
protein N-terminus binding
Source: RGD
Inferred from physical interactionⁱ
- 23831032
protein self-association Source: Ensembl
RNA polymerase II transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: RGD
Inferred from physical interactionⁱ
- 7623812
- 8106493

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway Source: Ensembl
brain development
Source: RGD
Inferred from expression patternⁱ
- 9814817
cell-abiotic substrate adhesion
Source: RGD
Inferred from expression patternⁱ
- 11600477
cellular response to dopamine
Source: RGD
Inferred from expression patternⁱ
- 20600660
cellular response to epidermal growth factor stimulus
Source: RGD
Inferred from expression patternⁱ
- 7623812
cellular response to nerve growth factor stimulus
Source: RGD
Inferred from expression patternⁱ
- 7623812
cellular response to peptide
Source: RGD
Inferred from expression patternⁱ
- 16706836
cellular response to transforming growth factor beta stimulus
Source: RGD
Inferred from expression patternⁱ
- 16628634
circadian rhythm
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
collagen metabolic process Source: Ensembl
endothelial cell morphogenesis Source: Ensembl
heart development Source: Ensembl
lung morphogenesis Source: Ensembl
lung vasculature development Source: Ensembl
negative regulation of apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 19137015
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 28270523
negative regulation of dendrite morphogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 19167333
negative regulation of DNA binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 7623812
negative regulation of DNA-binding transcription factor activity Source: Ensembl
negative regulation of endothelial cell differentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 20830586
negative regulation of neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of protein binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 23831032
negative regulation of protein homodimerization activity Source: Ensembl
negative regulation of transcription, DNA-templated Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 23831032
neuron differentiation
Source: RGD
Inferred from expression patternⁱ
- 7908517
positive regulation of actin filament bundle assembly
Source: RGD
Inferred from mutant phenotypeⁱ
- 16628634
positive regulation of epithelial cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 23335245
positive regulation of gene expression
Source: RGD
Inferred from mutant phenotypeⁱ
- 23335245
protein destabilization Source: Ensembl
regulation of angiogenesis Source: Ensembl
regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of MAPK cascade Source: Ensembl
regulation of vasculature development
Source: RGD
Inferred from mutant phenotypeⁱ
- 21472453
response to antibiotic Source: Ensembl
response to organic cyclic compound
Source: RGD
Inferred from expression patternⁱ
- 20600660
transcription, DNA-templated Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2559585 Oncogene Induced Senescence

Reactomeⁱ

R-RNO-2559585 Oncogene Induced Senescence

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-binding protein inhibitor ID-1 Alternative name(s): Inhibitor of DNA binding 1 Inhibitor of differentiation 1
Gene namesⁱ	Name:Id1 Synonyms:Id-1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	2858 Id1

RGDⁱ

2858 Id1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127238	1 – 164	DNA-binding protein inhibitor ID-1Add BLAST		164

Post-translational modificationⁱ

Phosphorylated in vitro by PKA and PKC.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P41135
PRIDEⁱ	P41135

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000021750 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P41135 baseline and differential
Genevisibleⁱ	P41135 RN

Interactionⁱ

Subunit structureⁱ

Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4, NKX2-5, CLOCK and ARNTL/BMAL1 (By similarity). Isoform Short can form homodimers.By similarity

GO - Molecular functionⁱ

protein C-terminus binding
Source: RGD
Inferred from direct assayⁱ
- 8106493
protein homodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 8106493
protein N-terminus binding
Source: RGD
Inferred from physical interactionⁱ
- 23831032
protein self-association Source: Ensembl
RNA polymerase II transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: RGD
Inferred from physical interactionⁱ
- 7623812
- 8106493

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247301, 2 interactors
IntActⁱ	P41135, 2 interactors
STRINGⁱ	10116.ENSRNOP00000052261

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P41135
SMRⁱ	P41135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 98	bHLHPROSITE-ProRule annotationAdd BLAST		53

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	91 – 104	Nuclear export signalBy similarityAdd BLAST		14

Phylogenomic databases

eggNOGⁱ	ENOG410IWDR Eukaryota ENOG4111VAY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000908
HOGENOMⁱ	HOG000234788
HOVERGENⁱ	HBG009009
InParanoidⁱ	P41135
KEGG Orthology (KO) More...KOⁱ	K04680
OMAⁱ	EQPVNVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VHR
PhylomeDBⁱ	P41135
TreeFamⁱ	TF326217

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR026052 DNA-bd_prot-inh IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR11723 PTHR11723, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

Isoform Long (identifier: P41135-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140        150
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILLWET 
       160 
KATGGGCPPY FSGA

