UniProtKB - P40890 (VTH2_YEAST)
Protein
VPS10 homolog 2
Gene
VTH2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.2 Publications
Miscellaneous
Present with 279 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-KW
- signal sequence binding Source: SGD
GO - Biological processi
- Golgi to endosome transport Source: GO_Central
- Golgi to vacuole transport Source: SGD
- post-Golgi vesicle-mediated transport Source: GO_Central
- protein targeting to vacuole Source: SGD
Keywordsi
Molecular function | Receptor |
Biological process | Protein transport, Transport |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: VPS10 homolog 2Alternative name(s): Sortilin VTH2 |
Gene namesi | Name:VTH2 Ordered Locus Names:YJL222W ORF Names:HRC1549, J0213 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YJL222W |
SGDi | S000003758, VTH2 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity
Cytosol
- cytosol Source: GOC
Golgi apparatus
- Golgi apparatus Source: GO_Central
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 1369 | LumenalSequence analysisAdd BLAST | 1348 | |
Transmembranei | 1370 – 1390 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1391 – 1549 | CytoplasmicSequence analysisAdd BLAST | 159 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000014331 | 22 – 1549 | VPS10 homolog 2Add BLAST | 1528 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 769 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 986 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P40890 |
PaxDbi | P40890 |
PRIDEi | P40890 |
PTM databases
iPTMneti | P40890 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33560, 12 interactors |
DIPi | DIP-6665N |
IntActi | P40890, 1 interactor |
STRINGi | 4932.YJL222W |
Miscellaneous databases
RNActi | P40890, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 57 – 68 | BNR 1Add BLAST | 12 | |
Repeati | 101 – 112 | BNR 2Add BLAST | 12 | |
Repeati | 159 – 170 | BNR 3Add BLAST | 12 | |
Repeati | 228 – 239 | BNR 4Add BLAST | 12 | |
Repeati | 393 – 404 | BNR 5Add BLAST | 12 | |
Repeati | 465 – 476 | BNR 6Add BLAST | 12 | |
Repeati | 511 – 522 | BNR 7Add BLAST | 12 | |
Repeati | 740 – 751 | BNR 8Add BLAST | 12 | |
Repeati | 837 – 848 | BNR 9Add BLAST | 12 | |
Repeati | 1040 – 1051 | BNR 10Add BLAST | 12 | |
Repeati | 1119 – 1130 | BNR 11Add BLAST | 12 | |
Repeati | 1160 – 1171 | BNR 12Add BLAST | 12 |
Sequence similaritiesi
Belongs to the VPS10-related sortilin family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203671 |
HOGENOMi | CLU_000700_0_0_1 |
InParanoidi | P40890 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR036278, Sialidase_sf IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF15902, Sortilin-Vps10, 2 hits PF15901, Sortilin_C, 2 hits |
SMARTi | View protein in SMART SM00602, VPS10, 2 hits |
SUPFAMi | SSF50939, SSF50939, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P40890-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR
60 70 80 90 100
AEEDSVEISF DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF
110 120 130 140 150
YVTDDQGKSW RPLTIPISEK ASNYFCDVTT HPIKKKHLII RCDLLTIKNS
160 170 180 190 200
GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG HISTARCDFI KSSEDSDLGG
210 220 230 240 250
NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL VQFKDKVVSR
260 270 280 290 300
YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ
310 320 330 340 350
IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ
360 370 380 390 400
FGYINVAYPG FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL
410 420 430 440 450
TWTNLKVVDR ENVDLFGCDV TKPERCSLQT HFYDLRNLNP SAGIMMISGI
460 470 480 490 500
VGDGSAYNWK EEKTFISRDS GLTWRLVHNS TGLYTTGDLG NIIMYIPYRS
510 520 530 540 550
NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD GSGSKFILTG
560 570 580 590 600
TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR
610 620 630 640 650
RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN
660 670 680 690 700
LIALSDICDK SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS
710 720 730 740 750
SDKEIVTTEN KFDFEIKFYQ YFDTVADESL VMLNSIGDAY ISHDGGQTIK
760 770 780 790 800
RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN IFLTHDRGYS FMIAKLPEAR
810 820 830 840 850
QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK DGGETFTEML
860 870 880 890 900
DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV
910 920 930 940 950
FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ
960 970 980 990 1000
DAFTILGSEE GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN
1010 1020 1030 1040 1050
TFGYVDFEKV QGLEGIIITN IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN
1060 1070 1080 1090 1100
FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG YTERKDIRDT YSSGSALGMM
1110 1120 1130 1140 1150
FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY GDHGGVLVLV
1160 1170 1180 1190 1200
PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE
1210 1220 1230 1240 1250
AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG
1260 1270 1280 1290 1300
HKTEFLRKTD EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT
1310 1320 1330 1340 1350
CKLVKGLSSA NGADICKKEP DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA
1360 1370 1380 1390 1400
PHPCPGKEKA FREKYSINTG AYALVFVTIL LVIFFVAWFV YDRGIRRNGG
1410 1420 1430 1440 1450
FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS AFQRAKAGTA
1460 1470 1480 1490 1500
QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS
1510 1520 1530 1540
EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34098 Genomic DNA Translation: CAA83988.1 Z49497 Genomic DNA Translation: CAA89519.1 BK006943 Genomic DNA Translation: DAA08591.1 |
PIRi | S50705 |
RefSeqi | NP_012313.1, NM_001181655.1 |
Genome annotation databases
EnsemblFungii | YJL222W_mRNA; YJL222W; YJL222W |
GeneIDi | 853233 |
KEGGi | sce:YJL222W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34098 Genomic DNA Translation: CAA83988.1 Z49497 Genomic DNA Translation: CAA89519.1 BK006943 Genomic DNA Translation: DAA08591.1 |
PIRi | S50705 |
RefSeqi | NP_012313.1, NM_001181655.1 |
3D structure databases
SMRi | P40890 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33560, 12 interactors |
DIPi | DIP-6665N |
IntActi | P40890, 1 interactor |
STRINGi | 4932.YJL222W |
PTM databases
iPTMneti | P40890 |
Proteomic databases
MaxQBi | P40890 |
PaxDbi | P40890 |
PRIDEi | P40890 |
Genome annotation databases
EnsemblFungii | YJL222W_mRNA; YJL222W; YJL222W |
GeneIDi | 853233 |
KEGGi | sce:YJL222W |
Organism-specific databases
EuPathDBi | FungiDB:YJL222W |
SGDi | S000003758, VTH2 |
Phylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203671 |
HOGENOMi | CLU_000700_0_0_1 |
InParanoidi | P40890 |
Miscellaneous databases
PROi | PR:P40890 |
RNActi | P40890, protein |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR036278, Sialidase_sf IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF15902, Sortilin-Vps10, 2 hits PF15901, Sortilin_C, 2 hits |
SMARTi | View protein in SMART SM00602, VPS10, 2 hits |
SUPFAMi | SSF50939, SSF50939, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VTH2_YEAST | |
Accessioni | P40890Primary (citable) accession number: P40890 Secondary accession number(s): D6VVX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names