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Protein

ADP-ribosylation factor 2

Gene

Arf102F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: FlyBase

GO - Biological processi

  • compound eye development Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein ADP-ribosylation Source: FlyBase
  • protein transport Source: UniProtKB-KW
  • synaptic vesicle endocytosis Source: FlyBase

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-5620916 VxPx cargo-targeting to cilium
R-DME-6807878 COPI-mediated anterograde transport
R-DME-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 2
Alternative name(s):
dARF II
Gene namesi
Name:Arf102F
Synonyms:ARF2
ORF Names:CG11027
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0013749 Arf102F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074432 – 180ADP-ribosylation factor 2Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP40945
PRIDEiP40945

Expressioni

Tissue specificityi

Uniformly distributed throughout adults.1 Publication

Gene expression databases

BgeeiFBgn0013749
ExpressionAtlasiP40945 baseline and differential
GenevisibleiP40945 DM

Interactioni

Protein-protein interaction databases

BioGridi68649, 28 interactors
DIPiDIP-17574N
IntActiP40945, 6 interactors
STRINGi7227.FBpp0088256

Structurei

3D structure databases

ProteinModelPortaliP40945
SMRiP40945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
InParanoidiP40945
KOiK07977
OMAiMVQEDEL
OrthoDBiEOG091G0S7S
PhylomeDBiP40945

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTISSLLT RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRDRI
110 120 130 140 150
TEAERELQNM LQEDELRDAV LLVFANKQDL PNAMTAAELT DKLRLNQLRN
160 170 180
RHWFIQSTCA TQGHGLYEGL DWLSAELAKK
Length:180
Mass (Da):20,617
Last modified:January 23, 2007 - v2
Checksum:iEED5B56F55BB728F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25062 Genomic DNA Translation: AAA53667.1
AE014135 Genomic DNA Translation: AAF59383.1
AY071450 mRNA Translation: AAL49072.1
PIRiA53859
RefSeqiNP_001259087.1, NM_001272158.1
NP_524631.1, NM_079892.3
UniGeneiDm.1888

Genome annotation databases

EnsemblMetazoaiFBtr0089192; FBpp0088256; FBgn0013749
FBtr0333699; FBpp0305852; FBgn0013749
GeneIDi43823
KEGGidme:Dmel_CG11027

Similar proteinsi

Entry informationi

Entry nameiARF2_DROME
AccessioniPrimary (citable) accession number: P40945
Secondary accession number(s): Q9V499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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