Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein inhibitor ID-1

Gene

ID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2559585 Oncogene Induced Senescence
SIGNORiP41134

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-1
Alternative name(s):
Class B basic helix-loop-helix protein 24
Short name:
bHLHb24
Inhibitor of DNA binding 1
Inhibitor of differentiation 1
Gene namesi
Name:ID1
Synonyms:BHLHB24, ID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125968.8
HGNCiHGNC:5360 ID1
MIMi600349 gene
neXtProtiNX_P41134

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3397
OpenTargetsiENSG00000125968
PharmGKBiPA29608

Chemistry databases

ChEMBLiCHEMBL1075116

Polymorphism and mutation databases

BioMutaiID1
DMDMi21264450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272361 – 155DNA-binding protein inhibitor ID-1Add BLAST155

Proteomic databases

EPDiP41134
MaxQBiP41134
PaxDbiP41134
PeptideAtlasiP41134
PRIDEiP41134
ProteomicsDBi55400
55401 [P41134-2]

PTM databases

iPTMnetiP41134
PhosphoSitePlusiP41134

Expressioni

Developmental stagei

Expression correlates with proliferation in some types of cells.

Gene expression databases

BgeeiENSG00000125968
GenevisibleiP41134 HS

Organism-specific databases

HPAiCAB025915
HPA051456
HPA058518

Interactioni

Subunit structurei

Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109623, 40 interactors
DIPiDIP-38112N
IntActiP41134, 32 interactors
MINTiP41134
STRINGi9606.ENSP00000365280

Structurei

3D structure databases

ProteinModelPortaliP41134
SMRiP41134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi98 – 111Nuclear export signalBy similarityAdd BLAST14

Phylogenomic databases

eggNOGiENOG410IWDR Eukaryota
ENOG4111VAY LUCA
GeneTreeiENSGT00390000000908
HOVERGENiHBG009009
InParanoidiP41134
KOiK04680
OMAiYIWDLEL
OrthoDBiEOG091G0VHR
PhylomeDBiP41134
TreeFamiTF326217

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform ID-A (identifier: P41134-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG
60 70 80 90 100
ARLPALLDEQ QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID
110 120 130 140 150
YIRDLQLELN SESEVGTPGG RGLPVRAPLS TLNGEISALT AEAACVPADD

RILCR
Length:155
Mass (Da):16,133
Last modified:May 27, 2002 - v3
Checksum:i480287384B667161
GO
Isoform ID-B (identifier: P41134-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-155: AACVPADDRILCR → VRSRSDH

Show »
Length:149
Mass (Da):15,586
Checksum:iDA265F6900663BC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16S → T in BAA02988 (PubMed:8294468).Curated1
Sequence conflicti16S → T in BAA02989 (PubMed:8294468).Curated1
Sequence conflicti46A → R (PubMed:8086456).Curated1
Sequence conflicti46A → R (PubMed:8294468).Curated1
Sequence conflicti48Missing (PubMed:8086456).Curated1
Sequence conflicti48Missing (PubMed:8294468).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04954463N → D. Corresponds to variant dbSNP:rs1802548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002108143 – 155AACVP…RILCR → VRSRSDH in isoform ID-B. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77956 mRNA Translation: CAA54920.1
D13889 mRNA Translation: BAA02988.1
D13890 mRNA Translation: BAA02989.1
S78986 mRNA Translation: AAB35037.1
S78825 mRNA Translation: AAB35038.1
U57645 Genomic DNA Translation: AAC13882.1
U57645 Genomic DNA Translation: AAC13883.1
BT007443 mRNA Translation: AAP36111.1
AK291152 mRNA Translation: BAF83841.1
AL110115 Genomic DNA No translation available.
AL117381 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76432.1
CH471077 Genomic DNA Translation: EAW76434.1
BC000613 mRNA Translation: AAH00613.1
BC012420 mRNA Translation: AAH12420.1
CCDSiCCDS13185.1 [P41134-1]
CCDS13186.1 [P41134-2]
PIRiA49727
B49727
JC5395
JC5396
S47524
RefSeqiNP_002156.2, NM_002165.3 [P41134-1]
NP_851998.1, NM_181353.2 [P41134-2]
UniGeneiHs.504609

Genome annotation databases

EnsembliENST00000376105; ENSP00000365273; ENSG00000125968 [P41134-2]
ENST00000376112; ENSP00000365280; ENSG00000125968 [P41134-1]
GeneIDi3397
KEGGihsa:3397
UCSCiuc002wwg.3 human [P41134-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiID1_HUMAN
AccessioniPrimary (citable) accession number: P41134
Secondary accession number(s): A8K537
, E1P5L4, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health