Length:164

Mass (Da):17,397

Last modified:February 1, 1995 - v1

Checksum:ⁱC782DDF4C4892D6D

GO

Isoform Short (identifier: P41135-2) [UniParc]FASTA Add to basket

Also known as: ID1.25

The sequence of this isoform differs from the canonical sequence as follows:
136-164: VRSESEYYIILLWETKATGGGCPPYFSGA → AACVPADDRILCR

« Hide

        10         20         30         40         50
MKVASSSAAA TAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140 
ELNSESEVAT AGGRGLPVRA PLSTLNGEIS ALAAEAACVP ADDRILCR

Show »

Length:148

Mass (Da):15,604

Checksum:ⁱ98D2128DB8A69EE2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	113	G → A in BAA01633 (PubMed:7908517).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002110	136 – 164	VRSES…YFSGA → AACVPADDRILCR in isoform Short. CuratedAdd BLAST		29

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23148 mRNA Translation: AAA20403.1 D10862 mRNA Translation: BAA01633.1 M86708 mRNA Translation: AAA41090.1
PIRⁱ	A53334 JC2111
NCBI Reference Sequences More...RefSeqⁱ	NP_036929.2, NM_012797.2 [P41135-2]
UniGeneⁱ	Rn.2113

Genome annotation databases

Ensemblⁱ	ENSRNOT00000029660; ENSRNOP00000052261; ENSRNOG00000021750 [P41135-2]
GeneIDⁱ	25261
KEGGⁱ	rno:25261
UCSC genome browser More...UCSCⁱ	RGD:2858 rat [P41135-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P41135	DNA-binding protein inhibitor ID-1		MOUSE		168	UniRef90_P20067
DNA-binding protein inhibitor ID-1		MOUSE		168
UPI00001EE2C9		MOUSE		154
P41135-2	Isoform ID-B of DNA-binding protein inhibitor ID-1		HUMAN		149	UniRef90_P41134-2
ID1 isoform 2		PANTR		149
Uncharacterized protein		PAPAN		163
DNA-binding protein inhibitor ID-1 isoform a		MACMU		154
Uncharacterized protein		CERAT		154
+41

Protein	Similar proteins		Species	Score	Length	Source
P41135	DNA-binding protein inhibitor ID-1		MOUSE		168	UniRef50_P20067
DNA-binding protein inhibitor ID-1		HUMAN		155
Inhibitor of DNA binding 1		MACFA		154
Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein		PANTR		155
DNA-binding protein inhibitor ID-1 isoform a		CALJA		155
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23148 mRNA Translation: AAA20403.1 D10862 mRNA Translation: BAA01633.1 M86708 mRNA Translation: AAA41090.1
PIRⁱ	A53334 JC2111
RefSeqⁱ	NP_036929.2, NM_012797.2 [P41135-2]
UniGeneⁱ	Rn.2113

3D structure databases

ProteinModelPortalⁱ	P41135
SMRⁱ	P41135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247301, 2 interactors
IntActⁱ	P41135, 2 interactors
STRINGⁱ	10116.ENSRNOP00000052261

Proteomic databases

PaxDbⁱ	P41135
PRIDEⁱ	P41135

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000029660; ENSRNOP00000052261; ENSRNOG00000021750 [P41135-2]
GeneIDⁱ	25261
KEGGⁱ	rno:25261
UCSCⁱ	RGD:2858 rat [P41135-1]

Organism-specific databases

CTDⁱ	3397
RGDⁱ	2858 Id1

Phylogenomic databases

eggNOGⁱ	ENOG410IWDR Eukaryota ENOG4111VAY LUCA
GeneTreeⁱ	ENSGT00390000000908
HOGENOMⁱ	HOG000234788
HOVERGENⁱ	HBG009009
InParanoidⁱ	P41135
KOⁱ	K04680
OMAⁱ	EQPVNVL
OrthoDBⁱ	EOG091G0VHR
PhylomeDBⁱ	P41135
TreeFamⁱ	TF326217

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2559585 Oncogene Induced Senescence

Reactomeⁱ

R-RNO-2559585 Oncogene Induced Senescence

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P41135

PROⁱ

PR:P41135

Gene expression databases

Bgeeⁱ	ENSRNOG00000021750 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P41135 baseline and differential
Genevisibleⁱ	P41135 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR026052 DNA-bd_prot-inh IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR11723 PTHR11723, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ID1_RAT
Accessionⁱ	P41135Primary (citable) accession number: P41135
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P41135 (ID1_RAT)

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DNA-binding protein inhibitor ID-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Golgi apparatus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