UniProtKB - P40917 (YAP4_YEAST)
AP-1-like transcription factor YAP4
CIN5
Functioni
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, and protein synthesis. It may also be involved in pleiotropic drug resistance. When overexpressed it confers increased resistance to cisplatin, the DNA-alkylating agents methylmethanosulfonate, and mitomycin C, the antimalarial drugs quinidine, mefloquine, and chloroquine, and increases cellular tolerance to sodium and lithium. Preferentially binds 5'-TTACTAA-3'.
6 PublicationsMiscellaneous
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- DNA-binding transcription factor binding Source: SGD
- sequence-specific DNA binding Source: SGD
GO - Biological processi
- hyperosmotic response Source: SGD
- hyperosmotic salinity response Source: SGD
- regulation of transcription by RNA polymerase II Source: SGD
- response to xenobiotic stimulus Source: SGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: AP-1-like transcription factor YAP4Alternative name(s): Chromosome instability protein 5 Transcription activator CIN5 |
Gene namesi | Name:CIN5 Synonyms:HAL6, SDS15, YAP4 Ordered Locus Names:YOR028C ORF Names:OR26.18 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005554, CIN5 |
VEuPathDBi | FungiDB:YOR028C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076524 | 1 – 295 | AP-1-like transcription factor YAP4Add BLAST | 295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 196 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P40917 |
PRIDEi | P40917 |
PTM databases
iPTMneti | P40917 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- DNA-binding transcription factor binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34431, 135 interactors |
DIPi | DIP-4351N |
IntActi | P40917, 5 interactors |
MINTi | P40917 |
STRINGi | 4932.YOR028C |
Miscellaneous databases
RNActi | P40917, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 237 – 295 | bZIPAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 181 – 205 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 239 – 260 | Basic motifBy similarityAdd BLAST | 22 | |
Regioni | 262 – 271 | Leucine-zipperBy similarity | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502SC5V, Eukaryota |
GeneTreei | ENSGT00940000176707 |
HOGENOMi | CLU_1103509_0_0_1 |
InParanoidi | P40917 |
OMAi | FESSYTT |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLMQIKMDNH PFNFQPILAS HSMTRDSTKP KKMTDTAFVP SPPVGFIKEE
60 70 80 90 100
NKADLHTISV VASNVTLPQI QLPKIATLEE PGYESRTGSL TDLSGRRNSV
110 120 130 140 150
NIGALCEDVP NTAGPHIARP VTINNLIPPS LPRLNTYQLR PQLSDTHLNC
160 170 180 190 200
HFNSNPYTTA SHAPFESSYT TASTFTSQPA ASYFPSNSTP ATRKNSATTN
210 220 230 240 250
LPSEERRRVS VSLSEQVFNE GERYNNDGQL IGKTGKPLRN TKRAAQNRSA
260 270 280 290
QKAFRQRREK YIKNLEEKSK LFDGLMKENS ELKKMIESLK SKLKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16780 Genomic DNA Translation: AAA52752.1 X87331 Genomic DNA Translation: CAA60744.1 Z74936 Genomic DNA Translation: CAA99218.1 BK006948 Genomic DNA Translation: DAA10810.1 |
PIRi | S50316 |
RefSeqi | NP_014671.1, NM_001183447.1 |
Genome annotation databases
EnsemblFungii | YOR028C_mRNA; YOR028C; YOR028C |
GeneIDi | 854193 |
KEGGi | sce:YOR028C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16780 Genomic DNA Translation: AAA52752.1 X87331 Genomic DNA Translation: CAA60744.1 Z74936 Genomic DNA Translation: CAA99218.1 BK006948 Genomic DNA Translation: DAA10810.1 |
PIRi | S50316 |
RefSeqi | NP_014671.1, NM_001183447.1 |
3D structure databases
AlphaFoldDBi | P40917 |
SMRi | P40917 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34431, 135 interactors |
DIPi | DIP-4351N |
IntActi | P40917, 5 interactors |
MINTi | P40917 |
STRINGi | 4932.YOR028C |
PTM databases
iPTMneti | P40917 |
Proteomic databases
PaxDbi | P40917 |
PRIDEi | P40917 |
Genome annotation databases
EnsemblFungii | YOR028C_mRNA; YOR028C; YOR028C |
GeneIDi | 854193 |
KEGGi | sce:YOR028C |
Organism-specific databases
SGDi | S000005554, CIN5 |
VEuPathDBi | FungiDB:YOR028C |
Phylogenomic databases
eggNOGi | ENOG502SC5V, Eukaryota |
GeneTreei | ENSGT00940000176707 |
HOGENOMi | CLU_1103509_0_0_1 |
InParanoidi | P40917 |
OMAi | FESSYTT |
Miscellaneous databases
PROi | PR:P40917 |
RNActi | P40917, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YAP4_YEAST | |
Accessioni | P40917Primary (citable) accession number: P40917 Secondary accession number(s): D6W294 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - SIMILARITY comments
Index of protein domains and families