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Entry version 163 (03 Jul 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Protein MKT1

Gene

MKT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for propagation of M2 dsRNA satellite at temperature above 30 degrees Celsius if an L-A RNA virus carrying NEX (N) is present in the cells.

Miscellaneous

Present with 3430 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33114-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MKT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MKT1
Ordered Locus Names:YNL085W
ORF Names:N2302
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YNL085W

Saccharomyces Genome Database

More...
SGDi
S000005029 MKT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000964951 – 830Protein MKT1Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40850

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P40850

PRoteomics IDEntifications database

More...
PRIDEi
P40850

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40850

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PBP1P532973EBI-10983,EBI-12961

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35738, 320 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1295 MKT1-PBP1 translation regulation complex

Database of interacting proteins

More...
DIPi
DIP-6530N

Protein interaction database and analysis system

More...
IntActi
P40850, 30 interactors

Molecular INTeraction database

More...
MINTi
P40850

STRING: functional protein association networks

More...
STRINGi
4932.YNL085W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113598

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40850

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHYLNTG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09902 H3TH_MKT1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022039 MKT1_C
IPR037314 MKT1_H3TH
IPR022040 MKT1_N
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR006085 XPG_DNA_repair_N

The PANTHER Classification System

More...
PANTHERi
PTHR11081 PTHR11081, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12246 MKT1_C, 1 hit
PF12247 MKT1_N, 1 hit
PF00752 XPG_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88723 SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40850-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKSLESFL FERGLVGSYA IEALNNCTLD IDVNHYVSRL LTNKREQYLD
60 70 80 90 100
AIGGFPTSLK MYLESDLKIF KDFNITPIFV FNGGLTYNQL EASGHFTAAS
110 120 130 140 150
ASASISSTTT SSSGTNATTR SNTESVLLQR SRGWTQWNNL ISSNQNSYID
160 170 180 190 200
QPIQPQEPFR HNTTIDSKAY QNDLIAYFIE HGYMYQVAPY SSWFQLAYLL
210 220 230 240 250
NSAYIDAIYG PTDCLMLDCV DRFILGMEFP NKEFRFIDRS RVMKDLGCTH
260 270 280 290 300
EEFIDIAMAV GNDLQPTTLP PLQIYPVPQL FDIALEMVLN TGTNFYAYQL
310 320 330 340 350
STTLQNDSKE NIQNYQRGIS ALRYMPVLKD TGKVELFVQE IVVSEEDSEK
360 370 380 390 400
NNKDGKKSNL SSPSSASSSA SPATTVTKNA SEKLTYEKSS TKEVRKPRDI
410 420 430 440 450
PNDVHDFIGQ MLPHEYYFYR SIGLVTGKLF DAIVTGVYPE EPPLGGGSST
460 470 480 490 500
SYKKLVSKSV EIFKNKEINL LTQPINRYYQ IKQIKQVKWY AANEPTTLTN
510 520 530 540 550
RMSPSMFETI NHLIVKTETS DEKEFSISEF ITTINGSSNM AKDFISEKVI
560 570 580 590 600
FPNSVPIESK LNSPFNLLST NFLRLLVLLE FFTFDFKEKL LEPTRWGEVF
610 620 630 640 650
LKLNELNIDS KYHESVIIFL VFLKCDVLKL DEEVQPPAPS ALSQATLRSY
660 670 680 690 700
PEESLYVLLI TRVLTLFQVD QKPSNYHGPI DKKTLIFRDH LSFIKENLNE
710 720 730 740 750
LFEAVLISSL TSGEFNRLSL DNFGWARKIV RYLPFKLDSP NTIMAMMWEF
760 770 780 790 800
FLQKYLHNGN AKNDALSLVA TEFNTYKSTP NLDEQFVESH RFLLEISKVM
810 820 830
QELNAAKLID ENVFKLFTKA VEFTTTALSS
Length:830
Mass (Da):94,495
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD976D8387E4F708
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti809 – 830IDENV…TALSS → TMKTCLNYH in AAC49470 (PubMed:7532890).CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti30D → G in strain: 2574, ATCC 24657 / D273-10B, ATCC 200060 / W303, Sigma 1278B, YJM 1129, YJM 270, YJM 627 and YJM 789. 1
Natural varianti453K → R in strain: ATCC 24657 / D273-10B, ATCC 200060 / W303, Sigma 1278B, YJM 1129, YJM 270, YJM 627 and YJM 789. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09129 Genomic DNA Translation: AAC49470.1
AF458969 Genomic DNA Translation: AAM00519.1
AF458975 Genomic DNA Translation: AAM00555.1
AF458977 Genomic DNA Translation: AAM00567.1
AF458978 Genomic DNA Translation: AAM00573.1
AF458980 Genomic DNA Translation: AAM00585.1
AF458981 Genomic DNA Translation: AAM00591.1
DQ116825 Genomic DNA Translation: AAZ23277.1
DQ116826 Genomic DNA Translation: AAZ23278.1
DQ116827 Genomic DNA Translation: AAZ23279.1
DQ116828 Genomic DNA Translation: AAZ23280.1
X89016 Genomic DNA Translation: CAA61425.1
Z71361 Genomic DNA Translation: CAA95961.1
Z71360 Genomic DNA Translation: CAA95960.1
BK006947 Genomic DNA Translation: DAA10460.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57537

