Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginase

Gene

ARG

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (ARG)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113Manganese 1PROSITE-ProRule annotation1
Metal bindingi141Manganese 1PROSITE-ProRule annotation1
Metal bindingi141Manganese 2PROSITE-ProRule annotation1
Metal bindingi143Manganese 2PROSITE-ProRule annotation1
Metal bindingi145Manganese 1PROSITE-ProRule annotation1
Binding sitei200SubstrateBy similarity1
Metal bindingi247Manganese 1PROSITE-ProRule annotation1
Metal bindingi247Manganese 2PROSITE-ProRule annotation1
Metal bindingi249Manganese 2PROSITE-ProRule annotation1
Binding sitei261SubstrateBy similarity1
Binding sitei292SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00158;UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1By similarity)
Gene namesi
Name:ARG
ORF Names:CPC735_005980
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides

Organism-specific databases

EuPathDBiFungiDB:CPC735_005980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737071 – 322ArginaseAdd BLAST322

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi222929.XP_003068571.1

Structurei

3D structure databases

ProteinModelPortaliP40906
SMRiP40906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni143 – 147Substrate bindingBy similarity5
Regioni154 – 156Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA
KOiK01476
OrthoDBiEOG092C3GMN

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40906-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPSTIKQK FIAKGHQLGV VAVGFSDGQP NQGVDPSGLI EAGLLDQLRD
60 70 80 90 100
DLEYDIRHDG QVHTYAEFVP EHDPNHRGMK KPRTVSAATQ QLSRQVYEHA
110 120 130 140 150
REGRLVLTLG GDHSIAIGTI SGTAKAIRER LGREMAVIWV DAHADINRPE
160 170 180 190 200
DSDSGNIHGM PLAFLTGLAK DDNEDMFGWL QPDNLISPRK LVYIGLRDVD
210 220 230 240 250
RAEKRLLREH GIKAFSMHDI DKYGIGRVVE MALAHIGQDT PIHLSFDVDA
260 270 280 290 300
LDPQWAPSTG TPVRGGLTLR EGDFIAESIH ETGSLVAMDL VEVNPTLETL
310 320
GASETIRAGC SLVRSALGDT LL
Length:322
Mass (Da):35,142
Last modified:November 3, 2009 - v2
Checksum:iD382603CC361F19A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153D → V in AAA65960 (PubMed:7867937).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36550 Genomic DNA Translation: AAA65960.1
ACFW01000030 Genomic DNA Translation: EER26426.1
PIRiJC4033
RefSeqiXP_003068571.1, XM_003068525.1
UniGeneiCpo.1414

Genome annotation databases

EnsemblFungiiEER26426; EER26426; CPC735_005980
GeneIDi9694054
KEGGicpw:CPC735_005980

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36550 Genomic DNA Translation: AAA65960.1
ACFW01000030 Genomic DNA Translation: EER26426.1
PIRiJC4033
RefSeqiXP_003068571.1, XM_003068525.1
UniGeneiCpo.1414

3D structure databases

ProteinModelPortaliP40906
SMRiP40906
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222929.XP_003068571.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEER26426; EER26426; CPC735_005980
GeneIDi9694054
KEGGicpw:CPC735_005980

Organism-specific databases

EuPathDBiFungiDB:CPC735_005980

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA
KOiK01476
OrthoDBiEOG092C3GMN

Enzyme and pathway databases

UniPathwayi
UPA00158;UER00270

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARGI_COCP7
AccessioniPrimary (citable) accession number: P40906
Secondary accession number(s): C5P9L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again