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Entry version 149 (29 Sep 2021)
Sequence version 4 (28 Jul 2009)
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Protein

Polyketide synthase PksM

Gene

pksM

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.

1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei569For beta-ketoacyl synthase 1 activityPROSITE-ProRule annotation1
Active sitei2476For beta-ketoacyl synthase 2 activityPROSITE-ProRule annotation1
Active sitei3690For beta-ketoacyl synthase 3 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processAntibiotic biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU17200-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA01003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase PksM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pksM
Synonyms:pksY
Ordered Locus Names:BSU17200
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001803001 – 4262Polyketide synthase PksMAdd BLAST4262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei327O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2222O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3446O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4172O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40872

PRoteomics IDEntifications database

More...
PRIDEi
P40872

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU17200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40872

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 367Carrier 1PROSITE-ProRule annotationAdd BLAST75
Domaini2188 – 2261Carrier 2PROSITE-ProRule annotationAdd BLAST74
Domaini3409 – 3486Carrier 3PROSITE-ProRule annotationAdd BLAST78
Domaini4135 – 4212Carrier 4PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni396 – 834Beta-ketoacyl synthase 1Add BLAST439
Regioni2275 – 2313DisorderedSequence analysisAdd BLAST39
Regioni2322 – 2737Beta-ketoacyl synthase 2Add BLAST416
Regioni3532 – 3947Beta-ketoacyl synthase 3Add BLAST416

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2750 – 2826Sequence analysisAdd BLAST77
Coiled coili4004 – 4033Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2275 – 2292Polar residuesSequence analysisAdd BLAST18
Compositional biasi2293 – 2307Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0236, Bacteria
COG0451, Bacteria
COG1020, Bacteria
COG1028, Bacteria
COG3321, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40872

