AP-1-like transcription factor YAP4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: InterPro
• repressing transcription factor binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae."
    Hanlon S.E., Rizzo J.M., Tatomer D.C., Lieb J.D., Buck M.J.
    PLoS One 6:e19060-e19060(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: SGDInferred from direct assayⁱ
  • "De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis."
    Fordyce P.M., Gerber D., Tran D., Zheng J., Li H., DeRisi J.L., Quake S.R.
    Nat Biotechnol 28:970-975(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions."
    Fernandes L., Rodrigues-Pousada C., Struhl K.
    Mol. Cell. Biol. 17:6982-6993(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, ISOLATION OF YAP FAMILY PROTEINS.

GO - Biological processⁱ

• hyperosmotic response Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization."
    Pereira J., Pimentel C., Amaral C., Menezes R.A., Rodrigues-Pousada C.
    Yeast 26:641-653(2009) [PubMed] [Europe PMC] [Abstract]
• hyperosmotic salinity response Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "Yeast putative transcription factors involved in salt tolerance."
    Mendizabal I., Rios G., Mulet J.M., Serrano R., de Larrinoa I.F.
    FEBS Lett. 425:323-328(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SALT TOLERANCE.
• regulation of transcription by RNA polymerase II Source: SGDInferred from sequence alignmentⁱ
  • Ref.7

    "Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae."
    Furuchi T., Ishikawa H., Miura N., Ishizuka M., Kajiya K., Kuge S., Naganuma A.
    Mol. Pharmacol. 59:470-474(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PLEIOTROPIC DRUG-RESISTANCE.
• response to drug Source: SGDInferred from mutant phenotypeⁱ
  • Ref.7

    "Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae."
    Furuchi T., Ishikawa H., Miura N., Ishizuka M., Kajiya K., Kuge S., Naganuma A.
    Mol. Pharmacol. 59:470-474(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PLEIOTROPIC DRUG-RESISTANCE.
  • "Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan."
    Zakrzewska A., Boorsma A., Brul S., Hellingwerf K.J., Klis F.M.
    Eukaryot Cell 4:703-715(2005) [PubMed] [Europe PMC] [Abstract]
  • Ref.5

    "Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs."
    Delling U., Raymond M., Schurr E.
    Antimicrob. Agents Chemother. 42:1034-1041(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, RESISTANCE TO ANTIMALARIAL DRUGS.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• repressing transcription factor binding Source: SGDInferred from direct assayⁱ
  • "The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae."
    Hanlon S.E., Rizzo J.M., Tatomer D.C., Lieb J.D., Buck M.J.
    PLoS One 6:e19060-e19060(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLMQIKMDNH PFNFQPILAS HSMTRDSTKP KKMTDTAFVP SPPVGFIKEE 
        60         70         80         90        100
NKADLHTISV VASNVTLPQI QLPKIATLEE PGYESRTGSL TDLSGRRNSV 
       110        120        130        140        150
NIGALCEDVP NTAGPHIARP VTINNLIPPS LPRLNTYQLR PQLSDTHLNC 
       160        170        180        190        200
HFNSNPYTTA SHAPFESSYT TASTFTSQPA ASYFPSNSTP ATRKNSATTN 
       210        220        230        240        250
LPSEERRRVS VSLSEQVFNE GERYNNDGQL IGKTGKPLRN TKRAAQNRSA 
       260        270        280        290 
QKAFRQRREK YIKNLEEKSK LFDGLMKENS ELKKMIESLK SKLKE      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XV
   Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
3. SIMILARITY comments
   Index of protein domains and families