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Entry version 145 (13 Feb 2019)
Sequence version 1 (01 Feb 1995)
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Protein

SIT4-associating protein SAP185

Gene

SAP185

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression.

Miscellaneous

Present with 11200 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • tRNA wobble uridine modification Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31553-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SIT4-associating protein SAP185
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAP185
Ordered Locus Names:YJL098W
ORF Names:J0840
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YJL098W

Saccharomyces Genome Database

More...
SGDi
S000003634 SAP185

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000461061 – 1058SIT4-associating protein SAP185Add BLAST1058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hyperphosphorylated in the absence of SIT4.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40856

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P40856

PRoteomics IDEntifications database

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PRIDEi
P40856

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40856

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIT4P206049EBI-16384,EBI-13707

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33659, 191 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1865 SIT4-SAP185 phosphatase complex

Database of interacting proteins

More...
DIPi
DIP-5851N

Protein interaction database and analysis system

More...
IntActi
P40856, 83 interactors

Molecular INTeraction database

More...
MINTi
P40856

STRING: functional protein association networks

More...
STRINGi
4932.YJL098W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P40856

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000248046

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40856

KEGG Orthology (KO)

More...
KOi
K15458

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQVESAN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007587 SAPS

The PANTHER Classification System

More...
PANTHERi
PTHR12634 PTHR12634, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04499 SAPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSFWKFGQ DFGSQSPLAK LLNRAFIKID DKPTSTEAGK IDSNSTDESL
60 70 80 90 100
ESNSFKSEDE EEEYELPNRE EDYKAYKPNL SLLNDLLDDE ELYTELMCSN
110 120 130 140 150
FKLLVYLKYP EVLSKLIDYV RNSTILESNI DRVTSEDRDL VRGEDKDTTE
160 170 180 190 200
DFENAKADKK NIDGTFEEKE RTRSGEEEEL ENEENDSASE DTRVTLPHEL
210 220 230 240 250
EEHDDTRRAR IAAEILSADV WPISSALIEN EGLLAKLWSI LRLPSPLSIE
260 270 280 290 300
ASTYFMKINE RLLDMNMDGI IEFILKKEHI VDDFLAHIDN PPLMDFLLKV
310 320 330 340 350
ISTDKPEISN GVIQLFKKQN LVPKLIHLLD PVFDSCTQSA AGDFLKALVT
360 370 380 390 400
ISGNCPNEIT SSIGPNELTR QLVSPNMMKQ LMDIMLKGGN SLNNGVGIII
410 420 430 440 450
ELIRKNNSDY DTIQTNYTTI ESHPPTDRDP IYLGYLVKMF SEHMADFNKI
460 470 480 490 500
LTEKKIPLLQ TSYGTIEPLG FERFKICELI AELLHCSNMT LLNEPSAYDI
510 520 530 540 550
VRERDAERER IFNSQNYVDS NDRSELKENE DDNTGDADDE VEDDTNQVES
560 570 580 590 600
ANTSIDGEEV IDKLNSLQIE TNKVNQNMNN EEQHSLMPDF NNGDFKDEED
610 620 630 640 650
ENPFEPQYSD VILDSSDIEK NFRVSPNVGD QLKISLQDTR VIDTMLEMFF
660 670 680 690 700
HFQWNNFLHN VVYDVVQQIF NGPLKIGYNR FLLDDLLINI RLTDMIINGN
710 720 730 740 750
NECIEYEKGH DTRLGYMGHL TLIAEEVTKF TAYIEEMNIT FENTEVMSSL
760 770 780 790 800
FESKWIAYTE DVLEDLKEKY NAILGDIAEE GDMLQDEEED AVYDKGERTM
810 820 830 840 850
GTVDDYINDI MQMDNVRCQE EEEDEGEGYV SFDEDEPQEY RNGDSVRSKE
860 870 880 890 900
SNSSEGKRDQ EQLYYEYVNE DGTKTRLNFN PDSDATEQVP GEVNRDHKIP
910 920 930 940 950
LKLKRSFTDA CKSETIPNNT VNAKEESVFQ FSNELSDGWE SSPSNSIPKR
960 970 980 990 1000
ASPSKNGMNS PMFQHQFELH SPTDEFGGHK DEILSAEGHD YDIDEYDELS
1010 1020 1030 1040 1050
DDSDEEYDNC EDEDSLDYAD SAAYALCRSK SKDKISWDEE EQARLMGVVK

FNSEHYRD
Length:1,058
Mass (Da):121,403
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD44DD53DDD87438
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77923 Genomic DNA Translation: CAA54892.1
X85021 Genomic DNA Translation: CAA59396.1
Z49373 Genomic DNA Translation: CAA89392.1
BK006943 Genomic DNA Translation: DAA08702.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50295

NCBI Reference Sequences

More...
RefSeqi
NP_012437.1, NM_001181531.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJL098W_mRNA; YJL098W_mRNA; YJL098W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853347

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJL098W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77923 Genomic DNA Translation: CAA54892.1
X85021 Genomic DNA Translation: CAA59396.1
Z49373 Genomic DNA Translation: CAA89392.1
BK006943 Genomic DNA Translation: DAA08702.1
PIRiS50295
RefSeqiNP_012437.1, NM_001181531.1

3D structure databases

ProteinModelPortaliP40856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33659, 191 interactors
ComplexPortaliCPX-1865 SIT4-SAP185 phosphatase complex
DIPiDIP-5851N
IntActiP40856, 83 interactors
MINTiP40856
STRINGi4932.YJL098W

PTM databases

iPTMnetiP40856

Proteomic databases

MaxQBiP40856
PaxDbiP40856
PRIDEiP40856

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL098W_mRNA; YJL098W_mRNA; YJL098W
GeneIDi853347
KEGGisce:YJL098W

Organism-specific databases

EuPathDBiFungiDB:YJL098W
SGDiS000003634 SAP185

Phylogenomic databases

GeneTreeiENSGT00390000009899
HOGENOMiHOG000248046
InParanoidiP40856
KOiK15458
OMAiNQVESAN

Enzyme and pathway databases

BioCyciYEAST:G3O-31553-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40856

Family and domain databases

InterProiView protein in InterPro
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSA185_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40856
Secondary accession number(s): D6VW86
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 13, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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