Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrosomal and chromosomal factor

Gene

corto

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential protein required for proper condensation of mitotic chromosomes and progression through mitosis (PubMed:9463384). Binds to specific polytene chromosome sites, many of which are shared with the posterior sex combs (Psc) protein (PubMed:9463384). Involved in maintaining Abd-B repression outside its normal expression domain (PubMed:18667003, PubMed:18286205).3 Publications

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromatin silencing Source: UniProtKB
  • epithelium development Source: FlyBase
  • imaginal disc-derived wing vein specification Source: FlyBase
  • male courtship behavior, veined wing generated song production Source: FlyBase
  • mitotic chromosome condensation Source: FlyBase
  • regulation of gene expression Source: FlyBase

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal and chromosomal factor
Short name:
CCF
Alternative name(s):
Chromocentrosomin
Gene namesi
Name:corto
Synonyms:ccf
ORF Names:CG2530
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010313 corto

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792561 – 550Centrosomal and chromosomal factorAdd BLAST550

Proteomic databases

PaxDbiP41046
PRIDEiP41046

Expressioni

Developmental stagei

Expressed during oogenesis, embryonic and larval stages.

Gene expression databases

BgeeiFBgn0010313 Expressed in 58 organ(s), highest expression level in embryo
ExpressionAtlasiP41046 baseline and differential
GenevisibleiP41046 DM

Interactioni

Subunit structurei

Homodimer (PubMed:12771214). Interacts with esc, Trl, E(z), scm and ph-p in vitro (PubMed:12771214). Found in vivo in an esc-containing complex, which may be the Esc/E(z) complex (PubMed:12771214). Also found in vivo in a Pc-containing complex that may be the PRC1 complex, but does not interact with Pc directly (PubMed:12771214). Interacts with cyclin CycG (PubMed:18286205).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi65830, 22 interactors
DIPiDIP-22699N
IntActiP41046, 6 interactors
STRINGi7227.FBpp0300441

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 44Sequence analysisAdd BLAST25
Coiled coili105 – 126Sequence analysisAdd BLAST22
Coiled coili239 – 274Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 410Gln-richAdd BLAST385
Compositional biasi84 – 89Poly-Ser6
Compositional biasi110 – 126Poly-GlnAdd BLAST17
Compositional biasi204 – 210Poly-Ser7
Compositional biasi215 – 220Poly-Gly6
Compositional biasi243 – 250Poly-Gln8
Compositional biasi253 – 258Poly-Gln6
Compositional biasi285 – 297Poly-GlnAdd BLAST13
Compositional biasi322 – 329Poly-Ala8
Compositional biasi332 – 336Poly-Ala5
Compositional biasi396 – 410Poly-GlnAdd BLAST15
Compositional biasi414 – 417Poly-Pro4
Compositional biasi466 – 469Poly-Gly4
Compositional biasi504 – 535Ala-richAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J3EQ Eukaryota
ENOG41124FF LUCA
HOGENOMiHOG000020467
InParanoidiP41046
OMAiRVEPLLM
OrthoDBiEOG091G11TX
PhylomeDBiP41046

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P41046-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMAACYANY DMSSLSHGMS ALSALQQQQQ QQQQQHSQTQ QQHHHQQQQQ
60 70 80 90 100
HMYHAAVAAH QQQLLQQQQQ QQHHRHHHQP ANTSSSSNSR HSHAAATQTQ
110 120 130 140 150
VAAAVANSRQ QQQQQQQQQQ QQQQQQTASS NSNAAPAPSP QKDYSIPLHV
160 170 180 190 200
DCSVEYELPN QPKPPAGQRV EPLLMIHPCY FRKMESQRRS PFVNNMHATA
210 220 230 240 250
RAVSSSSLSS GAALGGGGSG AAVATAPSSS AARRGARAAT SAQQQQQQQQ
260 270 280 290 300
RYQQQQQQLR QQHQQMSQMS QQAHYPQQQS SLVRQHQQQQ QQQQQQQRAS
310 320 330 340 350
SNQSQRQSQS QSQSQSHAAN SAAAAAAQAS IAAAAAGQWD QLAALAARTA
360 370 380 390 400
LTPHHMLHPH SHYAAKGSGG GAGGGKRDAM ISGSYGQTAV ASGKLQQSQV
410 420 430 440 450
QQQQPQQQQQ HCLPPPPWDA TSMLMDRSPM ATVPSNYQAG PDTNPMRLYS
460 470 480 490 500
ATPTAGAASG GSASVGGGGA VSGAGATGAV NTATDKLSGK YRQYLRSQRM
510 520 530 540 550
HPYAAAASLN LAAAAAAAGQ TSFVPFSSAA TAVAATPTFQ HLPQISCYNV
Length:550
Mass (Da):58,771
Last modified:May 24, 2005 - v2
Checksum:i41D79F0A107A582D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGR6A0A0B4LGR6_DROME
Corto, isoform B
corto 7128, anon-WO02059370.59, Ccf, ccf, Corto
550Annotation score:

Sequence cautioni

The sequence AAK92993 differs from that shown. Reason: Frameshift at position 200.Curated
The sequence BAA07853 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134A → T in AAC13917 (PubMed:9463384).Curated1
Sequence conflicti371 – 372GA → EQ in AAC13917 (PubMed:9463384).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35074 mRNA Translation: AAC13917.1
D43795 mRNA Translation: BAA07853.1 Frameshift.
AE014297 Genomic DNA Translation: AAF52073.1
BT023771 mRNA Translation: AAZ41779.1
AY051569 mRNA Translation: AAK92993.1 Frameshift.
RefSeqiNP_001246921.1, NM_001259992.2
NP_001246922.1, NM_001259993.3
NP_001246923.1, NM_001259994.2
NP_001287166.1, NM_001300237.1
NP_524231.2, NM_079507.4
UniGeneiDm.24160

Genome annotation databases

EnsemblMetazoaiFBtr0078844; FBpp0078485; FBgn0010313
FBtr0308118; FBpp0300440; FBgn0010313
FBtr0308119; FBpp0300441; FBgn0010313
FBtr0308120; FBpp0300442; FBgn0010313
FBtr0345141; FBpp0311362; FBgn0010313
GeneIDi40616
KEGGidme:Dmel_CG2530

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35074 mRNA Translation: AAC13917.1
D43795 mRNA Translation: BAA07853.1 Frameshift.
AE014297 Genomic DNA Translation: AAF52073.1
BT023771 mRNA Translation: AAZ41779.1
AY051569 mRNA Translation: AAK92993.1 Frameshift.
RefSeqiNP_001246921.1, NM_001259992.2
NP_001246922.1, NM_001259993.3
NP_001246923.1, NM_001259994.2
NP_001287166.1, NM_001300237.1
NP_524231.2, NM_079507.4
UniGeneiDm.24160

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65830, 22 interactors
DIPiDIP-22699N
IntActiP41046, 6 interactors
STRINGi7227.FBpp0300441

Proteomic databases

PaxDbiP41046
PRIDEiP41046

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078844; FBpp0078485; FBgn0010313
FBtr0308118; FBpp0300440; FBgn0010313
FBtr0308119; FBpp0300441; FBgn0010313
FBtr0308120; FBpp0300442; FBgn0010313
FBtr0345141; FBpp0311362; FBgn0010313
GeneIDi40616
KEGGidme:Dmel_CG2530

Organism-specific databases

CTDi40616
FlyBaseiFBgn0010313 corto

Phylogenomic databases

eggNOGiENOG410J3EQ Eukaryota
ENOG41124FF LUCA
HOGENOMiHOG000020467
InParanoidiP41046
OMAiRVEPLLM
OrthoDBiEOG091G11TX
PhylomeDBiP41046

Miscellaneous databases

ChiTaRSicorto fly
GenomeRNAii40616
PROiPR:P41046

Gene expression databases

BgeeiFBgn0010313 Expressed in 58 organ(s), highest expression level in embryo
ExpressionAtlasiP41046 baseline and differential
GenevisibleiP41046 DM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCORTO_DROME
AccessioniPrimary (citable) accession number: P41046
Secondary accession number(s): Q24271
, Q494K5, Q961I6, Q9VN76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again