UniProtKB - P41002 (CCNF_HUMAN)
Cyclin-F
CCNF
Functioni
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844, PubMed:27080313, PubMed:28852778).
The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:8706131, PubMed:20596027, PubMed:27653696, PubMed:26818844).
Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:27653696, PubMed:26818844).
Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027).
In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967).
In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844).
Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696).
May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911).
8 PublicationsMiscellaneous
GO - Molecular functioni
- anaphase-promoting complex binding Source: UniProtKB
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- mitotic cell cycle phase transition Source: GO_Central
- negative regulation of centrosome duplication Source: UniProtKB
- placenta development Source: Ensembl
- protein ubiquitination Source: UniProtKB
- re-entry into mitotic cell cycle Source: Ensembl
- regulation of cell cycle Source: UniProtKB
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | P41002 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P41002 |
SIGNORi | P41002 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-FAlternative name(s): F-box only protein 1 |
Gene namesi | Name:CCNF Synonyms:FBX1, FBXO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1591, CCNF |
MIMi | 600227, gene |
neXtProti | NX_P41002 |
VEuPathDBi | HostDB:ENSG00000162063 |
Subcellular locationi
Cytoskeleton
- centriole 1 Publication
Nucleus
- Nucleus 4 Publications
Other locations
- perinuclear region 1 Publication
Note: Localization to the centrosome is rare in S phase cells and increases in G2 cells. Localizes to both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase.2 Publications
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: HPA
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Other locations
- cell junction Source: HPA
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- SCF ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 (FTDALS5)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085177 | 3 | S → G in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs944306963Ensembl. | 1 | |
Natural variantiVAR_085178 | 97 | K → R in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1465313712EnsemblClinVar. | 1 | |
Natural variantiVAR_085179 | 181 | T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745821656Ensembl. | 1 | |
Natural variantiVAR_085180 | 195 | S → R in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1371569927EnsemblClinVar. | 1 | |
Natural variantiVAR_085181 | 392 | R → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs954539468EnsemblClinVar. | 1 | |
Natural variantiVAR_085182 | 509 | S → P in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs760953006Ensembl. | 1 | |
Natural variantiVAR_085183 | 543 | T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756914411Ensembl. | 1 | |
Natural variantiVAR_085184 | 621 | S → G in FTDALS5; increased 'Lys-48'-linked polyubiquitination of proteins targeted for proteasomal degradation, but no increase in 'Lys-63'-linked polyubiquitinated proteins; accumulation of ubiquitinated proteins including RRM2 and TARDBP/TDP43; impaired autophagosome-lysosome fusion; impaired degradation by the ubiquitin proteasome system (UPS); increased levels of ubiquitinated autophagy receptor SQSTM1/p62. 2 PublicationsCorresponds to variant dbSNP:rs778264897EnsemblClinVar. | 1 | |
Natural variantiVAR_085185 | 624 | E → K in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs771621178EnsemblClinVar. | 1 | |
Natural variantiVAR_085186 | 772 | I → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs762663630Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 35 – 36 | LP → AA: Impairs interaction with SKP1 and CUL1 and prevents degradation of CP110, leading to promote the formation of micronuclei. Increased interaction with RRM2 and lack of RRM2 ubiquitination. 2 Publications | 2 | |
