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UniProtKB - P40955 (CHS6_YEAST)
Protein
Chitin biosynthesis protein CHS6
Gene
CHS6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
7 PublicationsMiscellaneous
Present with 1180 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- fungal-type cell wall chitin biosynthetic process Source: SGD
- Golgi to plasma membrane transport Source: SGD
- protein transport Source: ComplexPortal
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Chitin biosynthesis protein CHS6Alternative name(s): Protein CSD3 |
Gene namesi | Name:CHS6 Synonyms:CSD3 Ordered Locus Names:YJL099W ORF Names:J0838 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003635, CHS6 |
VEuPathDBi | FungiDB:YJL099W |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane 4 Publications; Peripheral membrane protein 4 Publications
Note: Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Cytosol
- cytosol Source: SGD
Golgi apparatus
- exomer complex Source: SGD
Other locations
- membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
Abolishes CHS3 localization to the bud neck and plasma membrane, with increased protein localization to the trans-Golgi cisternae.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089662 | 1 – 746 | Chitin biosynthesis protein CHS6Add BLAST | 746 |
Proteomic databases
MaxQBi | P40955 |
PaxDbi | P40955 |
PRIDEi | P40955 |
PTM databases
iPTMneti | P40955 |
Interactioni
Subunit structurei
Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2, BUD7, and CHS6 as well as at least CHS5 and GTP-bound ARF1. The complex interacts with the cargo protein CHS3.
3 PublicationsBinary interactionsi
P40955
With | #Exp. | IntAct |
---|---|---|
ARF1 [P11076] | 3 | EBI-4649,EBI-2816 |
BCH1 [Q05029] | 5 | EBI-4649,EBI-27508 |
BUD7 [Q08754] | 2 | EBI-4649,EBI-32770 |
CHS5 [Q12114] | 17 | EBI-4649,EBI-4640 |
Protein-protein interaction databases
BioGRIDi | 33658, 231 interactors |
ComplexPortali | CPX-1719, Exomer complex |
DIPi | DIP-5682N |
IntActi | P40955, 12 interactors |
MINTi | P40955 |
STRINGi | 4932.YJL099W |
Miscellaneous databases
RNActi | P40955, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P40955 |
SMRi | P40955 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 734 – 746 | CHS5-bindingAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the CHAPS family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRF3, Eukaryota |
GeneTreei | ENSGT00940000176338 |
HOGENOMi | CLU_019711_0_0_1 |
InParanoidi | P40955 |
OMAi | CKFLPRC |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR015374, ChAPs IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR31975, PTHR31975, 1 hit |
Pfami | View protein in Pfam PF09295, ChAPs, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
P40955-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLFWPSETK KQNEIPGGDY TPGNSPSVQK GYQFLNRDIF KSCPRIMERQ
60 70 80 90 100
FGECLHNRTH LIKDLISSGN VGLGPIEIVH MSYLNKHEKE EFGEYFYVTG
110 120 130 140 150
IEVSGPAMPV EFLEVLKSSK RISKNISNNI ILTYCCFNFF SNLDIRIRYD
160 170 180 190 200
ADDTFQTTAI DCNKETTDLT MTEKMWEETF ASSVIRAIIT NTNPELKPPG
210 220 230 240 250
LVECPFYVGK DTISSCKKII ELLCRFLPRS LNCGWDSTKS MQATIVNNYL
260 270 280 290 300
MYSLKSFIAI TPSLVDFTID YLKGLTKKDP IHDIYYKTAM ITILDHIETK
310 320 330 340 350
ELDMITILNE TLDPLLSLLN DLPPRDADSA RLMNCMSDLL NIQTNFLLNR
360 370 380 390 400
GDYELALGVS NTSTELALDS FESWYNLARC HIKKEEYEKA LFAINSMPRL
410 420 430 440 450
RKNDGHLETM YSRFLTSNYY KKPLNGTREH YDLTAMEFTN LSGTLRNWKE
460 470 480 490 500
DELKRQIFGR IAMINEKKIG YTKEIWDDIA IKLGPICGPQ SVNLINYVSP
510 520 530 540 550
QEVKNIKNIN LIARNTIGKQ LGWFSGKIYG LLMEIVNKIG WNGLLNIRTE
560 570 580 590 600
AFMMETEFYQ ASNNIIDENG HIPMESRKKR FCEGWLDDLF LDLYQDLKLS
610 620 630 640 650
KISLSNKDEK HSGLEWELLG LIMLRTWHWE DAVACLRTSI VARFDPVSCQ
660 670 680 690 700
QLLKIYLQPP KNIQEVTLLD TDTIISLLIK KISYDCRYYN YCQIFNLQLL
710 720 730 740
EKLCNELGTH ILRNKILLQP SIGDEIMVMI DAMLAWIADL DHTVQP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15603 Genomic DNA Translation: AAA50840.1 X85021 Genomic DNA Translation: CAA59395.1 Z49374 Genomic DNA Translation: CAA89394.1 Z49373 Genomic DNA Translation: CAA89393.1 BK006943 Genomic DNA Translation: DAA08701.1 |
PIRi | S50226 |
RefSeqi | NP_012436.1, NM_001181532.1 |
Genome annotation databases
EnsemblFungii | YJL099W_mRNA; YJL099W; YJL099W |
GeneIDi | 853346 |
KEGGi | sce:YJL099W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15603 Genomic DNA Translation: AAA50840.1 X85021 Genomic DNA Translation: CAA59395.1 Z49374 Genomic DNA Translation: CAA89394.1 Z49373 Genomic DNA Translation: CAA89393.1 BK006943 Genomic DNA Translation: DAA08701.1 |
PIRi | S50226 |
RefSeqi | NP_012436.1, NM_001181532.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4WJW | X-ray | 2.59 | B | 1-746 | [»] | |
4YG8 | X-ray | 2.75 | B | 1-746 | [»] | |
AlphaFoldDBi | P40955 | |||||
SMRi | P40955 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33658, 231 interactors |
ComplexPortali | CPX-1719, Exomer complex |
DIPi | DIP-5682N |
IntActi | P40955, 12 interactors |
MINTi | P40955 |
STRINGi | 4932.YJL099W |
PTM databases
iPTMneti | P40955 |
Proteomic databases
MaxQBi | P40955 |
PaxDbi | P40955 |
PRIDEi | P40955 |
Genome annotation databases
EnsemblFungii | YJL099W_mRNA; YJL099W; YJL099W |
GeneIDi | 853346 |
KEGGi | sce:YJL099W |
Organism-specific databases
SGDi | S000003635, CHS6 |
VEuPathDBi | FungiDB:YJL099W |
Phylogenomic databases
eggNOGi | ENOG502QRF3, Eukaryota |
GeneTreei | ENSGT00940000176338 |
HOGENOMi | CLU_019711_0_0_1 |
InParanoidi | P40955 |
OMAi | CKFLPRC |
Miscellaneous databases
PROi | PR:P40955 |
RNActi | P40955, protein |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR015374, ChAPs IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR31975, PTHR31975, 1 hit |
Pfami | View protein in Pfam PF09295, ChAPs, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50293, TPR_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHS6_YEAST | |
Accessioni | P40955Primary (citable) accession number: P40955 Secondary accession number(s): D6VW85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families