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Protein

60S ribosomal protein L18a

Gene

RpL18A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Gene namesi
Name:RpL18A
ORF Names:CG6510
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010409 RpL18A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139321 – 17760S ribosomal protein L18aAdd BLAST177

Proteomic databases

PaxDbiP41093
PRIDEiP41093

Expressioni

Gene expression databases

BgeeiFBgn0010409
GenevisibleiP41093 DM

Interactioni

Protein-protein interaction databases

BioGridi62674, 27 interactors
DIPiDIP-19043N
IntActiP41093, 22 interactors
MINTiP41093
STRINGi7227.FBpp0086103

Structurei

3D structure databases

ProteinModelPortaliP41093
SMRiP41093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0829 Eukaryota
COG2157 LUCA
GeneTreeiENSGT00390000015797
InParanoidiP41093
KOiK02882
OMAiCRRPAIK
OrthoDBiEOG091G0LX4
PhylomeDBiP41093

Family and domain databases

HAMAPiMF_00273 Ribosomal_L18Ae, 1 hit
InterProiView protein in InterPro
IPR028877 50S_L18Ae/Ribosomal_L18a/L20
IPR023573 Ribosomal_L18a//L18Ae/LX
IPR021138 Ribosomal_L18a/L20_eukaryotes
PANTHERiPTHR10052 PTHR10052, 1 hit
PfamiView protein in Pfam
PF01775 Ribosomal_L18A, 1 hit
PIRSFiPIRSF002190 Ribosomal_L18a, 1 hit

Sequencei

Sequence statusi: Complete.

P41093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKGLLKEY EVVGRKLPSE KEPQTPLYKM RIFAPDNIVA KSRFWYFLRQ
60 70 80 90 100
LKKFKKTTGE IVSIKQVYET SPVKIKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TVGGAVTQCY RDMGARHRAR AHSIQIIKVD SIPAAKTRRV HVKQFHDSKI
160 170
KFPLVQRVHH KGNRKLFSFR KPRTYFQ
Length:177
Mass (Da):21,030
Last modified:February 1, 1995 - v1
Checksum:i4BD5E9A9F0799FA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75339 mRNA Translation: CAA53089.1
AE013599 Genomic DNA Translation: AAF57838.1
AY071222 mRNA Translation: AAL48844.1
PIRiS45364
RefSeqiNP_523774.1, NM_079050.3
UniGeneiDm.669

Genome annotation databases

EnsemblMetazoaiFBtr0086947; FBpp0086103; FBgn0010409
GeneIDi36985
KEGGidme:Dmel_CG6510

Similar proteinsi

Entry informationi

Entry nameiRL18A_DROME
AccessioniPrimary (citable) accession number: P41093
Secondary accession number(s): Q9V840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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