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Entry version 190 (23 Feb 2022)
Sequence version 2 (16 Apr 2002)
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Protein

Cyclin-F

Gene

CCNF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844, PubMed:27080313, PubMed:28852778).

The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:8706131, PubMed:20596027, PubMed:27653696, PubMed:26818844).

Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844).

Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027).

In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967).

In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844).

Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696).

May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911).

8 Publications

Miscellaneous

Founding member of the F-box domain protein family, which obtained its name from cyclin-F.1 Publication
Member of the cyclin family, however, unlike most members of the cyclin family, it does not bind or activate a cyclin-dependent kinase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P41002

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P41002

SIGNOR Signaling Network Open Resource

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SIGNORi
P41002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-F
Alternative name(s):
F-box only protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNF
Synonyms:FBX1, FBXO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1591, CCNF

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600227, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P41002

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000162063

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 (FTDALS5)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by frontotemporal dementia and/or amyotrophic lateral sclerosis in affected individuals. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. FTDALS5 is an autosomal dominant form with age-dependent penetrance. Penetrance is estimated to be 50% by age 56 and 100% by age 61.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0851773S → G in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs944306963Ensembl.1
Natural variantiVAR_08517897K → R in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1465313712EnsemblClinVar.1
Natural variantiVAR_085179181T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745821656Ensembl.1
Natural variantiVAR_085180195S → R in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1371569927EnsemblClinVar.1
Natural variantiVAR_085181392R → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs954539468EnsemblClinVar.1
Natural variantiVAR_085182509S → P in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs760953006Ensembl.1
Natural variantiVAR_085183543T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756914411Ensembl.1
Natural variantiVAR_085184621S → G in FTDALS5; increased 'Lys-48'-linked polyubiquitination of proteins targeted for proteasomal degradation, but no increase in 'Lys-63'-linked polyubiquitinated proteins; accumulation of ubiquitinated proteins including RRM2 and TARDBP/TDP43; impaired autophagosome-lysosome fusion; impaired degradation by the ubiquitin proteasome system (UPS); increased levels of ubiquitinated autophagy receptor SQSTM1/p62. 2 PublicationsCorresponds to variant dbSNP:rs778264897EnsemblClinVar.1
Natural variantiVAR_085185624E → K in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs771621178EnsemblClinVar.1
Natural variantiVAR_085186772I → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs762663630Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35 – 36LP → AA: Impairs interaction with SKP1 and CUL1 and prevents degradation of CP110, leading to promote the formation of micronuclei. Increased interaction with RRM2 and lack of RRM2 ubiquitination. 2 Publications2
Mutagenesisi309 – 310MR → AA: Reduces the interaction with MYBL2/BMYB. Disrupts the interaction with CDC6. Does not disrupt interaction with CUL1. 2 Publications2
Mutagenesisi309M → A: Reduced degradation of RRM2 after UV-induced DNA-damage. Abolishes the interaction with CP110 and RRM2; when associated with A-352. 2 Publications1
Mutagenesisi310 – 313RYIL → AYIA: Reduces the interaction with FZR1/CDH1. Reduced ubiquitination. Abolishes the interaction with FZR1/CDH1; when associated with 351-R--L-354. Loss of ubiquitination and impaired degradation; when associated with 351-R--L-354. 1 Publication4
Mutagenesisi343 – 346RRRL → ARRA: Reduces the interaction with FZR1/CDH1. 1 Publication4
Mutagenesisi349 – 352RYRL → AYRA: Reduces the interaction with FZR1/CDH1. 1 Publication4
Mutagenesisi351 – 354RLQL → ALQA: Reduces the interaction with FZR1/CDH1. Abolishes the interaction with FZR1/CDH1; when associated with 310-R--L-313. Loss of ubiquitination and impaired degradation; when associated with 310-R--L-313. 1 Publication4
Mutagenesisi352L → A: Abolishes the interaction with CP110 and RRM2; when associated with A-309. 2 Publications1
Mutagenesisi767 – 770RINL → AINA: Reduces the interaction with FZR1/CDH1. 1 Publication4

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
899

MalaCards human disease database

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MalaCardsi
CCNF
MIMi619141, phenotype

Open Targets

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OpenTargetsi
ENSG00000162063

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
803, Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26156

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P41002, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CCNF

Domain mapping of disease mutations (DMDM)

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DMDMi
20178283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804631 – 786Cyclin-FAdd BLAST786

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation depends on the C-terminal PEST sequence.1 Publication
Phosphorylated just before cells enter into mitosis.1 Publication
Ubiquitinated by the anaphase-promoting complex (APC/C); leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P41002

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P41002

MaxQB - The MaxQuant DataBase

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MaxQBi
P41002

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P41002

PeptideAtlas

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PeptideAtlasi
P41002

PRoteomics IDEntifications database

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PRIDEi
P41002

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55398

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P41002

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P41002

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with expression detected in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Appears in S phase, peaks in G2 phase, decreases in mitosis, lowest in early G1 phase and then accumulates again in late G1 and S phase (at protein level).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in an ATR-dependent manner in response to DNA damage induced by doxorubicin, camptothecin, UV-C, methyl methanesulfonate, nocodazole, or gamma-irradiation. Down-regulation in response to DNA damage is required to allow RRM2 accumulation within the nucleus and for efficient DNA repair.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162063, Expressed in female gonad and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P41002, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P41002, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000162063, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (PubMed:20596027).

