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Protein

Sexual differentiation process putative subtilase-type proteinase isp6

Gene

isp6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Charge relay systemBy similarity1
Active sitei253Charge relay systemBy similarity1
Active sitei409Charge relay systemBy similarity1

GO - Molecular functioni

  • endopeptidase activity Source: PomBase
  • peptidase activity Source: PomBase
  • serine-type endopeptidase activity Source: PomBase

GO - Biological processi

  • autophagy Source: PomBase
  • conjugation with cellular fusion Source: PomBase
  • vacuole organization Source: PomBase

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-SPO-8866427 VLDLR internalisation and degradation
R-SPO-8964038 LDL clearance

Protein family/group databases

MEROPSiS08.A54

Names & Taxonomyi

Protein namesi
Recommended name:
Sexual differentiation process putative subtilase-type proteinase isp6 (EC:3.4.21.-)
Gene namesi
Name:isp6
ORF Names:SPAC4A8.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.04
PomBaseiSPAC4A8.04 isp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764101 – 467Sexual differentiation process putative subtilase-type proteinase isp6Add BLAST467

Proteomic databases

MaxQBiP40903
PaxDbiP40903
PRIDEiP40903

Expressioni

Developmental stagei

Transcribed specifically during sexual development.

Interactioni

Protein-protein interaction databases

BioGridi279529, 5 interactors
STRINGi4896.SPAC4A8.04.1

Structurei

3D structure databases

ProteinModelPortaliP40903
SMRiP40903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 439Peptidase S8Add BLAST222

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Phylogenomic databases

HOGENOMiHOG000199176
InParanoidiP40903
KOiK01336
OMAiHVKESHA
OrthoDBiEOG092C4A4B
PhylomeDBiP40903

Family and domain databases

CDDicd04077 Peptidases_S8_PCSK9_Proteinase, 1 hit
Gene3Di3.30.70.80, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR034193 PCSK9_ProteinaseK-like
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR010259 S8pro/Inhibitor_I9
IPR037045 S8pro/Inhibitor_I9_sf
PfamiView protein in Pfam
PF05922 Inhibitor_I9, 1 hit
PF00082 Peptidase_S8, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P40903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIPYSNLFS AAAGLALFAS TACAAPVMPA TDSDIAHAGI RPELDNAFYD
60 70 80 90 100
SHGEAATPKH KPHAGPNAAP LLSASNADTT GLDSHYIIVL QPDLSEQEFQ
110 120 130 140 150
AHTNWVSEMH QMDIASQEDE YYDTSDSNYM FGLKHVYDFG EDSFKGYSGQ
160 170 180 190 200
FSSNIVEQIR LHPHVIAVER DQVVSIKKLE TQSGAPWGLA RISHKSVKYD
210 220 230 240 250
DIGKYVYDSS AGDNITAYVV DTGVSIHHVE FEGRASWGAT IPSGDVDEDN
260 270 280 290 300
NGHGTHVAGT IASRAYGVAK KAEIVAVKVL RSSGSGTMAD VIAGVEWTVR
310 320 330 340 350
HHKSSGKKTS VGNMSLGGGN SFVLDMAVDS AVTNGVIYAV AAGNEYDDAC
360 370 380 390 400
YSSPAASKKA ITVGASTIND QMAYFSNYGS CVDIFAPGLN ILSTWIGSNT
410 420 430 440 450
STNTISGTSM ATPHVAGLSA YYLGLHPAAS ASEVKDAIIK MGIHDVLLSI
460
PVGSSTINLL AFNGAQE
Length:467
Mass (Da):49,367
Last modified:February 1, 1995 - v1
Checksum:iA60A0EDF62ADF721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14063 mRNA Translation: BAA03149.1
CU329670 Genomic DNA Translation: CAB11474.1
PIRiS45493
RefSeqiNP_593815.1, NM_001019245.2

Genome annotation databases

EnsemblFungiiSPAC4A8.04.1; SPAC4A8.04.1:pep; SPAC4A8.04
GeneIDi2543097
KEGGispo:SPAC4A8.04

Similar proteinsi

Entry informationi

Entry nameiISP6_SCHPO
AccessioniPrimary (citable) accession number: P40903
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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