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Protein

Chloride anion exchanger

Gene

SLC26A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427601 Multifunctional anion exchangers
R-HSA-5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)

SIGNOR Signaling Network Open Resource

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SIGNORi
P40879

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.18 the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride anion exchanger
Alternative name(s):
Down-regulated in adenoma
Short name:
Protein DRA
Solute carrier family 26 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A3
Synonyms:DRA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000091138.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3018 SLC26A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126650 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P40879

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicCuratedAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 99ExtracellularCurated2
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 124CytoplasmicCurated4
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularCuratedAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197CytoplasmicCurated1
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 257ExtracellularCuratedAdd BLAST39
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 342CytoplasmicCuratedAdd BLAST64
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 374ExtracellularCuratedAdd BLAST11
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 411CytoplasmicCuratedAdd BLAST16
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 469ExtracellularCuratedAdd BLAST37
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 701CytoplasmicCuratedAdd BLAST211

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diarrhea 1, secretory chloride, congenital (DIAR1)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
See also OMIM:214700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007428120G → S in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833479EnsemblClinVar.1
Natural variantiVAR_007429124H → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs121913030EnsemblClinVar.1
Natural variantiVAR_066062129P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833480EnsemblClinVar.1
Natural variantiVAR_066063131P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833481EnsemblClinVar.1
Natural variantiVAR_007430131P → R in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833481EnsemblClinVar.1
Natural variantiVAR_077354134S → N in DIAR1. 1 Publication1
Natural variantiVAR_066064136M → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833483EnsemblClinVar.1
Natural variantiVAR_077355175R → S in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833484EnsemblClinVar.1
Natural variantiVAR_066065204Y → D in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833487EnsemblClinVar.1
Natural variantiVAR_012777206S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833488EnsemblClinVar.1
Natural variantiVAR_066066220H → P in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833489EnsemblClinVar.1
Natural variantiVAR_007432318Missing in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833491Ensembl.1
Natural variantiVAR_066067343C → Y in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833444EnsemblClinVar.1
Natural variantiVAR_066068344 – 349FGIAMV → DA in DIAR1. 1 Publication6
Natural variantiVAR_066069379G → A in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833446EnsemblClinVar.1
Natural variantiVAR_077356394S → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs1228273365Ensembl.1
Natural variantiVAR_066070398S → F in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs143839547Ensembl.1
Natural variantiVAR_077357438S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs763669046Ensembl.1
Natural variantiVAR_012778468D → V in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833454EnsemblClinVar.1
Natural variantiVAR_077358495Q → P in DIAR1. 1 Publication1
Natural variantiVAR_066071496L → R in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833457EnsemblClinVar.1
Natural variantiVAR_077359508C → R in DIAR1. 1 Publication1
Natural variantiVAR_066072520Y → C in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833462EnsemblClinVar.1
Natural variantiVAR_066073521K → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833463EnsemblClinVar.1
Natural variantiVAR_007433527Missing in DIAR1. 1 Publication1
Natural variantiVAR_066074544I → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833467EnsemblClinVar.1
Natural variantiVAR_077360547A → E in DIAR1. 1 Publication1
Natural variantiVAR_066075652D → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs140426439Ensembl.1
Natural variantiVAR_077361654S → P in DIAR1. 1 Publication1
Natural variantiVAR_077362675I → II in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs121913031Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1811

MalaCards human disease database

More...
MalaCardsi
SLC26A3
MIMi214700 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000091138

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
53689 Congenital chloride diarrhea

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35044

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
729367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801611 – 764Chloride anion exchangerAdd BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi161N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi165N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P40879

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40879

PeptideAtlas

More...
PeptideAtlasi
P40879

PRoteomics IDEntifications database

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PRIDEi
P40879

ProteomicsDB human proteome resource

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ProteomicsDBi
55383

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40879

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P40879

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091138 Expressed in 91 organ(s), highest expression level in colonic mucosa