Identification of Orthologs from Complete Genome Data

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OMAi
MHKDYSL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.10.129.110, 2 hits
3.40.47.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 3 hits
PF02801, Ketoacyl-synt_C, 3 hits
PF08659, KR, 2 hits
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 4 hits
PF14765, PS-DH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 3 hits
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 2 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS00098, THIOLASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITEQLHISL NNPIMSNHKV YGQALLPGLA YIDLIYQVFQ EHGYAYQELE
60 70 80 90 100
LKNLTIFYPL IADESYDIAL TIHVSERKEG TWSIIIDGQK QHGESLSDKR
110 120 130 140 150
QYVTADMHRK EQTAFAESID LNQWKSTADR ILNLDEIYEQ CRSQELVHTG
160 170 180 190 200
MMKAEGQIYE AKEGAVIDLA VGQEALRHSD AFLFHPTLID GSGIGSSCLI
210 220 230 240 250
SDQTMYLPLY YESFSASERL QKGCTARILS SSVRQKKELT YMTIEYFNSA
260 270 280 290 300
GQKVAELKQF AGKSVRNMSA FHSAKEIQEE RAAVSQNISR DYPAFEMYLR
310 320 330 340 350
QLLAKQLERP AEQMDIHAGY YELGLDSSSL LTVVQEIGDK VGADLAPTLL
360 370 380 390 400
FEFTTIAELA AHLADHYSIG EADDAVRQSP SPIDGVTSSP EIGEDIAIIG
410 420 430 440 450
MAGRYPKAKN IQEFWEQLKA GTDCITEIPN SRWEWKESDG LDSPAGKPLS
460 470 480 490 500
KWGGFIEEAD CFDPQFFRIS PREAEMMDPQ ERLFLETCWE AIEDAGYTPE
510 520 530 540 550
TIASPQGENK RQHVGVFAGV MHKDYSLIGA EALSEHNPFP LSLNYAQIAN
560 570 580 590 600
RVSYYCNFHG PSMAVDTVCS SSLTAVHLAI ESIRNGECEA ALAGGVNLSL
610 620 630 640 650
HPAKYISYGS VGMHSSDGYC HTFGKGGDGY VSGEGVGTVL LKPLRKAEQD
660 670 680 690 700
GDRIYAVIKG SAINHVGKVS GITVPSPVAQ ADVIEACLEK TGIDPRTISY
710 720 730 740 750
VEAHGTGTSL GDPIEVQGLV KAFSRNTQDK QFCSIGSVKS NIGHAEAAAG
760 770 780 790 800
ISGLTKTVLQ LHHKTLVPSL HSEELNPYLK LDQTPFFVQH ETKEWEQPSF
810 820 830 840 850
TENGVDVTYP RRAGLSSFGA SGSNAHLILE EYIPAESHSE TILTKNEEIV
860 870 880 890 900
IPLSARNKDR LQAYALKLLD FLSEDVNLLA LAYTMQAGRV EMEERAAFIV
910 920 930 940 950
KDIKDLTAKL RAFANGEEEI EGCWTGRAKE NQEAAGLASV NALNNNLIRD
960 970 980 990 1000
SEMMEMAKAW VQGKRVTWDD LYGDRKPLKI SVPTYPFARE RYWISVPEMK
1010 1020 1030 1040 1050
TSTVNHILHP LVHRNTSDFT EQRFSSVFTG TEFFLSDHVV QGQKILPGVA
1060 1070 1080 1090 1100
YLEMAREAAE KAAGDLDGEQ RVVSLKDIVW VRPITIESEP KEIHIGLFPE
1110 1120 1130 1140 1150
DNGDISFDIY SSSEHKEEAL TIHCQGRAVI SDEAETSILN LSSIQTECSL
1160 1170 1180 1190 1200
DTVTSEQCYA AFRKIGLDYG EGYQGIEKVY VGKDQLLAKI SLPAFLKNDK
1210 1220 1230 1240 1250
QHFALHPSLM DSAFHATVGF IVSSVNAAGQ AQTLSLPFAL QEVDIFSPCP
1260 1270 1280 1290 1300
EKIWSYIRYS SDSKAENKVR KYDIDLCDEN GRVCVRMKGA SMRALDGEQH
1310 1320 1330 1340 1350
SKPQLLTDSQ LTGHTVMIPV WEPVSLEAED NASFAGKRAV LCGAAEADRT
1360 1370 1380 1390 1400
FIKHHYPQIS FVDIRPADDI EAIADKLQAY GSIDHVLWIA PSHRGSIGSD
1410 1420 1430 1440 1450
GQEEAVLHLF KLVKACLQLG YGEKQLEWSL VTVQAQPVTQ HEAVQPAHAS
1460 1470 1480 1490 1500
IHGLAGTMAK EYPHWKIRLL DLEKGCTWPV NHMFALPADR LGHAWAYRNQ
1510 1520 1530 1540 1550
QWHQQQLIPY RSSLSGDTLY RKGGVYVVIG GAGYIGEAWS EYMIRRYQAQ
1560 1570 1580 1590 1600
IVWIGRSQLN AAIQSKIDRL SALGPEPFYI AADAADKHSL QQAYEQVKKR
1610 1620 1630 1640 1650
HPHIHGIVHS AMVLFEQSLE KMKPEEFTAG LAAKIDVSIR MAQVFRQENV
1660 1670 1680 1690 1700
DFVLFFSSLV AHIKNVKQSH YASGCTFADA FAHQLSQSWA CPVKVMNWGY
1710 1720 1730 1740 1750
WGNSEAAEDE HYVQLMNQIG LGLIEPAEAM KALEALLSGP VSQTAFIHTT
1760 1770 1780 1790 1800
KPVAVEGVNQ NEFITLYPEQ PSADAESLME RLPTTGRFQR VTHEELDDLL
1810 1820 1830 1840 1850
YRLLLGQLQT AELFDGYTLS VERLQQYKTR EFYGKWIRQS SEFLLQHGYL
1860 1870 1880 1890 1900
KKVGDSLVRK DQAEDIELLW LEWNAKKEKW LKDSETKAMV VLAEAMLQAL
1910 1920 1930 1940 1950
PDILTGKVPA TDIMFPHSSM ELVEGIYKHN QVADYFNKVL ADTLLAYLDE
1960 1970 1980 1990 2000
RLKHDPEASI RIMEIGAGTG GTSAGIFEKL KPYQKHINEY CYTDLSKAFL
2010 2020 2030 2040 2050
LHAEKEYGAE NPYLTYQLFD VEKPIDQQEF EAGGYDVVIA ANVLHATKNI
2060 2070 2080 2090 2100
RQTLRHTKAV MKNNGMLLLN EMAGNSLFPH ITFGLLEGWW LYEDPAVRIP