Mutagenesisi | 309 – 310 | MR → AA: Reduces the interaction with MYBL2/BMYB. Disrupts the interaction with CDC6. Does not disrupt interaction with CUL1. 2 Publications | 2 | |
Mutagenesisi | 309 | M → A: Reduced degradation of RRM2 after UV-induced DNA-damage. Abolishes the interaction with CP110 and RRM2; when associated with A-352. 2 Publications | 1 | |
Mutagenesisi | 310 – 313 | RYIL → AYIA: Reduces the interaction with FZR1/CDH1. Reduced ubiquitination. Abolishes the interaction with FZR1/CDH1; when associated with 351-R--L-354. Loss of ubiquitination and impaired degradation; when associated with 351-R--L-354. 1 Publication | 4 | |
Mutagenesisi | 343 – 346 | RRRL → ARRA: Reduces the interaction with FZR1/CDH1. 1 Publication | 4 | |
Mutagenesisi | 349 – 352 | RYRL → AYRA: Reduces the interaction with FZR1/CDH1. 1 Publication | 4 | |
Mutagenesisi | 351 – 354 | RLQL → ALQA: Reduces the interaction with FZR1/CDH1. Abolishes the interaction with FZR1/CDH1; when associated with 310-R--L-313. Loss of ubiquitination and impaired degradation; when associated with 310-R--L-313. 1 Publication | 4 | |
Mutagenesisi | 352 | L → A: Abolishes the interaction with CP110 and RRM2; when associated with A-309. 2 Publications | 1 | |
Mutagenesisi | 767 – 770 | RINL → AINA: Reduces the interaction with FZR1/CDH1. 1 Publication | 4 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 899 |
MalaCardsi | CCNF |
MIMi | 619141, phenotype |
OpenTargetsi | ENSG00000162063 |
Orphaneti | 803, Amyotrophic lateral sclerosis |
PharmGKBi | PA26156 |
Miscellaneous databases
Pharosi | P41002, Tbio |
Genetic variation databases
BioMutai | CCNF |
DMDMi | 20178283 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080463 | 1 – 786 | Cyclin-FAdd BLAST | 786 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P41002 |
MassIVEi | P41002 |
MaxQBi | P41002 |
PaxDbi | P41002 |
PeptideAtlasi | P41002 |
PRIDEi | P41002 |
ProteomicsDBi | 55398 |
PTM databases
iPTMneti | P41002 |
PhosphoSitePlusi | P41002 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000162063, Expressed in female gonad and 201 other tissues |
ExpressionAtlasi | P41002, baseline and differential |
Genevisiblei | P41002, HS |
Organism-specific databases
HPAi | ENSG00000162063, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF (PubMed:20596027).
Interacts with SKP1 (PubMed:8706131, PubMed:12122006).
Interacts with CUL1 (PubMed:26818844).
Interacts with CCNB1; interaction is required for nuclear localization of CCNB1 (PubMed:10716937, PubMed:20596027).
Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (PubMed:22441691).
Interacts (via the Cyclin N-terminal domain) with MYBL2/BMYB (PubMed:25557911).
Interacts with FZR1/CDH1 (via N-terminus) (PubMed:27653696).
Interacts with RRM2 (via Cy motif and when phosphorylated at 'Thr-33'); the interaction occurs exclusively in G2 and early M (PubMed:22632967).
Interacts with CDC6 (via Cy motif); the interaction takes place during G2 and M phase (PubMed:26818844).
9 PublicationsBinary interactionsi
P41002
Protein-protein interaction databases
BioGRIDi | 107339, 30 interactors |
CORUMi | P41002 |
DIPi | DIP-44939N |
IntActi | P41002, 6 interactors |
MINTi | P41002 |
STRINGi | 9606.ENSP00000380256 |
Miscellaneous databases
RNActi | P41002, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 76 | F-boxPROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 288 – 405 | Cyclin N-terminalSequence analysisAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 564 – 593 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 582 – 766 | PESTAdd BLAST | 185 | |
Regioni | 675 – 738 | DisorderedSequence analysisAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 20 – 28 | Nuclear localization signal 11 Publication | 9 | |
Motifi | 310 – 313 | D box 11 Publication | 4 | |