CleanEx database of gene expression profiles

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CleanExi
HS_SLC26A3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P40879 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P40879 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036055

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R2Q155995EBI-8542350,EBI-1149760

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108145, 1 interactor

Protein interaction database and analysis system

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IntActi
P40879, 2 interactors

Molecular INTeraction database

More...
MINTi
P40879

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345873

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P40879

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P40879

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 720STASPROSITE-ProRule annotationAdd BLAST196

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006546

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000639

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P40879

KEGG Orthology (KO)

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KOi
K14078

Identification of Orthologs from Complete Genome Data

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OMAi
MVEPVGN

Database of Orthologous Groups

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OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P40879

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030321 SLC26A3
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF19 PTHR11814:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P40879-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA
60 70 80 90 100
KRIVLSLFPI ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI
110 120 130 140 150
PPVYGLYASF FPAIIYLFFG TSRHISVGPF PILSMMVGLA VSGAVSKAVP
160 170 180 190 200
DRNATTLGLP NNSNNSSLLD DERVRVAAAA SVTVLSGIIQ LAFGILRIGF
210 220 230 240 250
VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP VSIFKVLYSV
260 270 280 290 300
FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA
310 320 330 340 350
AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA
360 370 380 390 400
FAVAFSVASV YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS
410 420 430 440 450
AVQESTGGKT QIAGLIGAII VLIVVLAIGF LLAPLQKSVL AALALGNLKG
460 470 480 490 500
MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI VLGLGLGLAA SVAFQLLTIV
510 520 530 540 550
FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC PSPIYFANIG
560 570 580 590 600
FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT
610 620 630 640 650
IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI
660 670 680 690 700
LDFSAVSFLD VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF
710 720 730 740 750
DGEVKSSIFF LTIHDAVLHI LMKKDYSTSK FNPSQEKDGK IDFTINTNGG
760
LRNRVYEVPV ETKF
Length:764
Mass (Da):84,505
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i694C5BC2D4121F6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFJ2C9JFJ2_HUMAN
Chloride anion exchanger
SLC26A3
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBL6F8WBL6_HUMAN
Chloride anion exchanger
SLC26A3
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05366068R → Q. Corresponds to variant dbSNP:rs10280704EnsemblClinVar.1
Natural variantiVAR_007428120G → S in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833479EnsemblClinVar.1
Natural variantiVAR_007429124H → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs121913030EnsemblClinVar.1
Natural variantiVAR_066062129P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833480EnsemblClinVar.1
Natural variantiVAR_066063131P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833481EnsemblClinVar.1
Natural variantiVAR_007430131P → R in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833481EnsemblClinVar.1
Natural variantiVAR_077354134S → N in DIAR1. 1 Publication1
Natural variantiVAR_066064136M → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833483EnsemblClinVar.1
Natural variantiVAR_077355175R → S in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833484EnsemblClinVar.1
Natural variantiVAR_066065204Y → D in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833487EnsemblClinVar.1
Natural variantiVAR_012777206S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833488EnsemblClinVar.1
Natural variantiVAR_066066220H → P in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833489EnsemblClinVar.1
Natural variantiVAR_007431307C → W1 PublicationCorresponds to variant dbSNP:rs34407351EnsemblClinVar.1
Natural variantiVAR_007432318Missing in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833491Ensembl.1
Natural variantiVAR_066067343C → Y in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833444EnsemblClinVar.1
Natural variantiVAR_066068344 – 349FGIAMV → DA in DIAR1. 1 Publication6
Natural variantiVAR_066069379G → A in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833446EnsemblClinVar.1
Natural variantiVAR_077356394S → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs1228273365Ensembl.1
Natural variantiVAR_066070398S → F in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs143839547Ensembl.1
Natural variantiVAR_077357438S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs763669046Ensembl.1
Natural variantiVAR_012778468D → V in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833454EnsemblClinVar.1
Natural variantiVAR_077358495Q → P in DIAR1. 1 Publication1
Natural variantiVAR_066071496L → R in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833457EnsemblClinVar.1
Natural variantiVAR_077359508C → R in DIAR1. 1 Publication1
Natural variantiVAR_066072520Y → C in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833462EnsemblClinVar.1
Natural variantiVAR_066073521K → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833463EnsemblClinVar.1
Natural variantiVAR_007433527Missing in DIAR1. 1 Publication1
Natural variantiVAR_066074544I → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833467EnsemblClinVar.1
Natural variantiVAR_077360547A → E in DIAR1. 1 Publication1
Natural variantiVAR_053661554R → Q. Corresponds to variant dbSNP:rs2301635Ensembl.1
Natural variantiVAR_066075652D → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs140426439Ensembl.1
Natural variantiVAR_077361654S → P in DIAR1. 1 Publication1
Natural variantiVAR_077362675I → II in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs121913031Ensembl.1
Natural variantiVAR_053662753N → S. Corresponds to variant dbSNP:rs35342296EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L02785 mRNA Translation: AAA58443.1
BC025671 mRNA Translation: AAH25671.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5748.1