2110 2120 2130 2140 2150
GCPGLHPDSW KAALESEGFE SVFFPAEAAH DLSHQIVAAS SNGLVRRMMK
2160 2170 2180 2190 2200
NVILPEKVVS QASNQEPAYI HTIDSEEAGQ SKHALLREKS TEYMKKLIGE
2210 2220 2230 2240 2250
TLKIPAGKIE SSEPLEKYGI DSIVVVQLTN TLRKEFDHVS STLFFEYQTI
2260 2270 2280 2290 2300
DALVEHFIKT KTEALMKLTG LDRQVQQHTP AESRTQSSQK PDQAAKRTRR
2310 2320 2330 2340 2350
FRKLGFSGEK ETPTNTLASR DVAVIGISGR YPQAETAEDF WNNLKEGRNC
2360 2370 2380 2390 2400
IEEIPKDRWD WKAYYDKEKG KEGSIYTKWG GFIKDMDKFD PLFFQISPLE
2410 2420 2430 2440 2450
AERMDPQERL FLQTAYASIE DAGYTPDSLC SSRKIGVFAG VMNKNYPTGY
2460 2470 2480 2490 2500
GYWSIANRIS YLLNFQGPSL AVDTACSSSL TAIHLALESI YSGSSDCAIA
2510 2520 2530 2540 2550
GGVNLVVDPV HYQNLSVMNM LSASDTCKSF GDDADGFVDG EGVGAIVLKP
2560 2570 2580 2590 2600
LQQAIADGDH IYGVIKASAI NSGGKTNGYT VPNPHAQAQV IKEAIERADI
2610 2620 2630 2640 2650
PARTISYLEA HGTGTALGDP IEIAGLTKAF EKDTQEKQFC AIGSSKSNIG
2660 2670 2680 2690 2700
HCESAAGIAG LTKILFQFKY GQIAPSLHAQ RLNPNIEFSH TPFVVQQQLG
2710 2720 2730 2740 2750
EWKRPVIGGQ EVPRRAGLSS FGAGGSNAHI ILEEYIPRTG AQTPKDHPPA
2760 2770 2780 2790 2800
LIVLSAKNME RLQEKAEQLL TAIKQKRYCE TDLIRIAYTL QTGREAMEER
2810 2820 2830 2840 2850
LAFIAESLED LERKLNDFIE NKADSLYLDR IDDNKKALAV LSADEDTEKI
2860 2870 2880 2890 2900
IEAWMSKGKY TKLLDLWVKG LSFDWGMLYG TQTPVRISLP AYPFAKERYW
2910 2920 2930 2940 2950
APGAAKAPVS IEQDHDQQTE EPFKVMTFQE VWKEEPATLT SKRIKTLICF
2960 2970 2980 2990 3000
LTEREKQNAF ASALKNVDQD TKVIFISQGE VYSKQSEYSY QIVRQEPVTF
3010 3020 3030 3040 3050
EKAFQSIKEE LGEPDAILYM WPMEDKRCIK DHSCIVYLLQ GMSAAKLHPS
3060 3070 3080 3090 3100
RLLLAGCFED SLDRSYLESW IGFERSLGLV LPHTKVTGIF QPAEQGSMDD
3110 3120 3130 3140 3150
WTRKVWAELQ ASTEQTVLYQ NLKRYVNHIE QTTIQPDNSK LKSGGTYLIT
3160 3170 3180 3190 3200
GGVGGLGYLF AKHLAKNYAA NLILTGRSPF NDEKQKQIKE LKDLGGEAMY
3210 3220 3230 3240 3250
AEADVSDPIA MGDCVKRGKD RFGAINGVIH AAGIESDSAI FDKKIESFQR
3260 3270 3280 3290 3300
IIEPKINGTI ALDEWLKNED LDFMCYFSSS SAVLGDFGCC DYAIGNRFQM
3310 3320 3330 3340 3350
AYAQYRNELH NGKTFVINWP VWKDGGMKIG DEETTDMYLK SSGQRFLEAE
3360 3370 3380 3390 3400
EGIRMFEHIL AQQDAQHLVI AGQPSRVSRF LGMTEPAIPE PATQAPLAQE
3410 3420 3430 3440 3450
NKDEVKTLSI EKRLEHDLKE HIHTLLKISK DKLNLNKNWA DFGFDSIYLA
3460 3470 3480 3490 3500
KFSNVLSKHF NIEVTPALFF GYSTLQELIS FFLTDHKELI EAFYRDDASE
3510 3520 3530 3540 3550
AQKPPEAYAV IPVALEPEAS KKSIRQVHDE PIAIIGMSGR FPQADSVHEL
3560 3570 3580 3590 3600
WDNLKNGKSC ISDIPGERRD WGRANRDPEK AVPRWGAFLK DIDRFDPLFF
3610 3620 3630 3640 3650
QISPKEAESM DPRQRIFLEE AWHTFEDAGY MGDRIKGKSC GVYVGVEEGE
3660 3670 3680 3690 3700
YAHLTGDTDY INGTQNATLS ARIAYALDLK GPNMALTAAC SSGLVAIHQA
3710 3720 3730 3740 3750
CSALRQGDCE MALAGGVSLN ISHMSFEALT RAEMLSPNGQ CKVFDQDANG
3760 3770 3780 3790 3800
LVPGEAVAAV LLKPLSKAIE DKDHIYGCIK ASGVNYDGKT NGITAPNPFS
3810 3820 3830 3840 3850
QAELIENIYE KNEINPLDIQ YVMAHSTGSN LGDPLEVQAL TSVFSKYTKQ
3860 3870 3880 3890 3900
KQFCMISSIK PLIGHTFAAS GTVALISMLM AMKNQIIPAT HHCESENPYI
3910 3920 3930 3940 3950
PFKESPFVLC KENRSWIKKN QKPRMGTIST TGISGTNAHA VIEEYIPDDQ
3960 3970 3980 3990 4000
PSTQRHQGSP QIFVISAQND DRLQDAACRM IAYLEQNHNL SLPDVAYTLQ
4010 4020 4030 4040 4050
VGRKAMEARL AIVANNQEQL VRKLKEYVEA MKNGGVSGQQ RSLYTGYTEG
4060 4070 4080 4090 4100
ILEEQDEAVL QALAKERNLE NIAECWVKGY QIPWELLHDG DDVRMVSLPG
4110 4120 4130 4140 4150
YPFARERYWI SSGTQQSEAV KQHSQDMKTE IDEPNGKTHI QKIIVQFLAR
4160 4170 4180 4190 4200
ELGISEDRIN FKRNFLDYGM DSILGRKLMR HIEKTTQLKM AGREILECQT
4210 4220 4230 4240 4250
VQALSDHLAL KAEKQNHSAA AHHIKGTYTD EQIIGLMQEV ALGKLDFKSV
4260
QNIIEGSKSY ES
Length:4,262
Mass (Da):475,621
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EC71F5C6358145F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78K → E in CAA84505 (Ref. 4) Curated1
Sequence conflicti703 – 715AHGTG…GDPIE → PMALAPHWEIRLK in CAA84505 (Ref. 4) CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13603.3
Z35133 Genomic DNA Translation: CAA84505.1

