UniProtKB - P40984 (UBC9_SCHPO)
Protein
SUMO-conjugating enzyme ubc9
Gene
hus5
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process.2 Publications
: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 93 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- SUMO activating enzyme activity Source: PomBase
- SUMO conjugating enzyme activity Source: PomBase
GO - Biological processi
- DNA repair Source: PomBase
- protein sumoylation Source: PomBase
- regulation of mitotic chromosome condensation Source: PomBase
Keywordsi
Molecular function | Transferase |
Biological process | DNA damage, Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-3108214, SUMOylation of DNA damage response and repair proteins R-SPO-3108232, SUMO E3 ligases SUMOylate target proteins R-SPO-3232118, SUMOylation of transcription factors R-SPO-3899300, SUMOylation of transcription cofactors R-SPO-4085377, SUMOylation of SUMOylation proteins R-SPO-4551638, SUMOylation of chromatin organization proteins R-SPO-4570464, SUMOylation of RNA binding proteins R-SPO-4615885, SUMOylation of DNA replication proteins R-SPO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation |
UniPathwayi | UPA00886 |
Names & Taxonomyi
Protein namesi | Recommended name: SUMO-conjugating enzyme ubc9 (EC:2.3.2.-)Alternative name(s): Ubiquitin carrier protein 9 Ubiquitin carrier protein hus5 Ubiquitin-conjugating enzyme E2-18 kDa |
Gene namesi | Name:hus5 Synonyms:ubc9 ORF Names:SPAC30D11.13 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC30D11.13 |
PomBasei | SPAC30D11.13, hus5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: PomBase
Nucleus
- nuclear heterochromatin Source: PomBase
- nucleus Source: PomBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082568 | 1 – 157 | SUMO-conjugating enzyme ubc9Add BLAST | 157 |
Proteomic databases
MaxQBi | P40984 |
PaxDbi | P40984 |
Interactioni
Binary interactionsi
P40984
With | #Exp. | IntAct |
---|---|---|
rad60 [Q9USX3] | 2 | EBI-966468,EBI-3650521 |
Protein-protein interaction databases
BioGRIDi | 278671, 15 interactors |
DIPi | DIP-35488N |
IntActi | P40984, 4 interactors |
STRINGi | 4896.SPAC30D11.13.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P40984 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 157 | UBC corePROSITE-ProRule annotationAdd BLAST | 154 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0424, Eukaryota |
HOGENOMi | CLU_030988_12_0_1 |
InParanoidi | P40984 |
OMAi | QEPAWRA |
PhylomeDBi | P40984 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR027230, Ubc9 IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
PANTHERi | PTHR24067:SF248, PTHR24067:SF248, 1 hit |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P40984-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSLCKTRLQ EERKQWRRDH PFGFYAKPCK SSDGGLDLMN WKVGIPGKPK
60 70 80 90 100
TSWEGGLYKL TMAFPEEYPT RPPKCRFTPP LFHPNVYPSG TVCLSILNEE
110 120 130 140 150
EGWKPAITIK QILLGIQDLL DDPNIASPAQ TEAYTMFKKD KVEYEKRVRA
QARENAP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81846 Genomic DNA Translation: CAA57438.1 CU329670 Genomic DNA Translation: CAA91899.1 |
PIRi | S62571 |
RefSeqi | NP_593204.1, NM_001018600.2 |
Genome annotation databases
EnsemblFungii | SPAC30D11.13.1; SPAC30D11.13.1:pep; SPAC30D11.13 |
GeneIDi | 2542196 |
KEGGi | spo:SPAC30D11.13 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81846 Genomic DNA Translation: CAA57438.1 CU329670 Genomic DNA Translation: CAA91899.1 |
PIRi | S62571 |
RefSeqi | NP_593204.1, NM_001018600.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3RCZ | X-ray | 1.90 | B | 2-157 | [»] | |
SMRi | P40984 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 278671, 15 interactors |
DIPi | DIP-35488N |
IntActi | P40984, 4 interactors |
STRINGi | 4896.SPAC30D11.13.1 |
Proteomic databases
MaxQBi | P40984 |
PaxDbi | P40984 |
Genome annotation databases
EnsemblFungii | SPAC30D11.13.1; SPAC30D11.13.1:pep; SPAC30D11.13 |
GeneIDi | 2542196 |
KEGGi | spo:SPAC30D11.13 |
Organism-specific databases
EuPathDBi | FungiDB:SPAC30D11.13 |
PomBasei | SPAC30D11.13, hus5 |
Phylogenomic databases
eggNOGi | KOG0424, Eukaryota |
HOGENOMi | CLU_030988_12_0_1 |
InParanoidi | P40984 |
OMAi | QEPAWRA |
PhylomeDBi | P40984 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
Reactomei | R-SPO-3108214, SUMOylation of DNA damage response and repair proteins R-SPO-3108232, SUMO E3 ligases SUMOylate target proteins R-SPO-3232118, SUMOylation of transcription factors R-SPO-3899300, SUMOylation of transcription cofactors R-SPO-4085377, SUMOylation of SUMOylation proteins R-SPO-4551638, SUMOylation of chromatin organization proteins R-SPO-4570464, SUMOylation of RNA binding proteins R-SPO-4615885, SUMOylation of DNA replication proteins R-SPO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Miscellaneous databases
PROi | PR:P40984 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR027230, Ubc9 IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
PANTHERi | PTHR24067:SF248, PTHR24067:SF248, 1 hit |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBC9_SCHPO | |
Accessioni | P40984Primary (citable) accession number: P40984 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families