Protein sequence database of the Protein Information Resource

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PIRi
A47456

NCBI Reference Sequences

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RefSeqi
NP_000102.1, NM_000111.2
XP_011514169.1, XM_011515867.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.1650

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340010; ENSP00000345873; ENSG00000091138

Database of genes from NCBI RefSeq genomes

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GeneIDi
1811

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1811

UCSC genome browser

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UCSCi
uc003ver.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02785 mRNA Translation: AAA58443.1
BC025671 mRNA Translation: AAH25671.1
CCDSiCCDS5748.1
PIRiA47456
RefSeqiNP_000102.1, NM_000111.2
XP_011514169.1, XM_011515867.2
UniGeneiHs.1650

3D structure databases

ProteinModelPortaliP40879
SMRiP40879
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108145, 1 interactor
IntActiP40879, 2 interactors
MINTiP40879
STRINGi9606.ENSP00000345873

Protein family/group databases

TCDBi2.A.53.2.18 the sulfate permease (sulp) family

PTM databases

iPTMnetiP40879
PhosphoSitePlusiP40879

Polymorphism and mutation databases

BioMutaiSLC26A3
DMDMi729367

Proteomic databases

jPOSTiP40879
PaxDbiP40879
PeptideAtlasiP40879
PRIDEiP40879
ProteomicsDBi55383

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1811
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340010; ENSP00000345873; ENSG00000091138
GeneIDi1811
KEGGihsa:1811
UCSCiuc003ver.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1811
DisGeNETi1811
EuPathDBiHostDB:ENSG00000091138.12

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC26A3
HGNCiHGNC:3018 SLC26A3
HPAiHPA036055
MalaCardsiSLC26A3
MIMi126650 gene
214700 phenotype
neXtProtiNX_P40879
OpenTargetsiENSG00000091138
Orphaneti53689 Congenital chloride diarrhea
PharmGKBiPA35044

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00940000153218
HOGENOMiHOG000006546
HOVERGENiHBG000639
InParanoidiP40879
KOiK14078
OMAiMVEPVGN
OrthoDBi690428at2759
PhylomeDBiP40879
TreeFamiTF313784

Enzyme and pathway databases

ReactomeiR-HSA-427601 Multifunctional anion exchangers
R-HSA-5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
SIGNORiP40879

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC26A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1811

Protein Ontology

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PROi
PR:P40879

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000091138 Expressed in 91 organ(s), highest expression level in colonic mucosa
CleanExiHS_SLC26A3
ExpressionAtlasiP40879 baseline and differential
GenevisibleiP40879 HS

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030321 SLC26A3
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF19 PTHR11814:SF19, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40879
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 16, 2019
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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