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Protein

Urease subunit gamma

Gene

ureA

Organism
Sporosarcina pasteurii (Bacillus pasteurii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease (ureC), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureAUniRule annotation
OrganismiSporosarcina pasteurii (Bacillus pasteurii)
Taxonomic identifieri1474 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPlanococcaceaeSporosarcina

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB02899 N-Carboxymethionine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000979911 – 100Urease subunit gammaAdd BLAST100

Post-translational modificationi

Although not discussed in the published references, Met-1 is represented in the submitted PDB entries as being modified by either a formyl, a carboxyl, or an acetyl group. The N-terminal is probably N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine.

Keywords - PTMi

Formylation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation5 Publications

Chemistry databases

BindingDBiP41022

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 25Combined sources21
Helixi32 – 49Combined sources18
Helixi53 – 59Combined sources7
Helixi60 – 62Combined sources3
Helixi66 – 68Combined sources3
Helixi73 – 76Combined sources4
Beta strandi78 – 86Combined sources9
Beta strandi89 – 97Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IE7X-ray1.85A1-100[»]
1S3TX-ray2.10A1-100[»]
1UBPX-ray1.65A1-100[»]
2UBPX-ray2.00A1-100[»]
3UBPX-ray2.00A1-100[»]
4AC7X-ray1.50A1-100[»]
4CEUX-ray1.58A1-100[»]
4CEXX-ray1.59A1-100[»]
4UBPX-ray1.55A1-100[»]
5A6TX-ray1.65A1-100[»]
5FSDX-ray1.75A1-100[»]
5FSEX-ray2.07A1-100[»]
5G4HX-ray1.50A1-100[»]
ProteinModelPortaliP41022
SMRiP41022
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41022

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Family and domain databases

CDDicd00390 Urease_gamma, 1 hit
Gene3Di3.30.280.10, 1 hit
HAMAPiMF_00739 Urease_gamma, 1 hit
InterProiView protein in InterPro
IPR012010 Urease_gamma
IPR002026 Urease_gamma/gamma-beta_su
IPR036463 Urease_gamma_sf
PANTHERiPTHR45301 PTHR45301, 1 hit
PfamiView protein in Pfam
PF00547 Urease_gamma, 1 hit
PIRSFiPIRSF001223 Urease_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002319 Urease_gamma_reg, 1 hit
SUPFAMiSSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR00193 urease_gam, 1 hit

Sequencei

Sequence statusi: Complete.

P41022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLNPAEKEK LQIFLASELL LRRKARGLKL NYPEAVAIIT SFIMEGARDG
60 70 80 90 100
KTVAMLMEEG KHVLTRDDVM EGVPEMIDDI QAEATFPDGT KLVTVHNPIS
Length:100
Mass (Da):11,146
Last modified:February 1, 1995 - v1
Checksum:i773EC3587BF6CA36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78411 Genomic DNA Translation: CAA55173.1
PIRiS47102

Similar proteinsi

Entry informationi

Entry nameiURE3_SPOPA
AccessioniPrimary (citable) accession number: P41022
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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