Interacts with SKP1 (PubMed:8706131, PubMed:12122006).

Interacts with CUL1 (PubMed:26818844).

Interacts with CCNB1; interaction is required for nuclear localization of CCNB1 (PubMed:10716937, PubMed:20596027).

Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (PubMed:22441691).

Interacts (via the Cyclin N-terminal domain) with MYBL2/BMYB (PubMed:25557911).

Interacts with FZR1/CDH1 (via N-terminus) (PubMed:27653696).

Interacts with RRM2 (via Cy motif and when phosphorylated at 'Thr-33'); the interaction occurs exclusively in G2 and early M (PubMed:22632967).

Interacts with CDC6 (via Cy motif); the interaction takes place during G2 and M phase (PubMed:26818844).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107339, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P41002

Database of interacting proteins

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DIPi
DIP-44939N

Protein interaction database and analysis system

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IntActi
P41002, 6 interactors

Molecular INTeraction database

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MINTi
P41002

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380256

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P41002, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P41002

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 76F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini288 – 405Cyclin N-terminalSequence analysisAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni564 – 593DisorderedSequence analysisAdd BLAST30
Regioni582 – 766PESTAdd BLAST185
Regioni675 – 738DisorderedSequence analysisAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi20 – 28Nuclear localization signal 11 Publication9
Motifi310 – 313D box 11 Publication4
Motifi343 – 346D box 21 Publication4
Motifi349 – 352D box 31 Publication4
Motifi351 – 354D box 41 Publication4
Motifi568 – 574Nuclear localization signal 21 Publication7
Motifi767 – 770D box 51 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi693 – 736Polar residuesSequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.1 Publication
The D box motifs 1-5 (amino acid sequence RxxL) are involved in substrate binding, such as FZR1/CDH1, and may be ubiquitinated.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0654, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00810000125541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_020348_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P41002

Identification of Orthologs from Complete Genome Data

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OMAi
FTWVFIR

Database of Orthologous Groups

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OrthoDBi
607108at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P41002

TreeFam database of animal gene trees

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TreeFami
TF101006

Family and domain databases

Conserved Domains Database

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CDDi
cd00043, CYCLIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10177, PTHR10177, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PF00646, F-box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SM00256, FBOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47954, SSF47954, 2 hits
SSF81383, SSF81383, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00292, CYCLINS, 1 hit
PS50181, FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P41002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE
60 70 80 90 100
DILAVRAVHS QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF
110 120 130 140 150
EAAVKLGIAY LYNEGLSVSD EARAEVNGLK ASRFFSLAER LNVGAAPFIW
160 170 180 190 200
LFIRPPWSVS GSCCKAVVHE SLRAECQLQR THKASILHCL GRVLSLFEDE
210 220 230 240 250
EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC LHSFRKLRDY
260 270 280 290 300
AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS
310 320 330 340 350
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY
360 370 380 390 400
RLQLLGIACM VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA
410 420 430 440 450
LEGKIRVPTV VDYKEVLLTL VPVELRTQHL CSFLCELSLL HTSLSAYAPA
460 470 480 490 500
RLAAAALLLA RLTHGQTQPW TTQLWDLTGF SYEDLIPCVL SLHKKCFHDD
510 520 530 540 550
APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL GVTQDSPDPP
560 570 580 590 600
TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
610 620 630 640 650
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC
660 670 680 690 700
QESSDEEACP EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS
710 720 730 740 750
GYSSVSTASP TSSVDGGLGA LPQPTSVLSL DSDSHTQPCH HQARKSCLQC
760 770 780
RPPSPPESSV PQQQVKRINL CIHSEEEDMN LGLVRL
Length:786
Mass (Da):87,640
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADB2FE41BC708898
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUD3H3BUD3_HUMAN
Cyclin-F
CCNF
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2P7H0Y2P7_HUMAN
Cyclin-F
CCNF
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252A → R in CAA85308 (PubMed:7896286).Curated1
Sequence conflicti324K → N in CAA85308 (PubMed:7896286).Curated1
Sequence conflicti434L → H in BAG36170 (PubMed:14702039).Curated1
Sequence conflicti600L → V in CAA85308 (PubMed:7896286).Curated1
Sequence conflicti662D → A in CAA85308 (PubMed:7896286).Curated1
Sequence conflicti710P → S in AAB60342 (PubMed:7813445).Curated1
Sequence conflicti731D → H in CAA85308 (PubMed:7896286).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0851773S → G in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs944306963Ensembl.1
Natural variantiVAR_08517897K → R in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1465313712EnsemblClinVar.1
Natural variantiVAR_085179181T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745821656Ensembl.1
Natural variantiVAR_085180195S → R in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1371569927EnsemblClinVar.1
Natural variantiVAR_085181392R → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs954539468EnsemblClinVar.1
Natural variantiVAR_085182509S → P in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs760953006Ensembl.1
Natural variantiVAR_085183543T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756914411Ensembl.1
Natural variantiVAR_085184621S → G in FTDALS5; increased 'Lys-48'-linked polyubiquitination of proteins targeted for proteasomal degradation, but no increase in 'Lys-63'-linked polyubiquitinated proteins; accumulation of ubiquitinated proteins including RRM2 and TARDBP/TDP43; impaired autophagosome-lysosome fusion; impaired degradation by the ubiquitin proteasome system (UPS); increased levels of ubiquitinated autophagy receptor SQSTM1/p62. 2 PublicationsCorresponds to variant dbSNP:rs778264897EnsemblClinVar.1
Natural variantiVAR_085185624E → K in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs771621178EnsemblClinVar.1
Natural variantiVAR_085186772I → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs762663630Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17105 mRNA Translation: AAB60342.1
Z36714 mRNA Translation: CAA85308.1
AK313371 mRNA Translation: BAG36170.1
AC106820 Genomic DNA No translation available.
BC012349 mRNA Translation: AAH12349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10467.1