Motifi | 343 – 346 | D box 21 Publication | 4 | |
Motifi | 349 – 352 | D box 31 Publication | 4 | |
Motifi | 351 – 354 | D box 41 Publication | 4 | |
Motifi | 568 – 574 | Nuclear localization signal 21 Publication | 7 | |
Motifi | 767 – 770 | D box 51 Publication | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 693 – 736 | Polar residuesSequence analysisAdd BLAST | 44 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00810000125541 |
HOGENOMi | CLU_020348_0_0_1 |
InParanoidi | P41002 |
OMAi | FTWVFIR |
OrthoDBi | 607108at2759 |
PhylomeDBi | P41002 |
TreeFami | TF101006 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit PF00646, F-box, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit SM00256, FBOX, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit PS50181, FBOX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE
60 70 80 90 100
DILAVRAVHS QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF
110 120 130 140 150
EAAVKLGIAY LYNEGLSVSD EARAEVNGLK ASRFFSLAER LNVGAAPFIW
160 170 180 190 200
LFIRPPWSVS GSCCKAVVHE SLRAECQLQR THKASILHCL GRVLSLFEDE
210 220 230 240 250
EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC LHSFRKLRDY
260 270 280 290 300
AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS
310 320 330 340 350
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY
360 370 380 390 400
RLQLLGIACM VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA
410 420 430 440 450
LEGKIRVPTV VDYKEVLLTL VPVELRTQHL CSFLCELSLL HTSLSAYAPA
460 470 480 490 500
RLAAAALLLA RLTHGQTQPW TTQLWDLTGF SYEDLIPCVL SLHKKCFHDD
510 520 530 540 550
APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL GVTQDSPDPP
560 570 580 590 600
TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
610 620 630 640 650
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC
660 670 680 690 700
QESSDEEACP EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS
710 720 730 740 750
GYSSVSTASP TSSVDGGLGA LPQPTSVLSL DSDSHTQPCH HQARKSCLQC
760 770 780
RPPSPPESSV PQQQVKRINL CIHSEEEDMN LGLVRL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BUD3 | H3BUD3_HUMAN | Cyclin-F | CCNF | 186 | Annotation score: | ||
H0Y2P7 | H0Y2P7_HUMAN | Cyclin-F | CCNF | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 252 | A → R in CAA85308 (PubMed:7896286).Curated | 1 | |
Sequence conflicti | 324 | K → N in CAA85308 (PubMed:7896286).Curated | 1 | |
Sequence conflicti | 434 | L → H in BAG36170 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 600 | L → V in CAA85308 (PubMed:7896286).Curated | 1 | |
Sequence conflicti | 662 | D → A in CAA85308 (PubMed:7896286).Curated | 1 | |
Sequence conflicti | 710 | P → S in AAB60342 (PubMed:7813445).Curated | 1 | |
Sequence conflicti | 731 | D → H in CAA85308 (PubMed:7896286).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085177 | 3 | S → G in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs944306963Ensembl. | 1 | |
Natural variantiVAR_085178 | 97 | K → R in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1465313712EnsemblClinVar. | 1 | |
Natural variantiVAR_085179 | 181 | T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745821656Ensembl. | 1 | |
Natural variantiVAR_085180 | 195 | S → R in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs1371569927EnsemblClinVar. | 1 | |
Natural variantiVAR_085181 | 392 | R → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs954539468EnsemblClinVar. | 1 | |
Natural variantiVAR_085182 | 509 | S → P in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs760953006Ensembl. | 1 | |
Natural variantiVAR_085183 | 543 | T → I in FTDALS5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756914411Ensembl. | 1 | |
Natural variantiVAR_085184 | 621 | S → G in FTDALS5; increased 'Lys-48'-linked polyubiquitination of proteins targeted for proteasomal degradation, but no increase in 'Lys-63'-linked polyubiquitinated proteins; accumulation of ubiquitinated proteins including RRM2 and TARDBP/TDP43; impaired autophagosome-lysosome fusion; impaired degradation by the ubiquitin proteasome system (UPS); increased levels of ubiquitinated autophagy receptor SQSTM1/p62. 2 PublicationsCorresponds to variant dbSNP:rs778264897EnsemblClinVar. | 1 | |
