Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP,ATP carrier protein 2, mitochondrial

Gene

AAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157ADPBy similarity1
Binding sitei169ADPBy similarity1
Binding sitei315ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR
  • copper ion binding Source: TAIR

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2, mitochondrial
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Gene namesi
Name:AAC2
Synonyms:ANT2
Ordered Locus Names:At5g13490
ORF Names:T6I14_20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G13490
TAIRilocus:2185041 AT5G13490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 111Helical; Name=1By similarityAdd BLAST28
Transmembranei152 – 176Helical; Name=2By similarityAdd BLAST25
Transmembranei185 – 205Helical; Name=3By similarityAdd BLAST21
Transmembranei256 – 277Helical; Name=4By similarityAdd BLAST22
Transmembranei291 – 311Helical; Name=5By similarityAdd BLAST21
Transmembranei351 – 371Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 74MitochondrionSequence analysisAdd BLAST74
ChainiPRO_000001924675 – 385ADP,ATP carrier protein 2, mitochondrialAdd BLAST311

Proteomic databases

PaxDbiP40941
PRIDEiP40941

PTM databases

SwissPalmiP40941

Expressioni

Gene expression databases

ExpressionAtlasiP40941 baseline and differential
GenevisibleiP40941 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi16471, 6 interactors
IntActiP40941, 2 interactors
STRINGi3702.AT5G13490.1

Structurei

3D structure databases

ProteinModelPortaliP40941
SMRiP40941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati82 – 175Solcar 1Add BLAST94
Repeati187 – 280Solcar 2Add BLAST94
Repeati288 – 374Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni315 – 320Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi315 – 320Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
InParanoidiP40941
KOiK05863
OMAiQHASKTI
OrthoDBiEOG09360DZB
PhylomeDBiP40941

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEQTQHPTI LQKVSGQLLS SSVSQDIRGY ASASKRPATY QKHAAYGNYS
60 70 80 90 100
NAAFQYPLVA ASQIATTTSP VFVQAPGEKG FTNFAIDFMM GGVSAAVSKT
110 120 130 140 150
AAAPIERVKL LIQNQDEMLK AGRLTEPYKG IRDCFGRTIR DEGIGSLWRG
160 170 180 190 200
NTANVIRYFP TQALNFAFKD YFKRLFNFKK DKDGYWKWFA GNLASGGAAG
210 220 230 240 250
ASSLLFVYSL DYARTRLAND SKSAKKGGGE RQFNGLVDVY KKTLKSDGIA
260 270 280 290 300
GLYRGFNISC AGIIVYRGLY FGLYDSVKPV LLTGDLQDSF FASFALGWLI
310 320 330 340 350
TNGAGLASYP IDTVRRRMMM TSGEAVKYKS SFDAFSQIVK KEGAKSLFKG
360 370 380
AGANILRAVA GAGVLAGYDK LQLIVFGKKY GSGGA
Length:385
Mass (Da):41,746
Last modified:June 6, 2002 - v2
Checksum:i87ADF762213207BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228G → R in CAA48579 (PubMed:8439563).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68592 mRNA Translation: CAA48579.1
AL391710 Genomic DNA Translation: CAC05426.1
CP002688 Genomic DNA Translation: AED91901.1
CP002688 Genomic DNA Translation: AED91902.1
AY050857 mRNA Translation: AAK92794.1
AY079407 mRNA Translation: AAL85138.1
PIRiS29852
RefSeqiNP_001031876.1, NM_001036799.2
NP_196853.1, NM_121352.4
UniGeneiAt.127

Genome annotation databases

EnsemblPlantsiAT5G13490.1; AT5G13490.1; AT5G13490
AT5G13490.2; AT5G13490.2; AT5G13490
GeneIDi831193
GrameneiAT5G13490.1; AT5G13490.1; AT5G13490
AT5G13490.2; AT5G13490.2; AT5G13490
KEGGiath:AT5G13490

Similar proteinsi

Entry informationi

Entry nameiADT2_ARATH
AccessioniPrimary (citable) accession number: P40941
Secondary accession number(s): Q9FY52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 6, 2002
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health