Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein inhibitor ID-1

Gene

ID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559585 Oncogene Induced Senescence

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P41134

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-1
Alternative name(s):
Class B basic helix-loop-helix protein 24
Short name:
bHLHb24
Inhibitor of DNA binding 1
Inhibitor of differentiation 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ID1
Synonyms:BHLHB24, ID
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125968.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5360 ID1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600349 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P41134

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3397

Open Targets

More...
OpenTargetsi
ENSG00000125968

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29608

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075116

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ID1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21264450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001272361 – 155DNA-binding protein inhibitor ID-1Add BLAST155

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P41134

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P41134

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P41134

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P41134

PeptideAtlas

More...
PeptideAtlasi
P41134

PRoteomics IDEntifications database

More...
PRIDEi
P41134

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55400
55401 [P41134-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P41134

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P41134

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression correlates with proliferation in some types of cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125968 Expressed in 219 organ(s), highest expression level in metanephric glomerulus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P41134 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025915
HPA051456
HPA058518

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109623, 42 interactors

Database of interacting proteins

More...
DIPi
DIP-38112N

Protein interaction database and analysis system

More...
IntActi
P41134, 33 interactors

Molecular INTeraction database

More...
MINTi
P41134

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365280

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P41134

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P41134

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 105bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi98 – 111Nuclear export signalBy similarityAdd BLAST14

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWDR Eukaryota
ENOG4111VAY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161109

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41134

KEGG Orthology (KO)

More...
KOi
K04680

Identification of Orthologs from Complete Genome Data

More...
OMAi
EQPVNVL

Database of Orthologous Groups

More...
OrthoDBi
1624054at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P41134

TreeFam database of animal gene trees

More...
TreeFami
TF326217

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11723 PTHR11723, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform ID-A (identifier: P41134-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG
60 70 80 90 100
ARLPALLDEQ QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID
110 120 130 140 150
YIRDLQLELN SESEVGTPGG RGLPVRAPLS TLNGEISALT AEAACVPADD

RILCR
Length:155
Mass (Da):16,133
Last modified:May 27, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i480287384B667161
GO
Isoform ID-B (identifier: P41134-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-155: AACVPADDRILCR → VRSRSDH

Show »
Length:149
Mass (Da):15,586
Checksum:iDA265F6900663BC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16S → T in BAA02988 (PubMed:8294468).Curated1
Sequence conflicti16S → T in BAA02989 (PubMed:8294468).Curated1
Sequence conflicti46A → R (PubMed:8086456).Curated1
Sequence conflicti46A → R (PubMed:8294468).Curated1
Sequence conflicti48Missing (PubMed:8086456).Curated1
Sequence conflicti48Missing (PubMed:8294468).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04954463N → D. Corresponds to variant dbSNP:rs1802548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002108143 – 155AACVP…RILCR → VRSRSDH in isoform ID-B. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77956 mRNA Translation: CAA54920.1
D13889 mRNA Translation: BAA02988.1
D13890 mRNA Translation: BAA02989.1
S78986 mRNA Translation: AAB35037.1
S78825 mRNA Translation: AAB35038.1
U57645 Genomic DNA Translation: AAC13882.1
U57645 Genomic DNA Translation: AAC13883.1
BT007443 mRNA Translation: AAP36111.1
AK291152 mRNA Translation: BAF83841.1
AL110115 Genomic DNA No translation available.
AL117381 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76432.1
CH471077 Genomic DNA Translation: EAW76434.1
BC000613 mRNA Translation: AAH00613.1
BC012420 mRNA Translation: AAH12420.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13185.1 [P41134-1]
CCDS13186.1 [P41134-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49727
B49727
JC5395
JC5396
S47524

NCBI Reference Sequences

More...
RefSeqi
NP_002156.2, NM_002165.3 [P41134-1]
NP_851998.1, NM_181353.2 [P41134-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.504609

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376105; ENSP00000365273; ENSG00000125968 [P41134-2]
ENST00000376112; ENSP00000365280; ENSG00000125968 [P41134-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3397

UCSC genome browser

More...
UCSCi
uc002wwg.3 human [P41134-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77956 mRNA Translation: CAA54920.1
D13889 mRNA Translation: BAA02988.1
D13890 mRNA Translation: BAA02989.1
S78986 mRNA Translation: AAB35037.1
S78825 mRNA Translation: AAB35038.1
U57645 Genomic DNA Translation: AAC13882.1
U57645 Genomic DNA Translation: AAC13883.1
BT007443 mRNA Translation: AAP36111.1
AK291152 mRNA Translation: BAF83841.1
AL110115 Genomic DNA No translation available.
AL117381 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76432.1
CH471077 Genomic DNA Translation: EAW76434.1
BC000613 mRNA Translation: AAH00613.1
BC012420 mRNA Translation: AAH12420.1
CCDSiCCDS13185.1 [P41134-1]
CCDS13186.1 [P41134-2]
PIRiA49727
B49727
JC5395
JC5396
S47524
RefSeqiNP_002156.2, NM_002165.3 [P41134-1]
NP_851998.1, NM_181353.2 [P41134-2]
UniGeneiHs.504609

3D structure databases

ProteinModelPortaliP41134
SMRiP41134
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109623, 42 interactors
DIPiDIP-38112N
IntActiP41134, 33 interactors
MINTiP41134
STRINGi9606.ENSP00000365280

Chemistry databases

ChEMBLiCHEMBL1075116

PTM databases

iPTMnetiP41134
PhosphoSitePlusiP41134

Polymorphism and mutation databases

BioMutaiID1
DMDMi21264450

Proteomic databases

EPDiP41134
jPOSTiP41134
MaxQBiP41134
PaxDbiP41134
PeptideAtlasiP41134
PRIDEiP41134
ProteomicsDBi55400
55401 [P41134-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376105; ENSP00000365273; ENSG00000125968 [P41134-2]
ENST00000376112; ENSP00000365280; ENSG00000125968 [P41134-1]
GeneIDi3397
KEGGihsa:3397
UCSCiuc002wwg.3 human [P41134-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3397
DisGeNETi3397
EuPathDBiHostDB:ENSG00000125968.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ID1
HGNCiHGNC:5360 ID1
HPAiCAB025915
HPA051456
HPA058518
MIMi600349 gene
neXtProtiNX_P41134
OpenTargetsiENSG00000125968
PharmGKBiPA29608

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWDR Eukaryota
ENOG4111VAY LUCA
GeneTreeiENSGT00940000161109
HOVERGENiHBG009009
InParanoidiP41134
KOiK04680
OMAiEQPVNVL
OrthoDBi1624054at2759
PhylomeDBiP41134
TreeFamiTF326217

Enzyme and pathway databases

ReactomeiR-HSA-2559585 Oncogene Induced Senescence
SIGNORiP41134

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ID1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3397

Protein Ontology

More...
PROi
PR:P41134

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125968 Expressed in 219 organ(s), highest expression level in metanephric glomerulus
GenevisibleiP41134 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiID1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41134
Secondary accession number(s): A8K537
, E1P5L4, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: January 16, 2019
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again