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Protein

Pre-mRNA-processing factor 17

Gene

CDC40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the second step of pre-mRNA splicing. Regulatory protein involved in replication and mitotic spindle formation and/or maintenance. Required for initiation and completion of S-phase and for initiation and completion of DNA replication. Might be required for the maintenance of microtubules. Essential only at elevated temperatures.

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • generation of catalytic spliceosome for second transesterification step Source: SGD
  • mRNA 3'-splice site recognition Source: SGD
  • mRNA branch site recognition Source: SGD

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-29914-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 17
Alternative name(s):
Cell division control protein 40
Gene namesi
Name:CDC40
Synonyms:PRP17, SLU4, XRS2
Ordered Locus Names:YDR364C
ORF Names:D9481.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR364C
SGDiS000002772 CDC40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511441 – 455Pre-mRNA-processing factor 17Add BLAST455

Proteomic databases

MaxQBiP40968
PaxDbiP40968
PRIDEiP40968

PTM databases

iPTMnetiP40968

Interactioni

Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP19P325237EBI-13834,EBI-493

Protein-protein interaction databases

BioGridi32421, 163 interactors
ComplexPortaliCPX-1651 PRP19-associated complex
DIPiDIP-1111N
IntActiP40968, 7 interactors
MINTiP40968
STRINGi4932.YDR364C

Structurei

Secondary structure

1455
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP40968
SMRiP40968
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati160 – 200WD 1Add BLAST41
Repeati204 – 243WD 2Add BLAST40
Repeati291 – 330WD 3Add BLAST40
Repeati334 – 373WD 4Add BLAST40
Repeati379 – 422WD 5Add BLAST44
Repeati424 – 454WD 6Add BLAST31

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00530000063583
HOGENOMiHOG000214672
InParanoidiP40968
KOiK12816
OMAiDIREKKH
OrthoDBiEOG092C2BKC

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR032847 PRPF17
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR43979 PTHR43979, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P40968-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLVDGYDTS SDSDLNFDEG KSVHEKKNGN LHEDTSYEPS SNNIHKRKSH
60 70 80 90 100
FTKSELKRRR KTRKGDGPWG SWSSSDDETS QASETQKEDQ DIFVHALAED
110 120 130 140 150
NLDSEQIEVE EVSHFYGKSE KDYQGRGYLY PPNDVDVDLR EERISFRCYL
160 170 180 190 200
PKKVIRNYPG HPEGTTALKF LPKTGHLILS GGNDHTIKIW DFYHDYECLR
210 220 230 240 250
DFQGHNKPIK ALRFTEDCQS FLSSSFDRSV KIWDTETGKV KTRLHLNSTP
260 270 280 290 300
ADVESRPTNP HEFIVGLSNS KILHYDDRVS ENQGLVQTYD HHLSSILALK
310 320 330 340 350
YFPDGSKFIS SSEDKTVRIW ENQINVPIKQ ISDTAQHSMP FLNVHPSQNY
360 370 380 390 400
FCAQSMDNRI YSFSLKPKYK RHPKKIFKGH SSAGYGISLA FSGDGRYICS
410 420 430 440 450
GDSKSRLFTW DWNTSRLLNN IKIPGNKPIT QVDWHPQETS KVICSGAAGK

IYVCD
Length:455
Mass (Da):52,048
Last modified:July 15, 1998 - v2
Checksum:i40AED5DB35319147
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti390A → T in AAA86875 (PubMed:7753021).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17018 Genomic DNA Translation: AAA86875.1
U28373 Genomic DNA Translation: AAB64800.1
BK006938 Genomic DNA Translation: DAA12203.1
PIRiS61159
RefSeqiNP_010652.3, NM_001180672.3

Genome annotation databases

EnsemblFungiiYDR364C; YDR364C; YDR364C
GeneIDi851968
KEGGisce:YDR364C

Similar proteinsi

Entry informationi

Entry nameiPRP17_YEAST
AccessioniPrimary (citable) accession number: P40968
Secondary accession number(s): D6VSZ3, Q06341
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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