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Entry version 156 (02 Dec 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Chromosome instability protein 1

Gene

CIN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for microtubule stability. Interacts with CIN4.

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • microtubule cytoskeleton organization Source: GO_Central
  • post-chaperonin tubulin folding pathway Source: InterPro
  • protein folding Source: SGD
  • tubulin complex assembly Source: SGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromosome instability protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CIN1
Ordered Locus Names:YOR349W
ORF Names:O6350
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
FungiDB:YOR349W

Saccharomyces Genome Database

More...
SGDi
S000005876, CIN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897611 – 1014Chromosome instability protein 1Add BLAST1014

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40987

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40987

PRoteomics IDEntifications database

More...
PRIDEi
P40987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34734, 226 interactors

Database of interacting proteins

More...
DIPi
DIP-5809N

Protein interaction database and analysis system

More...
IntActi
P40987, 2 interactors

Molecular INTeraction database

More...
MINTi
P40987

STRING: functional protein association networks

More...
STRINGi
4932.YOR349W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40987, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1943, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_288698_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40987

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVFAKFY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033162, TBCD

The PANTHER Classification System

More...
PANTHERi
PTHR12658, PTHR12658, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNIRALLDS IQSGVQTVSP EKHQQTIAAI NKFQDDPALL DTILPRCVPL
60 70 80 90 100
LTKSFFCMSQ RDQKLVAELF YNLDKISHSK VLKSLDTSIF RLNEILNYLQ
110 120 130 140 150
DRASPSSFSD VLCVYLNLSW LSVILLSPYA FKDKFNKTLQ VSSRFENYPI
160 170 180 190 200
CIPPINKIKA VLYFKNFTDA FDQLPEREQA NVPFLNQFLK LFIQSSEKAN
210 220 230 240 250
YYFSNENLRH LQQVALSNDG IKLLPKLFQI SFNHGSHDIL DAIVEFFHDH
260 270 280 290 300
LSSNSTDTRF QLAHSFAKIA KFLHQADPAS FIELIDYTIE NTVSLLQAPC
310 320 330 340 350
DSIDSNELHT SLLIIAEVAL AKILPIDLVD RVLTLIIPKT CHFQKSHFQI
360 370 380 390 400
IKGHHIRDST NFIIWSVIRS NRSNSLSPQV LQSLLSHLLI NAFFDPELII
410 420 430 440 450
RYSSFAALQE LLGRSNKSLA LNQNDIALIL QANWKDLPRS FEENSGLIRR
460 470 480 490 500
LFNPENTSKS AVCVWKVFRD WSFNWNLLEN LHLTTMKLNI DYNLVPLIKS
510 520 530 540 550
KLSSPALLQE VLNKAGSSVT QNCQILYLYL KLFENDVNCP KISEICIDIY
560 570 580 590 600
QKKIKFQLTT QAKRQFNDNS PELFQIFVIL KYWQLTGQND FNQELFWKFV
610 620 630 640 650
DIVSPQKKLN LYNEFIPIIQ QIISQCVSLN YTRIVQLIKS DNELTCRSIC
660 670 680 690 700
HMPDQEKMCS LFFSQFPLLS PQSRSLLIGE LDHHWDVRIS LLPSNSYRKF
710 720 730 740 750
RNIIINCLDD YTITQQGDVG RLVRIQALKL MQSHPDFLSG DCDSINPKLT
760 770 780 790 800
RLLAEPVPEI RKLSYQLLAS ATSQITVLSD SSILNFRHKQ GLSEEFWKGY
810 820 830 840 850
AVSAGAIHFT DSQLTSSIDS FIVYYRSLSP SQQLELCHDL IRIIPSAKQI
860 870 880 890 900
AESRIRDRNK DPLTGGMRFD TIKFTIHCVK FWTRIMESGL VVLHPNFNFQ
910 920 930 940 950
GVFAKFYNLH LLDCTTLRVS VIKFFPFLAI SCYHTMRENA DQKNLSNIIL
960 970 980 990 1000
KRLLVLVKRE YAATKSKFMT DQNVALQGMF QIFLELGVTR QLQALQVACQ
1010
KHELANILES DITL
Length:1,014
Mass (Da):116,648
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0BE6141869F9EA5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46420 Genomic DNA Translation: CAA86556.1
X95720 Genomic DNA Translation: CAA65036.1
Z75257 Genomic DNA Translation: CAA99677.1
Z75258 Genomic DNA Translation: CAA99679.1
BK006948 Genomic DNA Translation: DAA11110.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48235

NCBI Reference Sequences

More...
RefSeqi
NP_014994.3, NM_001183769.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR349W_mRNA; YOR349W; YOR349W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR349W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46420 Genomic DNA Translation: CAA86556.1
X95720 Genomic DNA Translation: CAA65036.1
Z75257 Genomic DNA Translation: CAA99677.1
Z75258 Genomic DNA Translation: CAA99679.1
BK006948 Genomic DNA Translation: DAA11110.1
PIRiS48235
RefSeqiNP_014994.3, NM_001183769.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34734, 226 interactors
DIPiDIP-5809N
IntActiP40987, 2 interactors
MINTiP40987
STRINGi4932.YOR349W

PTM databases

iPTMnetiP40987

Proteomic databases

MaxQBiP40987
PaxDbiP40987
PRIDEiP40987

Genome annotation databases

EnsemblFungiiYOR349W_mRNA; YOR349W; YOR349W
GeneIDi854531
KEGGisce:YOR349W

Organism-specific databases

EuPathDBiFungiDB:YOR349W
SGDiS000005876, CIN1

Phylogenomic databases

eggNOGiKOG1943, Eukaryota
HOGENOMiCLU_288698_0_0_1
InParanoidiP40987
OMAiGVFAKFY

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40987
RNActiP40987, protein

Family and domain databases

InterProiView protein in InterPro
IPR033162, TBCD
PANTHERiPTHR12658, PTHR12658, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIN1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40987
Secondary accession number(s): D6W344
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 2, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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