UniProtKB - P41077 (PNTAA_RICPR)
Protein
NAD(P) transhydrogenase subunit alpha part 1
Gene
pntAA
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Functioni
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.By similarity
Catalytic activityi
- EC:7.1.1.1By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 181 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 231 | NAD; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 131 – 134 | NADBy similarity | 4 | |
Nucleotide bindingi | 201 – 203 | NADBy similarity | 3 |
GO - Molecular functioni
- NAD+ binding Source: UniProtKB
- oxidoreductase activity Source: InterPro
Keywordsi
Molecular function | Translocase |
Ligand | NAD, NADP, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | RPRO272947:G1GT0-867-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: NAD(P) transhydrogenase subunit alpha part 1 (EC:7.1.1.1By similarity)Alternative name(s): Nicotinamide nucleotide transhydrogenase subunit alpha 1 Pyridine nucleotide transhydrogenase subunit alpha 1 |
Gene namesi | Name:pntAA Ordered Locus Names:RP863 |
Organismi | Rickettsia prowazekii (strain Madrid E) |
Taxonomic identifieri | 272947 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199020 | 1 – 383 | NAD(P) transhydrogenase subunit alpha part 1Add BLAST | 383 |
Proteomic databases
PRIDEi | P41077 |
Interactioni
Subunit structurei
Heterotrimer of two alpha chains and a beta (PntB) chain; in Rickettsia, the alpha chain is made of two subunits (PntAA and PntAB) and forms a dimer.
By similarityProtein-protein interaction databases
STRINGi | 272947.RP863 |
Family & Domainsi
Sequence similaritiesi
Belongs to the AlaDH/PNT family.Curated
Phylogenomic databases
eggNOGi | ENOG4108IIE Bacteria COG3288 LUCA |
HOGENOMi | HOG000022121 |
KOi | K00324 |
OMAi | AKVFIMG |
Family and domain databases
InterProi | View protein in InterPro IPR008142 AlaDH/PNT_CS1 IPR007886 AlaDH/PNT_N IPR007698 AlaDH/PNT_NAD(H)-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01262 AlaDh_PNT_C, 1 hit PF05222 AlaDh_PNT_N, 1 hit |
SMARTi | View protein in SMART SM01002 AlaDh_PNT_C, 1 hit SM01003 AlaDh_PNT_N, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00836 ALADH_PNT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P41077-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIVALKEKV KNETRTAITP EVAGLLIKKG YAVTVEKDIG LYAGFLDEEY
60 70 80 90 100
VAVGTKISSV PLEIISDADI ILKVQPSSVT DKYSELEFAK QGAIVVGLLS
110 120 130 140 150
PYLNHEYIKA AAKKNLTTFA MEFVPRITKA QNMDALSSQS NLVGYRAVIE
160 170 180 190 200
ASYHYTKAFP MMITAAGTIS ACKTLVLGVG VAGLQAIATA KRLGSIVAGY
210 220 230 240 250
DVRIATKEQV ESLGAKFVSP ELQEDLEEES GYASESSADY KAKQEKFLAK
260 270 280 290 300
IIKGYNIVIT TAQIPGKKAP MLVTDKMIES MMYGSVIVDI STSTGGNVEG
310 320 330 340 350
SEPDKIVTRH GVTIIGLLNL ASKIASDSSK LYSKNLYNFL TYALQDGQFN
360 370 380
MDDELVRDML ITKDGKIVNY IIREKYESIT DNG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ235273 Genomic DNA Translation: CAA15287.1 U02878 Unassigned DNA Translation: AAB81400.1 |
PIRi | G71648 |
RefSeqi | NP_221211.1, NC_000963.1 WP_004596753.1, NC_000963.1 |
Genome annotation databases
EnsemblBacteriai | CAA15287; CAA15287; CAA15287 |
GeneIDi | 883431 |
KEGGi | rpr:RP863 |
PATRICi | fig|272947.5.peg.902 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ235273 Genomic DNA Translation: CAA15287.1 U02878 Unassigned DNA Translation: AAB81400.1 |
PIRi | G71648 |
RefSeqi | NP_221211.1, NC_000963.1 WP_004596753.1, NC_000963.1 |
3D structure databases
SMRi | P41077 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272947.RP863 |
Proteomic databases
PRIDEi | P41077 |
Genome annotation databases
EnsemblBacteriai | CAA15287; CAA15287; CAA15287 |
GeneIDi | 883431 |
KEGGi | rpr:RP863 |
PATRICi | fig|272947.5.peg.902 |
Phylogenomic databases
eggNOGi | ENOG4108IIE Bacteria COG3288 LUCA |
HOGENOMi | HOG000022121 |
KOi | K00324 |
OMAi | AKVFIMG |
Enzyme and pathway databases
BioCyci | RPRO272947:G1GT0-867-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR008142 AlaDH/PNT_CS1 IPR007886 AlaDH/PNT_N IPR007698 AlaDH/PNT_NAD(H)-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01262 AlaDh_PNT_C, 1 hit PF05222 AlaDh_PNT_N, 1 hit |
SMARTi | View protein in SMART SM01002 AlaDh_PNT_C, 1 hit SM01003 AlaDh_PNT_N, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00836 ALADH_PNT_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PNTAA_RICPR | |
Accessioni | P41077Primary (citable) accession number: P41077 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 30, 2000 | |
Last modified: | September 18, 2019 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Rickettsia prowazekii
Rickettsia prowazekii (strain Madrid E): entries and gene names