NCBI Reference Sequences

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RefSeqi
NP_014314.3, NM_001182923.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL085W_mRNA; YNL085W_mRNA; YNL085W

Database of genes from NCBI RefSeq genomes

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GeneIDi
855639

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL085W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09129 Genomic DNA Translation: AAC49470.1
AF458969 Genomic DNA Translation: AAM00519.1
AF458975 Genomic DNA Translation: AAM00555.1
AF458977 Genomic DNA Translation: AAM00567.1
AF458978 Genomic DNA Translation: AAM00573.1
AF458980 Genomic DNA Translation: AAM00585.1
AF458981 Genomic DNA Translation: AAM00591.1
DQ116825 Genomic DNA Translation: AAZ23277.1
DQ116826 Genomic DNA Translation: AAZ23278.1
DQ116827 Genomic DNA Translation: AAZ23279.1
DQ116828 Genomic DNA Translation: AAZ23280.1
X89016 Genomic DNA Translation: CAA61425.1
Z71361 Genomic DNA Translation: CAA95961.1
Z71360 Genomic DNA Translation: CAA95960.1
BK006947 Genomic DNA Translation: DAA10460.1
PIRiS57537
RefSeqiNP_014314.3, NM_001182923.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi35738, 320 interactors
ComplexPortaliCPX-1295 MKT1-PBP1 translation regulation complex
DIPiDIP-6530N
IntActiP40850, 30 interactors
MINTiP40850
STRINGi4932.YNL085W

PTM databases

iPTMnetiP40850

Proteomic databases

MaxQBiP40850
PaxDbiP40850
PRIDEiP40850

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL085W_mRNA; YNL085W_mRNA; YNL085W
GeneIDi855639
KEGGisce:YNL085W

Organism-specific databases

EuPathDBiFungiDB:YNL085W
SGDiS000005029 MKT1

Phylogenomic databases

HOGENOMiHOG000113598
InParanoidiP40850
OMAiFHYLNTG

Enzyme and pathway databases

BioCyciYEAST:G3O-33114-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40850

Family and domain databases

CDDicd09902 H3TH_MKT1, 1 hit
InterProiView protein in InterPro
IPR022039 MKT1_C
IPR037314 MKT1_H3TH
IPR022040 MKT1_N
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR006085 XPG_DNA_repair_N
PANTHERiPTHR11081 PTHR11081, 1 hit
PfamiView protein in Pfam
PF12246 MKT1_C, 1 hit
PF12247 MKT1_N, 1 hit
PF00752 XPG_N, 1 hit
SMARTiView protein in SMART
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMKT1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40850
Secondary accession number(s): D6W194, Q45T81, Q8TF89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: July 3, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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