UniProtKB - P40933 (IL15_HUMAN)
Protein
Interleukin-15
Gene
IL15
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).2 Publications
GO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: InterPro
GO - Biological processi
- aging Source: Ensembl
- cell-cell signaling Source: ProtInc
- cell maturation Source: Ensembl
- cellular response to vitamin D Source: Ensembl
- extrathymic T cell selection Source: Ensembl
- hyaluronan metabolic process Source: Ensembl
- immune response Source: ProtInc
- inflammatory response Source: Ensembl
- interleukin-15-mediated signaling pathway Source: UniProtKB
- lymph node development Source: Ensembl
- macrophage differentiation Source: ARUK-UCL
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- neutrophil activation Source: UniProtKB
- NK T cell proliferation Source: Ensembl
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of cytokine production Source: GO_Central
- positive regulation of immune response Source: GO_Central
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of interleukin-17 production Source: BHF-UCL
- positive regulation of natural killer cell differentiation Source: Ensembl
- positive regulation of natural killer cell proliferation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of protein O-linked glycosylation Source: Ensembl
- positive regulation of T cell proliferation Source: GO_Central
- positive regulation of tissue remodeling Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
- regulation of defense response to virus by host Source: Ensembl
- regulation of T cell differentiation Source: Ensembl
- signal transduction Source: ProtInc
- skeletal muscle atrophy Source: Ensembl
- tyrosine phosphorylation of STAT protein Source: CACAO
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | P40933 |
Reactomei | R-HSA-8983432, Interleukin-15 signaling |
SignaLinki | P40933 |
SIGNORi | P40933 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-15Short name: IL-15 |
Gene namesi | Name:IL15 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5977, IL15 |
MIMi | 600554, gene |
neXtProti | NX_P40933 |
VEuPathDBi | HostDB:ENSG00000164136.16 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: HPA
Endosome
- endosome Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: ProtInc
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Other locations
- cell surface Source: Ensembl
- cytoplasm Source: ProtInc
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3600 |
OpenTargetsi | ENSG00000164136 |
PharmGKBi | PA29790 |
Miscellaneous databases
Pharosi | P40933, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712954 |
DrugBanki | DB01327, Cefazolin |
Genetic variation databases
BioMutai | IL15 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
PropeptideiPRO_0000015393 | 30 – 48 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000015394 | 49 – 162 | Interleukin-15Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 83 ↔ 133 | 1 Publication | ||
Disulfide bondi | 90 ↔ 136 | 1 Publication | ||
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P40933 |
PeptideAtlasi | P40933 |
PRIDEi | P40933 |
ProteomicsDBi | 55387 [P40933-1] 55388 [P40933-2] |
PTM databases
GlyGeni | P40933, 1 site |
iPTMneti | P40933 |
PhosphoSitePlusi | P40933 |
Expressioni
Tissue specificityi
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Gene expression databases
Bgeei | ENSG00000164136, Expressed in decidua and 190 other tissues |
Genevisiblei | P40933, HS |
Organism-specific databases
HPAi | ENSG00000164136, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 109813, 10 interactors |
CORUMi | P40933 |
DIPi | DIP-3046N |
IntActi | P40933, 5 interactors |
STRINGi | 9606.ENSP00000296545 |
Chemistry databases
BindingDBi | P40933 |
Miscellaneous databases
RNActi | P40933, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P40933 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P40933 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-15/IL-21 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | P40933 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
PhylomeDBi | P40933 |
TreeFami | TF336199 |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform IL15-S48AA (identifier: P40933-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRISKPHLRS ISIQCYLCLL LNSHFLTEAG IHVFILGCFS AGLPKTEANW
60 70 80 90 100
VNVISDLKKI EDLIQSMHID ATLYTESDVH PSCKVTAMKC FLLELQVISL
110 120 130 140 150
ESGDASIHDT VENLIILANN SLSSNGNVTE SGCKECEELE EKNIKEFLQS
160
FVHIVQMFIN TS
Isoform IL15-S21AA (identifier: P40933-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-37: MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILG → MVLGTIDLCS
Sequence cautioni