Protein sequence database of the Protein Information Resource

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PIRi
A55501

NCBI Reference Sequences

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RefSeqi
NP_001752.2, NM_001761.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397066; ENSP00000380256; ENSG00000162063

Database of genes from NCBI RefSeq genomes

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GeneIDi
899

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:899

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000397066.9; ENSP00000380256.4; NM_001761.3; NP_001752.2

UCSC genome browser

More...
UCSCi
uc002cqd.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17105 mRNA Translation: AAB60342.1
Z36714 mRNA Translation: CAA85308.1
AK313371 mRNA Translation: BAG36170.1
AC106820 Genomic DNA No translation available.
BC012349 mRNA Translation: AAH12349.1
CCDSiCCDS10467.1
PIRiA55501
RefSeqiNP_001752.2, NM_001761.2

3D structure databases

SMRiP41002
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107339, 30 interactors
CORUMiP41002
DIPiDIP-44939N
IntActiP41002, 6 interactors
MINTiP41002
STRINGi9606.ENSP00000380256

PTM databases

iPTMnetiP41002
PhosphoSitePlusiP41002

Genetic variation databases

BioMutaiCCNF
DMDMi20178283

Proteomic databases

jPOSTiP41002
MassIVEiP41002
MaxQBiP41002
PaxDbiP41002
PeptideAtlasiP41002
PRIDEiP41002
ProteomicsDBi55398

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10421, 224 antibodies from 32 providers

The DNASU plasmid repository

More...
DNASUi
899

Genome annotation databases

EnsembliENST00000397066; ENSP00000380256; ENSG00000162063
GeneIDi899
KEGGihsa:899
MANE-SelectiENST00000397066.9; ENSP00000380256.4; NM_001761.3; NP_001752.2
UCSCiuc002cqd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
899
DisGeNETi899

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCNF
HGNCiHGNC:1591, CCNF
HPAiENSG00000162063, Tissue enhanced (lymphoid)
MalaCardsiCCNF
MIMi600227, gene
619141, phenotype
neXtProtiNX_P41002
OpenTargetsiENSG00000162063
Orphaneti803, Amyotrophic lateral sclerosis
PharmGKBiPA26156
VEuPathDBiHostDB:ENSG00000162063

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0654, Eukaryota
GeneTreeiENSGT00810000125541
HOGENOMiCLU_020348_0_0_1
InParanoidiP41002
OMAiFTWVFIR
OrthoDBi607108at2759
PhylomeDBiP41002
TreeFamiTF101006

Enzyme and pathway databases

PathwayCommonsiP41002
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP41002
SIGNORiP41002

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
899, 64 hits in 1109 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCNF, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCNF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
899
PharosiP41002, Tbio

Protein Ontology

More...
PROi
PR:P41002
RNActiP41002, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162063, Expressed in female gonad and 201 other tissues
ExpressionAtlasiP41002, baseline and differential
GenevisibleiP41002, HS

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR10177, PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PF00646, F-box, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SM00256, FBOX, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
SSF81383, SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit
PS50181, FBOX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P41002
Secondary accession number(s): B2R8H3, Q96EG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 16, 2002
Last modified: February 23, 2022
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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