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UniProtKB - P40897 (OPT1_YEAST)

Entry version 148 (07 Oct 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Oligopeptide transporter 1

Gene

OPT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane.2 Publications

Miscellaneous

Present with 2870 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=53.9 µM for glutathione2 Publications
  2. KM=310 µM for leucine enkephalin2 Publications
  1. Vmax=10 nmol/min/mg enzyme for glutathione2 Publications

pH dependencei

Optimum pH is 5.5.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P40897

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.67.1.3, the oligopeptide transporter (opt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oligopeptide transporter 1
Alternative name(s):
High affinity glutathione transporter 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OPT1
Synonyms:GSH11, HGT1
Ordered Locus Names:YJL212C
ORF Names:HRD799, J0236
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		FungiDB:YJL212C

Saccharomyces Genome Database

More...SGDi		S000003748, OPT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 108ExtracellularSequence analysisAdd BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 135CytoplasmicSequence analysis6
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 177ExtracellularSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 210CytoplasmicSequence analysisAdd BLAST12
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 276ExtracellularSequence analysisAdd BLAST45
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 313CytoplasmicSequence analysisAdd BLAST16
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 359ExtracellularSequence analysisAdd BLAST25
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 428CytoplasmicSequence analysisAdd BLAST48
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 482ExtracellularSequence analysisAdd BLAST33
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 508CytoplasmicSequence analysis5
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 540ExtracellularSequence analysisAdd BLAST11
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Topological domaini562 – 590CytoplasmicSequence analysisAdd BLAST29
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 659ExtracellularSequence analysisAdd BLAST48
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21
Topological domaini681 – 736CytoplasmicSequence analysisAdd BLAST56
Transmembranei737 – 757HelicalSequence analysisAdd BLAST21
Topological domaini758 – 799ExtracellularSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002137881 – 799Oligopeptide transporter 1Add BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphothreonineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P40897

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40897

PRoteomics IDEntifications database

More...PRIDEi		P40897

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40897

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33547, 57 interactors

Database of interacting proteins

More...DIPi		DIP-5691N

STRING: functional protein association networks

More...STRINGi		4932.YJL212C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P40897, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the oligopeptide OPT transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2262, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176656

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004965_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40897

Identification of Orthologs from Complete Genome Data

More...OMAi		NQHVGLN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004648, Oligpept_transpt
IPR004813, OPT

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03169, OPT, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00727, ISP4_OPT, 1 hit
TIGR00728, OPT_sfam, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTIYRESDS LESEPSPTPT TIPIQINMEE EKKDAFVKNI DEDVNNLTAT 
        60         70         80         90        100
TDEEDRDPES QKFDRHSIQE EGLVWKGDPT YLPNSPYPEV RSAVSIEDDP 
       110        120        130        140        150
TIRLNHWRTW FLTTVFVVVF AGVNQFFSLR YPSLEINFLV AQVVCYPIGR 
       160        170        180        190        200
ILALLPDWKC SKVPFFDLNP GPFTKKEHAV VTIAVALTSS TAYAMYILNA 
       210        220        230        240        250
QGSFYNMKLN VGYQFLLVWT SQMIGYGAAG LTRRWVVNPA SSIWPQTLIS 
       260        270        280        290        300
VSLFDSLHSR KVEKTVANGW TMPRYRFFLI VLIGSFIWYW VPGFLFTGLS 
       310        320        330        340        350
YFNVILWGSK TRHNFIANTI FGTQSGLGAL PITFDYTQVS QAMSGSVFAT 
       360        370        380        390        400
PFYVSANTYA SVLIFFVIVL PCLYFTNTWY AKYMPVISGS TYDNTQNKYN 
       410        420        430        440        450
VTKILNEDYS INLEKYKEYS PVFVPFSYLL SYALNFAAVI AVFVHCILYH 
       460        470        480        490        500
GKDIVAKFKD RKNGGTDIHM RIYSKNYKDC PDWWYLLLQI VMIGLGFVAV 
       510        520        530        540        550
CCFDTKFPAW AFVIAILISL VNFIPQGILE AMTNQHVGLN IITELICGYM 
       560        570        580        590        600
LPLRPMANLL FKLYGFIVMR QGLNLSRDLK LAMYMKVSPR LIFAVQIYAT 
       610        620        630        640        650
IISGMVNVGV QEWMMHNIDG LCTTDQPNGF TCANGRTVFN ASIIWSLPKY 
       660        670        680        690        700
LFSSGRIYNP LMWFFLIGLL FPLAVYAVQW KFPKFKFAKH IHTPVFFTGP 
       710        720        730        740        750
GNIPPSTPYN YSLFFAMSFC LNLIRKRWRA WFNKYNFVMG AGVEAGVAIS 
       760        770        780        790 
VVIIFLCVQY PGGKLSWWGN NVWKRTYDND YKKFYTLKKG ETFGYDKWW
Length:799
Mass (Da):91,616
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF81676CC9B30759
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z34098 Genomic DNA Translation: CAA83999.1
Z49487 Genomic DNA Translation: CAA89509.1
BK006943 Genomic DNA Translation: DAA08599.1

Protein sequence database of the Protein Information Resource

More...PIRi		S50773

NCBI Reference Sequences

More...RefSeqi		NP_012323.1, NM_001181645.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YJL212C_mRNA; YJL212C; YJL212C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853218

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YJL212C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA Translation: CAA83999.1
Z49487 Genomic DNA Translation: CAA89509.1
BK006943 Genomic DNA Translation: DAA08599.1
PIRiS50773
RefSeqiNP_012323.1, NM_001181645.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33547, 57 interactors
DIPiDIP-5691N
STRINGi4932.YJL212C

Protein family/group databases

TCDBi2.A.67.1.3, the oligopeptide transporter (opt) family

PTM databases

iPTMnetiP40897

Proteomic databases

MaxQBiP40897
PaxDbiP40897
PRIDEiP40897

Genome annotation databases

EnsemblFungiiYJL212C_mRNA; YJL212C; YJL212C
GeneIDi853218
KEGGisce:YJL212C

Organism-specific databases

EuPathDBiFungiDB:YJL212C
SGDiS000003748, OPT1

Phylogenomic databases

eggNOGiKOG2262, Eukaryota
GeneTreeiENSGT00940000176656
HOGENOMiCLU_004965_1_1_1
InParanoidiP40897
OMAiNQHVGLN

Enzyme and pathway databases

SABIO-RKiP40897

Miscellaneous databases

Protein Ontology

More...PROi		PR:P40897
RNActiP40897, protein

Family and domain databases

InterProiView protein in InterPro
IPR004648, Oligpept_transpt
IPR004813, OPT
PfamiView protein in Pfam
PF03169, OPT, 1 hit
TIGRFAMsiTIGR00727, ISP4_OPT, 1 hit
TIGR00728, OPT_sfam, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40897
Secondary accession number(s): D6VVY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 7, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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