Natural variantiVAR_085185 | 624 | E → K in FTDALS5; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs771621178EnsemblClinVar. | 1 | |
Natural variantiVAR_085186 | 772 | I → T in FTDALS5; unknown pathological significance; impaired degradation by the ubiquitin proteasome system (UPS). 1 PublicationCorresponds to variant dbSNP:rs762663630Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17105 mRNA Translation: AAB60342.1 Z36714 mRNA Translation: CAA85308.1 AK313371 mRNA Translation: BAG36170.1 AC106820 Genomic DNA No translation available. BC012349 mRNA Translation: AAH12349.1 |
CCDSi | CCDS10467.1 |
PIRi | A55501 |
RefSeqi | NP_001752.2, NM_001761.2 |
Genome annotation databases
Ensembli | ENST00000397066; ENSP00000380256; ENSG00000162063 |
GeneIDi | 899 |
KEGGi | hsa:899 |
MANE-Selecti | ENST00000397066.9; ENSP00000380256.4; NM_001761.3; NP_001752.2 |
UCSCi | uc002cqd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17105 mRNA Translation: AAB60342.1 Z36714 mRNA Translation: CAA85308.1 AK313371 mRNA Translation: BAG36170.1 AC106820 Genomic DNA No translation available. BC012349 mRNA Translation: AAH12349.1 |
CCDSi | CCDS10467.1 |
PIRi | A55501 |
RefSeqi | NP_001752.2, NM_001761.2 |
3D structure databases
SMRi | P41002 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107339, 30 interactors |
CORUMi | P41002 |
DIPi | DIP-44939N |
IntActi | P41002, 6 interactors |
MINTi | P41002 |
STRINGi | 9606.ENSP00000380256 |
PTM databases
iPTMneti | P41002 |
PhosphoSitePlusi | P41002 |
Genetic variation databases
BioMutai | CCNF |
DMDMi | 20178283 |
Proteomic databases
jPOSTi | P41002 |
MassIVEi | P41002 |
MaxQBi | P41002 |
PaxDbi | P41002 |
PeptideAtlasi | P41002 |
PRIDEi | P41002 |
ProteomicsDBi | 55398 |
Protocols and materials databases
Antibodypediai | 10421, 224 antibodies from 32 providers |
DNASUi | 899 |
Genome annotation databases
Ensembli | ENST00000397066; ENSP00000380256; ENSG00000162063 |
GeneIDi | 899 |
KEGGi | hsa:899 |
MANE-Selecti | ENST00000397066.9; ENSP00000380256.4; NM_001761.3; NP_001752.2 |
UCSCi | uc002cqd.2, human |
Organism-specific databases
CTDi | 899 |
DisGeNETi | 899 |
GeneCardsi | CCNF |
HGNCi | HGNC:1591, CCNF |
HPAi | ENSG00000162063, Tissue enhanced (lymphoid) |
MalaCardsi | CCNF |
MIMi | 600227, gene 619141, phenotype |
neXtProti | NX_P41002 |
OpenTargetsi | ENSG00000162063 |
Orphaneti | 803, Amyotrophic lateral sclerosis |
PharmGKBi | PA26156 |
VEuPathDBi | HostDB:ENSG00000162063 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00810000125541 |
HOGENOMi | CLU_020348_0_0_1 |
InParanoidi | P41002 |
OMAi | FTWVFIR |
OrthoDBi | 607108at2759 |
PhylomeDBi | P41002 |
TreeFami | TF101006 |
Enzyme and pathway databases
PathwayCommonsi | P41002 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | P41002 |
SIGNORi | P41002 |
Miscellaneous databases
BioGRID-ORCSi | 899, 64 hits in 1109 CRISPR screens |
ChiTaRSi | CCNF, human |
GeneWikii | CCNF |
GenomeRNAii | 899 |
Pharosi | P41002, Tbio |
PROi | PR:P41002 |
RNActi | P41002, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162063, Expressed in female gonad and 201 other tissues |
ExpressionAtlasi | P41002, baseline and differential |
Genevisiblei | P41002, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit PF00646, F-box, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit SM00256, FBOX, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit PS50181, FBOX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNF_HUMAN | |
Accessioni | P41002Primary (citable) accession number: P41002 Secondary accession number(s): B2R8H3, Q96EG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | April 16, 2002 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families