The sequence CAA71044 differs from that shown. Man-made cDNA with a signal peptide sequence to increase protein secretion (substitution with a signal peptide derived from the mouse IgV kappa chain).Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 | E → K in AAB97518 (PubMed:9405632).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002660 | 1 – 37 | MRISK…VFILG → MVLGTIDLCS in isoform IL15-S21AA. 6 PublicationsAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14407 mRNA Translation: AAA21551.1 X91233 Genomic DNA Translation: CAA62616.1 X94223 mRNA Translation: CAA63914.1 X94222 mRNA Translation: CAA63913.1 AF031167 mRNA Translation: AAB97518.1 Y09908 mRNA Translation: CAA71044.1 Sequence problems. AY720442 mRNA Translation: AAU21241.1 AK122993 mRNA Translation: BAG53839.1 AK290619 mRNA Translation: BAF83308.1 CR541980 mRNA Translation: CAG46777.1 CR542007 mRNA Translation: CAG46804.1 CH471056 Genomic DNA Translation: EAX05083.1 CH471056 Genomic DNA Translation: EAX05084.1 CH471056 Genomic DNA Translation: EAX05085.1 CH471056 Genomic DNA Translation: EAX05086.1 CH471056 Genomic DNA Translation: EAX05087.1 BC018149 mRNA Translation: AAH18149.1 BC100961 mRNA Translation: AAI00962.1 BC100962 mRNA Translation: AAI00963.1 BC100963 mRNA Translation: AAI00964.1 Z38000 mRNA Translation: CAA86100.1 |
CCDSi | CCDS3755.1 [P40933-1] CCDS3756.1 [P40933-2] |
RefSeqi | NP_000576.1, NM_000585.4 [P40933-1] NP_751915.1, NM_172175.2 [P40933-2] |
Genome annotation databases
Ensembli | ENST00000296545; ENSP00000296545; ENSG00000164136 [P40933-1] ENST00000320650; ENSP00000323505; ENSG00000164136 [P40933-1] ENST00000394159; ENSP00000377714; ENSG00000164136 [P40933-2] ENST00000477265; ENSP00000436914; ENSG00000164136 [P40933-2] ENST00000514653; ENSP00000422271; ENSG00000164136 [P40933-2] ENST00000529613; ENSP00000435462; ENSG00000164136 [P40933-1] |
GeneIDi | 3600 |
KEGGi | hsa:3600 |
UCSCi | uc003iis.4, human [P40933-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Interleukin-15 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14407 mRNA Translation: AAA21551.1 X91233 Genomic DNA Translation: CAA62616.1 X94223 mRNA Translation: CAA63914.1 X94222 mRNA Translation: CAA63913.1 AF031167 mRNA Translation: AAB97518.1 Y09908 mRNA Translation: CAA71044.1 Sequence problems. AY720442 mRNA Translation: AAU21241.1 AK122993 mRNA Translation: BAG53839.1 AK290619 mRNA Translation: BAF83308.1 CR541980 mRNA Translation: CAG46777.1 CR542007 mRNA Translation: CAG46804.1 CH471056 Genomic DNA Translation: EAX05083.1 CH471056 Genomic DNA Translation: EAX05084.1 CH471056 Genomic DNA Translation: EAX05085.1 CH471056 Genomic DNA Translation: EAX05086.1 CH471056 Genomic DNA Translation: EAX05087.1 BC018149 mRNA Translation: AAH18149.1 BC100961 mRNA Translation: AAI00962.1 BC100962 mRNA Translation: AAI00963.1 BC100963 mRNA Translation: AAI00964.1 Z38000 mRNA Translation: CAA86100.1 |
CCDSi | CCDS3755.1 [P40933-1] CCDS3756.1 [P40933-2] |
RefSeqi | NP_000576.1, NM_000585.4 [P40933-1] NP_751915.1, NM_172175.2 [P40933-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XQB | X-ray | 2.60 | A | 49-162 | [»] | |
2Z3Q | X-ray | 1.85 | A/C | 49-162 | [»] | |
2Z3R | X-ray | 2.00 | A/C/E/G/I/K/M/O | 49-162 | [»] | |
4GS7 | X-ray | 2.35 | A | 49-162 | [»] | |
SMRi | P40933 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109813, 10 interactors |
CORUMi | P40933 |
DIPi | DIP-3046N |
IntActi | P40933, 5 interactors |
STRINGi | 9606.ENSP00000296545 |
Chemistry databases
BindingDBi | P40933 |
ChEMBLi | CHEMBL3712954 |
DrugBanki | DB01327, Cefazolin |
PTM databases
GlyGeni | P40933, 1 site |
iPTMneti | P40933 |
PhosphoSitePlusi | P40933 |
Genetic variation databases
BioMutai | IL15 |
Proteomic databases
PaxDbi | P40933 |
PeptideAtlasi | P40933 |
PRIDEi | P40933 |
ProteomicsDBi | 55387 [P40933-1] 55388 [P40933-2] |
Protocols and materials databases
ABCDi | P40933, 1 sequenced antibody |
Antibodypediai | 3844, 1083 antibodies |
DNASUi | 3600 |
Genome annotation databases
Ensembli | ENST00000296545; ENSP00000296545; ENSG00000164136 [P40933-1] ENST00000320650; ENSP00000323505; ENSG00000164136 [P40933-1] ENST00000394159; ENSP00000377714; ENSG00000164136 [P40933-2] ENST00000477265; ENSP00000436914; ENSG00000164136 [P40933-2] ENST00000514653; ENSP00000422271; ENSG00000164136 [P40933-2] ENST00000529613; ENSP00000435462; ENSG00000164136 [P40933-1] |
GeneIDi | 3600 |
KEGGi | hsa:3600 |
UCSCi | uc003iis.4, human [P40933-1] |
Organism-specific databases
CTDi | 3600 |
DisGeNETi | 3600 |
GeneCardsi | IL15 |
HGNCi | HGNC:5977, IL15 |
HPAi | ENSG00000164136, Low tissue specificity |
MIMi | 600554, gene |
neXtProti | NX_P40933 |
OpenTargetsi | ENSG00000164136 |
PharmGKBi | PA29790 |
VEuPathDBi | HostDB:ENSG00000164136.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | P40933 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
PhylomeDBi | P40933 |
TreeFami | TF336199 |
Enzyme and pathway databases
PathwayCommonsi | P40933 |
Reactomei | R-HSA-8983432, Interleukin-15 signaling |
SignaLinki | P40933 |
SIGNORi | P40933 |
Miscellaneous databases
BioGRID-ORCSi | 3600, 2 hits in 858 CRISPR screens |
ChiTaRSi | IL15, human |
EvolutionaryTracei | P40933 |
GeneWikii | Interleukin_15 |
GenomeRNAii | 3600 |
Pharosi | P40933, Tbio |
PROi | PR:P40933 |
RNActi | P40933, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164136, Expressed in decidua and 190 other tissues |
Genevisiblei | P40933, HS |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL15_HUMAN | |
Accessioni | P40933Primary (citable) accession number: P40933 Secondary accession number(s): D3DNZ2 Q9UBA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM