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UniProtKB - P40900 (ISP4_SCHPO)
Protein
Sexual differentiation process protein isp4
Gene
isp4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
GO - Molecular functioni
- oligopeptide transmembrane transporter activity Source: GO_Central
- tetrapeptide transmembrane transporter activity Source: PomBase
GO - Biological processi
- protein transport Source: UniProtKB-KW
- tetrapeptide transmembrane transport Source: PomBase
Keywordsi
Biological process | Peptide transport, Protein transport, Transport |
Protein family/group databases
TCDBi | 2.A.67.1.2, the oligopeptide transporter (opt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sexual differentiation process protein isp4 |
Gene namesi | Name:isp4 ORF Names:SPBC29B5.02c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC29B5.02c, isp4 |
VEuPathDBi | FungiDB:SPBC29B5.02c |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: PomBase
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 413 – 433 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 461 – 481 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 512 – 532 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 537 – 557 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 572 – 592 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 611 – 631 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 642 – 662 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 683 – 703 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 732 – 752 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213787 | 1 – 785 | Sexual differentiation process protein isp4Add BLAST | 785 |
Proteomic databases
MaxQBi | P40900 |
PaxDbi | P40900 |
PTM databases
iPTMneti | P40900 |
Expressioni
Developmental stagei
Transcribed specifically during sexual development.
Interactioni
Protein-protein interaction databases
BioGRIDi | 276893, 11 interactors |
STRINGi | 4896.SPBC29B5.02c.1 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 28 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the oligopeptide OPT transporter family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2262, Eukaryota |
HOGENOMi | CLU_004965_1_1_1 |
InParanoidi | P40900 |
OMAi | NYDEGGH |
PhylomeDBi | P40900 |
Family and domain databases
InterProi | View protein in InterPro IPR004648, Oligpept_transpt IPR004813, OPT |
PANTHERi | PTHR22601, PTHR22601, 1 hit |
Pfami | View protein in Pfam PF03169, OPT, 1 hit |
TIGRFAMsi | TIGR00727, ISP4_OPT, 1 hit TIGR00728, OPT_sfam, 1 hit |
i Sequence
Sequence statusi: Complete.
P40900-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGSINESPI EEHMNDSPST KEKADSVDIS DYIVSHSDDS LSKDIKKDTK
60 70 80 90 100
SFLDVEHGEI STVDEFEEDS PYPEVRAAVP PTDDPSMPCN TIRMWTIGLI
110 120 130 140 150
YSTVGAAVNM FFSLRNPTVT LSVLISELLA YPALQIWDLI FPDREFRIGR
160 170 180 190 200
LKFNFKPGPF NVKEHALIVV MSSVSFGNAY STDIILAQRV HYKQRFGFGY
210 220 230 240 250
EICLTLATQL IGYGLAGLSR RLLVRPASML WPVNLVQCTL IKTLHRKDLR
260 270 280 290 300
NAVANGWRIS PFRFFLYVFI ASFIWNWFPS YIFQALSLFA WVTWIRPNSP
310 320 330 340 350
TVNQIFGEST GISILPMTFD WNQISAYILS PLMAPADALM NILLGVILFF
360 370 380 390 400
WIVTPALNFT NTWYGDYLPI SSSGIIDHFG NSYNVTRILT KDATFDLDAY
410 420 430 440 450
QNYSPIFMST TYALAFGLSF ASITSVIFHV ILYHGKEIYD RLRDPPAPDI
460 470 480 490 500
HEKLMKAYDE VPFYWYLSVF LAFFGMMMGT IYGWKTETPW WVIIVGVIFS
510 520 530 540 550
AVWFIPIGIV QAITNIQLGL NVFTEFIVGY MYPGRPLAMM IFKTVGYITM
560 570 580 590 600
TQGLAFAADL KFGHYMKLPP RIMFYTQMIA TIWSCFVQIG VLDWALGNID
610 620 630 640 650
NVCQADQPDN YTCPNATVFF NSSVIWGVIG PKRMFSGKNT YTGLQYFWLA
660 670 680 690 700
GVLGTILFWA LWKKWPQKWW GQLNGPLIFG GTGYIPPATP VNYLAWSGIG
710 720 730 740 750
LFFNYYLKKI FADWWQKYNF TLSAALDTGT QLSVIILFFC LQLPMVNFPD
760 770 780
WWGNDGAFNT LDATGAAVRK LVNESAGEFF GPAEW
Sequence cautioni
The sequence BAA12193 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 725 | Missing in BAA03147 (PubMed:7954893).Curated | 1 | |
Sequence conflicti | 777 – 785 | GEFFGPAEW → R in BAA03147 (PubMed:7954893).Curated | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14061 mRNA Translation: BAA03147.1 D83992 Genomic DNA Translation: BAA12193.1 Frameshift. CU329671 Genomic DNA Translation: CAC05511.1 AB027895 Genomic DNA Translation: BAA87199.1 |
PIRi | S45495 |
RefSeqi | NP_595653.1, NM_001021547.2 |
Genome annotation databases
EnsemblFungii | SPBC29B5.02c.1; SPBC29B5.02c.1:pep; SPBC29B5.02c |
GeneIDi | 2540364 |
KEGGi | spo:SPBC29B5.02c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14061 mRNA Translation: BAA03147.1 D83992 Genomic DNA Translation: BAA12193.1 Frameshift. CU329671 Genomic DNA Translation: CAC05511.1 AB027895 Genomic DNA Translation: BAA87199.1 |
PIRi | S45495 |
RefSeqi | NP_595653.1, NM_001021547.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 276893, 11 interactors |
STRINGi | 4896.SPBC29B5.02c.1 |
Protein family/group databases
TCDBi | 2.A.67.1.2, the oligopeptide transporter (opt) family |
PTM databases
iPTMneti | P40900 |
Proteomic databases
MaxQBi | P40900 |
PaxDbi | P40900 |
Genome annotation databases
EnsemblFungii | SPBC29B5.02c.1; SPBC29B5.02c.1:pep; SPBC29B5.02c |
GeneIDi | 2540364 |
KEGGi | spo:SPBC29B5.02c |
Organism-specific databases
PomBasei | SPBC29B5.02c, isp4 |
VEuPathDBi | FungiDB:SPBC29B5.02c |
Phylogenomic databases
eggNOGi | KOG2262, Eukaryota |
HOGENOMi | CLU_004965_1_1_1 |
InParanoidi | P40900 |
OMAi | NYDEGGH |
PhylomeDBi | P40900 |
Miscellaneous databases
PROi | PR:P40900 |
Family and domain databases
InterProi | View protein in InterPro IPR004648, Oligpept_transpt IPR004813, OPT |
PANTHERi | PTHR22601, PTHR22601, 1 hit |
Pfami | View protein in Pfam PF03169, OPT, 1 hit |
TIGRFAMsi | TIGR00727, ISP4_OPT, 1 hit TIGR00728, OPT_sfam, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ISP4_SCHPO | |
Accessioni | P40900Primary (citable) accession number: P40900 Secondary accession number(s): P78943, Q9HGP2, Q9UU01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | August 14, 2001 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families