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Protein

Translation initiation factor eIF-2B subunit delta

Gene

EIF2B4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:EIF2B4
Synonyms:EIF2BD
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001560692 – 523Translation initiation factor eIF-2B subunit deltaAdd BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei129PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP41111

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022102

Structurei

3D structure databases

ProteinModelPortaliP41111
SMRiP41111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1467 Eukaryota
COG1184 LUCA
HOGENOMiHOG000176924
HOVERGENiHBG051459
InParanoidiP41111
KOiK03680

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVAVAVRE DSGSGMKAEL SARPGAGGKE MTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGTDVDT ASAVSAAQCP GPAREAPGPG SQSSTPGEKV PAGRTKAELR
110 120 130 140 150
AERRAKQEAE RALKQARKGE QGGPPPQASP STAGEAPAGG KRLTEHTQAD
160 170 180 190 200
DPTLLRRLVR KSERQQVPTR KDYGSKVSLF SHLPQYSRQN SLTQYMSIPS
210 220 230 240 250
SVIHPAMVRL GLQYSQGLIS GSNARCIALL RALQQVIQDY TTPPNEELSR
260 270 280 290 300
DLVNKLKPYI CFLTQCRPLS ASMYNAIKFL NKEITGVSST KREEEAKAEL
310 320 330 340 350
QAAADRYVQE KIVLAAQAIL RFASKKISNG DVILVYGCSS LVSRILQEAW
360 370 380 390 400
SEGRKFRVVV VDSRPRLEGR HMLRFLVRAG VPASYLLIPA ASYVLPEVSK
410 420 430 440 450
VLLGAHALLA NGSVMSRVGT AQLALVARAH NVPVLVCCET YKFCERVQTD
460 470 480 490 500
AFVSNELDDP DDLQCERGDH VALANWQSHP SLRLLNLVYD VTPPELVDLV
510 520
ITELGMIPCS SVPVVLRVKS SDQ
Length:523
Mass (Da):57,121
Last modified:November 1, 1997 - v2
Checksum:i057895B1E9D25558
GO

Sequence cautioni

The sequence CAA53204 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75451 mRNA Translation: CAA53204.1 Different initiation.
PIRiS42727
RefSeqiNP_001076241.1, NM_001082772.1
UniGeneiOcu.2101

Genome annotation databases

GeneIDi100009560
KEGGiocu:100009560

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75451 mRNA Translation: CAA53204.1 Different initiation.
PIRiS42727
RefSeqiNP_001076241.1, NM_001082772.1
UniGeneiOcu.2101

3D structure databases

ProteinModelPortaliP41111
SMRiP41111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022102

Proteomic databases

PRIDEiP41111

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009560
KEGGiocu:100009560

Organism-specific databases

CTDi8890

Phylogenomic databases

eggNOGiKOG1467 Eukaryota
COG1184 LUCA
HOGENOMiHOG000176924
HOVERGENiHBG051459
InParanoidiP41111
KOiK03680

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BD_RABIT
AccessioniPrimary (citable) accession number: P41111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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