DNA-binding protein inhibitor ID-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein."
    Loveys D.A., Streiff M.B., Kato G.J.
    Nucleic Acids Res 24:2813-2820(1996) [PubMed] [Europe PMC] [Abstract]
• leptomycin B binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues."
    Kurooka H., Sugai M., Mori K., Yokota Y.
    Biochem Biophys Res Commun 433:579-585(2013) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein domain specific binding Source: MGIInferred from direct assayⁱ
  • Ref.1

    "An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene."
    Christy B.A., Sanders L.K., Lau L.F., Copeland N.G., Jenkins N.A., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 88:1815-1819(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• transcription regulator inhibitor activity Source: UniProtKBInferred from direct assayⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to leptomycin B Source: MGIInferred from direct assayⁱ
  • "The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues."
    Kurooka H., Sugai M., Mori K., Yokota Y.
    Biochem Biophys Res Commun 433:579-585(2013) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of the helix-loop-helix gene Id3 during murine embryonic development."
    Ellmeier W., Weith A.
    Dev Dyn 203:163-173(1995) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• circadian rhythm Source: UniProtKBInferred from expression patternⁱ
  • Ref.5

    "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION.
• epithelial cell differentiation Source: MGIInferred from direct assayⁱ
  • "Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti."
    Jones J.M., Montcouquiol M., Dabdoub A., Woods C., Kelley M.W.
    J Neurosci 26:550-558(2006) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells."
    Fraidenraich D., Stillwell E., Romero E., Wilkes D., Manova K., Basson C.T., Benezra R.
    Science 306:247-252(2004) [PubMed] [Europe PMC] [Abstract]
• metanephros development Source: UniProtKBInferred from expression patternⁱ
  • "Expression of the helix-loop-helix gene Id3 during murine embryonic development."
    Ellmeier W., Weith A.
    Dev Dyn 203:163-173(1995) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: UniProtKB-KW
• negative regulation of DNA-binding transcription factor activity Source: MGI
• negative regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues."
    Kurooka H., Sugai M., Mori K., Yokota Y.
    Biochem Biophys Res Commun 433:579-585(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of myoblast differentiation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.7

    "Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction."
    Mohamed J.S., Lopez M.A., Cox G.A., Boriek A.M.
    J. Biol. Chem. 288:24560-24568(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN MYOBLAST DIFFERENTIATION, INTERACTION WITH ANKRD2, TISSUE SPECIFICITY.
• negative regulation of osteoblast differentiation Source: MGIInferred from genetic interactionⁱ
  • "Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells."
    Peng Y., Kang Q., Luo Q., Jiang W., Si W., Liu B.A., Luu H.H., Park J.K., Li X., Luo J., Montag A.G., Haydon R.C., He T.C.
    J Biol Chem 279:32941-32949(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION.
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • Ref.1

    "An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene."
    Christy B.A., Sanders L.K., Lau L.F., Copeland N.G., Jenkins N.A., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 88:1815-1819(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• neuron differentiation Source: Ensembl
• notochord development Source: UniProtKBInferred from expression patternⁱ
  • "Expression of the helix-loop-helix gene Id3 during murine embryonic development."
    Ellmeier W., Weith A.
    Dev Dyn 203:163-173(1995) [PubMed] [Europe PMC] [Abstract]
• odontogenesis Source: UniProtKBInferred from expression patternⁱ
  • "Expression of the helix-loop-helix gene Id3 during murine embryonic development."
    Ellmeier W., Weith A.
    Dev Dyn 203:163-173(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGI
• positive regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: MGI
• regulation of DNA replication Source: MGI
• response to wounding Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein."
    Loveys D.A., Streiff M.B., Kato G.J.
    Nucleic Acids Res 24:2813-2820(1996) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein domain specific binding Source: MGIInferred from direct assayⁱ
  • Ref.1

    "An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene."
    Christy B.A., Sanders L.K., Lau L.F., Copeland N.G., Jenkins N.A., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 88:1815-1819(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKALSPVRGC YEAVCCLSER SLAIARGRGK SPSTEEPLSL LDDMNHCYSR 
        60         70         80         90        100
LRELVPGVPR GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ 
       110 
TAELTPELVI SKDKRSFCH                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot