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Entry version 121 (17 Jun 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

EIF4G1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
Alternative name(s):
p220
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G1
Synonyms:EIF4G
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133231 – 1402Eukaryotic translation initiation factor 4 gamma 1Add BLAST1402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphothreonineBy similarity1
Modified residuei27PhosphothreonineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei452PhosphothreonineBy similarity1
Modified residuei490Omega-N-methylarginineBy similarity1
Modified residuei499Omega-N-methylarginineBy similarity1
Modified residuei832PhosphoserineBy similarity1
Modified residuei836Omega-N-methylarginineBy similarity1
Modified residuei846Omega-N-methylarginineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei896PhosphoserineBy similarity1
Modified residuei899N6-acetyllysineBy similarity1
Modified residuei948PhosphoserineBy similarity1
Modified residuei950PhosphoserineBy similarity1
Modified residuei988Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei990PhosphoserineBy similarity1
Modified residuei997PhosphoserineBy similarity1
Modified residuei1012PhosphoserineBy similarity1
Modified residuei1014PhosphothreonineBy similarity1
Modified residuei1034PhosphoserineBy similarity1
Modified residuei1041PhosphoserineBy similarity1
Modified residuei1399PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-988 by PRKCA induces binding to MKNK1.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P41110

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3.

Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1.

Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E.

Interacts with EIF4E3.

Interacts with CIRBP and MIF4GD.

Interacts with RBM4.

Interacts with HNRNPD/AUF1; the interaction requires RNA (By similarity). Directly interacts with EIF4G1 in an RNA-independent manner (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000005299

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P41110

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 793MIF4GPROSITE-ProRule annotationAdd BLAST227
Domaini1044 – 1166MIPROSITE-ProRule annotationAdd BLAST123
Domaini1231 – 1401W2PROSITE-ProRule annotationAdd BLAST171

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 192Poly-Pro5
Compositional biasi262 – 275Poly-GluAdd BLAST14
Compositional biasi1393 – 1398Poly-Glu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P41110

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF10 PTHR23253:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P41110-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGARTVSTP TPPQTGGGVE PQANGETPQV AVIVRSDDRS QGAIIGGRPG
60 70 80 90 100
LPGPEHSPSE SQPSSPSPTP SPPPILEPGS EPNLAVLSLP GDTMTSGMIQ
110 120 130 140 150
MPVEEPAPIS REAGEPYCLS PEPTPLAEPI LEVEVTLSKP VPVSEFSSSP
160 170 180 190 200
IQVLTPLASH KMEIHEPNGV VPSEDLEPEV ESSPELAPPP PPACLSESPV
210 220 230 240 250
PIAPTTQPEE LLNGAPSPPA VDLSPVCEPE DQAKEDTASA TPPAVPSATP
260 270 280 290 300
ATAPPATSPA QEEEGEEEEE EEEGEAGAAE SDKGGEDLHP TESTPVPGHL
310 320 330 340 350
PQNVEAVAAT QVAVSVPKRR RKIKELNKKE AVGDLLDAFK EVNPAVPEVE
360 370 380 390 400
NQPPAGNNPT PESEGSSGPS RPEEADETWD AKEDKIHNAE NIQPGEQKYE
410 420 430 440 450
YKSDQWRPLN LEEKKRYDRE FLLGFQFIFC QYAEAGGLPH ISDVVLEKAN
460 470 480 490 500
KTPLRPLDPS RLSGINCGPD FTPSFANLGR PALSSRGPPR GGPGGELPRG
510 520 530 540 550
AAGLGPRRSL QPRPPKGARK LIASVIMTED IKLNKAEKAW KPSSKRTAAD
560 570 580 590 600
KDRGEEDADG SKTQDLFRRV RSILNKLTPQ MFQQLMKQVT QLAIDTEGAS
610 620 630 640 650
KGSLTSSLRR PFQNPTSQWP SQHVPLPHGA ESATTEKPTV TVNFRKLLLN
660 670 680 690 700
RCQKEFEKDK DDDEVFEKKQ KEMDEAATAE ERERLKEELE EARDIARRCS
710 720 730 740 750
LGNIKFIGEL FKLKMLTEAI MHDCVVKLLR HDEESLEFLC RLLTTIGKDL
760 770 780 790 800
DFEKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD
810 820 830 840 850
QGPKTIDQIH KEAEMEEHRE HIKVQQLMAK GSDKRRGGPP GPPISRGLPL
860 870 880 890 900
VDDGGWNTVP ISKGSRPIDT SRLTKITKPG SIDSNNQLFA PGGRLSWGKG
910 920 930 940 950
SSGSGAKPSD AASEVSRPAT STLNRFSALQ QAVPTESTDN RRVVQRSSLS
960 970 980 990 1000
RERGGKAGEP RRRLERSERG GDRGDRLDRA RTPATKRSFS KEVEERSRER
1010 1020 1030 1040 1050
PSQPEGLRKA ASLTEDRDRG RDAAKREAAL PPVSCAKAAL SEEELEKKSK
1060 1070 1080 1090 1100
AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGIESTL ERSAIARERM
1110 1120 1130 1140 1150
GQLLHQLLCA GHLSTAQYYQ GLYEILELAE DMEIDIPHVW LYLAELVTPI
1160 1170 1180 1190 1200
MQEGGVPMGE LFREITKHLR PLGKAASLLL EILRLLCKSK GPKKVAYCGV
1210 1220 1230 1240 1250
RLGSAGKNFC LEGQDVGAFI TEQKVEYTLG EESEAPGQRA LSSEELSRQL
1260 1270 1280 1290 1300
EKVLKEGSSN QRVFDWIEAN LSEQQIASNT LVRALMTAVC YSAIIFETPL
1310 1320 1330 1340 1350
RVDVAVLKGD RICYRNTCVI AEGAARLYAL QALVVTLEQP ANLLRMFFDA
1360 1370 1380 1390 1400
LYDEDVVKEE AFYSWESSKD PAEQQGKGVA LKSVTAFFKW LREVEEEESD

HN
Length:1,402
Mass (Da):154,051
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FD85D7E30519230
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22090 mRNA Translation: AAA31242.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I46707

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22090 mRNA Translation: AAA31242.1
PIRiI46707

3D structure databases

SMRiP41110
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005299

Proteomic databases

PRIDEiP41110

Phylogenomic databases

InParanoidiP41110

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G1_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41110
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 17, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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