Protein sequence database of the Protein Information Resource

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PIRi
C69679

NCBI Reference Sequences

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RefSeqi
NP_389601.3, NC_000964.3
WP_003245093.1, NZ_JNCM01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
CAB13603; CAB13603; BSU_17200

Database of genes from NCBI RefSeq genomes

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GeneIDi
940026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bsu:BSU17200

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|224308.179.peg.1865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13603.3
Z35133 Genomic DNA Translation: CAA84505.1
PIRiC69679
RefSeqiNP_389601.3, NC_000964.3
WP_003245093.1, NZ_JNCM01000035.1

3D structure databases

SMRiP40872
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU17200

Proteomic databases

PaxDbiP40872
PRIDEiP40872

Genome annotation databases

EnsemblBacteriaiCAB13603; CAB13603; BSU_17200
GeneIDi940026
KEGGibsu:BSU17200
PATRICifig|224308.179.peg.1865

Phylogenomic databases

eggNOGiCOG0236, Bacteria
COG0451, Bacteria
COG1020, Bacteria
COG1028, Bacteria
COG3321, Bacteria
InParanoidiP40872
OMAiMHKDYSL

Enzyme and pathway databases

UniPathwayiUPA01003
BioCyciBSUB:BSU17200-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.10.129.110, 2 hits
3.40.47.10, 3 hits
InterProiView protein in InterPro
IPR036736, ACP-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS
PfamiView protein in Pfam
PF16197, KAsynt_C_assoc, 3 hits
PF00109, ketoacyl-synt, 3 hits
PF02801, Ketoacyl-synt_C, 3 hits
PF08659, KR, 2 hits
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 4 hits
PF14765, PS-DH, 2 hits
SMARTiView protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 3 hits
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 3 hits
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 3 hits
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 2 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS00098, THIOLASE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKSM_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40872
Secondary accession number(s): O31781
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 28, 2009
Last modified: September 29, 2021
This is version 149 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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